NI200900103A - Inhibidores de transcriptasa inversa no nucleosídicos - Google Patents

Inhibidores de transcriptasa inversa no nucleosídicos

Info

Publication number
NI200900103A
NI200900103A NI200900103A NI200900103A NI200900103A NI 200900103 A NI200900103 A NI 200900103A NI 200900103 A NI200900103 A NI 200900103A NI 200900103 A NI200900103 A NI 200900103A NI 200900103 A NI200900103 A NI 200900103A
Authority
NI
Nicaragua
Prior art keywords
reverse transcriptase
transcriptase inhibitors
compounds
prophylaxis
formula
Prior art date
Application number
NI200900103A
Other languages
English (en)
Inventor
J Anthony Neville
Gómez Robert
M Jolly Samson
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of NI200900103A publication Critical patent/NI200900103A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41921,2,3-Triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/16Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D249/18Benzotriazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Los compuestos de la Fórmula I: (I), son inhibidores de transcriptasa inversa de VIH, en la que Q, R2, R3, R6, T1, T2, y T3 se definen en el presente documento. Los compuestos de la Fórmula I, y sus sales y profármacos farmacéuticamente aceptables, son de utilidad en la inhibición de transcriptasa inversa de VIH, en la profilaxis y tratamiento de infección por VIH y en la profilaxis, retraso del inicio o de la progresión, y tratamiento del SIDA. Los compuestos y sus sales pueden emplearse como ingredientes en composiciones farmacéuticas, opcionalmente combinados con otros antivirales, inmunomoduladores, antibióticos o vacunas.
NI200900103A 2006-12-13 2009-05-28 Inhibidores de transcriptasa inversa no nucleosídicos NI200900103A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87462906P 2006-12-13 2006-12-13

Publications (1)

Publication Number Publication Date
NI200900103A true NI200900103A (es) 2010-01-26

Family

ID=39277099

Family Applications (1)

Application Number Title Priority Date Filing Date
NI200900103A NI200900103A (es) 2006-12-13 2009-05-28 Inhibidores de transcriptasa inversa no nucleosídicos

Country Status (29)

Country Link
US (2) US7781454B2 (es)
EP (1) EP2121638B1 (es)
JP (1) JP5123949B2 (es)
KR (1) KR20090087481A (es)
CN (1) CN101558050A (es)
AR (1) AR064199A1 (es)
AU (1) AU2007334598B2 (es)
BR (1) BRPI0720196A2 (es)
CA (1) CA2673093A1 (es)
CL (1) CL2007003594A1 (es)
CR (1) CR10843A (es)
DO (1) DOP2009000138A (es)
EA (1) EA200970572A1 (es)
EC (1) ECSP099373A (es)
GE (1) GEP20115320B (es)
GT (1) GT200900158A (es)
HN (1) HN2009001160A (es)
IL (1) IL199103A0 (es)
MA (1) MA31036B1 (es)
MX (1) MX2009006285A (es)
NI (1) NI200900103A (es)
NO (1) NO20092636L (es)
NZ (1) NZ577637A (es)
PE (1) PE20081448A1 (es)
SV (1) SV2009003294A (es)
TN (1) TN2009000243A1 (es)
TW (1) TW200831085A (es)
WO (2) WO2008076225A2 (es)
ZA (1) ZA200903395B (es)

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Also Published As

Publication number Publication date
CR10843A (es) 2009-08-12
US20080275097A1 (en) 2008-11-06
US7781454B2 (en) 2010-08-24
JP5123949B2 (ja) 2013-01-23
SV2009003294A (es) 2009-11-09
US20100286192A1 (en) 2010-11-11
NZ577637A (en) 2011-05-27
ECSP099373A (es) 2009-07-31
HN2009001160A (es) 2011-10-11
MX2009006285A (es) 2009-06-23
PE20081448A1 (es) 2008-10-19
ZA200903395B (en) 2010-05-26
BRPI0720196A2 (pt) 2013-12-31
KR20090087481A (ko) 2009-08-17
GEP20115320B (en) 2011-10-25
AU2007334598A1 (en) 2008-06-26
IL199103A0 (en) 2010-03-28
JP2010510989A (ja) 2010-04-08
EP2121638B1 (en) 2016-05-25
TW200831085A (en) 2008-08-01
EA200970572A1 (ru) 2009-12-30
GT200900158A (es) 2009-10-14
TN2009000243A1 (en) 2010-10-18
DOP2009000138A (es) 2009-11-15
CN101558050A (zh) 2009-10-14
NO20092636L (no) 2009-09-08
AR064199A1 (es) 2009-03-18
CA2673093A1 (en) 2008-06-26
WO2008076225A3 (en) 2008-08-07
WO2008076225A2 (en) 2008-06-26
MA31036B1 (fr) 2009-12-01
AU2007334598B2 (en) 2013-01-17
WO2008076223A1 (en) 2008-06-26
EP2121638A2 (en) 2009-11-25
CL2007003594A1 (es) 2008-05-30

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