ATE48421T1 - Hustenstillende und schleimregulierende 2substituierte thiazole. - Google Patents

Hustenstillende und schleimregulierende 2substituierte thiazole.

Info

Publication number
ATE48421T1
ATE48421T1 AT85109445T AT85109445T ATE48421T1 AT E48421 T1 ATE48421 T1 AT E48421T1 AT 85109445 T AT85109445 T AT 85109445T AT 85109445 T AT85109445 T AT 85109445T AT E48421 T1 ATE48421 T1 AT E48421T1
Authority
AT
Austria
Prior art keywords
sub
group
hydrogen
murph
regulator
Prior art date
Application number
AT85109445T
Other languages
English (en)
Inventor
Carmelo A Gandolfi
Silvano Spinelli
Odoardo Tofanetti
Raimondo Russo
Sergio Tognella
Original Assignee
Boehringer Biochemia Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB08419254A external-priority patent/GB2164333B/en
Priority claimed from GB08517553A external-priority patent/GB2177690A/en
Application filed by Boehringer Biochemia Srl filed Critical Boehringer Biochemia Srl
Application granted granted Critical
Publication of ATE48421T1 publication Critical patent/ATE48421T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/10Expectorants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/14Antitussive agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00Ethers; Compounds having groups, groups or groups
    • C07C43/02Ethers
    • C07C43/20Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/255Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/20Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 hydrogenated in the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D319/00Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/101,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/141,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/161,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/201,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Detergent Compositions (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT85109445T 1984-07-27 1985-07-26 Hustenstillende und schleimregulierende 2substituierte thiazole. ATE48421T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB08419254A GB2164333B (en) 1984-07-27 1984-07-27 Antitussive and mucus regulating 2-substituted thiazolidines
GB08517553A GB2177690A (en) 1985-07-11 1985-07-11 Antitussive and mucus regulating 2-substituted thiazolidines
EP85109445A EP0169581B1 (de) 1984-07-27 1985-07-26 Hustenstillende und schleimregulierende 2-substituierte Thiazole

Publications (1)

Publication Number Publication Date
ATE48421T1 true ATE48421T1 (de) 1989-12-15

Family

ID=26288033

Family Applications (1)

Application Number Title Priority Date Filing Date
AT85109445T ATE48421T1 (de) 1984-07-27 1985-07-26 Hustenstillende und schleimregulierende 2substituierte thiazole.

Country Status (14)

Country Link
US (1) US4857643A (de)
EP (1) EP0169581B1 (de)
JP (1) JPS6163669A (de)
AT (1) ATE48421T1 (de)
AU (1) AU582770B2 (de)
CA (1) CA1270250A (de)
DE (1) DE3574590D1 (de)
DK (1) DK169474B1 (de)
ES (1) ES8605249A1 (de)
GR (1) GR851845B (de)
HU (1) HU195492B (de)
IE (1) IE58518B1 (de)
IL (1) IL75891A (de)
NZ (1) NZ212831A (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2177690A (en) * 1985-07-11 1987-01-28 Boehringer Biochemia Srl Antitussive and mucus regulating 2-substituted thiazolidines
NO174506B (no) * 1984-10-30 1994-02-07 Usv Pharma Corp Analogifremgangsmaate ved fremstilling av terapeutisk aktive forbindelser
IT1196485B (it) * 1986-07-14 1988-11-16 Zambon Spa Derivati dell'acido tiazolidin-4-carbossilico ad attivita' farmaceutica
IT1203932B (it) * 1987-04-17 1989-02-23 Boehringer Biochemia Srl 2-sulfinil-acetil-1,3-tiazolidine, loro preparazione e composizioni farmaceutiche
IT1228251B (it) * 1987-07-02 1991-06-05 Boehringer Biochemia Srl Amidi di amino-tioacetali ciclici, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
IT1223565B (it) * 1987-12-21 1990-09-19 Zambon Spa Derivati dell'acido tiazolidin 4 carbossilico ad attivita' farmaceutica
IT1216119B (it) * 1988-03-17 1990-02-22 Boehringer Biochemia Srl Beta_carbonil_carbossiamidi di 1,3_tiazolidine.
US5420289A (en) * 1989-10-27 1995-05-30 American Home Products Corporation Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase
IT1270594B (it) * 1994-07-07 1997-05-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
CA2433090A1 (en) * 2000-12-27 2002-07-04 Kyowa Hakko Kogyo Co., Ltd. Dipeptidyl peptidase iv inhibitor
EP2070915A1 (de) * 2007-12-03 2009-06-17 A.M.S.A. ANONIMA MATERIE SINTETICHE E AFFINI S.p.A. Neues Verfahren zur Synthese von Moguistein
WO2011089576A2 (en) * 2010-01-25 2011-07-28 Kareus Therapeuttics Sa NOVEL COMPOSITIONS FOR REDUCING Aß 42 PRODUCTION AND THEIR USE IN TREATING ALZHEIMER'S DISEASE (AD)
CN102653527A (zh) * 2011-12-22 2012-09-05 东莞达信生物技术有限公司 一种莫吉司坦合成工艺

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR8266M (de) * 1968-12-31 1970-10-26
DE2926771A1 (de) * 1979-07-03 1981-01-15 Hoechst Ag Thiazolidinderivate und verfahren zu ihrer herstellung
IT1194793B (it) * 1981-05-12 1988-09-28 Corvi Camillo Spa Derivati tiazolidinici ad attivita' farmacologica,procedimento per la loro preparazione e composizioni farmaceutiche contenenti detti derivati
US4649146A (en) * 1983-01-31 1987-03-10 Fujisawa Pharmaceutical Co., Ltd. Thiazole derivatives and pharmaceutical composition comprising the same
DE3404786A1 (de) * 1984-02-10 1985-08-14 Ludwig Heumann & Co GmbH, 8500 Nürnberg Neue alkanolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltendes arzneimittel
US4732934A (en) * 1986-12-08 1988-03-22 General Electric Company Functionalized thermoplastic polymers, blends prepared therefrom, and methods for preparing blends

Also Published As

Publication number Publication date
EP0169581A3 (en) 1987-05-13
CA1270250A (en) 1990-06-12
EP0169581A2 (de) 1986-01-29
DK341985A (da) 1986-01-28
DK341985D0 (da) 1985-07-26
HU195492B (en) 1988-05-30
AU4524285A (en) 1986-01-30
IL75891A0 (en) 1985-12-31
ES545575A0 (es) 1986-03-16
ES8605249A1 (es) 1986-03-16
DE3574590D1 (de) 1990-01-11
US4857643A (en) 1989-08-15
DK169474B1 (da) 1994-11-07
HUT38921A (en) 1986-07-28
AU582770B2 (en) 1989-04-13
EP0169581B1 (de) 1989-12-06
NZ212831A (en) 1988-05-30
JPS6163669A (ja) 1986-04-01
IL75891A (en) 1989-07-31
IE851879L (en) 1986-01-27
GR851845B (de) 1985-12-02
JPH0576944B2 (de) 1993-10-25
IE58518B1 (en) 1993-10-06

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEFA Change of the company name
REN Ceased due to non-payment of the annual fee