LU86051A1 - 1,2-benzisothiazol-3-ylpiperazines analgesiques - Google Patents
1,2-benzisothiazol-3-ylpiperazines analgesiques Download PDFInfo
- Publication number
- LU86051A1 LU86051A1 LU86051A LU86051A LU86051A1 LU 86051 A1 LU86051 A1 LU 86051A1 LU 86051 A LU86051 A LU 86051A LU 86051 A LU86051 A LU 86051A LU 86051 A1 LU86051 A1 LU 86051A1
- Authority
- LU
- Luxembourg
- Prior art keywords
- compound
- benzisothiazole
- piperazinyl
- formula
- hydrogen atom
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/643,614 US4590196A (en) | 1984-08-23 | 1984-08-23 | Analgesic 1,2-benzisothiazol-3-ylpiperazine derivatives |
US64361484 | 1984-08-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
LU86051A1 true LU86051A1 (fr) | 1986-02-28 |
Family
ID=24581577
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LU86051A LU86051A1 (fr) | 1984-08-23 | 1985-08-22 | 1,2-benzisothiazol-3-ylpiperazines analgesiques |
Country Status (22)
Country | Link |
---|---|
US (1) | US4590196A (es) |
JP (1) | JPS61112063A (es) |
KR (1) | KR920008820B1 (es) |
AT (1) | AT396685B (es) |
AU (1) | AU586182B2 (es) |
BE (1) | BE903106A (es) |
CA (1) | CA1249587A (es) |
CH (1) | CH667268A5 (es) |
DE (1) | DE3530089A1 (es) |
DK (1) | DK381485A (es) |
ES (1) | ES8704485A1 (es) |
FI (1) | FI82039C (es) |
FR (1) | FR2569404B1 (es) |
GB (1) | GB2163432B (es) |
GR (1) | GR852017B (es) |
IE (1) | IE58608B1 (es) |
IT (1) | IT1187730B (es) |
LU (1) | LU86051A1 (es) |
NL (1) | NL8502310A (es) |
PT (1) | PT81007B (es) |
SE (1) | SE464304B (es) |
ZA (1) | ZA856387B (es) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0625181B2 (ja) * | 1985-03-27 | 1994-04-06 | 住友製薬株式会社 | 新規なイミド誘導体 |
US4999356A (en) * | 1987-08-07 | 1991-03-12 | Hoechst-Roussel Pharmaceuticals, Inc. | 1-phenyl-3-(1-piperazinyl)-1H-indazoles |
US4880930A (en) * | 1987-11-30 | 1989-11-14 | New James S | Psychotropic acyclic amide derivatives |
US4957916A (en) * | 1988-08-05 | 1990-09-18 | Janssen Pharmaceutica N.V. | Antipsychotic 3-piperazinylbenzazole derivatives |
US5015740A (en) * | 1988-08-05 | 1991-05-14 | Janssen Pharmaceutica N.V. | Antipsychotic 3-piperazinylbenzazole derivatives |
NZ230045A (en) | 1988-08-05 | 1990-11-27 | Janssen Pharmaceutica Nv | 3-piperazinylbenzazole derivatives and pharmaceutical compositions |
US5077295A (en) * | 1988-09-16 | 1991-12-31 | Pfizer Inc. | Antipsychoic 4-(4-(3-benzisothiazolyl)-1-piperazinyl)buytl bridged bicycle imides |
US5070090A (en) * | 1989-05-15 | 1991-12-03 | Janssen Pharmaceutica N.V. | Antipicorpaviral herterocyclic-substituted morpholinyl alkylphenol ethers |
GB8911158D0 (en) * | 1989-05-16 | 1989-07-05 | Janssen Pharmaceutica Nv | Antiviral pyridazinamines |
NZ233525A (en) * | 1989-05-15 | 1991-09-25 | Janssen Pharmaceutica Nv | Piperidinyl, pyrrolidinyl and piperazinyl alkylphenol ethers and pharmaceutical compositions |
DE69021645T2 (de) * | 1989-05-19 | 1996-02-22 | Hoechst-Roussel Pharmaceuticals Inc., Somerville, N.J. | N-(aryloxyalkyl)heteroarylpiperidine und -heteroarylpiperazine, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikamente. |
US5561128A (en) * | 1989-05-19 | 1996-10-01 | Hoechst-Roussel Pharmaceuticals, Inc. | N-[(4-(heteroaryl)-1-piperidinyl)alkyl]-10,11-dihydro-5H-dibenz[B,F]azepines and related compounds and their therapeutic utility |
US5364866A (en) * | 1989-05-19 | 1994-11-15 | Hoechst-Roussel Pharmaceuticals, Inc. | Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics |
US5776963A (en) * | 1989-05-19 | 1998-07-07 | Hoechst Marion Roussel, Inc. | 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility |
US4956368A (en) * | 1989-07-24 | 1990-09-11 | Bristol-Myers Company | Metabolites and prodrug formulations of 8-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione |
US4954503A (en) * | 1989-09-11 | 1990-09-04 | Hoechst-Roussel Pharmaceuticals, Inc. | 3-(1-substituted-4-piperazinyl)-1H-indazoles |
FR2671350A1 (fr) * | 1991-01-08 | 1992-07-10 | Adir | Nouveaux derives de benzisoxazole et de benzisothiazole, leur procede de preparation, et les compositions pharmaceutiques les renfermant. |
JP2800953B2 (ja) * | 1990-07-06 | 1998-09-21 | 住友製薬株式会社 | 新規なイミド誘導体 |
US5328920A (en) * | 1991-04-17 | 1994-07-12 | Hoechst-Roussel Pharmaceuticals Incorporated | Substituted (pyridinylamino)-indoles |
DE69332691T2 (de) * | 1992-11-23 | 2003-12-18 | Aventis Pharmaceuticals Inc., Cincinnati | Substituierte 3-(aminoalkylamino)-1,2-benzisoxazole und verwandte verbindungen |
DE69524598T2 (de) * | 1994-06-20 | 2002-07-11 | Takeda Chemical Industries, Ltd. | Kondensierte imidazolderivate, ihre herstellung und verwendung |
JPH08157460A (ja) * | 1994-12-08 | 1996-06-18 | Sumitomo Seika Chem Co Ltd | イソチアゾール誘導体の製造方法 |
JP3701044B2 (ja) * | 1995-04-24 | 2005-09-28 | 住友精化株式会社 | シアノベンゼンスルフェニルハライドおよびそれを用いる3−置換ベンゾイソチアゾールの製造方法 |
ES2157442T3 (es) * | 1995-06-06 | 2001-08-16 | Aventis Pharma Inc | Derivados de benzoisoxazol y de indazol, utilizados como agentes neurolepticos. |
HU225921B1 (en) * | 1995-11-07 | 2008-01-28 | Pfizer | Process and intermediates for preparing 3-(1-piperazinyl)-1,2-benzisothiazole |
JP3996228B2 (ja) * | 1996-10-11 | 2007-10-24 | 住友精化株式会社 | 3−ピペラジニルベンズイソチアゾール類の製造法 |
DE19651038A1 (de) * | 1996-12-09 | 1998-06-10 | Bayer Ag | Verfahren zur Herstellung von 3-Chlorbenzisothiazolen |
AU4062900A (en) * | 1999-04-06 | 2000-10-23 | Sepracor, Inc. | Methods and compositions for the treatment of neuroleptic and related disorders using ziprasidone metabolites |
US7030142B1 (en) | 1999-04-06 | 2006-04-18 | Sepracor Inc. | Methods for the treatment of neuroleptic and related disorders using ziprasidone metabolites |
US20050049295A1 (en) * | 2003-06-12 | 2005-03-03 | Dr. Reddy's Laboratories Limited | Process for the preparation of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1piperazinyl) ethyl)-6-chloro-1, 3-dihydro-2h-indol-2-one hydrochloride (ziprasidone hydrochloride) and its intermediate |
WO2006091858A1 (en) * | 2005-02-25 | 2006-08-31 | Rigel Pharmaceuticals, Inc. | Benzisothiazoles useful for treating or preventing hcv infection |
CN100387583C (zh) * | 2006-05-19 | 2008-05-14 | 浙江工业大学 | 一种3-氯-1,2-苯并异噻唑类化合物的合成方法 |
CN102040563B (zh) * | 2009-10-16 | 2014-04-16 | 上海开拓者化学研究管理有限公司 | 一种3-芳基苯并[d]异噻唑的制备方法 |
CN102040564B (zh) * | 2009-10-16 | 2012-11-21 | 上海开拓者化学研究管理有限公司 | 一种3-胺基苯并[d]异噻唑的制备方法 |
US8664404B2 (en) | 2010-04-02 | 2014-03-04 | Sumitomo Seika Chemicals Co., Ltd. | Method for producing 3-halo-1,2-benzisothiazoles |
EP2736905A4 (en) | 2011-07-28 | 2015-07-29 | Mapi Pharma Ltd | INTERMEDIATE COMPOUNDS AND PROCESS FOR THE PREPARATION OF LURASIDONE AND SALTS THEREOF |
CN103204823B (zh) * | 2013-03-18 | 2015-07-15 | 寿光新泰精细化工有限公司 | 一种1,2-苯并异噻唑-3-酮的提纯方法 |
CN105037293A (zh) * | 2015-06-04 | 2015-11-11 | 大丰跃龙化学有限公司 | 一种bit生产中固废再利用工艺 |
TWI704145B (zh) * | 2015-06-05 | 2020-09-11 | 芬蘭商奧利安公司 | 新醫藥化合物 |
CN106543107B (zh) * | 2016-11-04 | 2019-02-01 | 山东铂源药业有限公司 | 一种1-boc-哌嗪的合成方法 |
CN108794424A (zh) * | 2018-07-16 | 2018-11-13 | 连云港市三联化工有限公司 | 一种bit的溶剂精制方法 |
CN116283820A (zh) * | 2023-03-23 | 2023-06-23 | 寿光新泰精细化工有限公司 | 3-卤代-1,2-苯并异噻唑的制备方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1670907B2 (de) * | 1967-08-16 | 1976-07-22 | Bayer Ag, 5090 Leverkusen | N-disubstituierte 3-amino-1,2benzisothiazole und verfahren in ihrer herstellung |
US4112105A (en) * | 1977-05-04 | 1978-09-05 | Sterling Drug Inc. | Anti-inflammatory 3-(substituted-amino)-2,1-benzisothiazoles |
US4104388A (en) * | 1977-05-23 | 1978-08-01 | E. R. Squibb & Sons, Inc. | 3-Substituted benzisothiazole, 1,1-dioxides |
US4396770A (en) * | 1982-04-09 | 1983-08-02 | Hoechst-Roussel Pharmaceuticals Inc. | 1-[3-(6-Fluoro-1,2-benzisoxazol-3-yl)propyl]-4-hydroxy-4-phenylpiperidines |
JPS5815965A (ja) * | 1981-07-23 | 1983-01-29 | Nippon Tokushu Noyaku Seizo Kk | ベンゾイソチアゾ−ル誘導体並びにその塩酸塩、その製法、及び農業用殺菌剤 |
US4355037A (en) * | 1981-11-12 | 1982-10-19 | Hoechst-Roussel Pharmaceuticals | 3-(4-Piperidyl)-1,2-benzisoxales |
US4411901A (en) * | 1981-12-23 | 1983-10-25 | Mead Johnson & Company | Benzisothiazole and benzisoxazole piperazine derivatives |
US4452799A (en) * | 1981-12-23 | 1984-06-05 | Mead Johnson & Company | Benzisothiazole and benzisoxazole piperazine derivatives |
US4524206A (en) * | 1983-09-12 | 1985-06-18 | Mead Johnson & Company | 1-Heteroaryl-4-(2,5-pyrrolidinedion-1-yl)alkyl)piperazine derivatives |
-
1984
- 1984-08-23 US US06/643,614 patent/US4590196A/en not_active Expired - Fee Related
-
1985
- 1985-08-16 CA CA000488887A patent/CA1249587A/en not_active Expired
- 1985-08-20 FI FI853193A patent/FI82039C/fi not_active IP Right Cessation
- 1985-08-20 GR GR852017A patent/GR852017B/el unknown
- 1985-08-22 FR FR8512635A patent/FR2569404B1/fr not_active Expired
- 1985-08-22 SE SE8503922A patent/SE464304B/sv not_active IP Right Cessation
- 1985-08-22 ES ES546347A patent/ES8704485A1/es not_active Expired
- 1985-08-22 CH CH3606/85A patent/CH667268A5/de not_active IP Right Cessation
- 1985-08-22 IE IE206785A patent/IE58608B1/en not_active IP Right Cessation
- 1985-08-22 KR KR1019850006060A patent/KR920008820B1/ko not_active IP Right Cessation
- 1985-08-22 LU LU86051A patent/LU86051A1/fr unknown
- 1985-08-22 BE BE0/215496A patent/BE903106A/fr not_active IP Right Cessation
- 1985-08-22 ZA ZA856387A patent/ZA856387B/xx unknown
- 1985-08-22 PT PT81007A patent/PT81007B/pt not_active IP Right Cessation
- 1985-08-22 GB GB08521050A patent/GB2163432B/en not_active Expired
- 1985-08-22 JP JP60185015A patent/JPS61112063A/ja active Pending
- 1985-08-22 IT IT21968/85A patent/IT1187730B/it active
- 1985-08-22 DK DK381485A patent/DK381485A/da not_active Application Discontinuation
- 1985-08-22 NL NL8502310A patent/NL8502310A/nl not_active Application Discontinuation
- 1985-08-22 AU AU46533/85A patent/AU586182B2/en not_active Ceased
- 1985-08-22 DE DE19853530089 patent/DE3530089A1/de not_active Ceased
- 1985-08-23 AT AT0246985A patent/AT396685B/de not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
LU86051A1 (fr) | 1,2-benzisothiazol-3-ylpiperazines analgesiques | |
JP2617546B2 (ja) | 3‐〔4(1‐置換‐4‐ピペラジニル)ブチル〕‐4‐チアゾリジノンおよびその製法 | |
CH634318A5 (fr) | Quinazolines. | |
FR2501690A1 (fr) | Derives heterocycliques du type 1,2,4-triazole, leur preparation et leur application pharmacologique | |
EP0243018B1 (en) | Thiolactam-n-acetic acid derivatives, their production and use | |
EP0433149B1 (fr) | Antagonistes de la sérotonine, leur préparation et les médicaments les contenant | |
FR2552759A1 (fr) | Composes de la 1,2,4-triazolone et leur application pharmacologique | |
EP0494817B1 (fr) | Dérivés de benzisoxazole et de benzisothiazole, leur procédé de préparation et les compositions pharmaceutiques les renfermant | |
FR2662695A1 (fr) | Amino-2 polyfluoroalcoxy-6 benzoselenazoles, leur preparation et les medicaments les contenant. | |
EP0375510B1 (fr) | Dérivés d'imino-2 polyfluoroalcoxy-6 benzothiazole, leurs procédés de préparation et les médicaments les contenant | |
EP0374041A1 (fr) | Médicaments à base de dérivés de la benzothiazolamine-2, dérivés et leur préparation | |
FR2581064A1 (fr) | Derive antipsychotique a base de 8-(4-(4-(1-exo-1,2-benzisothiazol-3-yl)-1-piperazinyl)-butyl)-8-azaspiro(4,5)decane-7,9-dione et son procede de preparation | |
CA1100968A (fr) | Procedes de preparation de nouvelles piperazines disubstituees | |
CA2010529A1 (fr) | Derives de la 1-arylsulfonyl 2-piperidinone, leur procede et les intermediaires de preparation, leur application comme medicaments et les compositions les renfermant | |
EP0005091B1 (fr) | Nouvelles pipérazines monosubstituées, leurs procédés de préparation et les compositions pharmaceutiques les renfermant | |
EP0579169B1 (en) | Alkylenediamine derivatives | |
EP0532602A1 (fr) | Derives de benzothiazole, leur preparation et les medicaments les contenant. | |
FR2620120A1 (fr) | Nouveau derive de benzofuranne utile notamment comme inhibiteur de la contraction reflexe de la vessie | |
JPH0859638A (ja) | 新規なヘテロ環誘導体又はその塩 | |
CA2021031A1 (fr) | Derives d'imino-2(heterocyclylalkyl)-3 benzothiazoline, leurs procedes de preparation et les medicaments les contenant | |
EP0408437A2 (fr) | Dérivés d'alkylimino-2 benzothiazoline, leurs procédés de préparation et les médicaments les contenant | |
FR2542741A1 (fr) | 3,4-diamino-1,2,5-thiadiazoles substitues possedant une activite antagoniste du recepteur-h2 de l'histamine | |
JPH107647A (ja) | 新規なチオ尿素誘導体又はその塩 | |
TW200306842A (en) | Biologically active 4H-benzo[1,4]oxazin-3-ones | |
FR2649981A1 (fr) | Derives de dihydropyrimidothiazine, leur procede de preparation et compositions pharmaceutiques les contenant |