NL8502310A - Analgetisch werkzame 1,2-benzisothiazol-3-ylpiperazine derivaten. - Google Patents
Analgetisch werkzame 1,2-benzisothiazol-3-ylpiperazine derivaten. Download PDFInfo
- Publication number
- NL8502310A NL8502310A NL8502310A NL8502310A NL8502310A NL 8502310 A NL8502310 A NL 8502310A NL 8502310 A NL8502310 A NL 8502310A NL 8502310 A NL8502310 A NL 8502310A NL 8502310 A NL8502310 A NL 8502310A
- Authority
- NL
- Netherlands
- Prior art keywords
- benzisothiazole
- piperazinyl
- compound
- hydrogen
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US64361484 | 1984-08-23 | ||
US06/643,614 US4590196A (en) | 1984-08-23 | 1984-08-23 | Analgesic 1,2-benzisothiazol-3-ylpiperazine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
NL8502310A true NL8502310A (nl) | 1986-03-17 |
Family
ID=24581577
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NL8502310A NL8502310A (nl) | 1984-08-23 | 1985-08-22 | Analgetisch werkzame 1,2-benzisothiazol-3-ylpiperazine derivaten. |
Country Status (22)
Country | Link |
---|---|
US (1) | US4590196A (ko) |
JP (1) | JPS61112063A (ko) |
KR (1) | KR920008820B1 (ko) |
AT (1) | AT396685B (ko) |
AU (1) | AU586182B2 (ko) |
BE (1) | BE903106A (ko) |
CA (1) | CA1249587A (ko) |
CH (1) | CH667268A5 (ko) |
DE (1) | DE3530089A1 (ko) |
DK (1) | DK381485A (ko) |
ES (1) | ES8704485A1 (ko) |
FI (1) | FI82039C (ko) |
FR (1) | FR2569404B1 (ko) |
GB (1) | GB2163432B (ko) |
GR (1) | GR852017B (ko) |
IE (1) | IE58608B1 (ko) |
IT (1) | IT1187730B (ko) |
LU (1) | LU86051A1 (ko) |
NL (1) | NL8502310A (ko) |
PT (1) | PT81007B (ko) |
SE (1) | SE464304B (ko) |
ZA (1) | ZA856387B (ko) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0625181B2 (ja) * | 1985-03-27 | 1994-04-06 | 住友製薬株式会社 | 新規なイミド誘導体 |
US4999356A (en) * | 1987-08-07 | 1991-03-12 | Hoechst-Roussel Pharmaceuticals, Inc. | 1-phenyl-3-(1-piperazinyl)-1H-indazoles |
US4880930A (en) * | 1987-11-30 | 1989-11-14 | New James S | Psychotropic acyclic amide derivatives |
US5015740A (en) * | 1988-08-05 | 1991-05-14 | Janssen Pharmaceutica N.V. | Antipsychotic 3-piperazinylbenzazole derivatives |
NZ230045A (en) | 1988-08-05 | 1990-11-27 | Janssen Pharmaceutica Nv | 3-piperazinylbenzazole derivatives and pharmaceutical compositions |
US4957916A (en) * | 1988-08-05 | 1990-09-18 | Janssen Pharmaceutica N.V. | Antipsychotic 3-piperazinylbenzazole derivatives |
WO1990002552A1 (en) * | 1988-09-16 | 1990-03-22 | Pfizer Inc. | Antipsychotic 4-[4-(3-benzisothiazolyl)-1-piperazinyl]butyl bridged bicyclic imides |
GB8911158D0 (en) * | 1989-05-16 | 1989-07-05 | Janssen Pharmaceutica Nv | Antiviral pyridazinamines |
NZ233525A (en) * | 1989-05-15 | 1991-09-25 | Janssen Pharmaceutica Nv | Piperidinyl, pyrrolidinyl and piperazinyl alkylphenol ethers and pharmaceutical compositions |
US5070090A (en) * | 1989-05-15 | 1991-12-03 | Janssen Pharmaceutica N.V. | Antipicorpaviral herterocyclic-substituted morpholinyl alkylphenol ethers |
US5364866A (en) * | 1989-05-19 | 1994-11-15 | Hoechst-Roussel Pharmaceuticals, Inc. | Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics |
US5776963A (en) * | 1989-05-19 | 1998-07-07 | Hoechst Marion Roussel, Inc. | 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility |
DE69021645T2 (de) * | 1989-05-19 | 1996-02-22 | Hoechst Roussel Pharma | N-(aryloxyalkyl)heteroarylpiperidine und -heteroarylpiperazine, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikamente. |
US5561128A (en) * | 1989-05-19 | 1996-10-01 | Hoechst-Roussel Pharmaceuticals, Inc. | N-[(4-(heteroaryl)-1-piperidinyl)alkyl]-10,11-dihydro-5H-dibenz[B,F]azepines and related compounds and their therapeutic utility |
US4956368A (en) * | 1989-07-24 | 1990-09-11 | Bristol-Myers Company | Metabolites and prodrug formulations of 8-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione |
US4954503A (en) * | 1989-09-11 | 1990-09-04 | Hoechst-Roussel Pharmaceuticals, Inc. | 3-(1-substituted-4-piperazinyl)-1H-indazoles |
FR2671350A1 (fr) * | 1991-01-08 | 1992-07-10 | Adir | Nouveaux derives de benzisoxazole et de benzisothiazole, leur procede de preparation, et les compositions pharmaceutiques les renfermant. |
JP2800953B2 (ja) * | 1990-07-06 | 1998-09-21 | 住友製薬株式会社 | 新規なイミド誘導体 |
US5328920A (en) * | 1991-04-17 | 1994-07-12 | Hoechst-Roussel Pharmaceuticals Incorporated | Substituted (pyridinylamino)-indoles |
CA2149918A1 (en) * | 1992-11-23 | 1994-06-09 | Mark G. Palermo | Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds |
EP0767790B1 (en) * | 1994-06-20 | 2001-12-12 | Takeda Chemical Industries, Ltd. | Condensed imidazole compounds, their production and use |
JPH08157460A (ja) * | 1994-12-08 | 1996-06-18 | Sumitomo Seika Chem Co Ltd | イソチアゾール誘導体の製造方法 |
JP3701044B2 (ja) * | 1995-04-24 | 2005-09-28 | 住友精化株式会社 | シアノベンゼンスルフェニルハライドおよびそれを用いる3−置換ベンゾイソチアゾールの製造方法 |
ATE199147T1 (de) * | 1995-06-06 | 2001-02-15 | Aventis Pharma Inc | Benzisoxazol- und indazol- derivate als antipsychotika |
EP0874834B1 (en) * | 1995-11-07 | 2000-12-13 | Pfizer Inc. | Processes and intermediates for preparing 3-(1-piperazinyl)-1,2-benzisothiazole |
JP3996228B2 (ja) * | 1996-10-11 | 2007-10-24 | 住友精化株式会社 | 3−ピペラジニルベンズイソチアゾール類の製造法 |
DE19651038A1 (de) * | 1996-12-09 | 1998-06-10 | Bayer Ag | Verfahren zur Herstellung von 3-Chlorbenzisothiazolen |
US7030142B1 (en) | 1999-04-06 | 2006-04-18 | Sepracor Inc. | Methods for the treatment of neuroleptic and related disorders using ziprasidone metabolites |
JP2002541098A (ja) * | 1999-04-06 | 2002-12-03 | セプラコア インコーポレーテッド | ジプラシドン代謝産物を用いる神経弛緩薬性障害および関連障害を治療するための方法および組成物 |
US20050049295A1 (en) * | 2003-06-12 | 2005-03-03 | Dr. Reddy's Laboratories Limited | Process for the preparation of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1piperazinyl) ethyl)-6-chloro-1, 3-dihydro-2h-indol-2-one hydrochloride (ziprasidone hydrochloride) and its intermediate |
US7776847B2 (en) * | 2005-02-25 | 2010-08-17 | Rigel Pharmaceuticals, Inc. | Benzisothiazoles useful for treating or preventing HCV infection |
CN100387583C (zh) * | 2006-05-19 | 2008-05-14 | 浙江工业大学 | 一种3-氯-1,2-苯并异噻唑类化合物的合成方法 |
CN102040563B (zh) * | 2009-10-16 | 2014-04-16 | 上海开拓者化学研究管理有限公司 | 一种3-芳基苯并[d]异噻唑的制备方法 |
CN102040564B (zh) * | 2009-10-16 | 2012-11-21 | 上海开拓者化学研究管理有限公司 | 一种3-胺基苯并[d]异噻唑的制备方法 |
WO2011125423A1 (ja) | 2010-04-02 | 2011-10-13 | 住友精化株式会社 | 3-ハロ-1,2-ベンゾイソチアゾール類の製造方法 |
WO2013014665A1 (en) | 2011-07-28 | 2013-01-31 | Mapi Pharma Ltd. | Intermediate compounds and process for the preparation of lurasidone and salts thereof |
CN103204823B (zh) * | 2013-03-18 | 2015-07-15 | 寿光新泰精细化工有限公司 | 一种1,2-苯并异噻唑-3-酮的提纯方法 |
CN105037293A (zh) * | 2015-06-04 | 2015-11-11 | 大丰跃龙化学有限公司 | 一种bit生产中固废再利用工艺 |
TWI704145B (zh) * | 2015-06-05 | 2020-09-11 | 芬蘭商奧利安公司 | 新醫藥化合物 |
CN106543107B (zh) * | 2016-11-04 | 2019-02-01 | 山东铂源药业有限公司 | 一种1-boc-哌嗪的合成方法 |
CN108794424A (zh) * | 2018-07-16 | 2018-11-13 | 连云港市三联化工有限公司 | 一种bit的溶剂精制方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1670907B2 (de) * | 1967-08-16 | 1976-07-22 | Bayer Ag, 5090 Leverkusen | N-disubstituierte 3-amino-1,2benzisothiazole und verfahren in ihrer herstellung |
US4112105A (en) * | 1977-05-04 | 1978-09-05 | Sterling Drug Inc. | Anti-inflammatory 3-(substituted-amino)-2,1-benzisothiazoles |
US4104388A (en) * | 1977-05-23 | 1978-08-01 | E. R. Squibb & Sons, Inc. | 3-Substituted benzisothiazole, 1,1-dioxides |
US4396770A (en) * | 1982-04-09 | 1983-08-02 | Hoechst-Roussel Pharmaceuticals Inc. | 1-[3-(6-Fluoro-1,2-benzisoxazol-3-yl)propyl]-4-hydroxy-4-phenylpiperidines |
JPS5815965A (ja) * | 1981-07-23 | 1983-01-29 | Nippon Tokushu Noyaku Seizo Kk | ベンゾイソチアゾ−ル誘導体並びにその塩酸塩、その製法、及び農業用殺菌剤 |
US4355037A (en) * | 1981-11-12 | 1982-10-19 | Hoechst-Roussel Pharmaceuticals | 3-(4-Piperidyl)-1,2-benzisoxales |
US4411901A (en) * | 1981-12-23 | 1983-10-25 | Mead Johnson & Company | Benzisothiazole and benzisoxazole piperazine derivatives |
US4452799A (en) * | 1981-12-23 | 1984-06-05 | Mead Johnson & Company | Benzisothiazole and benzisoxazole piperazine derivatives |
US4524206A (en) * | 1983-09-12 | 1985-06-18 | Mead Johnson & Company | 1-Heteroaryl-4-(2,5-pyrrolidinedion-1-yl)alkyl)piperazine derivatives |
-
1984
- 1984-08-23 US US06/643,614 patent/US4590196A/en not_active Expired - Fee Related
-
1985
- 1985-08-16 CA CA000488887A patent/CA1249587A/en not_active Expired
- 1985-08-20 GR GR852017A patent/GR852017B/el unknown
- 1985-08-20 FI FI853193A patent/FI82039C/fi not_active IP Right Cessation
- 1985-08-22 DK DK381485A patent/DK381485A/da not_active Application Discontinuation
- 1985-08-22 CH CH3606/85A patent/CH667268A5/de not_active IP Right Cessation
- 1985-08-22 NL NL8502310A patent/NL8502310A/nl not_active Application Discontinuation
- 1985-08-22 DE DE19853530089 patent/DE3530089A1/de not_active Ceased
- 1985-08-22 IT IT21968/85A patent/IT1187730B/it active
- 1985-08-22 JP JP60185015A patent/JPS61112063A/ja active Pending
- 1985-08-22 ES ES546347A patent/ES8704485A1/es not_active Expired
- 1985-08-22 KR KR1019850006060A patent/KR920008820B1/ko not_active IP Right Cessation
- 1985-08-22 IE IE206785A patent/IE58608B1/en not_active IP Right Cessation
- 1985-08-22 GB GB08521050A patent/GB2163432B/en not_active Expired
- 1985-08-22 BE BE0/215496A patent/BE903106A/fr not_active IP Right Cessation
- 1985-08-22 AU AU46533/85A patent/AU586182B2/en not_active Ceased
- 1985-08-22 SE SE8503922A patent/SE464304B/sv not_active IP Right Cessation
- 1985-08-22 PT PT81007A patent/PT81007B/pt not_active IP Right Cessation
- 1985-08-22 FR FR8512635A patent/FR2569404B1/fr not_active Expired
- 1985-08-22 LU LU86051A patent/LU86051A1/fr unknown
- 1985-08-22 ZA ZA856387A patent/ZA856387B/xx unknown
- 1985-08-23 AT AT0246985A patent/AT396685B/de not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NL8502310A (nl) | Analgetisch werkzame 1,2-benzisothiazol-3-ylpiperazine derivaten. | |
KR0130976B1 (ko) | 3-[4-(1-치환된-4-피페라지닐)부틸]-4-티아졸리디논, 이의 제조방법 및 이를 포함하는 약제학적 조성물 | |
US4613600A (en) | Antidepressant 1,2,4-triazolone compounds | |
EP0433149B1 (fr) | Antagonistes de la sérotonine, leur préparation et les médicaments les contenant | |
HU214032B (en) | Process for producing benzoisothiazole and benzoisoxazole-3-carboxamide derivatives and pharmaceutical compositions comprising such compounds as active ingredient | |
EP0243018B1 (en) | Thiolactam-n-acetic acid derivatives, their production and use | |
DK148688B (da) | Analogifremgangsmaade til fremstilling af basisk substituerede 7-alkylteofyllinderivater eller salte deraf med farmaceutisk acceptable syrer | |
CA1245650A (en) | Processes for preparing novel benzothiazine derivatives | |
FR2675801A1 (fr) | Piperidines, leur preparation et les medicaments les contenant. | |
FR2628425A1 (fr) | Derives d'isoindolinone, leurs procedes de preparation et les medicaments les contenant | |
HU207731B (en) | Process for producing aryl-piperazinyl-alkylene-phenyl-p-heterocyclic compounds, pharmaceutically acceptable acid additional salts and pharmaceutical compositions containing them as active components | |
EP0511073A1 (fr) | Antisérotonines, leur préparation et les médicaments les contenant | |
HU199124B (en) | Process for producing benzazepine sulfonamides and antiarrhythmic agents comprising these compounds | |
WO1994003425A2 (en) | Carbostyril derivatives for the treatment of arrhythmia | |
US6187769B1 (en) | Benzoxazepine derivatives and their salts and medicaments containing the same | |
US5773437A (en) | Alkylenediamine derivatives | |
EP0579169B1 (en) | Alkylenediamine derivatives | |
RO113465B1 (ro) | Derivati alchilici ai trazodonei, procedeu pentru prepararea acestora si intermediari de sinteza | |
EP0409692A2 (fr) | Dérivés d'imino-2 hétérocyclylalkyl-3 benzothiazoline, leur préparation et les médicaments les contenant | |
JPS63275572A (ja) | 1,5−ベンゾチアゼピン誘導体 | |
HU194193B (en) | Process for preparing new 4-/amino-methylidene/-3-aryl-5/4h/-isoxazolinone derivatives and pharmaceutical compositions containing such compounds as active ingredients | |
JPS6326753B2 (ko) | ||
JPS63253079A (ja) | チアジアゾ−ル誘導体及びその製造法 | |
FR2578842A1 (fr) | Nouveaux derives de la pyrrolo(1,2-a) azepinone, leur preparation et les compositions pharmaceutiques qui les contiennent | |
JPS6345270A (ja) | 1,4−ベンゾオキサジン誘導体,その製造法およびそれを含有する医薬用組成物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
DNT | Communications of changes of names of applicants whose applications have been laid open to public inspection |
Free format text: BRISTOL-MYERS SQUIBB COMPANY |
|
BA | A request for search or an international-type search has been filed | ||
BB | A search report has been drawn up | ||
BC | A request for examination has been filed | ||
BV | The patent application has lapsed |