EA201290976A1 - Ненуклеозидные ингибиторы обратной транскриптазы - Google Patents
Ненуклеозидные ингибиторы обратной транскриптазыInfo
- Publication number
- EA201290976A1 EA201290976A1 EA201290976A EA201290976A EA201290976A1 EA 201290976 A1 EA201290976 A1 EA 201290976A1 EA 201290976 A EA201290976 A EA 201290976A EA 201290976 A EA201290976 A EA 201290976A EA 201290976 A1 EA201290976 A1 EA 201290976A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- reverse transcriptase
- transcriptase inhibitors
- preventing
- compounds
- nucleoside reverse
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Гетероароматические соединения формулы (I) представляют собой ингибиторы обратной транскриптазы, где R, R, R, Rи Rимеют значения, определенные в описании. Соединения формулы (I) и их фармацевтически приемлемые соли являются полезными в ингибировании ВИЧ обратной транскриптазы, профилактике и лечении инфекций, вызываемых ВИЧ, и в профилактике, препятствовании возникновению или развитию и в лечении СПИД. Соединения и их соли могут быть применены в качестве ингредиентов в фармацевтических композициях, необязательно в сочетании с другими антивирусами, иммуномодуляторами, антибиотиками или вакцинами.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31882410P | 2010-03-30 | 2010-03-30 | |
| US32157310P | 2010-04-07 | 2010-04-07 | |
| PCT/CA2011/000320 WO2011120133A1 (en) | 2010-03-30 | 2011-03-28 | Non-nucleoside reverse transcriptase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201290976A1 true EA201290976A1 (ru) | 2013-03-29 |
| EA024804B1 EA024804B1 (ru) | 2016-10-31 |
Family
ID=44710363
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201290976A EA024804B1 (ru) | 2010-03-30 | 2011-03-28 | Ненуклеозидные ингибиторы обратной транскриптазы, композиции, их содержащие, и их применение |
Country Status (44)
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA024804B1 (ru) * | 2010-03-30 | 2016-10-31 | Мерк Кэнэда Инк. | Ненуклеозидные ингибиторы обратной транскриптазы, композиции, их содержащие, и их применение |
| US20140031250A1 (en) | 2010-10-07 | 2014-01-30 | David Tsai Ting | Biomarkers of Cancer |
| BR112015005997A8 (pt) * | 2012-09-26 | 2023-04-11 | Merck Sharp & Dohme | Composto |
| JO3470B1 (ar) | 2012-10-08 | 2020-07-05 | Merck Sharp & Dohme | مشتقات 5- فينوكسي-3h-بيريميدين-4-أون واستخدامها كمثبطات ناسخ عكسي ل hiv |
| US9663490B2 (en) * | 2012-12-05 | 2017-05-30 | Merck Sharp & Dohme Corp. | Process for making reverse transcriptase inhibitors |
| JP6387094B2 (ja) * | 2013-11-22 | 2018-09-05 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | 非ヌクレオシド逆転写酵素阻害剤の組成物 |
| MX367369B (es) | 2013-12-04 | 2019-08-16 | Merck Sharp & Dohme | Proceso para preparar inhibidores de la transcriptasa inversa. |
| WO2015153304A1 (en) * | 2014-04-01 | 2015-10-08 | Merck Sharp & Dohme Corp. | Prodrugs of hiv reverse transcriptase inhibitors |
| US10603282B2 (en) | 2015-12-02 | 2020-03-31 | Merck Sharp & Dohme Corp. | Pharmaceutical compositions containing doravirine, tenofovir disoproxil fumarate and lamivudine |
| WO2018175271A1 (en) * | 2017-03-24 | 2018-09-27 | Merck Sharp & Dohme Corp. | Formulation for parenteral administration |
| AU2018255954B2 (en) | 2017-04-18 | 2024-04-04 | Cipla Limited | Combination therapy for use in treating retroviral infections |
| EP3749330A4 (en) | 2018-02-06 | 2021-11-17 | The General Hospital Corporation | REPEAT RNA AS A BIOMARKER OF TUMOR IMMUNE REACTION |
| CN110801455B (zh) * | 2019-11-12 | 2020-06-02 | 河北医科大学第二医院 | 用于治疗mrsa的药物组合物及其应用 |
| CN114163309B (zh) * | 2021-12-27 | 2023-04-25 | 甘肃皓天医药科技有限责任公司 | 一种多拉韦林中间体的制备方法 |
| CN114349690B (zh) * | 2022-02-15 | 2023-04-25 | 甘肃皓天医药科技有限责任公司 | 一种多拉韦林中间体合成方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9904045D0 (sv) | 1999-11-09 | 1999-11-09 | Astra Ab | Compounds |
| TW200423930A (en) * | 2003-02-18 | 2004-11-16 | Hoffmann La Roche | Non-nucleoside reverse transcriptase inhibitors |
| JP4485520B2 (ja) | 2003-03-24 | 2010-06-23 | エフ．ホフマン−ラ ロシュ アーゲー | 逆転写酵素阻害剤としてのベンジル−ピリダジノン類 |
| TW200505441A (en) * | 2003-03-24 | 2005-02-16 | Hoffmann La Roche | Non-nucleoside reverse transcriptase inhibitorsⅠ |
| US7166738B2 (en) | 2004-04-23 | 2007-01-23 | Roche Palo Alto Llc | Non-nucleoside reverse transcriptase inhibitors |
| WO2005102989A1 (en) | 2004-04-23 | 2005-11-03 | F. Hoffmann-La Roche Ag | Non-nucleoside reverse transcriptase inhibitors |
| EP1831157A2 (en) | 2004-12-22 | 2007-09-12 | Pfizer Limited | Nonnucleoside inhibitors of hiv-1 reverse transcriptase |
| AR057455A1 (es) | 2005-07-22 | 2007-12-05 | Merck & Co Inc | Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica |
| EP1940782B1 (en) | 2005-10-19 | 2009-03-11 | F.Hoffmann-La Roche Ag | N-phenyl phenylacetamide non-nucleoside reverse transcriptase inhibitors |
| JP2009515826A (ja) | 2005-10-19 | 2009-04-16 | エフ．ホフマン−ラ ロシュ アーゲー | フェニル−アセトアミドｎｎｒｔ阻害剤 |
| TW200831085A (en) | 2006-12-13 | 2008-08-01 | Merck & Co Inc | Non-nucleoside reverse transcriptase inhibitors |
| CA2705834A1 (en) * | 2007-11-20 | 2009-05-28 | Merck Sharp & Dohme Corp. | Pyridinone non-nucleoside reverse transcriptase inhibitors |
| EA024804B1 (ru) * | 2010-03-30 | 2016-10-31 | Мерк Кэнэда Инк. | Ненуклеозидные ингибиторы обратной транскриптазы, композиции, их содержащие, и их применение |
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2011
- 2011-03-28 EA EA201290976A patent/EA024804B1/ru active Protection Beyond IP Right Term
- 2011-03-28 SG SG2012072401A patent/SG184347A1/en unknown
- 2011-03-28 ME MEP-2016-282A patent/ME02570B/me unknown
- 2011-03-28 LT LTEP15157348.2T patent/LT2924034T/lt unknown
- 2011-03-28 CN CN201180018074.2A patent/CN102971308B/zh active Active
- 2011-03-28 ME MEP-2015-76A patent/ME02181B/me unknown
- 2011-03-28 HU HUE15157348A patent/HUE031785T2/en unknown
- 2011-03-28 PT PT151573482T patent/PT2924034T/pt unknown
- 2011-03-28 BR BR112012024691-7A patent/BR112012024691B1/pt active IP Right Grant
- 2011-03-28 RS RS20161093A patent/RS55505B1/sr unknown
- 2011-03-28 ES ES11761856.1T patent/ES2536295T3/es active Active
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- 2011-03-28 JP JP2012538161A patent/JP5281718B2/ja active Active
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- 2011-03-28 DK DK15157348.2T patent/DK2924034T3/en active
- 2011-03-28 SI SI201131054A patent/SI2924034T1/sl unknown
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- 2011-03-28 AU AU2011235568A patent/AU2011235568B2/en active Active
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- 2011-03-28 DK DK11761856.1T patent/DK2552902T3/en active
- 2011-03-28 MX MX2012011379A patent/MX2012011379A/es active IP Right Grant
- 2011-03-28 HU HUE11761856A patent/HUE025336T2/en unknown
- 2011-03-28 WO PCT/CA2011/000320 patent/WO2011120133A1/en active Application Filing
- 2011-03-28 CA CA2794377A patent/CA2794377C/en active Active
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- 2011-03-28 SI SI201130491T patent/SI2552902T1/sl unknown
- 2011-03-28 EP EP15157348.2A patent/EP2924034B1/en active Active
- 2011-03-28 MA MA35324A patent/MA34170B1/fr unknown
- 2011-03-28 US US13/073,631 patent/US8486975B2/en active Active
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- 2011-03-29 AR ARP110101028A patent/AR080859A1/es active IP Right Grant
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2012
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2013
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- 2013-05-23 JP JP2013108533A patent/JP5886790B2/ja not_active Expired - Fee Related
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2014
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2015
- 2015-04-20 HR HRP20150427TT patent/HRP20150427T1/hr unknown
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2016
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2017
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2019
- 2019-04-09 HU HUS1900022C patent/HUS1900022I1/hu unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): KG MD TJ TM |
|
| ND4A | Extension of term of a eurasian patent |