ES546347A0 - Un procedimiento para la preparacion de derivados de piperazina 1,4-disustituidos. - Google Patents

Un procedimiento para la preparacion de derivados de piperazina 1,4-disustituidos.

Info

Publication number
ES546347A0
ES546347A0 ES546347A ES546347A ES546347A0 ES 546347 A0 ES546347 A0 ES 546347A0 ES 546347 A ES546347 A ES 546347A ES 546347 A ES546347 A ES 546347A ES 546347 A0 ES546347 A0 ES 546347A0
Authority
ES
Spain
Prior art keywords
disstituted
procedure
preparation
piperazine derivatives
piperazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES546347A
Other languages
English (en)
Other versions
ES8704485A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ES546347A0 publication Critical patent/ES546347A0/es
Publication of ES8704485A1 publication Critical patent/ES8704485A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ES546347A 1984-08-23 1985-08-22 Un procedimiento para la preparacion de derivados de piperazina 1,4-disustituidos. Expired ES8704485A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/643,614 US4590196A (en) 1984-08-23 1984-08-23 Analgesic 1,2-benzisothiazol-3-ylpiperazine derivatives

Publications (2)

Publication Number Publication Date
ES546347A0 true ES546347A0 (es) 1987-04-01
ES8704485A1 ES8704485A1 (es) 1987-04-01

Family

ID=24581577

Family Applications (1)

Application Number Title Priority Date Filing Date
ES546347A Expired ES8704485A1 (es) 1984-08-23 1985-08-22 Un procedimiento para la preparacion de derivados de piperazina 1,4-disustituidos.

Country Status (22)

Country Link
US (1) US4590196A (es)
JP (1) JPS61112063A (es)
KR (1) KR920008820B1 (es)
AT (1) AT396685B (es)
AU (1) AU586182B2 (es)
BE (1) BE903106A (es)
CA (1) CA1249587A (es)
CH (1) CH667268A5 (es)
DE (1) DE3530089A1 (es)
DK (1) DK381485A (es)
ES (1) ES8704485A1 (es)
FI (1) FI82039C (es)
FR (1) FR2569404B1 (es)
GB (1) GB2163432B (es)
GR (1) GR852017B (es)
IE (1) IE58608B1 (es)
IT (1) IT1187730B (es)
LU (1) LU86051A1 (es)
NL (1) NL8502310A (es)
PT (1) PT81007B (es)
SE (1) SE464304B (es)
ZA (1) ZA856387B (es)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0625181B2 (ja) * 1985-03-27 1994-04-06 住友製薬株式会社 新規なイミド誘導体
US4999356A (en) * 1987-08-07 1991-03-12 Hoechst-Roussel Pharmaceuticals, Inc. 1-phenyl-3-(1-piperazinyl)-1H-indazoles
US4880930A (en) * 1987-11-30 1989-11-14 New James S Psychotropic acyclic amide derivatives
US4957916A (en) * 1988-08-05 1990-09-18 Janssen Pharmaceutica N.V. Antipsychotic 3-piperazinylbenzazole derivatives
US5015740A (en) * 1988-08-05 1991-05-14 Janssen Pharmaceutica N.V. Antipsychotic 3-piperazinylbenzazole derivatives
NZ230045A (en) 1988-08-05 1990-11-27 Janssen Pharmaceutica Nv 3-piperazinylbenzazole derivatives and pharmaceutical compositions
US5077295A (en) * 1988-09-16 1991-12-31 Pfizer Inc. Antipsychoic 4-(4-(3-benzisothiazolyl)-1-piperazinyl)buytl bridged bicycle imides
US5070090A (en) * 1989-05-15 1991-12-03 Janssen Pharmaceutica N.V. Antipicorpaviral herterocyclic-substituted morpholinyl alkylphenol ethers
GB8911158D0 (en) * 1989-05-16 1989-07-05 Janssen Pharmaceutica Nv Antiviral pyridazinamines
NZ233525A (en) * 1989-05-15 1991-09-25 Janssen Pharmaceutica Nv Piperidinyl, pyrrolidinyl and piperazinyl alkylphenol ethers and pharmaceutical compositions
DE69021645T2 (de) * 1989-05-19 1996-02-22 Hoechst-Roussel Pharmaceuticals Inc., Somerville, N.J. N-(aryloxyalkyl)heteroarylpiperidine und -heteroarylpiperazine, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikamente.
US5561128A (en) * 1989-05-19 1996-10-01 Hoechst-Roussel Pharmaceuticals, Inc. N-[(4-(heteroaryl)-1-piperidinyl)alkyl]-10,11-dihydro-5H-dibenz[B,F]azepines and related compounds and their therapeutic utility
US5364866A (en) * 1989-05-19 1994-11-15 Hoechst-Roussel Pharmaceuticals, Inc. Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics
US5776963A (en) * 1989-05-19 1998-07-07 Hoechst Marion Roussel, Inc. 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility
US4956368A (en) * 1989-07-24 1990-09-11 Bristol-Myers Company Metabolites and prodrug formulations of 8-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione
US4954503A (en) * 1989-09-11 1990-09-04 Hoechst-Roussel Pharmaceuticals, Inc. 3-(1-substituted-4-piperazinyl)-1H-indazoles
FR2671350A1 (fr) * 1991-01-08 1992-07-10 Adir Nouveaux derives de benzisoxazole et de benzisothiazole, leur procede de preparation, et les compositions pharmaceutiques les renfermant.
JP2800953B2 (ja) * 1990-07-06 1998-09-21 住友製薬株式会社 新規なイミド誘導体
US5328920A (en) * 1991-04-17 1994-07-12 Hoechst-Roussel Pharmaceuticals Incorporated Substituted (pyridinylamino)-indoles
DE69332691T2 (de) * 1992-11-23 2003-12-18 Aventis Pharmaceuticals Inc., Cincinnati Substituierte 3-(aminoalkylamino)-1,2-benzisoxazole und verwandte verbindungen
DE69524598T2 (de) * 1994-06-20 2002-07-11 Takeda Chemical Industries, Ltd. Kondensierte imidazolderivate, ihre herstellung und verwendung
JPH08157460A (ja) * 1994-12-08 1996-06-18 Sumitomo Seika Chem Co Ltd イソチアゾール誘導体の製造方法
JP3701044B2 (ja) * 1995-04-24 2005-09-28 住友精化株式会社 シアノベンゼンスルフェニルハライドおよびそれを用いる３−置換ベンゾイソチアゾールの製造方法
ES2157442T3 (es) * 1995-06-06 2001-08-16 Aventis Pharma Inc Derivados de benzoisoxazol y de indazol, utilizados como agentes neurolepticos.
HU225921B1 (en) * 1995-11-07 2008-01-28 Pfizer Process and intermediates for preparing 3-(1-piperazinyl)-1,2-benzisothiazole
JP3996228B2 (ja) * 1996-10-11 2007-10-24 住友精化株式会社 ３−ピペラジニルベンズイソチアゾール類の製造法
DE19651038A1 (de) * 1996-12-09 1998-06-10 Bayer Ag Verfahren zur Herstellung von 3-Chlorbenzisothiazolen
AU4062900A (en) * 1999-04-06 2000-10-23 Sepracor, Inc. Methods and compositions for the treatment of neuroleptic and related disorders using ziprasidone metabolites
US7030142B1 (en) 1999-04-06 2006-04-18 Sepracor Inc. Methods for the treatment of neuroleptic and related disorders using ziprasidone metabolites
US20050049295A1 (en) * 2003-06-12 2005-03-03 Dr. Reddy's Laboratories Limited Process for the preparation of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1piperazinyl) ethyl)-6-chloro-1, 3-dihydro-2h-indol-2-one hydrochloride (ziprasidone hydrochloride) and its intermediate
WO2006091858A1 (en) * 2005-02-25 2006-08-31 Rigel Pharmaceuticals, Inc. Benzisothiazoles useful for treating or preventing hcv infection
CN100387583C (zh) * 2006-05-19 2008-05-14 浙江工业大学 一种3-氯-1,2-苯并异噻唑类化合物的合成方法
CN102040563B (zh) * 2009-10-16 2014-04-16 上海开拓者化学研究管理有限公司 一种3-芳基苯并[d]异噻唑的制备方法
CN102040564B (zh) * 2009-10-16 2012-11-21 上海开拓者化学研究管理有限公司 一种3-胺基苯并[d]异噻唑的制备方法
US8664404B2 (en) 2010-04-02 2014-03-04 Sumitomo Seika Chemicals Co., Ltd. Method for producing 3-halo-1,2-benzisothiazoles
EP2736905A4 (en) 2011-07-28 2015-07-29 Mapi Pharma Ltd INTERMEDIATE COMPOUNDS AND PROCESS FOR THE PREPARATION OF LURASIDONE AND SALTS THEREOF
CN103204823B (zh) * 2013-03-18 2015-07-15 寿光新泰精细化工有限公司 一种1,2-苯并异噻唑-3-酮的提纯方法
CN105037293A (zh) * 2015-06-04 2015-11-11 大丰跃龙化学有限公司 一种bit生产中固废再利用工艺
TWI704145B (zh) * 2015-06-05 2020-09-11 芬蘭商奧利安公司 新醫藥化合物
CN106543107B (zh) * 2016-11-04 2019-02-01 山东铂源药业有限公司 一种1-boc-哌嗪的合成方法
CN108794424A (zh) * 2018-07-16 2018-11-13 连云港市三联化工有限公司 一种bit的溶剂精制方法
CN116283820A (zh) * 2023-03-23 2023-06-23 寿光新泰精细化工有限公司 3-卤代-1,2-苯并异噻唑的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670907B2 (de) * 1967-08-16 1976-07-22 Bayer Ag, 5090 Leverkusen N-disubstituierte 3-amino-1,2benzisothiazole und verfahren in ihrer herstellung
US4112105A (en) * 1977-05-04 1978-09-05 Sterling Drug Inc. Anti-inflammatory 3-(substituted-amino)-2,1-benzisothiazoles
US4104388A (en) * 1977-05-23 1978-08-01 E. R. Squibb & Sons, Inc. 3-Substituted benzisothiazole, 1,1-dioxides
US4396770A (en) * 1982-04-09 1983-08-02 Hoechst-Roussel Pharmaceuticals Inc. 1-[3-(6-Fluoro-1,2-benzisoxazol-3-yl)propyl]-4-hydroxy-4-phenylpiperidines
JPS5815965A (ja) * 1981-07-23 1983-01-29 Nippon Tokushu Noyaku Seizo Kk ベンゾイソチアゾ−ル誘導体並びにその塩酸塩、その製法、及び農業用殺菌剤
US4355037A (en) * 1981-11-12 1982-10-19 Hoechst-Roussel Pharmaceuticals 3-(4-Piperidyl)-1,2-benzisoxales
US4411901A (en) * 1981-12-23 1983-10-25 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4452799A (en) * 1981-12-23 1984-06-05 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4524206A (en) * 1983-09-12 1985-06-18 Mead Johnson & Company 1-Heteroaryl-4-(2,5-pyrrolidinedion-1-yl)alkyl)piperazine derivatives

Also Published As

Publication number Publication date
FI82039C (fi) 1991-01-10
IT1187730B (it) 1987-12-23
ZA856387B (en) 1986-04-30
PT81007B (pt) 1987-12-30
IT8521968A0 (it) 1985-08-22
ATA246985A (de) 1993-03-15
SE8503922L (sv) 1986-02-24
BE903106A (fr) 1986-02-24
JPS61112063A (ja) 1986-05-30
SE8503922D0 (sv) 1985-08-22
SE464304B (sv) 1991-04-08
PT81007A (en) 1985-09-01
FR2569404B1 (fr) 1988-07-01
DE3530089A1 (de) 1986-03-06
GR852017B (es) 1985-12-24
LU86051A1 (fr) 1986-02-28
DK381485D0 (da) 1985-08-22
CH667268A5 (de) 1988-09-30
AU586182B2 (en) 1989-07-06
FI853193A0 (fi) 1985-08-20
GB2163432B (en) 1988-06-22
NL8502310A (nl) 1986-03-17
FI853193L (fi) 1986-02-24
AU4653385A (en) 1986-02-27
IE58608B1 (en) 1993-10-20
US4590196A (en) 1986-05-20
KR920008820B1 (ko) 1992-10-09
FR2569404A1 (fr) 1986-02-28
DK381485A (da) 1986-02-24
GB2163432A (en) 1986-02-26
AT396685B (de) 1993-11-25
IE852067L (en) 1986-02-23
CA1249587A (en) 1989-01-31
KR860001807A (ko) 1986-03-22
GB8521050D0 (en) 1985-09-25
FI82039B (fi) 1990-09-28
ES8704485A1 (es) 1987-04-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970612