NO118548B - - Google Patents

Download PDF

Info

Publication number
NO118548B
NO118548B NO155188A NO15518864A NO118548B NO 118548 B NO118548 B NO 118548B NO 155188 A NO155188 A NO 155188A NO 15518864 A NO15518864 A NO 15518864A NO 118548 B NO118548 B NO 118548B
Authority
NO
Norway
Prior art keywords
benzenesulfonyl
ethyl
urea
melting point
benzamido
Prior art date
Application number
NO155188A
Other languages
English (en)
Norwegian (no)
Inventor
K Muth
F Schmidt
H Weber
W Aumueller
R Weyer
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Priority to NO16030465A priority Critical patent/NO118553B/no
Priority to NO16030265A priority patent/NO118551B/no
Priority to NO16030165A priority patent/NO118550B/no
Priority to NO16030765A priority patent/NO118556B/no
Priority to NO16030365A priority patent/NO118552B/no
Priority to NO16030665A priority patent/NO118555B/no
Priority to NO16030565A priority patent/NO118554B/no
Publication of NO118548B publication Critical patent/NO118548B/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/52—Y being a hetero atom
    • C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
    • C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/59—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/22—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO155188A 1963-10-19 1964-10-17 NO118548B (is")

Priority Applications (7)

Application Number Priority Date Filing Date Title
NO16030465A NO118553B (is") 1963-10-19 1965-11-02
NO16030265A NO118551B (is") 1963-10-19 1965-11-02
NO16030165A NO118550B (is") 1963-10-19 1965-11-02
NO16030765A NO118556B (is") 1963-10-19 1965-11-02
NO16030365A NO118552B (is") 1963-10-19 1965-11-02
NO16030665A NO118555B (is") 1963-10-19 1965-11-02
NO16030565A NO118554B (is") 1963-10-19 1965-11-02

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DEF41042A DE1185180B (de) 1963-10-19 1963-10-19 Verfahren zur Herstellung von Benzolsulfonylharnstoffen
DEF0042062 1964-02-20
DEF0042933 1964-05-21
DEF0043268 1964-06-26

Publications (1)

Publication Number Publication Date
NO118548B true NO118548B (is") 1970-01-12

Family

ID=27436911

Family Applications (1)

Application Number Title Priority Date Filing Date
NO155188A NO118548B (is") 1963-10-19 1964-10-17

Country Status (21)

Country Link
US (2) US3426067A (is")
AT (5) AT267541B (is")
BE (1) BE654561A (is")
CH (1) CH529115A (is")
CY (1) CY436A (is")
DE (1) DE1185180B (is")
DK (7) DK119052B (is")
ES (1) ES312472A1 (is")
FI (1) FI44597B (is")
FR (2) FR1473834A (is")
GB (1) GB1080705A (is")
IL (1) IL22259A (is")
IS (1) IS765B6 (is")
IT (1) IT1061504B (is")
LU (1) LU47099A1 (is")
MC (1) MC488A1 (is")
MY (1) MY6800113A (is")
NL (1) NL6412137A (is")
NO (1) NO118548B (is")
OA (1) OA01367A (is")
SE (8) SE311151B (is")

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1185180B (de) * 1963-10-19 1965-01-14 Hoechst Ag Verfahren zur Herstellung von Benzolsulfonylharnstoffen
DE1493672C3 (de) * 1964-08-01 1974-05-02 Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt Verfahren zur Herstellung von Benzolsulfonylharnstoffen
DE1443905C3 (de) * 1964-10-30 1979-03-15 Hoechst Ag, 6000 Frankfurt benzolsulfonyl] -N'-cyclohexylharnstoff, Verfahren zu seiner Herstellung und seine Verwendung
DE1518816C3 (de) * 1965-03-24 1975-05-22 Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt Benzolsulfonylharnstoffe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
US4066639A (en) * 1965-05-06 1978-01-03 Hoechst Aktiengesellschaft Benzene-sulfonyl semicarbazides and process for preparing them
DE1518895C3 (de) * 1965-12-02 1978-12-07 Hoechst Ag, 6000 Frankfurt Benzolsulfonylharnstoffe, Verfahren zu ihrer Herstellung und deren Verwendung
US3454635A (en) * 1965-07-27 1969-07-08 Hoechst Ag Benzenesulfonyl-ureas and process for their manufacture
DE1244174C2 (de) * 1965-09-10 1968-01-18 Hoechst Ag Verfahren zur Herstellung von Benzolsulfonylharnstoffen
US3932503A (en) * 1966-05-28 1976-01-13 Hoechst Aktiengesellschaft Benzenesulfonyl ureas
US3932658A (en) * 1969-02-25 1976-01-13 Hoechst Aktiengesellschaft Composition and method for lower blood sugar containing N-[4-(β-<2-methoxy-5-chloro-benzamido>-ethyl)-benzenesulfonyl]-N'-cyclopentyl-urea
NL138933B (nl) * 1969-03-26 1973-05-15 Erba Carlo Spa Werkwijze voor het bereiden van benzeensulfonylureumderivaten met bloedsuikerspiegelverlagende werking.
BE754454A (fr) * 1969-08-06 1971-02-05 Bayer Ag Nouveaux composes hypoglycemiques du type d'arylsulfonylurees et d'arylsulfonylsemicarbazides contenant des groupes carbonamide
US3957866A (en) * 1970-09-23 1976-05-18 J. Uriach & Cia S.A. Cyclopentyl carbamide derivative and process for its production
ES384463A1 (es) * 1970-09-23 1973-10-01 Uriach & Cia Sa J Procedimiento para la obtencion de n-4 - (beta-o-anisamido etil) - bencenosulfonil - n'ciclopentilcarbamida.
US4072758A (en) * 1970-09-23 1978-02-07 J. Uriach Y Cia, S.A. Compositions and methods for effecting glucoreduction
BE791638A (fr) * 1971-11-20 1973-05-21 Hoechst Ag Sulfonyl-urees, leur procede de preparation et leurs applications
DE2230543A1 (de) * 1972-06-22 1974-01-17 Hoechst Ag Benzolsulfonylharnstoffe und verfahren zu ihrer herstellung
US4067998A (en) * 1974-02-11 1978-01-10 The Dow Chemical Company 2-((3,5-Di-tert-butylphenyl)thio) alkanoic acids and derivatives
DE2413514C3 (de) * 1974-03-21 1982-03-04 Hoechst Ag, 6000 Frankfurt N-Acylaminoathylbenzolsulfonyl-N'-methylharnstoffe, Verfahren zu ihrer Herstellung und deren Verwendung
AU528362B2 (en) * 1978-06-22 1983-04-28 Societe D:Etudes De Produits Chimiques Phenoxy isobutyramides
DE3211934A1 (de) * 1982-03-31 1983-10-13 Hoechst Ag, 6230 Frankfurt Salicylsaeurederivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung
US4916163A (en) * 1985-06-04 1990-04-10 The Upjohn Company Spray-dried lactose formulation of micronized glyburide
EP0612724B1 (de) * 1993-02-23 1996-12-27 Hoechst Aktiengesellschaft Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe- Verfahren zu ihrer Herstellung und ihre Verwendung als Pharmazeutika
HU226462B1 (en) * 1995-02-17 2008-12-29 Hoechst Ag Substituted benzol-sulfonyl-ureas and -thioureas, process for producing them, pharmaceutical compositions containing them, and their use
CN1195524C (zh) 1998-09-10 2005-04-06 阿文蒂斯药物德国有限公司 苯磺酰(硫)脲与β－受体阻滞剂联合在制备用于心脏迷走神经机能障碍治疗和预防的药物中的用途
DE19923086A1 (de) 1999-05-20 2000-11-23 Aventis Pharma Gmbh Cinnamoylaminoalkyl-substituierte Benzolsulfonamidderivate, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
US20010036479A1 (en) 2000-01-14 2001-11-01 Gillian Cave Glyburide composition
DE10054482A1 (de) 2000-11-03 2002-05-08 Aventis Pharma Gmbh Heteroarylacryloylaminoalkyl-substituierte Benzolsulfonamidderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE10054481A1 (de) 2000-11-03 2002-05-08 Aventis Pharma Gmbh Acylaminoalkyl-substituierte Benzolsulfonamidderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
AU2003224917A1 (en) * 2002-04-11 2003-10-27 Carbomer Diabetes imaging probes
US20060201981A1 (en) * 2003-06-30 2006-09-14 Meyer Dean E Clip support member for golf bag
EP1836169B9 (en) * 2004-12-28 2012-07-04 Kinex Pharmaceuticals, LLC Compositions and methods of treating cell proliferation disorders
EP1899294B1 (en) * 2005-06-13 2015-03-18 Merck Sharp & Dohme Limited Therapeutic agents
US8883852B2 (en) 2008-10-22 2014-11-11 University of Pittburgh—Of the Commonwealth System of Higher Education Radioprotective agents
WO2012079164A1 (en) * 2010-12-16 2012-06-21 The Governing Council Of The University Of Toronto Activators of cylindrical proteases
US11840543B2 (en) 2017-05-24 2023-12-12 The University Of Queensland Compounds and uses
CN112979571B (zh) * 2021-02-24 2023-01-31 中国药科大学 一类akr1c3选择性抑制剂及其制备方法与用途
US20250263367A1 (en) * 2021-05-17 2025-08-21 The United States of America, as represented by the Secretary, Department of Health and Human Serice A facile and odor-free approach to convert sulfonyl urea derivatives to chalcogenide sulfonyl urea derivatives
WO2025097000A1 (en) 2023-11-01 2025-05-08 Yale University Antibody-based methods for treating polycystic kidney disease

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL218580A (is") * 1960-04-28
DE1185180B (de) * 1963-10-19 1965-01-14 Hoechst Ag Verfahren zur Herstellung von Benzolsulfonylharnstoffen

Also Published As

Publication number Publication date
AT267541B (de) 1969-01-10
ES312472A1 (es) 1967-04-01
SE334621B (is") 1971-05-03
DE1443890B2 (de) 1973-02-01
AT262309B (de) 1968-06-10
BE654561A (is") 1965-04-20
DE1443878A1 (de) 1968-12-12
SE334606B (is") 1971-05-03
DE1443894A1 (de) 1969-04-24
IS1424A7 (is) 1964-10-16
DE1443878B2 (de) 1973-02-01
CY436A (en) 1968-03-22
MC488A1 (fr) 1965-06-04
FR1473834A (fr) 1967-03-24
DK119052B (da) 1970-11-09
IS765B6 (is) 1970-12-01
DK120588B (da) 1971-06-21
CH529115A (de) 1972-10-15
NL6412137A (is") 1965-04-20
FR4316M (is") 1966-08-01
DE1443890A1 (de) 1969-02-20
AT261627B (de) 1968-05-10
FI44597B (is") 1971-08-31
SE334607B (is") 1971-05-03
IL22259A (en) 1969-05-28
SE334608B (is") 1971-05-03
DE1185180B (de) 1965-01-14
DK119455B (da) 1971-01-11
OA01367A (fr) 1969-07-04
AT262308B (de) 1968-06-10
GB1080705A (en) 1967-08-23
SE334605B (is") 1971-05-03
US3507961A (en) 1970-04-21
DK120741B (da) 1971-07-12
DK119105B (da) 1970-11-16
IT1061504B (it) 1983-04-11
DK120534B (da) 1971-06-14
AT278027B (de) 1970-01-26
LU47099A1 (is") 1966-04-07
SE334603B (is") 1971-05-03
SE334604B (is") 1971-05-03
US3426067A (en) 1969-02-04
MY6800113A (en) 1968-12-31
DK120742B (da) 1971-07-12
SE311151B (is") 1969-06-02

Similar Documents

Publication Publication Date Title
NO118548B (is")
NO155188B (no) Bevegelig fottrinn for et kjoeretoey.
NO159136B (no) Truseinnlegg.
NO159166B (no) Analogifremgangsmaate for fremstilling av farmakologisk aktive benzoazepinderivater.
IE50635B1 (en) Sulfonyl ureas,process for their manufacture,pharmaceutical formulations containing them and their use
CA2543602A1 (en) Triazole compounds and uses related thereto
NO159754B (no) Fremgangsmaate for bestemmelse av karsinoembryonalt antigen (cea).
NO145805B (no) Tannhjulsdrev.
NO160305B (no) Elektrode som omfatter en elektrokatalysator.
NO151837B (no) Anordning ved fagverk for bruk under bygging av bygninger og andre konstruksjoner
NO163432B (no) Fremgangsmaate for fremstilling av frisk ost.
JP2010504940A (ja) スルホンアミド誘導体
US3860619A (en) Sulphonylurea derivatives
JPH0952876A (ja) ４−スルホニル−または４−スルフィニルベンゾイルグアニジン誘導体
UA44237C2 (uk) Арилбензоїлгуанідини, спосіб їх отримання, фармацевтична композиція
NO159998B (no) Analogifremgangsmaate ved fremstilling av et nytt terapeutisk aktivtsulfonamidderivat.
NO163506B (no) Montering av senkbar tildekning ved lysarmatur.
NO171182B (no) Vandig geldannende blanding egnet for selektiv permeabilitetsmodifikasjon av underjordiske lag ved hydrokarbonutvinning
US3449346A (en) Benzenesulfonyl ureas
NO117362B (is")
US3546234A (en) Benzene-sulfonyl-semicarbazides
NO165846B (no) Vinylkloridmateriale, samt fremgangsmaate for fremstillingav et slikt.
NO122920B (is")
NO122923B (is")
US3709908A (en) Benzenesulfonyl ureas having hypoglycemic activity