MX9804107A - Derivados de quinolina. - Google Patents

Derivados de quinolina.

Info

Publication number
MX9804107A
MX9804107A MX9804107A MX9804107A MX9804107A MX 9804107 A MX9804107 A MX 9804107A MX 9804107 A MX9804107 A MX 9804107A MX 9804107 A MX9804107 A MX 9804107A MX 9804107 A MX9804107 A MX 9804107A
Authority
MX
Mexico
Prior art keywords
compound
quinoline derivatives
optionally substituted
group
solvate
Prior art date
Application number
MX9804107A
Other languages
English (en)
Spanish (es)
Inventor
Giuseppe Arnaldo Mari Giardina
Mario Grugni
Luca Francesco Raveglia
Carlo Farino
Original Assignee
Smithkline Beecham Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI952461 external-priority patent/IT1276170B1/it
Priority claimed from ITMI961689 external-priority patent/IT1307331B1/it
Application filed by Smithkline Beecham Spa filed Critical Smithkline Beecham Spa
Publication of MX9804107A publication Critical patent/MX9804107A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
    • C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
MX9804107A 1995-11-24 1998-05-22 Derivados de quinolina. MX9804107A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI952461 IT1276170B1 (it) 1995-11-24 1995-11-24 Derivati chinolinici
ITMI961689 IT1307331B1 (it) 1996-08-02 1996-08-02 Derivati chinolinici

Publications (1)

Publication Number Publication Date
MX9804107A true MX9804107A (es) 1998-09-30

Family

ID=26331326

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9804107A MX9804107A (es) 1995-11-24 1998-05-22 Derivados de quinolina.

Country Status (26)

Country Link
US (1) US6277862B1 (cg-RX-API-DMAC7.html)
EP (1) EP0876347B1 (cg-RX-API-DMAC7.html)
JP (1) JP2000501104A (cg-RX-API-DMAC7.html)
KR (1) KR19990071597A (cg-RX-API-DMAC7.html)
CN (1) CN1207730A (cg-RX-API-DMAC7.html)
AP (1) AP9801237A0 (cg-RX-API-DMAC7.html)
AR (1) AR004972A1 (cg-RX-API-DMAC7.html)
AT (1) ATE289994T1 (cg-RX-API-DMAC7.html)
BG (1) BG102558A (cg-RX-API-DMAC7.html)
BR (1) BR9611820A (cg-RX-API-DMAC7.html)
CA (1) CA2238298A1 (cg-RX-API-DMAC7.html)
CZ (1) CZ157998A3 (cg-RX-API-DMAC7.html)
DE (1) DE69634416T2 (cg-RX-API-DMAC7.html)
EA (1) EA002124B1 (cg-RX-API-DMAC7.html)
ES (1) ES2236757T3 (cg-RX-API-DMAC7.html)
IL (1) IL124522A0 (cg-RX-API-DMAC7.html)
MX (1) MX9804107A (cg-RX-API-DMAC7.html)
NO (1) NO311212B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ323387A (cg-RX-API-DMAC7.html)
OA (1) OA11010A (cg-RX-API-DMAC7.html)
PL (1) PL326967A1 (cg-RX-API-DMAC7.html)
SK (1) SK66798A3 (cg-RX-API-DMAC7.html)
TR (1) TR199800924T2 (cg-RX-API-DMAC7.html)
TW (1) TW353066B (cg-RX-API-DMAC7.html)
UY (1) UY24733A1 (cg-RX-API-DMAC7.html)
WO (1) WO1997021680A1 (cg-RX-API-DMAC7.html)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993007751A1 (en) 1991-10-18 1993-04-29 Monsanto Company Fungicides for the control of take-all disease of plants
SE9703407D0 (sv) * 1997-09-19 1997-09-19 Astra Ab New use
SE9802073D0 (sv) 1998-06-11 1998-06-11 Astra Ab New use
GB9825554D0 (en) 1998-11-20 1999-01-13 Smithkline Beecham Spa Novel Compounds
US7037922B1 (en) * 2000-03-10 2006-05-02 Neurogen Corporation Aryl fused 2,4-disubstituted pyridines: NK3 receptor ligands
ATE247652T1 (de) 1999-03-29 2003-09-15 Neurogen Corp 4-substituierte chinolinderivate als nk-3 und/oder gaba(a) rezeptor liganden
AU4802500A (en) 1999-04-26 2000-11-10 Neurogen Corporation 2-aminoquinolinecarboxamides: neurokinin receptor ligands
ATE318266T1 (de) * 2001-04-11 2006-03-15 Glaxosmithkline Spa 3-substituierte chinolin-4- carbonsäureamidderivate als nk-3- und nk-2- rezeptorantagonisten
WO2002089802A2 (en) * 2001-05-08 2002-11-14 Schering Corporation Use of neurokinin receptor antagonists to treat androgen-dependent diseases
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
DK1594517T3 (da) 2003-01-28 2007-10-29 Microbia Inc Sammensætninger til behandlingen af gastrointestinale lidelser
GB0303086D0 (en) 2003-02-11 2003-03-19 Merck Sharp & Dohme New compounds
GB0419192D0 (en) 2004-08-27 2004-09-29 Merck Sharp & Dohme Therapeutic agents
US20070249670A1 (en) * 2004-11-09 2007-10-25 Smithkline Beecham Corporation Glycogen Phosphorylase Inhibitor Compounds and Pharmaceutical Compositions Thereof
GB0425077D0 (en) * 2004-11-12 2004-12-15 Smithkline Beecham Corp Novel compounds
GB0515580D0 (en) 2005-07-29 2005-09-07 Merck Sharp & Dohme Therapeutic compounds
US20080287492A1 (en) * 2005-08-11 2008-11-20 Astrazeneca Ab Alkylpyridyl Quinolines as Nk3 Receptor Modulators
AR057130A1 (es) 2005-09-21 2007-11-14 Astrazeneca Ab Quinolinas de alquilsulfoxido y una composicion farmaceutica
TW200804288A (en) 2005-12-12 2008-01-16 Astrazeneca Ab Alkylsulphonamide quinolines
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
ES2559319T3 (es) 2007-06-04 2016-02-11 Synergy Pharmaceuticals Inc. Agonistas de guanilato cliclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
US8034782B2 (en) 2008-07-16 2011-10-11 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
AU2008309003A1 (en) * 2007-09-28 2009-04-09 Glaxosmithkline Llc Glycogen phosphorylase inhibitor compound and pharmaceutical composition thereof
EP2197845A1 (en) * 2007-09-28 2010-06-23 GlaxoSmithKline LLC Glycogen phosphorylase inhibitor compound and pharmaceutical composition thereof
EP2328910B1 (en) 2008-06-04 2014-08-06 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
WO2018129556A1 (en) 2017-01-09 2018-07-12 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
JP5502106B2 (ja) 2008-12-31 2014-05-28 アーデリクス，インコーポレーテッド 体液貯留または塩分過負荷と関連する障害および消化管障害の治療におけるｎｈｅ媒介性アンチポートを阻害するための組成物および方法
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
WO2014029983A1 (en) 2012-08-21 2014-02-27 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
US10376481B2 (en) 2012-08-21 2019-08-13 Ardelyx, Inc. Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
WO2014151200A2 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
AU2014235215A1 (en) 2013-03-15 2015-10-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
PT2983667T (pt) 2013-04-12 2019-07-11 Ardelyx Inc Compostos e métodos de ligação ao nhe3 para inibir o transporte de fosfato
CA2909752A1 (en) 2013-04-19 2014-10-23 Astrazeneca Ab A nk3 receptor antagonist compound (nk3ra) for use in a method for the treatment of polycystic ovary syndrome (pcos)
BR112015030326A2 (pt) 2013-06-05 2017-08-29 Synergy Pharmaceuticals Inc Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos
WO2017072629A1 (en) 2015-10-29 2017-05-04 Cadila Healthcare Limited Pharmaceutical combination of nk3 receptor antagonist and biguanides
JP7292207B2 (ja) 2017-01-09 2023-06-16 アルデリックス， インコーポレイテッド 消化管障害を処置するために有用な化合物
US11147884B2 (en) 2017-01-09 2021-10-19 Ardelyx, Inc. Inhibitors of NHE-mediated antiport

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2538388B1 (fr) * 1982-12-24 1985-06-21 Pharmuka Lab Nouveaux derives de naphtalene- ou azanaphtalenecarboxamide, leurs procedes de preparation et leur utilisation comme medicaments
JPS63119455A (ja) * 1986-06-27 1988-05-24 Nippon Shinyaku Co Ltd グリシン誘導体
ATE246677T1 (de) * 1994-05-27 2003-08-15 Smithkline Beecham Farma Chinolinderivate als tachykinin nk3 rezeptor antagonisten
IT1270615B (it) * 1994-07-14 1997-05-07 Smithkline Beecham Farma Uso di derivati di chinolina

Also Published As

Publication number Publication date
EA002124B1 (ru) 2001-12-24
NO311212B1 (no) 2001-10-29
UY24733A1 (es) 2001-08-27
CZ157998A3 (cs) 1998-12-16
DE69634416T2 (de) 2005-12-29
NZ323387A (en) 2000-02-28
IL124522A0 (en) 1998-12-06
EP0876347A1 (en) 1998-11-11
ATE289994T1 (de) 2005-03-15
CA2238298A1 (en) 1997-06-19
US6277862B1 (en) 2001-08-21
TW353066B (en) 1999-02-21
BR9611820A (pt) 1999-07-13
AR004972A1 (es) 1999-04-07
SK66798A3 (en) 1999-01-11
NO982331D0 (no) 1998-05-22
EP0876347B1 (en) 2005-03-02
TR199800924T2 (xx) 1998-08-21
JP2000501104A (ja) 2000-02-02
ES2236757T3 (es) 2005-07-16
OA11010A (en) 2003-03-06
PL326967A1 (en) 1998-11-09
AP9801237A0 (en) 1998-06-30
DE69634416D1 (de) 2005-04-07
KR19990071597A (ko) 1999-09-27
BG102558A (bg) 1999-03-31
EA199800477A1 (ru) 1998-12-24
CN1207730A (zh) 1999-02-10
NO982331L (no) 1998-07-22
WO1997021680A1 (en) 1997-06-19

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