MXPA06014249A - Derivados de quinazolinona utiles como antagonistas vanilloides. - Google Patents
Derivados de quinazolinona utiles como antagonistas vanilloides.Info
- Publication number
- MXPA06014249A MXPA06014249A MXPA06014249A MXPA06014249A MXPA06014249A MX PA06014249 A MXPA06014249 A MX PA06014249A MX PA06014249 A MXPA06014249 A MX PA06014249A MX PA06014249 A MXPA06014249 A MX PA06014249A MX PA06014249 A MXPA06014249 A MX PA06014249A
- Authority
- MX
- Mexico
- Prior art keywords
- carbon atoms
- alkyl
- amino
- hydroxyl
- compound
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title description 8
- AVRPFRMDMNDIDH-UHFFFAOYSA-N 1h-quinazolin-2-one Chemical class C1=CC=CC2=NC(O)=NC=C21 AVRPFRMDMNDIDH-UHFFFAOYSA-N 0.000 title description 5
- 150000003839 salts Chemical group 0.000 claims abstract description 47
- 239000002253 acid Substances 0.000 claims abstract description 25
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
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- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
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- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Cereal-Derived Products (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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| MXPA06014249A true MXPA06014249A (es) | 2007-02-19 |
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| MA (1) | MA28685B1 (enExample) |
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| GB0525068D0 (en) * | 2005-12-08 | 2006-01-18 | Novartis Ag | Organic compounds |
| EA200900330A1 (ru) | 2006-08-23 | 2009-08-28 | Ньюроджен Корпорейшн | Аналоги 2-феноксипиримидинона |
| CA2668579A1 (en) * | 2006-11-06 | 2008-06-05 | Neurogen Corporation | Cis-cyclohexyl substituted pyrimidinone derivatives |
| ES2648225T3 (es) * | 2007-07-18 | 2017-12-29 | Novartis Ag | Combinaciones sinérgicas de antagonistas de VR-1 e inhibidores de COX-2 |
| US8915362B2 (en) | 2008-10-08 | 2014-12-23 | Ultimed, Inc. | Sharps container |
| US8349852B2 (en) * | 2009-01-13 | 2013-01-08 | Novartis Ag | Quinazolinone derivatives useful as vanilloid antagonists |
| AR080056A1 (es) | 2010-02-01 | 2012-03-07 | Novartis Ag | Derivados de ciclohexil-amida como antagonistas de los receptores de crf |
| CN102762572A (zh) | 2010-02-01 | 2012-10-31 | 诺瓦提斯公司 | 作为CRF-1受体拮抗剂的吡唑并[5,1b]*唑衍生物 |
| EP2531490B1 (en) | 2010-02-02 | 2014-10-15 | Novartis AG | Cyclohexyl amide derivatives as crf receptor antagonists |
| UY34094A (es) | 2011-05-27 | 2013-01-03 | Novartis Ag | Derivados de la piperidina 3-espirocíclica como agonistas de receptores de la ghrelina |
| WO2013164790A1 (en) | 2012-05-03 | 2013-11-07 | Novartis Ag | L-malate salt of 2, 7 - diaza - spiro [4.5 ] dec- 7 - yle derivatives and crystalline forms thereof as ghrelin receptor agonists |
| US9776975B2 (en) | 2013-03-05 | 2017-10-03 | University Of Notre Dame Du Lac | Quinazolinone antibiotics |
| US10016425B2 (en) | 2016-11-03 | 2018-07-10 | King Saud University | Anti-ulcerative colitis compound |
| EP3873608A1 (en) | 2018-10-31 | 2021-09-08 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds having hpk1 inhibitory activity |
| EP4371987B9 (en) | 2018-10-31 | 2025-11-26 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds as hpk1 inhibitors |
| US20200261456A1 (en) * | 2019-02-15 | 2020-08-20 | Novartis Ag | Methods for treating ocular surface pain |
| JP6994061B2 (ja) | 2019-02-15 | 2022-01-14 | ノバルティス アーゲー | ４－（７－ヒドロキシ－２－イソプロピル－４－オキソ－４ｈ－キナゾリン－３－イル）－ベンゾニトリルの製剤 |
| JP2022520410A (ja) | 2019-02-15 | 2022-03-30 | ノバルティス アーゲー | ４－（７－ヒドロキシ－２－イソプロピル－４－オキソ－４ｈ－キナゾリン－３－イル）－ベンゾニトリルの結晶形態及びその製剤 |
| US11453681B2 (en) | 2019-05-23 | 2022-09-27 | Gilead Sciences, Inc. | Substituted eneoxindoles and uses thereof |
| RU2755206C1 (ru) | 2020-05-20 | 2021-09-14 | Федеральное государственное бюджетное учреждение науки Тихоокеанский институт биоорганической химии им. Г.Б. Елякова Дальневосточного отделения Российской академии наук (ТИБОХ ДВО РАН) | Средство пролонгированного анальгетического действия и лекарственный препарат на его основе |
| US12459902B2 (en) * | 2020-08-06 | 2025-11-04 | Bausch + Lomb Ireland Limited | Crystalline forms of 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile and formulations thereof |
| US20230416207A1 (en) * | 2020-11-17 | 2023-12-28 | Crystal Pharmatech Co., Ltd. | Crystalline forms of quinazolinone compound and process for preparing the same |
| AR125196A1 (es) | 2021-03-26 | 2023-06-21 | Novartis Ag | Derivados de ciclobutilo 1,3-sustituidos y sus usos |
| JP2025531367A (ja) | 2022-09-21 | 2025-09-19 | ボシュ ＋ ロム アイルランド リミテッド | Ｔｒｐｖ１アンタゴニストの結晶多形形態およびその製剤 |
| KR20250030194A (ko) | 2023-08-24 | 2025-03-05 | 코웨이 주식회사 | 출수 장치 |
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| GB0412768D0 (en) | 2004-06-08 | 2004-07-07 | Novartis Ag | Organic compounds |
| GB0412769D0 (en) | 2004-06-08 | 2004-07-07 | Novartis Ag | Organic compounds |
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| GB0525068D0 (en) | 2005-12-08 | 2006-01-18 | Novartis Ag | Organic compounds |
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2004
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2005
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- 2005-06-08 RU RU2010112450/04A patent/RU2449995C2/ru active
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- 2005-06-08 RU RU2006146632/04A patent/RU2396261C2/ru active
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- 2005-06-08 AT AT05750584T patent/ATE376833T1/de active
- 2005-06-08 EP EP05750584A patent/EP1755606B2/en not_active Expired - Lifetime
- 2005-06-08 PL PL05750584T patent/PL1755606T5/pl unknown
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2007
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2009
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