NL191488C - Op de 5-plaats gesubstitueerde 10,11-dihydro-5H-dibenzo£a,d|cyclohepteen-5,10-iminen en farmaceutische preparaten die deze bevatten. - Google Patents

Op de 5-plaats gesubstitueerde 10,11-dihydro-5H-dibenzo£a,d|cyclohepteen-5,10-iminen en farmaceutische preparaten die deze bevatten.

Info

Publication number
NL191488C
NL191488C NL7808847A NL7808847A NL191488C NL 191488 C NL191488 C NL 191488C NL 7808847 A NL7808847 A NL 7808847A NL 7808847 A NL7808847 A NL 7808847A NL 191488 C NL191488 C NL 191488C
Authority
NL
Netherlands
Prior art keywords
cyclohepteen
dibenzo
imines
dihydro
pharmaceutical preparations
Prior art date
Application number
NL7808847A
Other languages
English (en)
Dutch (nl)
Other versions
NL191488B (nl
NL7808847A (nl
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of NL7808847A publication Critical patent/NL7808847A/xx
Publication of NL191488B publication Critical patent/NL191488B/xx
Application granted granted Critical
Publication of NL191488C publication Critical patent/NL191488C/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C07D295/116—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings with the doubly bound oxygen or sulfur atoms directly attached to a carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NL7808847A 1977-09-19 1978-08-28 Op de 5-plaats gesubstitueerde 10,11-dihydro-5H-dibenzo£a,d|cyclohepteen-5,10-iminen en farmaceutische preparaten die deze bevatten. NL191488C (nl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US83463977A 1977-09-19 1977-09-19

Publications (3)

Publication Number Publication Date
NL7808847A NL7808847A (nl) 1979-03-21
NL191488B NL191488B (nl) 1995-04-03
NL191488C true NL191488C (nl) 1995-08-04

Family

ID=25267426

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7808847A NL191488C (nl) 1977-09-19 1978-08-28 Op de 5-plaats gesubstitueerde 10,11-dihydro-5H-dibenzo£a,d|cyclohepteen-5,10-iminen en farmaceutische preparaten die deze bevatten.

Country Status (33)

Country Link
JP (1) JPS5463100A (sv)
AR (1) AR231544A1 (sv)
AT (1) AT370103B (sv)
AU (1) AU520178B2 (sv)
BE (1) BE870562A (sv)
CA (1) CA1129850A (sv)
CH (1) CH637954A5 (sv)
CY (1) CY1283A (sv)
DE (1) DE2840786A1 (sv)
DK (1) DK153843C (sv)
ES (7) ES473492A1 (sv)
FI (1) FI65618C (sv)
FR (1) FR2403334A1 (sv)
GB (2) GB2004872B (sv)
GR (1) GR65703B (sv)
HK (1) HK30885A (sv)
HU (1) HU180868B (sv)
IE (1) IE47355B1 (sv)
IL (1) IL55521A0 (sv)
IT (1) IT1113279B (sv)
KE (1) KE3501A (sv)
LU (1) LU80262A1 (sv)
NL (1) NL191488C (sv)
NO (1) NO151861C (sv)
NZ (1) NZ188361A (sv)
PH (1) PH15920A (sv)
PL (3) PL121605B1 (sv)
PT (1) PT68544A (sv)
SE (1) SE437520B (sv)
SG (1) SG9585G (sv)
SU (2) SU895288A3 (sv)
YU (1) YU41432B (sv)
ZA (1) ZA785291B (sv)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4232158A (en) * 1979-06-04 1980-11-04 Merck & Co., Inc. 10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imines
US4477668A (en) * 1982-04-07 1984-10-16 Merck & Co., Inc. Process for 5-methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5,10-imine
GB8719199D0 (en) * 1987-08-13 1987-09-23 Merck Sharp & Dohme Chemical compounds
US5686614A (en) * 1995-04-11 1997-11-11 Neurogen Corporation Preparation of chiral 5-aminocarbonyl-5H-dibenzo a,d!cyclohepten-5,10-imines by optical resolution
US5739337A (en) * 1996-03-08 1998-04-14 Neurogen Corporation Process for preparing dibenzo-1-carboxamido-1,4-azabicyclo 3.2.1!octanes
US10583171B2 (en) 2015-11-30 2020-03-10 INSERM (Institut National de la Santé et de la Recherche Médicale) NMDAR antagonists for the treatment of diseases associated with angiogenesis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE794904A (fr) * 1972-02-04 1973-08-02 Roussel Uclaf Nouveaux derives du dibenzocycloheptene et leur preparation
BE829075A (fr) * 1974-05-15 1975-11-14 9,10-dihydroanthracen-9,10-imines substituees et leurs analogues heterocycliques (aza)

Also Published As

Publication number Publication date
JPS5639315B2 (sv) 1981-09-11
AR231544A1 (es) 1984-12-28
YU41432B (en) 1987-06-30
ES483283A1 (es) 1980-04-16
CH637954A5 (de) 1983-08-31
IT1113279B (it) 1986-01-20
FI65618B (fi) 1984-02-29
SE437520B (sv) 1985-03-04
AU520178B2 (en) 1982-01-21
ZA785291B (en) 1980-04-30
HU180868B (en) 1983-04-29
FI782680A (fi) 1979-03-20
GB2004872B (en) 1982-04-15
PH15920A (en) 1983-04-22
IL55521A0 (en) 1978-12-17
NO783017L (no) 1979-03-20
PL121605B1 (en) 1982-05-31
BE870562A (fr) 1979-03-19
PL209632A1 (pl) 1979-06-04
IE781866L (en) 1979-03-19
FR2403334A1 (fr) 1979-04-13
ES483285A1 (es) 1980-09-01
NO151861B (no) 1985-03-11
JPS5463100A (en) 1979-05-21
DE2840786A1 (de) 1979-03-22
GB2004872A (en) 1979-04-11
ES473492A1 (es) 1980-07-16
ES483287A1 (es) 1980-04-16
NL191488B (nl) 1995-04-03
SE7809187L (sv) 1979-03-20
NO151861C (no) 1985-06-19
ES483288A1 (es) 1980-04-16
IE47355B1 (en) 1984-02-22
LU80262A1 (fr) 1979-06-01
IT7851126A0 (it) 1978-09-18
DK389978A (da) 1979-03-20
CY1283A (en) 1985-07-05
ATA669778A (de) 1982-07-15
SG9585G (en) 1985-08-08
PL118478B1 (en) 1981-10-31
PT68544A (en) 1978-10-01
DE2840786C2 (sv) 1987-05-21
DK153843B (da) 1988-09-12
CA1129850A (en) 1982-08-17
ES483284A1 (es) 1980-09-01
GR65703B (en) 1980-10-22
FI65618C (fi) 1984-06-11
ES483286A1 (es) 1980-04-16
YU219678A (en) 1983-02-28
AU3966878A (en) 1980-03-13
FR2403334B1 (sv) 1982-11-19
AT370103B (de) 1983-03-10
DK153843C (da) 1989-01-23
SU895288A3 (ru) 1981-12-30
NL7808847A (nl) 1979-03-21
SU915800A3 (en) 1982-03-23
GB2061947A (en) 1981-05-20
NZ188361A (en) 1982-06-29
HK30885A (en) 1985-04-26
KE3501A (en) 1985-02-22
GB2061947B (en) 1982-08-04
PL112834B1 (en) 1980-11-29

Similar Documents

Publication Publication Date Title
NL190552C (nl) 1-Fenyl-4-alkyl-7,8-dialkoxy-5H-2,3-benzodiazepinederivaten en farmaceutische preparaten, die deze bevatten.
NL7810520A (nl) Nieuwe 2,6-diaminonebularinen, alsmede farmaceutische preparaten die deze verbindingen bevatten.
NL189196C (nl) 1-fenyl-2-azolyl-4,4-dimethyl-penteen-3-ol derivaten en fungicide-preparaten die zo&#39;n verbinding bevatten.
NL192202B (nl) 2(1H)-pyridinonderivaten en farmaceutische preparaten die deze derivaten bevatten.
NL7811692A (nl) Fenylglycine-derivaten en preparaten die ze bevatten.
NL7810865A (nl) 6,7-dialkoxy-4-piperidinochinazolinen, farmaceutische preparaten die ze bevatten, en werkwijzen voor de be- reiding daarvan.
BE860688A (fr) Machine d&#39;enseignement, notamment de langues
NL7805588A (nl) 3,3,3-triarylalkyl-4-fenylalkyl-4-hydroxypiperidinen met geneeskrachtige activiteit.
NL190848C (nl) 2alfa-cyaan-4alfa,5alfa-epoxy-3-oxo-androstaanverbindingen, alsmede preparaten die deze verbindingen bevatten.
NL7808179A (nl) 4-gesubstitueerde pyrazolen, alsmede preparaten die de- ze verbindingen bevatten.
NL190520B (nl) Op plaats 1 gesubstitueerde, 7-gesubstitueerde amino-6-halogeen-4-oxo-1,4-dihydrochinoline-3-carbonzuren en farmaceutische preparaten, die deze bevatten.
IT7925677A0 (it) &#34;3&#34;,4&#34;-diaciltilosina eprocedimento per la sua produzione.
NL191488C (nl) Op de 5-plaats gesubstitueerde 10,11-dihydro-5H-dibenzo£a,d|cyclohepteen-5,10-iminen en farmaceutische preparaten die deze bevatten.
IT7821144A0 (it) Ghiera d&#39;estrusione.
NL7801921A (nl) Farmaceutische preparaten.
NL7803720A (nl) (1,5)pyrido2,3-bbenzothiazepine-derivaten.
NL7803448A (nl) Nieuwe benzothiadiazinederivaten, alsmede farmaceutische preparaten die deze verbindingen bevatten.
NL174646C (nl) 6,7-dimethoxy-4-amino-2-piperidinochinazolinen en farmaceutische preparaten die ze bevatten.
NO780809L (no) Papirprodukt.
NO853995L (no) &#34;2-(2`,2`,2`-trihalogenetyl)-4-halogencyklobutan-1-oner.
NL7804977A (nl) Nieuwe 4-hydroxythiazolidinethion-2-derivaten, de be- reiding ervan en preparaten, die de nieuwe derivaten bevatten.
NL184896C (nl) Pyranochinolinonderivaten en gevormde farmaceutische preparaten die deze bevatten.
NL7810922A (nl) Nieuwe isochimolinederivaten, de bereiding ervan, als- mede preparaten, die de isochinolinederivaten bevatten.
NL7811247A (nl) Baggerkop.
NL7812127A (nl) N&#39;-fenyl-n-methylureumderivaten.

Legal Events

Date Code Title Description
BB A search report has been drawn up
A85 Still pending on 85-01-01
BC A request for examination has been filed
V4 Discontinued because of reaching the maximum lifetime of a patent

Free format text: 980828