CY2019026I1 - Μη νουκλεοσιδικοι αναστολεις αναστροφης μεταγραφασης - Google Patents

Μη νουκλεοσιδικοι αναστολεις αναστροφης μεταγραφασης

Info

Publication number
CY2019026I1
CY2019026I1 CY2019026C CY2019026C CY2019026I1 CY 2019026 I1 CY2019026 I1 CY 2019026I1 CY 2019026 C CY2019026 C CY 2019026C CY 2019026 C CY2019026 C CY 2019026C CY 2019026 I1 CY2019026 I1 CY 2019026I1
Authority
CY
Cyprus
Prior art keywords
reverse transcription
nucleoside inhibitors
nucleoside
inhibitors
transcription
Prior art date
Application number
CY2019026C
Other languages
English (en)
Other versions
CY2019026I2 (el
Original Assignee
Merck Canada Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44710363&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY2019026(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Canada Inc. filed Critical Merck Canada Inc.
Publication of CY2019026I2 publication Critical patent/CY2019026I2/el
Publication of CY2019026I1 publication Critical patent/CY2019026I1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
CY2019026C 2010-03-30 2019-05-16 Μη νουκλεοσιδικοι αναστολεις αναστροφης μεταγραφασης CY2019026I1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31882410P 2010-03-30 2010-03-30
US32157310P 2010-04-07 2010-04-07
PCT/CA2011/000320 WO2011120133A1 (en) 2010-03-30 2011-03-28 Non-nucleoside reverse transcriptase inhibitors

Publications (2)

Publication Number Publication Date
CY2019026I2 CY2019026I2 (el) 2020-05-29
CY2019026I1 true CY2019026I1 (el) 2020-05-29

Family

ID=44710363

Family Applications (3)

Application Number Title Priority Date Filing Date
CY20171100114T CY1118774T1 (el) 2010-03-30 2017-01-25 Φαρμακευτικη συνθεση η οποια περιλαμβανει εναν μη νουκλεοσιδικο αναστολεα αναστροφης μεταγραφασης
CY2019026C CY2019026I1 (el) 2010-03-30 2019-05-16 Μη νουκλεοσιδικοι αναστολεις αναστροφης μεταγραφασης
CY2019025C CY2019025I2 (el) 2010-03-30 2019-05-16 Φαρμακευτικη συνθεση η οποια περιλαμβανει εναν μη νουκλεοσιδικο αναστολεα αναστροφης μεταγραφασης

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY20171100114T CY1118774T1 (el) 2010-03-30 2017-01-25 Φαρμακευτικη συνθεση η οποια περιλαμβανει εναν μη νουκλεοσιδικο αναστολεα αναστροφης μεταγραφασης

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY2019025C CY2019025I2 (el) 2010-03-30 2019-05-16 Φαρμακευτικη συνθεση η οποια περιλαμβανει εναν μη νουκλεοσιδικο αναστολεα αναστροφης μεταγραφασης

Country Status (44)

Country Link
US (2) US8486975B2 (el)
EP (2) EP2924034B1 (el)
JP (2) JP5281718B2 (el)
KR (1) KR101421861B1 (el)
CN (1) CN102971308B (el)
AR (1) AR080859A1 (el)
AU (1) AU2011235568B2 (el)
BR (1) BR112012024691B1 (el)
CA (1) CA2794377C (el)
CL (1) CL2012002744A1 (el)
CO (1) CO6630126A2 (el)
CR (1) CR20120503A (el)
CY (3) CY1118774T1 (el)
DK (2) DK2924034T3 (el)
DO (1) DOP2012000256A (el)
EA (1) EA024804B1 (el)
EC (1) ECSP12012201A (el)
ES (2) ES2536295T3 (el)
FI (1) FIC20190021I1 (el)
GE (1) GEP20156368B (el)
HK (2) HK1175471A1 (el)
HN (1) HN2012002039A (el)
HR (2) HRP20150427T1 (el)
HU (4) HUE031785T2 (el)
IL (2) IL222030A (el)
LT (3) LT2924034T (el)
LU (2) LUC00113I2 (el)
MA (1) MA34170B1 (el)
ME (2) ME02570B (el)
MX (1) MX2012011379A (el)
MY (1) MY163979A (el)
NI (1) NI201200146A (el)
NL (1) NL300980I2 (el)
NO (2) NO2019019I1 (el)
NZ (1) NZ602670A (el)
PE (1) PE20130158A1 (el)
PL (2) PL2552902T3 (el)
PT (2) PT2924034T (el)
RS (2) RS55505B1 (el)
SG (1) SG184347A1 (el)
SI (2) SI2924034T1 (el)
TN (1) TN2012000455A1 (el)
TW (1) TWI458719B (el)
WO (1) WO2011120133A1 (el)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA024804B1 (ru) * 2010-03-30 2016-10-31 Мерк Кэнэда Инк. Ненуклеозидные ингибиторы обратной транскриптазы, композиции, их содержащие, и их применение
US20140031250A1 (en) 2010-10-07 2014-01-30 David Tsai Ting Biomarkers of Cancer
BR112015005997A8 (pt) * 2012-09-26 2023-04-11 Merck Sharp & Dohme Composto
JO3470B1 (ar) 2012-10-08 2020-07-05 Merck Sharp & Dohme مشتقات 5- فينوكسي-3h-بيريميدين-4-أون واستخدامها كمثبطات ناسخ عكسي ل hiv
US9663490B2 (en) * 2012-12-05 2017-05-30 Merck Sharp & Dohme Corp. Process for making reverse transcriptase inhibitors
JP6387094B2 (ja) * 2013-11-22 2018-09-05 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． 非ヌクレオシド逆転写酵素阻害剤の組成物
MX367369B (es) 2013-12-04 2019-08-16 Merck Sharp & Dohme Proceso para preparar inhibidores de la transcriptasa inversa.
WO2015153304A1 (en) * 2014-04-01 2015-10-08 Merck Sharp & Dohme Corp. Prodrugs of hiv reverse transcriptase inhibitors
US10603282B2 (en) 2015-12-02 2020-03-31 Merck Sharp & Dohme Corp. Pharmaceutical compositions containing doravirine, tenofovir disoproxil fumarate and lamivudine
WO2018175271A1 (en) * 2017-03-24 2018-09-27 Merck Sharp & Dohme Corp. Formulation for parenteral administration
AU2018255954B2 (en) 2017-04-18 2024-04-04 Cipla Limited Combination therapy for use in treating retroviral infections
EP3749330A4 (en) 2018-02-06 2021-11-17 The General Hospital Corporation REPEAT RNA AS A BIOMARKER OF TUMOR IMMUNE REACTION
CN110801455B (zh) * 2019-11-12 2020-06-02 河北医科大学第二医院 用于治疗mrsa的药物组合物及其应用
CN114163309B (zh) * 2021-12-27 2023-04-25 甘肃皓天医药科技有限责任公司 一种多拉韦林中间体的制备方法
CN114349690B (zh) * 2022-02-15 2023-04-25 甘肃皓天医药科技有限责任公司 一种多拉韦林中间体合成方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9904045D0 (sv) 1999-11-09 1999-11-09 Astra Ab Compounds
TW200423930A (en) * 2003-02-18 2004-11-16 Hoffmann La Roche Non-nucleoside reverse transcriptase inhibitors
JP4485520B2 (ja) 2003-03-24 2010-06-23 エフ．ホフマン−ラ ロシュ アーゲー 逆転写酵素阻害剤としてのベンジル−ピリダジノン類
TW200505441A (en) * 2003-03-24 2005-02-16 Hoffmann La Roche Non-nucleoside reverse transcriptase inhibitorsⅠ
US7166738B2 (en) 2004-04-23 2007-01-23 Roche Palo Alto Llc Non-nucleoside reverse transcriptase inhibitors
WO2005102989A1 (en) 2004-04-23 2005-11-03 F. Hoffmann-La Roche Ag Non-nucleoside reverse transcriptase inhibitors
EP1831157A2 (en) 2004-12-22 2007-09-12 Pfizer Limited Nonnucleoside inhibitors of hiv-1 reverse transcriptase
AR057455A1 (es) 2005-07-22 2007-12-05 Merck & Co Inc Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica
EP1940782B1 (en) 2005-10-19 2009-03-11 F.Hoffmann-La Roche Ag N-phenyl phenylacetamide non-nucleoside reverse transcriptase inhibitors
JP2009515826A (ja) 2005-10-19 2009-04-16 エフ．ホフマン−ラ ロシュ アーゲー フェニル−アセトアミドｎｎｒｔ阻害剤
TW200831085A (en) 2006-12-13 2008-08-01 Merck & Co Inc Non-nucleoside reverse transcriptase inhibitors
CA2705834A1 (en) * 2007-11-20 2009-05-28 Merck Sharp & Dohme Corp. Pyridinone non-nucleoside reverse transcriptase inhibitors
EA024804B1 (ru) * 2010-03-30 2016-10-31 Мерк Кэнэда Инк. Ненуклеозидные ингибиторы обратной транскриптазы, композиции, их содержащие, и их применение

Also Published As

Publication number Publication date
PT2552902E (pt) 2015-06-02
PL2924034T3 (pl) 2017-07-31
NL300980I2 (nl) 2021-06-17
SG184347A1 (en) 2012-11-29
EA024804B1 (ru) 2016-10-31
EP2552902B1 (en) 2015-03-11
EP2924034A1 (en) 2015-09-30
CA2794377A1 (en) 2011-10-06
TW201139409A (en) 2011-11-16
US20130296382A1 (en) 2013-11-07
IL233334A (en) 2015-09-24
TWI458719B (zh) 2014-11-01
MA34170B1 (fr) 2013-04-03
ES2536295T3 (es) 2015-05-22
PE20130158A1 (es) 2013-02-28
HUS1900022I1 (hu) 2019-05-28
LTPA2019507I1 (lt) 2019-04-25
HK1175471A1 (en) 2013-07-05
ES2609636T3 (es) 2017-04-21
US8486975B2 (en) 2013-07-16
DK2552902T3 (en) 2015-06-15
ME02181B (me) 2015-10-20
SI2552902T1 (sl) 2015-10-30
NL300980I1 (nl) 2019-04-24
KR101421861B1 (ko) 2014-07-22
GEP20156368B (en) 2015-09-25
NI201200146A (es) 2013-03-18
NO2019019I1 (no) 2019-04-24
CY1118774T1 (el) 2017-07-12
KR20120128703A (ko) 2012-11-27
SI2924034T1 (sl) 2017-05-31
MY163979A (en) 2017-11-15
RS55505B1 (sr) 2017-05-31
EP2552902A4 (en) 2013-09-04
HRP20161680T1 (hr) 2017-01-27
CY2019025I1 (el) 2019-11-27
JP2013510800A (ja) 2013-03-28
EP2924034B1 (en) 2016-11-02
JP2013209405A (ja) 2013-10-10
JP5886790B2 (ja) 2016-03-16
LTC2552902I2 (lt) 2019-12-10
AR080859A1 (es) 2012-05-16
HUE031785T2 (en) 2017-08-28
IL222030A (en) 2014-07-31
EP2552902A1 (en) 2013-02-06
PT2924034T (pt) 2017-01-06
ECSP12012201A (es) 2012-10-30
FIC20190021I1 (fi) 2019-04-17
IL233334A0 (en) 2014-09-01
NO2019018I1 (no) 2019-04-24
CY2019025I2 (el) 2019-11-27
LTC2924034I2 (lt) 2020-10-12
HUE025336T2 (en) 2016-03-29
CA2794377C (en) 2015-06-16
CN102971308A (zh) 2013-03-13
CN102971308B (zh) 2015-02-04
HN2012002039A (es) 2015-08-24
TN2012000455A1 (en) 2014-01-30
CL2012002744A1 (es) 2012-12-14
LTPA2019506I1 (lt) 2019-04-25
LT2924034T (lt) 2016-12-27
PL2552902T3 (pl) 2015-10-30
CR20120503A (es) 2013-01-09
US20110245296A1 (en) 2011-10-06
AU2011235568B2 (en) 2013-09-12
EA201290976A1 (ru) 2013-03-29
WO2011120133A1 (en) 2011-10-06
CY2019026I2 (el) 2020-05-29
HRP20150427T1 (hr) 2015-07-03
HUS1900021I1 (hu) 2019-05-28
MX2012011379A (es) 2012-11-30
ME02570B (me) 2017-06-20
AU2011235568A1 (en) 2012-11-01
BR112012024691B1 (pt) 2020-11-17
CO6630126A2 (es) 2013-03-01
RS54017B1 (en) 2015-10-30
JP5281718B2 (ja) 2013-09-04
LUC00114I1 (el) 2019-04-17
DOP2012000256A (es) 2012-12-15
LUC00113I2 (el) 2024-05-22
NZ602670A (en) 2014-09-26
LUC00114I2 (el) 2020-07-10
DK2924034T3 (en) 2017-02-06
BR112012024691A2 (pt) 2019-07-02
HK1209121A1 (en) 2016-03-24

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