EA200970572A1 - Ненуклеозидные ингибиторы обратной транскриптазы - Google Patents

Ненуклеозидные ингибиторы обратной транскриптазы

Info

Publication number
EA200970572A1
EA200970572A1 EA200970572A EA200970572A EA200970572A1 EA 200970572 A1 EA200970572 A1 EA 200970572A1 EA 200970572 A EA200970572 A EA 200970572A EA 200970572 A EA200970572 A EA 200970572A EA 200970572 A1 EA200970572 A1 EA 200970572A1
Authority
EA
Eurasian Patent Office
Prior art keywords
reverse transcriptase
transcriptase inhibitors
compounds
nucleoside reverse
preventing
Prior art date
Application number
EA200970572A
Other languages
English (en)
Inventor
Невилл Дж. Энтони
Роберт Гомес
Самсон М. Джолли
Original Assignee
Мерк Энд Ко., Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Энд Ко., Инк. filed Critical Мерк Энд Ко., Инк.
Publication of EA200970572A1 publication Critical patent/EA200970572A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D249/18—Benzotriazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Соединения формулы (I)представляющие собой ингибиторы обратной транскриптазы ВИЧ, где Q, R, R, Т, Ти Ттакие, как определено в описании. Соединения формулы (I) и их фармацевтически приемлемые соли и пролекарства являются полезными для ингибирования обратной транскриптазы ВИЧ, профилактики и лечения инфицирования ВИЧ и для профилактики, задержки наступления или прогрессирования и лечения СПИД. Соединения и их соли могут применяться в качестве компонентов фармацевтических композиций, необязательно в комбинации с другими противовирусными средствами, иммуномодуляторами, антибиотиками или вакцинами.
EA200970572A 2006-12-13 2007-12-06 Ненуклеозидные ингибиторы обратной транскриптазы EA200970572A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87462906P 2006-12-13 2006-12-13
PCT/US2007/024974 WO2008076223A1 (en) 2006-12-13 2007-12-06 Non-nucleoside reverse transcriptase inhibitors

Publications (1)

Publication Number Publication Date
EA200970572A1 true EA200970572A1 (ru) 2009-12-30

Family

ID=39277099

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200970572A EA200970572A1 (ru) 2006-12-13 2007-12-06 Ненуклеозидные ингибиторы обратной транскриптазы

Country Status (29)

Country Link
US (2) US7781454B2 (ru)
EP (1) EP2121638B1 (ru)
JP (1) JP5123949B2 (ru)
KR (1) KR20090087481A (ru)
CN (1) CN101558050A (ru)
AR (1) AR064199A1 (ru)
AU (1) AU2007334598B2 (ru)
BR (1) BRPI0720196A2 (ru)
CA (1) CA2673093A1 (ru)
CL (1) CL2007003594A1 (ru)
CR (1) CR10843A (ru)
DO (1) DOP2009000138A (ru)
EA (1) EA200970572A1 (ru)
EC (1) ECSP099373A (ru)
GE (1) GEP20115320B (ru)
GT (1) GT200900158A (ru)
HN (1) HN2009001160A (ru)
IL (1) IL199103A0 (ru)
MA (1) MA31036B1 (ru)
MX (1) MX2009006285A (ru)
NI (1) NI200900103A (ru)
NO (1) NO20092636L (ru)
NZ (1) NZ577637A (ru)
PE (1) PE20081448A1 (ru)
SV (1) SV2009003294A (ru)
TN (1) TN2009000243A1 (ru)
TW (1) TW200831085A (ru)
WO (2) WO2008076225A2 (ru)
ZA (1) ZA200903395B (ru)

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Also Published As

Publication number Publication date
US20100286192A1 (en) 2010-11-11
SV2009003294A (es) 2009-11-09
DOP2009000138A (es) 2009-11-15
TW200831085A (en) 2008-08-01
NZ577637A (en) 2011-05-27
GT200900158A (es) 2009-10-14
CA2673093A1 (en) 2008-06-26
EP2121638B1 (en) 2016-05-25
EP2121638A2 (en) 2009-11-25
WO2008076225A2 (en) 2008-06-26
ECSP099373A (es) 2009-07-31
WO2008076225A3 (en) 2008-08-07
MX2009006285A (es) 2009-06-23
NI200900103A (es) 2010-01-26
CN101558050A (zh) 2009-10-14
CL2007003594A1 (es) 2008-05-30
IL199103A0 (en) 2010-03-28
KR20090087481A (ko) 2009-08-17
NO20092636L (no) 2009-09-08
AU2007334598B2 (en) 2013-01-17
US20080275097A1 (en) 2008-11-06
ZA200903395B (en) 2010-05-26
AR064199A1 (es) 2009-03-18
HN2009001160A (es) 2011-10-11
GEP20115320B (en) 2011-10-25
CR10843A (es) 2009-08-12
AU2007334598A1 (en) 2008-06-26
MA31036B1 (fr) 2009-12-01
US7781454B2 (en) 2010-08-24
WO2008076223A1 (en) 2008-06-26
JP5123949B2 (ja) 2013-01-23
JP2010510989A (ja) 2010-04-08
TN2009000243A1 (en) 2010-10-18
BRPI0720196A2 (pt) 2013-12-31
PE20081448A1 (es) 2008-10-19

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