BE903106A - 1,2-benzisothiazol-3-ylpiperazines analgesiques - Google Patents

1,2-benzisothiazol-3-ylpiperazines analgesiques

Info

Publication number
BE903106A
BE903106A BE0/215496A BE215496A BE903106A BE 903106 A BE903106 A BE 903106A BE 0/215496 A BE0/215496 A BE 0/215496A BE 215496 A BE215496 A BE 215496A BE 903106 A BE903106 A BE 903106A
Authority
BE
Belgium
Prior art keywords
analgesics
ylpiperazines
benzisothiazol
hydrogen atom
radical
Prior art date
Application number
BE0/215496A
Other languages
English (en)
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of BE903106A publication Critical patent/BE903106A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Analgésiques non opiacés de formule I où R1 représente un atome d'hydrogène ou radical alcoyle aralcoyle, ou aryloxyalcoyle, R2 représente un radical alcoyle ou atome d'hydrogène et R3 et R4 sont choisis indépendamment parmi les atomes d'hydrogène et radicaux alcoyle, acyloxy, alcoxy, alcoylthio, halogéno, hydroxyle et trifluorométhyle, et leurs sels d'addition d'acides pharmaceutiquement acceptables.
BE0/215496A 1984-08-23 1985-08-22 1,2-benzisothiazol-3-ylpiperazines analgesiques BE903106A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/643,614 US4590196A (en) 1984-08-23 1984-08-23 Analgesic 1,2-benzisothiazol-3-ylpiperazine derivatives

Publications (1)

Publication Number Publication Date
BE903106A true BE903106A (fr) 1986-02-24

Family

ID=24581577

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/215496A BE903106A (fr) 1984-08-23 1985-08-22 1,2-benzisothiazol-3-ylpiperazines analgesiques

Country Status (22)

Country Link
US (1) US4590196A (fr)
JP (1) JPS61112063A (fr)
KR (1) KR920008820B1 (fr)
AT (1) AT396685B (fr)
AU (1) AU586182B2 (fr)
BE (1) BE903106A (fr)
CA (1) CA1249587A (fr)
CH (1) CH667268A5 (fr)
DE (1) DE3530089A1 (fr)
DK (1) DK381485A (fr)
ES (1) ES8704485A1 (fr)
FI (1) FI82039C (fr)
FR (1) FR2569404B1 (fr)
GB (1) GB2163432B (fr)
GR (1) GR852017B (fr)
IE (1) IE58608B1 (fr)
IT (1) IT1187730B (fr)
LU (1) LU86051A1 (fr)
NL (1) NL8502310A (fr)
PT (1) PT81007B (fr)
SE (1) SE464304B (fr)
ZA (1) ZA856387B (fr)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0625181B2 (ja) * 1985-03-27 1994-04-06 住友製薬株式会社 新規なイミド誘導体
US4999356A (en) * 1987-08-07 1991-03-12 Hoechst-Roussel Pharmaceuticals, Inc. 1-phenyl-3-(1-piperazinyl)-1H-indazoles
US4880930A (en) * 1987-11-30 1989-11-14 New James S Psychotropic acyclic amide derivatives
US5015740A (en) * 1988-08-05 1991-05-14 Janssen Pharmaceutica N.V. Antipsychotic 3-piperazinylbenzazole derivatives
NZ230045A (en) 1988-08-05 1990-11-27 Janssen Pharmaceutica Nv 3-piperazinylbenzazole derivatives and pharmaceutical compositions
US4957916A (en) * 1988-08-05 1990-09-18 Janssen Pharmaceutica N.V. Antipsychotic 3-piperazinylbenzazole derivatives
US5077295A (en) * 1988-09-16 1991-12-31 Pfizer Inc. Antipsychoic 4-(4-(3-benzisothiazolyl)-1-piperazinyl)buytl bridged bicycle imides
NZ233525A (en) * 1989-05-15 1991-09-25 Janssen Pharmaceutica Nv Piperidinyl, pyrrolidinyl and piperazinyl alkylphenol ethers and pharmaceutical compositions
US5070090A (en) * 1989-05-15 1991-12-03 Janssen Pharmaceutica N.V. Antipicorpaviral herterocyclic-substituted morpholinyl alkylphenol ethers
GB8911158D0 (en) * 1989-05-16 1989-07-05 Janssen Pharmaceutica Nv Antiviral pyridazinamines
US5776963A (en) * 1989-05-19 1998-07-07 Hoechst Marion Roussel, Inc. 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility
US5364866A (en) * 1989-05-19 1994-11-15 Hoechst-Roussel Pharmaceuticals, Inc. Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics
ES2076253T3 (es) * 1989-05-19 1995-11-01 Hoechst Roussel Pharma N-(ariloxialquil)-heteroarilpiperidinas y -heteroarilpiperazinas, un procedimiento para su preparacion y su uso como medicamentos.
US5561128A (en) * 1989-05-19 1996-10-01 Hoechst-Roussel Pharmaceuticals, Inc. N-[(4-(heteroaryl)-1-piperidinyl)alkyl]-10,11-dihydro-5H-dibenz[B,F]azepines and related compounds and their therapeutic utility
US4956368A (en) * 1989-07-24 1990-09-11 Bristol-Myers Company Metabolites and prodrug formulations of 8-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione
US4954503A (en) * 1989-09-11 1990-09-04 Hoechst-Roussel Pharmaceuticals, Inc. 3-(1-substituted-4-piperazinyl)-1H-indazoles
FR2671350A1 (fr) * 1991-01-08 1992-07-10 Adir Nouveaux derives de benzisoxazole et de benzisothiazole, leur procede de preparation, et les compositions pharmaceutiques les renfermant.
JP2800953B2 (ja) * 1990-07-06 1998-09-21 住友製薬株式会社 新規なイミド誘導体
US5328920A (en) * 1991-04-17 1994-07-12 Hoechst-Roussel Pharmaceuticals Incorporated Substituted (pyridinylamino)-indoles
ES2187518T3 (es) * 1992-11-23 2003-06-16 Aventis Pharma Inc 3-(aminoalquilamino)-1-2-benzisoxazoles sustituidos y compuestos relacionados.
CN1046725C (zh) * 1994-06-20 1999-11-24 武田药品工业株式会社 稠合的咪唑化合物,它们的制备和应用
JPH08157460A (ja) * 1994-12-08 1996-06-18 Sumitomo Seika Chem Co Ltd イソチアゾール誘導体の製造方法
JP3701044B2 (ja) * 1995-04-24 2005-09-28 住友精化株式会社 シアノベンゼンスルフェニルハライドおよびそれを用いる３−置換ベンゾイソチアゾールの製造方法
DE69611783T2 (de) * 1995-06-06 2001-09-20 Aventis Pharma Inc Benzisoxazol- und indazol- derivate als antipsychotika
DK0874834T3 (da) * 1995-11-07 2001-02-19 Pfizer Fremgangsmåder og mellemprodukter til fremstilling af 3-(1-piperazinyl)-1,2-benzisothiazol
JP3996228B2 (ja) * 1996-10-11 2007-10-24 住友精化株式会社 ３−ピペラジニルベンズイソチアゾール類の製造法
DE19651038A1 (de) * 1996-12-09 1998-06-10 Bayer Ag Verfahren zur Herstellung von 3-Chlorbenzisothiazolen
CA2363942A1 (fr) * 1999-04-06 2000-10-12 Sepracor Inc. Methodes et compositions pour le traitement des troubles neuroleptiques et associes au moyen de metabolites de ziprasidone
US7030142B1 (en) 1999-04-06 2006-04-18 Sepracor Inc. Methods for the treatment of neuroleptic and related disorders using ziprasidone metabolites
US20050049295A1 (en) * 2003-06-12 2005-03-03 Dr. Reddy's Laboratories Limited Process for the preparation of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1piperazinyl) ethyl)-6-chloro-1, 3-dihydro-2h-indol-2-one hydrochloride (ziprasidone hydrochloride) and its intermediate
JP2008531596A (ja) * 2005-02-25 2008-08-14 ライジェル ファーマシューティカルズ， インコーポレイテッド Ｈｃｖ感染を治療または予防するのに有用なベンゾイソチアゾール
CN100387583C (zh) * 2006-05-19 2008-05-14 浙江工业大学 一种3-氯-1,2-苯并异噻唑类化合物的合成方法
CN102040563B (zh) * 2009-10-16 2014-04-16 上海开拓者化学研究管理有限公司 一种3-芳基苯并[d]异噻唑的制备方法
CN102040564B (zh) * 2009-10-16 2012-11-21 上海开拓者化学研究管理有限公司 一种3-胺基苯并[d]异噻唑的制备方法
CN102822153B (zh) 2010-04-02 2015-04-29 住友精化株式会社 3-卤代-1,2-苯并异噻唑类的制备方法
US8981095B2 (en) 2011-07-28 2015-03-17 Mapi Pharma Ltd. Intermediate compounds and process for the preparation of lurasidone and salts thereof
CN103204823B (zh) * 2013-03-18 2015-07-15 寿光新泰精细化工有限公司 一种1,2-苯并异噻唑-3-酮的提纯方法
CN105037293A (zh) * 2015-06-04 2015-11-11 大丰跃龙化学有限公司 一种bit生产中固废再利用工艺
TWI704145B (zh) * 2015-06-05 2020-09-11 芬蘭商奧利安公司 新醫藥化合物
CN106543107B (zh) * 2016-11-04 2019-02-01 山东铂源药业有限公司 一种1-boc-哌嗪的合成方法
CN108794424A (zh) * 2018-07-16 2018-11-13 连云港市三联化工有限公司 一种bit的溶剂精制方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670907B2 (de) * 1967-08-16 1976-07-22 Bayer Ag, 5090 Leverkusen N-disubstituierte 3-amino-1,2benzisothiazole und verfahren in ihrer herstellung
US4112105A (en) * 1977-05-04 1978-09-05 Sterling Drug Inc. Anti-inflammatory 3-(substituted-amino)-2,1-benzisothiazoles
US4104388A (en) * 1977-05-23 1978-08-01 E. R. Squibb & Sons, Inc. 3-Substituted benzisothiazole, 1,1-dioxides
US4396770A (en) * 1982-04-09 1983-08-02 Hoechst-Roussel Pharmaceuticals Inc. 1-[3-(6-Fluoro-1,2-benzisoxazol-3-yl)propyl]-4-hydroxy-4-phenylpiperidines
JPS5815965A (ja) * 1981-07-23 1983-01-29 Nippon Tokushu Noyaku Seizo Kk ベンゾイソチアゾ−ル誘導体並びにその塩酸塩、その製法、及び農業用殺菌剤
US4355037A (en) * 1981-11-12 1982-10-19 Hoechst-Roussel Pharmaceuticals 3-(4-Piperidyl)-1,2-benzisoxales
US4411901A (en) * 1981-12-23 1983-10-25 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4452799A (en) * 1981-12-23 1984-06-05 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4524206A (en) * 1983-09-12 1985-06-18 Mead Johnson & Company 1-Heteroaryl-4-(2,5-pyrrolidinedion-1-yl)alkyl)piperazine derivatives

Also Published As

Publication number Publication date
PT81007B (pt) 1987-12-30
ZA856387B (en) 1986-04-30
KR860001807A (ko) 1986-03-22
GB2163432B (en) 1988-06-22
FI82039B (fi) 1990-09-28
AU586182B2 (en) 1989-07-06
ES8704485A1 (es) 1987-04-01
JPS61112063A (ja) 1986-05-30
DK381485A (da) 1986-02-24
IT8521968A0 (it) 1985-08-22
FI853193A0 (fi) 1985-08-20
ATA246985A (de) 1993-03-15
FI853193L (fi) 1986-02-24
CA1249587A (fr) 1989-01-31
KR920008820B1 (ko) 1992-10-09
SE8503922D0 (sv) 1985-08-22
GB8521050D0 (en) 1985-09-25
FR2569404B1 (fr) 1988-07-01
DE3530089A1 (de) 1986-03-06
GB2163432A (en) 1986-02-26
FI82039C (fi) 1991-01-10
CH667268A5 (de) 1988-09-30
LU86051A1 (fr) 1986-02-28
AU4653385A (en) 1986-02-27
DK381485D0 (da) 1985-08-22
IT1187730B (it) 1987-12-23
GR852017B (fr) 1985-12-24
AT396685B (de) 1993-11-25
SE8503922L (sv) 1986-02-24
ES546347A0 (es) 1987-04-01
NL8502310A (nl) 1986-03-17
PT81007A (en) 1985-09-01
IE58608B1 (en) 1993-10-20
FR2569404A1 (fr) 1986-02-28
IE852067L (en) 1986-02-23
SE464304B (sv) 1991-04-08
US4590196A (en) 1986-05-20

Similar Documents

Publication Publication Date Title
BE903106A (fr) 1,2-benzisothiazol-3-ylpiperazines analgesiques
FR2592048A1 (fr) Inhibiteurs d'ureido-renine, a action therapeutique
FI87762C (fi) Fenylnaftalenderivat och kosmetiska kompositioner innehaollande dessa derivat
ES8604128A1 (es) Un procedimiento para la preparacion de nuevos derivados de bencenosulfonamida
TW375615B (en) Galanthamine derivatives and their use as medicaments
FR2506306A1 (fr) Nouveaux derives de l'amidinopiperidine, leur procede de preparation et leur application en therapeutique
FR2637183A1 (fr) Nouveaux inhibiteurs de la biosynthese du cholesterol et leur preparation
FR2391722A1 (fr) Perfectionnements a des composes exercant une action de froid physiologique sur le systeme nerveux du corps humain et compositions contenant ce
HUP9801881A2 (hu) Hidroximsavszármazékok, előállításuk és alkalmazásuk, a vegyületeket hatóanyagként tartalmazó kártevőirtó és gombairtó készítmények
HUP9900865A2 (hu) Vírusellenes hatású benzimidazolszármazékok, előállításuk és alkalmazásuk, a vegyületeket tartalmazó gyógyászati készítmények
TNSN86144A1 (fr) Procede pour la preparation de derives de la flavone
BE904641A (fr) 5-pyrimidine-carboxamides et traitement de la leucemie et des tumeurs avec ces derniers.
ATE48421T1 (de) Hustenstillende und schleimregulierende 2substituierte thiazole.
KR920021534A (ko) 류코트리엔 b_4길항 물질
ES8601850A1 (es) Un procedimiento para preparar derivados de ciclobutano
FR2659653B1 (fr) Derives de l'uree, leur preparation et les medicaments les contenant.
BE904983A (fr) Acides propenylaminothiazolylcephalosporaniques 3-substitues et leurs esters.
BE900607A (fr) Agents prophylactiques et medicaments anti-adhesifs contenant un derive de benzylamine ayant une action secretolytique.
EP0591030A3 (fr) 1-Hétéroaryl-azétidines et -pyrrolidines comme 5-HT3 agonistes
ATE32216T1 (de) Diphenylmethylimin-derivate.
GB2095672B (en) Morpholines
BE902150A (fr) Derives de la 1h, 7h-pyrazolo (1,5-a) pyrimidine-7-one et procede pour leur preparation.
BE905018A (fr) Nouveaux benzamides, leur procede de preparation et leur application dans le domaine therapeutique.
BE899918A (fr) Amides d'acides carboxyliques et leurs derives, leur preparation et leur application en therapeutique.
ES8703457A1 (es) Un procedimiento para la preparacion de nuevos derivados de tiacetona.

Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: BRISTOL-MYERS CY

Effective date: 19940831