ES459348A1 - Procedimiento para preparar compuestos tetraciclicos. - Google Patents

Procedimiento para preparar compuestos tetraciclicos.

Info

Publication number
ES459348A1
ES459348A1 ES459348A ES459348A ES459348A1 ES 459348 A1 ES459348 A1 ES 459348A1 ES 459348 A ES459348 A ES 459348A ES 459348 A ES459348 A ES 459348A ES 459348 A1 ES459348 A1 ES 459348A1
Authority
ES
Spain
Prior art keywords
activity
pyridine ring
represents hydrogen
tetracyclic compounds
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES459348A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo NV
Original Assignee
Akzo NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=19823518&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES459348(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Akzo NV filed Critical Akzo NV
Publication of ES459348A1 publication Critical patent/ES459348A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Abstract

Procedimiento para preparar compuestos tetracíclicos de fórmula: (Ver fórmula I) o una sal de los mismos, donde A representa un anillo de piridina o un anillo de piridina sustituído con halógeno, R1 representa hidrógeno, alcohilo (1-6 C), alcoxi (1-6 C), alcohiltio (1-6 C), halógeno, hidroxilo, mercapto o trifluorometilo, R2 representa hidrógeno o un grupo alcohilo o aralcohilo inferior, y n y m representan los valores 1, 2 ó 3, con la salvedad de que la suma n + m ha de ser 2, 3 ó 4.
ES459348A 1975-04-05 1977-05-31 Procedimiento para preparar compuestos tetraciclicos. Expired ES459348A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NLAANVRAGE7504075,A NL189199C (nl) 1975-04-05 1975-04-05 Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten.

Publications (1)

Publication Number Publication Date
ES459348A1 true ES459348A1 (es) 1978-03-16

Family

ID=19823518

Family Applications (2)

Application Number Title Priority Date Filing Date
ES446634A Expired ES446634A1 (es) 1975-04-05 1976-04-02 Procedimiento para preparar compuestos tetraacidicos.
ES459348A Expired ES459348A1 (es) 1975-04-05 1977-05-31 Procedimiento para preparar compuestos tetraciclicos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES446634A Expired ES446634A1 (es) 1975-04-05 1976-04-02 Procedimiento para preparar compuestos tetraacidicos.

Country Status (17)

Country Link
US (1) US4062848A (es)
JP (1) JPS5942678B2 (es)
BE (1) BE840362A (es)
CA (1) CA1076571A (es)
CH (1) CH622261A5 (es)
DE (1) DE2614406A1 (es)
DK (1) DK142498B (es)
ES (2) ES446634A1 (es)
FI (1) FI62087C (es)
FR (1) FR2305986A1 (es)
GB (1) GB1543171A (es)
HU (1) HU179401B (es)
IE (1) IE42969B1 (es)
LU (1) LU74680A1 (es)
NL (2) NL189199C (es)
SE (1) SE422941B (es)
ZA (1) ZA761756B (es)

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JPS63177670A (ja) * 1987-01-31 1988-07-21 Fujitsu General Ltd 文字放送受信装置
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CA2026925A1 (en) * 1989-10-05 1991-04-06 Hiroshi Fukumi Tetracyclic compounds having anti-allergic and anti-asthmatic activities, their preparation and use
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AU781221B2 (en) * 1999-04-19 2005-05-12 Teva Pharmaceutical Industries Ltd. Novel synthesis and crystallization of piperazine ring-containing compounds
US6545149B2 (en) * 1999-04-19 2003-04-08 Teva Pharmaceutical Industries Ltd. Synthesis and crystallization of piperazine ring-containing compounds
CN1679586A (zh) * 1999-04-19 2005-10-12 特瓦制药工业有限公司 含哌嗪环化合物的新型合成和结晶方法
US6281207B1 (en) * 1999-09-15 2001-08-28 Reed Richter Treatment of movement disorders by administration of mirtazapine
WO2001025185A1 (fr) * 1999-09-30 2001-04-12 Sumika Fine Chemicals Co., Ltd. Procede de production de derive de piperazine
WO2001038329A1 (fr) * 1999-11-24 2001-05-31 Sumika Fine Chemicals Co., Ltd. Cristaux de mirtazapine anhydre et leur procede d'obtention
WO2001042239A1 (fr) * 1999-12-13 2001-06-14 Sumika Fine Chemicals Co., Ltd. Procede de preparation d'un compose pyridinemethanol
CA2396066A1 (en) * 2000-01-19 2001-07-26 Akzo Nobel N.V. Drug combination for the treatment of depression and related disorders comprising mirtazapine and gepirone
CZ302368B6 (cs) 2000-02-11 2011-04-13 N.V. Organon Farmaceutický prostredek
IN190478B (es) * 2000-11-07 2003-08-02 Sun Pharmaceutical Ind Ltd
US6660730B2 (en) * 2000-11-27 2003-12-09 Sumika Fine Chemicals Co., Ltd. Anhydrous mirtazapine and process for preparing the same
US20030105082A1 (en) * 2001-12-03 2003-06-05 Murphy Greer Marechal Methods for improving the therapeutic response of humans having major depression and carrying the gene for apolipoprotein E4
US20040106124A1 (en) * 2001-02-12 2004-06-03 Murphy Greer M. Methods for improving the treatment of major depression by genotyping for the gene for apolipoproteine e4 and for improving the terapeutic response of humans having major depression and carrying the gene for apolipoprotein e4
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US20040192754A1 (en) * 2003-03-24 2004-09-30 Shapira Nathan Andrew Methods for treating idiopathic hyperhidrosis and associated conditions
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JP4848704B2 (ja) * 2004-08-24 2011-12-28 住友化学株式会社 ２−（４−メチル−２−フェニルピペラジン−１−イル）−３−シアノピリジンの製造方法
TW200631584A (en) * 2004-11-15 2006-09-16 Akzo Nobel Nv A medicament related to mirtazapine for the treatment of hot flush
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KR102540021B1 (ko) 2020-12-02 2023-06-07 (주)유케이케미팜 대량 생산에 적합한 미르타자핀의 제조방법

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Also Published As

Publication number Publication date
NL7504075A (nl) 1976-10-07
NL189199C (nl) 1993-02-01
GB1543171A (en) 1979-03-28
FI62087C (fi) 1982-11-10
JPS51122099A (en) 1976-10-25
AU1236176A (en) 1977-09-29
LU74680A1 (es) 1976-11-11
NL940007I2 (nl) 1994-10-17
DE2614406C2 (es) 1992-02-20
CH622261A5 (es) 1981-03-31
DE2614406A1 (de) 1976-10-14
JPS5942678B2 (ja) 1984-10-16
BE840362A (fr) 1976-10-04
FI62087B (fi) 1982-07-30
FI760884A (es) 1976-10-06
CA1076571A (en) 1980-04-29
NL940007I1 (nl) 1994-06-01
FR2305986A1 (fr) 1976-10-29
US4062848A (en) 1977-12-13
NL189199B (nl) 1992-09-01
DK142498C (es) 1981-07-06
IE42969L (en) 1976-10-05
ZA761756B (en) 1977-03-30
IE42969B1 (en) 1980-11-19
DK142498B (da) 1980-11-10
HU179401B (en) 1982-10-28
FR2305986B1 (es) 1980-06-13
DK142676A (es) 1976-10-06
ES446634A1 (es) 1977-11-01
SE422941B (sv) 1982-04-05
SE7603931L (sv) 1976-10-06

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