NL193752C - 1,3-Dihydro-4-(aroyl)-2H-imidazool-2-onen en anti-hypertensief, cardiotoon en anti-trombotisch werkzaam farmaceutisch preparaat. - Google Patents
1,3-Dihydro-4-(aroyl)-2H-imidazool-2-onen en anti-hypertensief, cardiotoon en anti-trombotisch werkzaam farmaceutisch preparaat. Download PDFInfo
- Publication number
- NL193752C NL193752C NL8003498A NL8003498A NL193752C NL 193752 C NL193752 C NL 193752C NL 8003498 A NL8003498 A NL 8003498A NL 8003498 A NL8003498 A NL 8003498A NL 193752 C NL193752 C NL 193752C
- Authority
- NL
- Netherlands
- Prior art keywords
- dihydro
- imidazol
- methyl
- branched
- straight
- Prior art date
Links
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- 230000003276 anti-hypertensive effect Effects 0.000 title claims description 8
- 230000003177 cardiotonic effect Effects 0.000 title claims description 6
- 230000002785 anti-thrombosis Effects 0.000 title claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 3
- 239000003146 anticoagulant agent Substances 0.000 title description 7
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- RZWZRACFZGVKFM-UHFFFAOYSA-N propanoyl chloride Chemical compound CCC(Cl)=O RZWZRACFZGVKFM-UHFFFAOYSA-N 0.000 description 1
- AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 1
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- PUGUQINMNYINPK-UHFFFAOYSA-N tert-butyl 4-(2-chloroacetyl)piperazine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCN(C(=O)CCl)CC1 PUGUQINMNYINPK-UHFFFAOYSA-N 0.000 description 1
- QEMXHQIAXOOASZ-UHFFFAOYSA-N tetramethylammonium Chemical compound C[N+](C)(C)C QEMXHQIAXOOASZ-UHFFFAOYSA-N 0.000 description 1
- 229910052718 tin Inorganic materials 0.000 description 1
- 239000011135 tin Substances 0.000 description 1
- UBZYKBZMAMTNKW-UHFFFAOYSA-J titanium tetrabromide Chemical compound Br[Ti](Br)(Br)Br UBZYKBZMAMTNKW-UHFFFAOYSA-J 0.000 description 1
- XJDNKRIXUMDJCW-UHFFFAOYSA-J titanium tetrachloride Chemical compound Cl[Ti](Cl)(Cl)Cl XJDNKRIXUMDJCW-UHFFFAOYSA-J 0.000 description 1
- YONPGGFAJWQGJC-UHFFFAOYSA-K titanium(iii) chloride Chemical compound Cl[Ti](Cl)Cl YONPGGFAJWQGJC-UHFFFAOYSA-K 0.000 description 1
- FEONEKOZSGPOFN-UHFFFAOYSA-K tribromoiron Chemical compound Br[Fe](Br)Br FEONEKOZSGPOFN-UHFFFAOYSA-K 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4980879A | 1979-06-18 | 1979-06-18 | |
| US4980879 | 1979-06-18 | ||
| US11920780A | 1980-02-07 | 1980-02-07 | |
| US11920780 | 1980-02-07 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NL8003498A NL8003498A (nl) | 1980-12-22 |
| NL193752B NL193752B (nl) | 2000-05-01 |
| NL193752C true NL193752C (nl) | 2000-09-04 |
Family
ID=26727558
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL8003498A NL193752C (nl) | 1979-06-18 | 1980-06-17 | 1,3-Dihydro-4-(aroyl)-2H-imidazool-2-onen en anti-hypertensief, cardiotoon en anti-trombotisch werkzaam farmaceutisch preparaat. |
| NL300015C NL300015I1 (nl) | 1979-06-18 | 2000-09-04 | 1,3-Dihydro-4-(aroyl)-2H-imidazool-2-onen en anti-hypertensief, cardiotoon en anti-trombotisch werkzaam farmaceutisch preparaat. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL300015C NL300015I1 (nl) | 1979-06-18 | 2000-09-04 | 1,3-Dihydro-4-(aroyl)-2H-imidazool-2-onen en anti-hypertensief, cardiotoon en anti-trombotisch werkzaam farmaceutisch preparaat. |
Country Status (20)
| Country | Link |
|---|---|
| AT (1) | AT375349B (cs) |
| AU (1) | AU532783B2 (cs) |
| CA (1) | CA1132554A (cs) |
| CH (1) | CH646155A5 (cs) |
| DE (1) | DE3021792A1 (cs) |
| DK (1) | DK160269C (cs) |
| ES (1) | ES492255A0 (cs) |
| FR (1) | FR2459233A1 (cs) |
| GB (1) | GB2055364B (cs) |
| HK (1) | HK61486A (cs) |
| HU (1) | HU186736B (cs) |
| IE (1) | IE50646B1 (cs) |
| IL (1) | IL60243A (cs) |
| IT (1) | IT1143922B (cs) |
| MY (1) | MY8600709A (cs) |
| NL (2) | NL193752C (cs) |
| NO (1) | NO152841C (cs) |
| NZ (1) | NZ193935A (cs) |
| PH (1) | PH18683A (cs) |
| SE (2) | SE447107B (cs) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH18106A (en) * | 1981-02-18 | 1985-03-21 | Merrell Dow Pharma | Novel-4-aroylimidazol-2-ones |
| US4405628A (en) * | 1981-03-05 | 1983-09-20 | Merrell Dow Pharmaceuticals Inc. | 4-Pyridylimidazolones and method of use |
| US4526981A (en) * | 1981-05-04 | 1985-07-02 | Merrell Dow Pharmaceuticals Inc. | [1,2-Dihydro-4(5)-acyl-2-oxo-2H-imidazol-4(5)-yl] methyl nitrates |
| CA1167853A (en) * | 1981-05-04 | 1984-05-22 | J. Martin Grisar | 4-oxymethyl-5-acyl-1,3-dihydro-2h-imidazol-2-ones |
| US4371737A (en) * | 1981-05-04 | 1983-02-01 | Merrell Dow Pharmaceuticals Inc. | 5-Aminomethyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives |
| US4381393A (en) * | 1981-05-04 | 1983-04-26 | Merrell Dow Pharmaceuticals Inc. | 4-Aminomethyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones |
| US4329471A (en) * | 1981-05-04 | 1982-05-11 | Merrell Dow Pharmaceuticals Inc. | 4-(4-Phenyl-1-piperidinyl)methyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones |
| US4329470A (en) * | 1981-05-04 | 1982-05-11 | Merrell Dow Pharmaceuticals Inc. | 5-(4-Phenyl 1-piperidinyl)methyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives |
| US4367236A (en) * | 1981-11-04 | 1983-01-04 | Merrell Dow Pharmaceuticals Inc. | Method for the treatment of cardiac failure with alkanoylimidazol-2-one derivatives |
| US4410540A (en) * | 1981-11-04 | 1983-10-18 | Merrell Dow Pharmaceuticals Inc. | Cardiotonic 4-aroylimidazolidin-2-ones |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
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| US2441933A (en) * | 1945-07-30 | 1948-05-18 | Hoffmann La Roche | Substituted imidazolones and process of making them |
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1980
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- 1980-06-05 IE IE1162/80A patent/IE50646B1/en not_active IP Right Cessation
- 1980-06-06 SE SE8004253A patent/SE447107B/sv not_active IP Right Cessation
- 1980-06-06 AU AU59118/80A patent/AU532783B2/en not_active Expired
- 1980-06-06 IL IL60243A patent/IL60243A/xx unknown
- 1980-06-09 ES ES492255A patent/ES492255A0/es active Granted
- 1980-06-11 DE DE19803021792 patent/DE3021792A1/de active Granted
- 1980-06-13 AT AT0314280A patent/AT375349B/de not_active IP Right Cessation
- 1980-06-16 CH CH462780A patent/CH646155A5/de not_active IP Right Cessation
- 1980-06-16 PH PH24143A patent/PH18683A/en unknown
- 1980-06-17 DK DK259080A patent/DK160269C/da not_active IP Right Cessation
- 1980-06-17 FR FR8013434A patent/FR2459233A1/fr active Granted
- 1980-06-17 HU HU801506A patent/HU186736B/hu unknown
- 1980-06-17 CA CA354,197A patent/CA1132554A/en not_active Expired
- 1980-06-17 NO NO801796A patent/NO152841C/no unknown
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- 1980-06-17 IT IT48997/80A patent/IT1143922B/it active Protection Beyond IP Right Term
- 1980-06-18 GB GB8019898A patent/GB2055364B/en not_active Expired
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1985
- 1985-03-25 SE SE8501452A patent/SE464559B/sv not_active IP Right Cessation
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1986
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- 1986-12-30 MY MY709/86A patent/MY8600709A/xx unknown
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2000
- 2000-09-04 NL NL300015C patent/NL300015I1/nl unknown
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