SE8503922D0 - Analgesic 1,2-benzisothiazol-3-ylpiperazine derivatives - Google Patents

Analgesic 1,2-benzisothiazol-3-ylpiperazine derivatives

Info

Publication number
SE8503922D0
SE8503922D0 SE8503922A SE8503922A SE8503922D0 SE 8503922 D0 SE8503922 D0 SE 8503922D0 SE 8503922 A SE8503922 A SE 8503922A SE 8503922 A SE8503922 A SE 8503922A SE 8503922 D0 SE8503922 D0 SE 8503922D0
Authority
SE
Sweden
Prior art keywords
benzisothiazol
analgesic
alkyl
hydrogen
ylpiperazine
Prior art date
Application number
SE8503922A
Other languages
English (en)
Other versions
SE464304B (sv
SE8503922L (sv
Inventor
D W Smith
J P Yevich
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of SE8503922D0 publication Critical patent/SE8503922D0/sv
Publication of SE8503922L publication Critical patent/SE8503922L/sv
Publication of SE464304B publication Critical patent/SE464304B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SE8503922A 1984-08-23 1985-08-22 1,2-bensisotiazol-3-yl-piperazinderivat, farmaceutisk komposition daerav samt foerfarande foer framstaellning daerav SE464304B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/643,614 US4590196A (en) 1984-08-23 1984-08-23 Analgesic 1,2-benzisothiazol-3-ylpiperazine derivatives

Publications (3)

Publication Number Publication Date
SE8503922D0 true SE8503922D0 (sv) 1985-08-22
SE8503922L SE8503922L (sv) 1986-02-24
SE464304B SE464304B (sv) 1991-04-08

Family

ID=24581577

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8503922A SE464304B (sv) 1984-08-23 1985-08-22 1,2-bensisotiazol-3-yl-piperazinderivat, farmaceutisk komposition daerav samt foerfarande foer framstaellning daerav

Country Status (22)

Country Link
US (1) US4590196A (sv)
JP (1) JPS61112063A (sv)
KR (1) KR920008820B1 (sv)
AT (1) AT396685B (sv)
AU (1) AU586182B2 (sv)
BE (1) BE903106A (sv)
CA (1) CA1249587A (sv)
CH (1) CH667268A5 (sv)
DE (1) DE3530089A1 (sv)
DK (1) DK381485A (sv)
ES (1) ES8704485A1 (sv)
FI (1) FI82039C (sv)
FR (1) FR2569404B1 (sv)
GB (1) GB2163432B (sv)
GR (1) GR852017B (sv)
IE (1) IE58608B1 (sv)
IT (1) IT1187730B (sv)
LU (1) LU86051A1 (sv)
NL (1) NL8502310A (sv)
PT (1) PT81007B (sv)
SE (1) SE464304B (sv)
ZA (1) ZA856387B (sv)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0625181B2 (ja) * 1985-03-27 1994-04-06 住友製薬株式会社 新規なイミド誘導体
US4999356A (en) * 1987-08-07 1991-03-12 Hoechst-Roussel Pharmaceuticals, Inc. 1-phenyl-3-(1-piperazinyl)-1H-indazoles
US4880930A (en) * 1987-11-30 1989-11-14 New James S Psychotropic acyclic amide derivatives
US4957916A (en) * 1988-08-05 1990-09-18 Janssen Pharmaceutica N.V. Antipsychotic 3-piperazinylbenzazole derivatives
NZ230045A (en) 1988-08-05 1990-11-27 Janssen Pharmaceutica Nv 3-piperazinylbenzazole derivatives and pharmaceutical compositions
US5015740A (en) * 1988-08-05 1991-05-14 Janssen Pharmaceutica N.V. Antipsychotic 3-piperazinylbenzazole derivatives
HUT61760A (en) * 1988-09-16 1993-03-01 Pfizer Process for producing bridged, bicyclic imides comprising 4-/4-(3-benzisothiazolyl)-1-piperazinyl/-butyl group and pharmaceutical compositions comprising such compounds
NZ233525A (en) * 1989-05-15 1991-09-25 Janssen Pharmaceutica Nv Piperidinyl, pyrrolidinyl and piperazinyl alkylphenol ethers and pharmaceutical compositions
US5070090A (en) * 1989-05-15 1991-12-03 Janssen Pharmaceutica N.V. Antipicorpaviral herterocyclic-substituted morpholinyl alkylphenol ethers
GB8911158D0 (en) * 1989-05-16 1989-07-05 Janssen Pharmaceutica Nv Antiviral pyridazinamines
US5561128A (en) * 1989-05-19 1996-10-01 Hoechst-Roussel Pharmaceuticals, Inc. N-[(4-(heteroaryl)-1-piperidinyl)alkyl]-10,11-dihydro-5H-dibenz[B,F]azepines and related compounds and their therapeutic utility
US5776963A (en) * 1989-05-19 1998-07-07 Hoechst Marion Roussel, Inc. 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility
DE69021645T2 (de) * 1989-05-19 1996-02-22 Hoechst Roussel Pharma N-(aryloxyalkyl)heteroarylpiperidine und -heteroarylpiperazine, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikamente.
US5364866A (en) * 1989-05-19 1994-11-15 Hoechst-Roussel Pharmaceuticals, Inc. Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics
US4956368A (en) * 1989-07-24 1990-09-11 Bristol-Myers Company Metabolites and prodrug formulations of 8-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione
US4954503A (en) * 1989-09-11 1990-09-04 Hoechst-Roussel Pharmaceuticals, Inc. 3-(1-substituted-4-piperazinyl)-1H-indazoles
FR2671350A1 (fr) * 1991-01-08 1992-07-10 Adir Nouveaux derives de benzisoxazole et de benzisothiazole, leur procede de preparation, et les compositions pharmaceutiques les renfermant.
JP2800953B2 (ja) * 1990-07-06 1998-09-21 住友製薬株式会社 新規なイミド誘導体
US5328920A (en) * 1991-04-17 1994-07-12 Hoechst-Roussel Pharmaceuticals Incorporated Substituted (pyridinylamino)-indoles
NZ258747A (en) * 1992-11-23 1997-02-24 Hoechst Marion Roussel Inc Sub 3-heterocyclyalkylamino benzisoxazole derivatives; medicaments
CN1046725C (zh) * 1994-06-20 1999-11-24 武田药品工业株式会社 稠合的咪唑化合物,它们的制备和应用
JPH08157460A (ja) * 1994-12-08 1996-06-18 Sumitomo Seika Chem Co Ltd イソチアゾール誘導体の製造方法
JP3701044B2 (ja) * 1995-04-24 2005-09-28 住友精化株式会社 シアノベンゼンスルフェニルハライドおよびそれを用いる３−置換ベンゾイソチアゾールの製造方法
DK0833820T3 (da) * 1995-06-06 2001-04-17 Aventis Pharma Inc Benzisoxazol- og indazolderivater som antipsykotiske midler
DK0874834T3 (da) * 1995-11-07 2001-02-19 Pfizer Fremgangsmåder og mellemprodukter til fremstilling af 3-(1-piperazinyl)-1,2-benzisothiazol
JP3996228B2 (ja) * 1996-10-11 2007-10-24 住友精化株式会社 ３−ピペラジニルベンズイソチアゾール類の製造法
DE19651038A1 (de) * 1996-12-09 1998-06-10 Bayer Ag Verfahren zur Herstellung von 3-Chlorbenzisothiazolen
US7030142B1 (en) 1999-04-06 2006-04-18 Sepracor Inc. Methods for the treatment of neuroleptic and related disorders using ziprasidone metabolites
AU4062900A (en) * 1999-04-06 2000-10-23 Sepracor, Inc. Methods and compositions for the treatment of neuroleptic and related disorders using ziprasidone metabolites
US20050049295A1 (en) * 2003-06-12 2005-03-03 Dr. Reddy's Laboratories Limited Process for the preparation of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1piperazinyl) ethyl)-6-chloro-1, 3-dihydro-2h-indol-2-one hydrochloride (ziprasidone hydrochloride) and its intermediate
EP1853573A1 (en) * 2005-02-25 2007-11-14 Rigel Pharmaceuticals, Inc. Benzisothiazoles useful for treating or preventing hcv infection
CN100387583C (zh) * 2006-05-19 2008-05-14 浙江工业大学 一种3-氯-1,2-苯并异噻唑类化合物的合成方法
CN102040564B (zh) * 2009-10-16 2012-11-21 上海开拓者化学研究管理有限公司 一种3-胺基苯并[d]异噻唑的制备方法
CN102040563B (zh) * 2009-10-16 2014-04-16 上海开拓者化学研究管理有限公司 一种3-芳基苯并[d]异噻唑的制备方法
WO2011125423A1 (ja) 2010-04-02 2011-10-13 住友精化株式会社 ３－ハロ－１，２－ベンゾイソチアゾール類の製造方法
US8981095B2 (en) 2011-07-28 2015-03-17 Mapi Pharma Ltd. Intermediate compounds and process for the preparation of lurasidone and salts thereof
CN103204823B (zh) * 2013-03-18 2015-07-15 寿光新泰精细化工有限公司 一种1,2-苯并异噻唑-3-酮的提纯方法
CN105037293A (zh) * 2015-06-04 2015-11-11 大丰跃龙化学有限公司 一种bit生产中固废再利用工艺
TWI704145B (zh) * 2015-06-05 2020-09-11 芬蘭商奧利安公司 新醫藥化合物
CN106543107B (zh) * 2016-11-04 2019-02-01 山东铂源药业有限公司 一种1-boc-哌嗪的合成方法
CN108794424A (zh) * 2018-07-16 2018-11-13 连云港市三联化工有限公司 一种bit的溶剂精制方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670907B2 (de) * 1967-08-16 1976-07-22 Bayer Ag, 5090 Leverkusen N-disubstituierte 3-amino-1,2benzisothiazole und verfahren in ihrer herstellung
US4112105A (en) * 1977-05-04 1978-09-05 Sterling Drug Inc. Anti-inflammatory 3-(substituted-amino)-2,1-benzisothiazoles
US4104388A (en) * 1977-05-23 1978-08-01 E. R. Squibb & Sons, Inc. 3-Substituted benzisothiazole, 1,1-dioxides
US4396770A (en) * 1982-04-09 1983-08-02 Hoechst-Roussel Pharmaceuticals Inc. 1-[3-(6-Fluoro-1,2-benzisoxazol-3-yl)propyl]-4-hydroxy-4-phenylpiperidines
JPS5815965A (ja) * 1981-07-23 1983-01-29 Nippon Tokushu Noyaku Seizo Kk ベンゾイソチアゾ−ル誘導体並びにその塩酸塩、その製法、及び農業用殺菌剤
US4355037A (en) * 1981-11-12 1982-10-19 Hoechst-Roussel Pharmaceuticals 3-(4-Piperidyl)-1,2-benzisoxales
US4411901A (en) * 1981-12-23 1983-10-25 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4452799A (en) * 1981-12-23 1984-06-05 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4524206A (en) * 1983-09-12 1985-06-18 Mead Johnson & Company 1-Heteroaryl-4-(2,5-pyrrolidinedion-1-yl)alkyl)piperazine derivatives

Also Published As

Publication number Publication date
US4590196A (en) 1986-05-20
FR2569404A1 (fr) 1986-02-28
KR860001807A (ko) 1986-03-22
ES8704485A1 (es) 1987-04-01
NL8502310A (nl) 1986-03-17
FI853193A0 (fi) 1985-08-20
GB2163432B (en) 1988-06-22
GB8521050D0 (en) 1985-09-25
BE903106A (fr) 1986-02-24
FI853193L (fi) 1986-02-24
FR2569404B1 (fr) 1988-07-01
FI82039C (sv) 1991-01-10
PT81007A (en) 1985-09-01
GB2163432A (en) 1986-02-26
CH667268A5 (de) 1988-09-30
IT8521968A0 (it) 1985-08-22
FI82039B (fi) 1990-09-28
AU4653385A (en) 1986-02-27
ZA856387B (en) 1986-04-30
SE464304B (sv) 1991-04-08
IE852067L (en) 1986-02-23
IE58608B1 (en) 1993-10-20
AU586182B2 (en) 1989-07-06
DK381485D0 (da) 1985-08-22
DE3530089A1 (de) 1986-03-06
JPS61112063A (ja) 1986-05-30
ATA246985A (de) 1993-03-15
LU86051A1 (fr) 1986-02-28
AT396685B (de) 1993-11-25
IT1187730B (it) 1987-12-23
ES546347A0 (es) 1987-04-01
KR920008820B1 (ko) 1992-10-09
CA1249587A (en) 1989-01-31
SE8503922L (sv) 1986-02-24
GR852017B (sv) 1985-12-24
PT81007B (pt) 1987-12-30
DK381485A (da) 1986-02-24

Similar Documents

Publication Publication Date Title
SE8503922D0 (sv) Analgesic 1,2-benzisothiazol-3-ylpiperazine derivatives
FI870219A0 (fi) Hypoglykemiska tiazolidindioner.
ES2045109T3 (es) 1-fenil-3-naftaleniloxipropanaminas.
FI792005A (fi) 2-(2-alkoxietyl)-2'-hydroxi-6,7-benzomorfaner deras syraadditionssalter dessa innehaollande laekemedel och foerfarande foer deras framstaellning
DE3572170D1 (de) Quinolonecarboxylic acid derivatives
KR890011596A (ko) 불면증 치료용 의약품의 제조에 있어서 1,4-이치환-피페리디닐 화합물의 용도
DE3360904D1 (de) A fungicidal indanylbenzamide
ES2068413T3 (es) Derivados de 4-fenilftalazina.
ES8800571A1 (es) Procedimiento para preparar un derivado de 1,3-oxazolidina-2-ona.
NO890440L (no) Fremgangsmaate for fremstilling av terapeutisk aktive isokinolinderivater.
DK67384A (da) N-iminopyridiniumbetainderivater
KR880007494A (ko) 5-아릴-3h-1,2,4-트리아졸-3-온 및 진경제로서의 그들의 용도
FR2666741B1 (fr) Composition therapeutique pour inhiber l'agregation plaquettaire.
ES8707939A1 (es) Procedimiento para preparar derivados de n-carboxialquil-2--oxo-3-diaril-5,6-triazinas
DE3782229D1 (de) Verwendung von 2-oxo-imidazolidin-derivaten zur behandlung von nierenkrankheiten.
PT73996A (fr) Thiovinyl-3 cephalosporines
JPS5430191A (en) 2-(1-piperazinylmethyl)-5-phenyloxazoles and their pharmaceutically permissi ble acid addition salt
DK74594A (da) Fremgangsmåde til fremstilling af paroxetin eller et farmaceutisk acceptabelt salt deraf

Legal Events

Date Code Title Description
NAL Patent in force

Ref document number: 8503922-0

Format of ref document f/p: F

NUG Patent has lapsed

Ref document number: 8503922-0

Format of ref document f/p: F