NL189199C - Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten. - Google Patents
Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten.Info
- Publication number
- NL189199C NL189199C NLAANVRAGE7504075,A NL7504075A NL189199C NL 189199 C NL189199 C NL 189199C NL 7504075 A NL7504075 A NL 7504075A NL 189199 C NL189199 C NL 189199C
- Authority
- NL
- Netherlands
- Prior art keywords
- pharmaceutical preparations
- benz
- aryl
- preparing
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Priority Applications (20)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NLAANVRAGE7504075,A NL189199C (nl) | 1975-04-05 | 1975-04-05 | Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten. |
ZA761756A ZA761756B (en) | 1975-04-05 | 1976-03-23 | Tetracyclic compounds |
IE614/76A IE42969B1 (en) | 1975-04-05 | 1976-03-23 | Tetracyclic compounds |
US05/669,544 US4062848A (en) | 1975-04-05 | 1976-03-23 | Tetracyclic compounds |
AU12361/76A AU493450B2 (en) | 1976-03-25 | Diazolo, diazino and diazepino [1,2-a] otrudi azeoube derivatives | |
GB12270/76A GB1543171A (en) | 1975-04-05 | 1976-03-26 | Tetracyclic compounds |
CH388676A CH622261A5 (sv) | 1975-04-05 | 1976-03-29 | |
DK142676AA DK142498B (da) | 1975-04-05 | 1976-03-30 | Analogifremgangsmåde til fremstilling af benzopyridoazepinderivater. |
FI760884A FI62087C (fi) | 1975-04-05 | 1976-04-01 | Foerfarande foer framstaellning av 1,2,3,4,10,14b-hexahydrobenso(c)pyrazino(1,2-a)pyridoazepinderivat med antihistamin- oc centralnervstimulerande aktivitet |
ES446634A ES446634A1 (es) | 1975-04-05 | 1976-04-02 | Procedimiento para preparar compuestos tetraacidicos. |
DE19762614406 DE2614406A1 (de) | 1975-04-05 | 1976-04-02 | Tetracyclische verbindungen, verfahren zu deren herstellung und arzneimittel, enthaltend diese verbindungen |
BE165832A BE840362A (fr) | 1975-04-05 | 1976-04-02 | Composes tetracycliques contenant un noyau azepine |
SE7603931A SE422941B (sv) | 1975-04-05 | 1976-04-02 | Analogiforfarande for framstellning av tetracykliska pyrido-bensazepinforeningar |
FR7609686A FR2305986A1 (fr) | 1975-04-05 | 1976-04-02 | Composes tetracycliques contenant un noyau azepine |
CA249,439A CA1076571A (en) | 1975-04-05 | 1976-04-02 | Tetracyclic derivatives of benzo-pyrido azepines |
LU74680A LU74680A1 (sv) | 1975-04-05 | 1976-04-02 | |
JP51037678A JPS5942678B2 (ja) | 1975-04-05 | 1976-04-02 | 四環式化合物及びその製法 |
HU76AO437A HU179401B (en) | 1975-04-05 | 1976-04-05 | Process for preparing tetracuclic benzo-pyrazino/imidazo,diazepino/-pyrido-azepine derivatives further pharmaceutical compositions containing thereof |
ES459348A ES459348A1 (es) | 1975-04-05 | 1977-05-31 | Procedimiento para preparar compuestos tetraciclicos. |
NL940007C NL940007I2 (nl) | 1975-04-05 | 1994-04-21 | Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwi jze ter bereiding van de toe te passen benz(aryl)azepinederivaten. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NLAANVRAGE7504075,A NL189199C (nl) | 1975-04-05 | 1975-04-05 | Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten. |
Publications (3)
Publication Number | Publication Date |
---|---|
NL7504075A NL7504075A (nl) | 1976-10-07 |
NL189199B NL189199B (nl) | 1992-09-01 |
NL189199C true NL189199C (nl) | 1993-02-01 |
Family
ID=19823518
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NLAANVRAGE7504075,A NL189199C (nl) | 1975-04-05 | 1975-04-05 | Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten. |
NL940007C NL940007I2 (nl) | 1975-04-05 | 1994-04-21 | Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwi jze ter bereiding van de toe te passen benz(aryl)azepinederivaten. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NL940007C NL940007I2 (nl) | 1975-04-05 | 1994-04-21 | Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwi jze ter bereiding van de toe te passen benz(aryl)azepinederivaten. |
Country Status (17)
Country | Link |
---|---|
US (1) | US4062848A (sv) |
JP (1) | JPS5942678B2 (sv) |
BE (1) | BE840362A (sv) |
CA (1) | CA1076571A (sv) |
CH (1) | CH622261A5 (sv) |
DE (1) | DE2614406A1 (sv) |
DK (1) | DK142498B (sv) |
ES (2) | ES446634A1 (sv) |
FI (1) | FI62087C (sv) |
FR (1) | FR2305986A1 (sv) |
GB (1) | GB1543171A (sv) |
HU (1) | HU179401B (sv) |
IE (1) | IE42969B1 (sv) |
LU (1) | LU74680A1 (sv) |
NL (2) | NL189199C (sv) |
SE (1) | SE422941B (sv) |
ZA (1) | ZA761756B (sv) |
Families Citing this family (74)
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US4515792A (en) * | 1982-09-30 | 1985-05-07 | Ciba-Geigy Corporation | Tetracyclic heterocycles and antidepressant compositions thereof |
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JPS63177670A (ja) * | 1987-01-31 | 1988-07-21 | Fujitsu General Ltd | 文字放送受信装置 |
JPS63215179A (ja) * | 1987-03-03 | 1988-09-07 | Fujitsu General Ltd | 受信装置 |
JPH055746Y2 (sv) * | 1988-04-27 | 1993-02-15 | ||
PT95522B (pt) * | 1989-10-05 | 1997-08-29 | Sankyo Co | Processo para a preparacao de novos compostos tetraciclicos com accao anti-alergica e anti-asmatica e de composicoes farmaceuticas que os contem |
EP0539164A1 (en) * | 1991-10-23 | 1993-04-28 | Sankyo Company Limited | Nitrogen-containing tetracyclic compounds having anti-allergic and anti-asthmatic activities, their preparation and use |
IL121076A (en) * | 1996-06-19 | 2000-10-31 | Akzo Nobel Nv | Pharmaceutical combinations comprising mirtazapine and one or more selective serotonin reuptake inhibitors |
EP1067934B1 (en) * | 1998-04-02 | 2003-11-26 | Akzo Nobel N.V. | Oral liquid solution comprising the antidepressant mirtazapine |
CZ20013658A3 (cs) * | 1999-04-19 | 2002-08-14 | Teva Pharmaceutical Industries Ltd. | Syntéza a krystalizace sloučenin obsahujících piperazinový kruh |
US6545149B2 (en) | 1999-04-19 | 2003-04-08 | Teva Pharmaceutical Industries Ltd. | Synthesis and crystallization of piperazine ring-containing compounds |
AU781221B2 (en) * | 1999-04-19 | 2005-05-12 | Teva Pharmaceutical Industries Ltd. | Novel synthesis and crystallization of piperazine ring-containing compounds |
JP2002542234A (ja) | 1999-04-19 | 2002-12-10 | テバ ファーマシューティカル インダストリーズ リミティド | ピペラジン環の新規合成 |
US6281207B1 (en) * | 1999-09-15 | 2001-08-28 | Reed Richter | Treatment of movement disorders by administration of mirtazapine |
WO2001025185A1 (fr) * | 1999-09-30 | 2001-04-12 | Sumika Fine Chemicals Co., Ltd. | Procede de production de derive de piperazine |
WO2001038329A1 (fr) * | 1999-11-24 | 2001-05-31 | Sumika Fine Chemicals Co., Ltd. | Cristaux de mirtazapine anhydre et leur procede d'obtention |
WO2001042239A1 (fr) | 1999-12-13 | 2001-06-14 | Sumika Fine Chemicals Co., Ltd. | Procede de preparation d'un compose pyridinemethanol |
KR20020068404A (ko) * | 2000-01-19 | 2002-08-27 | 악조 노벨 엔.브이. | 미르타자핀을 포함하는, 우울증 및 관련 장애 치료용 약물조합물 |
RU2270680C2 (ru) | 2000-02-11 | 2006-02-27 | Акцо Нобель Н.В. | Применение миртазапина для лечения расстройств сна |
IN190478B (sv) * | 2000-11-07 | 2003-08-02 | Sun Pharmaceutical Ind Ltd | |
US6660730B2 (en) | 2000-11-27 | 2003-12-09 | Sumika Fine Chemicals Co., Ltd. | Anhydrous mirtazapine and process for preparing the same |
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JP6433809B2 (ja) * | 2015-02-20 | 2018-12-05 | 株式会社トクヤマ | 1−(3−ヒドロキシメチルピリジル−2−)−2−フェニル−4−メチルピペラジンの製造方法 |
KR102540021B1 (ko) | 2020-12-02 | 2023-06-07 | (주)유케이케미팜 | 대량 생산에 적합한 미르타자핀의 제조방법 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL129434C (sv) * | 1966-03-12 | |||
NL7202963A (sv) * | 1972-03-07 | 1973-09-11 | ||
US3959470A (en) * | 1972-11-28 | 1976-05-25 | Mikhail Davidovich Mashkovsky | Psychotropic medicinal preparation |
-
1975
- 1975-04-05 NL NLAANVRAGE7504075,A patent/NL189199C/xx not_active IP Right Cessation
-
1976
- 1976-03-23 IE IE614/76A patent/IE42969B1/en unknown
- 1976-03-23 ZA ZA761756A patent/ZA761756B/xx unknown
- 1976-03-23 US US05/669,544 patent/US4062848A/en not_active Expired - Lifetime
- 1976-03-26 GB GB12270/76A patent/GB1543171A/en not_active Expired
- 1976-03-29 CH CH388676A patent/CH622261A5/de not_active IP Right Cessation
- 1976-03-30 DK DK142676AA patent/DK142498B/da active Protection Beyond IP Right Term
- 1976-04-01 FI FI760884A patent/FI62087C/fi not_active IP Right Cessation
- 1976-04-02 JP JP51037678A patent/JPS5942678B2/ja not_active Expired
- 1976-04-02 BE BE165832A patent/BE840362A/xx not_active IP Right Cessation
- 1976-04-02 FR FR7609686A patent/FR2305986A1/fr active Granted
- 1976-04-02 ES ES446634A patent/ES446634A1/es not_active Expired
- 1976-04-02 SE SE7603931A patent/SE422941B/sv active Protection Beyond IP Right Term
- 1976-04-02 DE DE19762614406 patent/DE2614406A1/de active Granted
- 1976-04-02 LU LU74680A patent/LU74680A1/xx unknown
- 1976-04-02 CA CA249,439A patent/CA1076571A/en not_active Expired
- 1976-04-05 HU HU76AO437A patent/HU179401B/hu unknown
-
1977
- 1977-05-31 ES ES459348A patent/ES459348A1/es not_active Expired
-
1994
- 1994-04-21 NL NL940007C patent/NL940007I2/nl unknown
Also Published As
Publication number | Publication date |
---|---|
HU179401B (en) | 1982-10-28 |
SE422941B (sv) | 1982-04-05 |
FR2305986B1 (sv) | 1980-06-13 |
ES459348A1 (es) | 1978-03-16 |
NL7504075A (nl) | 1976-10-07 |
LU74680A1 (sv) | 1976-11-11 |
NL940007I2 (nl) | 1994-10-17 |
AU1236176A (en) | 1977-09-29 |
NL189199B (nl) | 1992-09-01 |
IE42969B1 (en) | 1980-11-19 |
GB1543171A (en) | 1979-03-28 |
IE42969L (en) | 1976-10-05 |
BE840362A (fr) | 1976-10-04 |
DK142498C (sv) | 1981-07-06 |
DK142676A (sv) | 1976-10-06 |
JPS5942678B2 (ja) | 1984-10-16 |
DK142498B (da) | 1980-11-10 |
ES446634A1 (es) | 1977-11-01 |
DE2614406C2 (sv) | 1992-02-20 |
FI760884A (sv) | 1976-10-06 |
DE2614406A1 (de) | 1976-10-14 |
ZA761756B (en) | 1977-03-30 |
SE7603931L (sv) | 1976-10-06 |
FI62087B (fi) | 1982-07-30 |
CH622261A5 (sv) | 1981-03-31 |
JPS51122099A (en) | 1976-10-25 |
CA1076571A (en) | 1980-04-29 |
US4062848A (en) | 1977-12-13 |
FR2305986A1 (fr) | 1976-10-29 |
FI62087C (fi) | 1982-11-10 |
NL940007I1 (nl) | 1994-06-01 |
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BC | A request for examination has been filed | ||
A85 | Still pending on 85-01-01 | ||
AC1 | Application for a supplementary protection certificate |
Free format text: 940007, 940421 |
|
KC1 | Grant of a supplementary protection certificate |
Free format text: 940007, 950405, EXPIRES:20000404 |
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V4 | Discontinued because of reaching the maximum lifetime of a patent |