LU86051A1 - 1,2-benzisothiazol-3-ylpiperazines analgesiques - Google Patents

1,2-benzisothiazol-3-ylpiperazines analgesiques Download PDF

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Publication number
LU86051A1
LU86051A1 LU86051A LU86051A LU86051A1 LU 86051 A1 LU86051 A1 LU 86051A1 LU 86051 A LU86051 A LU 86051A LU 86051 A LU86051 A LU 86051A LU 86051 A1 LU86051 A1 LU 86051A1
Authority
LU
Luxembourg
Prior art keywords
compound
benzisothiazole
piperazinyl
formula
hydrogen atom
Prior art date
Application number
LU86051A
Other languages
English (en)
French (fr)
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of LU86051A1 publication Critical patent/LU86051A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
LU86051A 1984-08-23 1985-08-22 1,2-benzisothiazol-3-ylpiperazines analgesiques LU86051A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64361484 1984-08-23
US06/643,614 US4590196A (en) 1984-08-23 1984-08-23 Analgesic 1,2-benzisothiazol-3-ylpiperazine derivatives

Publications (1)

Publication Number Publication Date
LU86051A1 true LU86051A1 (fr) 1986-02-28

Family

ID=24581577

Family Applications (1)

Application Number Title Priority Date Filing Date
LU86051A LU86051A1 (fr) 1984-08-23 1985-08-22 1,2-benzisothiazol-3-ylpiperazines analgesiques

Country Status (22)

Country Link
US (1) US4590196A (ko)
JP (1) JPS61112063A (ko)
KR (1) KR920008820B1 (ko)
AT (1) AT396685B (ko)
AU (1) AU586182B2 (ko)
BE (1) BE903106A (ko)
CA (1) CA1249587A (ko)
CH (1) CH667268A5 (ko)
DE (1) DE3530089A1 (ko)
DK (1) DK381485A (ko)
ES (1) ES8704485A1 (ko)
FI (1) FI82039C (ko)
FR (1) FR2569404B1 (ko)
GB (1) GB2163432B (ko)
GR (1) GR852017B (ko)
IE (1) IE58608B1 (ko)
IT (1) IT1187730B (ko)
LU (1) LU86051A1 (ko)
NL (1) NL8502310A (ko)
PT (1) PT81007B (ko)
SE (1) SE464304B (ko)
ZA (1) ZA856387B (ko)

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JPH0625181B2 (ja) * 1985-03-27 1994-04-06 住友製薬株式会社 新規なイミド誘導体
US4999356A (en) * 1987-08-07 1991-03-12 Hoechst-Roussel Pharmaceuticals, Inc. 1-phenyl-3-(1-piperazinyl)-1H-indazoles
US4880930A (en) * 1987-11-30 1989-11-14 New James S Psychotropic acyclic amide derivatives
US5015740A (en) * 1988-08-05 1991-05-14 Janssen Pharmaceutica N.V. Antipsychotic 3-piperazinylbenzazole derivatives
NZ230045A (en) 1988-08-05 1990-11-27 Janssen Pharmaceutica Nv 3-piperazinylbenzazole derivatives and pharmaceutical compositions
US4957916A (en) * 1988-08-05 1990-09-18 Janssen Pharmaceutica N.V. Antipsychotic 3-piperazinylbenzazole derivatives
WO1990002552A1 (en) * 1988-09-16 1990-03-22 Pfizer Inc. Antipsychotic 4-[4-(3-benzisothiazolyl)-1-piperazinyl]butyl bridged bicyclic imides
GB8911158D0 (en) * 1989-05-16 1989-07-05 Janssen Pharmaceutica Nv Antiviral pyridazinamines
NZ233525A (en) * 1989-05-15 1991-09-25 Janssen Pharmaceutica Nv Piperidinyl, pyrrolidinyl and piperazinyl alkylphenol ethers and pharmaceutical compositions
US5070090A (en) * 1989-05-15 1991-12-03 Janssen Pharmaceutica N.V. Antipicorpaviral herterocyclic-substituted morpholinyl alkylphenol ethers
US5364866A (en) * 1989-05-19 1994-11-15 Hoechst-Roussel Pharmaceuticals, Inc. Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics
US5776963A (en) * 1989-05-19 1998-07-07 Hoechst Marion Roussel, Inc. 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility
DE69021645T2 (de) * 1989-05-19 1996-02-22 Hoechst Roussel Pharma N-(aryloxyalkyl)heteroarylpiperidine und -heteroarylpiperazine, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikamente.
US5561128A (en) * 1989-05-19 1996-10-01 Hoechst-Roussel Pharmaceuticals, Inc. N-[(4-(heteroaryl)-1-piperidinyl)alkyl]-10,11-dihydro-5H-dibenz[B,F]azepines and related compounds and their therapeutic utility
US4956368A (en) * 1989-07-24 1990-09-11 Bristol-Myers Company Metabolites and prodrug formulations of 8-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione
US4954503A (en) * 1989-09-11 1990-09-04 Hoechst-Roussel Pharmaceuticals, Inc. 3-(1-substituted-4-piperazinyl)-1H-indazoles
FR2671350A1 (fr) * 1991-01-08 1992-07-10 Adir Nouveaux derives de benzisoxazole et de benzisothiazole, leur procede de preparation, et les compositions pharmaceutiques les renfermant.
JP2800953B2 (ja) * 1990-07-06 1998-09-21 住友製薬株式会社 新規なイミド誘導体
US5328920A (en) * 1991-04-17 1994-07-12 Hoechst-Roussel Pharmaceuticals Incorporated Substituted (pyridinylamino)-indoles
CA2149918A1 (en) * 1992-11-23 1994-06-09 Mark G. Palermo Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds
EP0767790B1 (en) * 1994-06-20 2001-12-12 Takeda Chemical Industries, Ltd. Condensed imidazole compounds, their production and use
JPH08157460A (ja) * 1994-12-08 1996-06-18 Sumitomo Seika Chem Co Ltd イソチアゾール誘導体の製造方法
JP3701044B2 (ja) * 1995-04-24 2005-09-28 住友精化株式会社 シアノベンゼンスルフェニルハライドおよびそれを用いる３−置換ベンゾイソチアゾールの製造方法
ATE199147T1 (de) * 1995-06-06 2001-02-15 Aventis Pharma Inc Benzisoxazol- und indazol- derivate als antipsychotika
EP0874834B1 (en) * 1995-11-07 2000-12-13 Pfizer Inc. Processes and intermediates for preparing 3-(1-piperazinyl)-1,2-benzisothiazole
JP3996228B2 (ja) * 1996-10-11 2007-10-24 住友精化株式会社 ３−ピペラジニルベンズイソチアゾール類の製造法
DE19651038A1 (de) * 1996-12-09 1998-06-10 Bayer Ag Verfahren zur Herstellung von 3-Chlorbenzisothiazolen
US7030142B1 (en) 1999-04-06 2006-04-18 Sepracor Inc. Methods for the treatment of neuroleptic and related disorders using ziprasidone metabolites
JP2002541098A (ja) * 1999-04-06 2002-12-03 セプラコア インコーポレーテッド ジプラシドン代謝産物を用いる神経弛緩薬性障害および関連障害を治療するための方法および組成物
US20050049295A1 (en) * 2003-06-12 2005-03-03 Dr. Reddy's Laboratories Limited Process for the preparation of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1piperazinyl) ethyl)-6-chloro-1, 3-dihydro-2h-indol-2-one hydrochloride (ziprasidone hydrochloride) and its intermediate
US7776847B2 (en) * 2005-02-25 2010-08-17 Rigel Pharmaceuticals, Inc. Benzisothiazoles useful for treating or preventing HCV infection
CN100387583C (zh) * 2006-05-19 2008-05-14 浙江工业大学 一种3-氯-1,2-苯并异噻唑类化合物的合成方法
CN102040563B (zh) * 2009-10-16 2014-04-16 上海开拓者化学研究管理有限公司 一种3-芳基苯并[d]异噻唑的制备方法
CN102040564B (zh) * 2009-10-16 2012-11-21 上海开拓者化学研究管理有限公司 一种3-胺基苯并[d]异噻唑的制备方法
WO2011125423A1 (ja) 2010-04-02 2011-10-13 住友精化株式会社 ３－ハロ－１，２－ベンゾイソチアゾール類の製造方法
WO2013014665A1 (en) 2011-07-28 2013-01-31 Mapi Pharma Ltd. Intermediate compounds and process for the preparation of lurasidone and salts thereof
CN103204823B (zh) * 2013-03-18 2015-07-15 寿光新泰精细化工有限公司 一种1,2-苯并异噻唑-3-酮的提纯方法
CN105037293A (zh) * 2015-06-04 2015-11-11 大丰跃龙化学有限公司 一种bit生产中固废再利用工艺
TWI704145B (zh) * 2015-06-05 2020-09-11 芬蘭商奧利安公司 新醫藥化合物
CN106543107B (zh) * 2016-11-04 2019-02-01 山东铂源药业有限公司 一种1-boc-哌嗪的合成方法
CN108794424A (zh) * 2018-07-16 2018-11-13 连云港市三联化工有限公司 一种bit的溶剂精制方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670907B2 (de) * 1967-08-16 1976-07-22 Bayer Ag, 5090 Leverkusen N-disubstituierte 3-amino-1,2benzisothiazole und verfahren in ihrer herstellung
US4112105A (en) * 1977-05-04 1978-09-05 Sterling Drug Inc. Anti-inflammatory 3-(substituted-amino)-2,1-benzisothiazoles
US4104388A (en) * 1977-05-23 1978-08-01 E. R. Squibb & Sons, Inc. 3-Substituted benzisothiazole, 1,1-dioxides
US4396770A (en) * 1982-04-09 1983-08-02 Hoechst-Roussel Pharmaceuticals Inc. 1-[3-(6-Fluoro-1,2-benzisoxazol-3-yl)propyl]-4-hydroxy-4-phenylpiperidines
JPS5815965A (ja) * 1981-07-23 1983-01-29 Nippon Tokushu Noyaku Seizo Kk ベンゾイソチアゾ−ル誘導体並びにその塩酸塩、その製法、及び農業用殺菌剤
US4355037A (en) * 1981-11-12 1982-10-19 Hoechst-Roussel Pharmaceuticals 3-(4-Piperidyl)-1,2-benzisoxales
US4411901A (en) * 1981-12-23 1983-10-25 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4452799A (en) * 1981-12-23 1984-06-05 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4524206A (en) * 1983-09-12 1985-06-18 Mead Johnson & Company 1-Heteroaryl-4-(2,5-pyrrolidinedion-1-yl)alkyl)piperazine derivatives

Also Published As

Publication number Publication date
NL8502310A (nl) 1986-03-17
GR852017B (ko) 1985-12-24
FR2569404B1 (fr) 1988-07-01
KR860001807A (ko) 1986-03-22
GB2163432B (en) 1988-06-22
FI82039B (fi) 1990-09-28
JPS61112063A (ja) 1986-05-30
FI853193L (fi) 1986-02-24
AU586182B2 (en) 1989-07-06
IE852067L (en) 1986-02-23
PT81007B (pt) 1987-12-30
IE58608B1 (en) 1993-10-20
GB2163432A (en) 1986-02-26
SE8503922D0 (sv) 1985-08-22
SE8503922L (sv) 1986-02-24
SE464304B (sv) 1991-04-08
FI82039C (fi) 1991-01-10
DK381485D0 (da) 1985-08-22
DK381485A (da) 1986-02-24
AT396685B (de) 1993-11-25
GB8521050D0 (en) 1985-09-25
DE3530089A1 (de) 1986-03-06
IT8521968A0 (it) 1985-08-22
US4590196A (en) 1986-05-20
ZA856387B (en) 1986-04-30
ES546347A0 (es) 1987-04-01
FI853193A0 (fi) 1985-08-20
ATA246985A (de) 1993-03-15
AU4653385A (en) 1986-02-27
CA1249587A (en) 1989-01-31
KR920008820B1 (ko) 1992-10-09
IT1187730B (it) 1987-12-23
PT81007A (en) 1985-09-01
FR2569404A1 (fr) 1986-02-28
CH667268A5 (de) 1988-09-30
ES8704485A1 (es) 1987-04-01
BE903106A (fr) 1986-02-24

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