MX9803264A - Metodo y preparaciones para estabilizar materiales biologicos por metodos de secado sin congelamiento. - Google Patents

Metodo y preparaciones para estabilizar materiales biologicos por metodos de secado sin congelamiento.

Info

Publication number
MX9803264A
MX9803264A MX9803264A MX9803264A MX9803264A MX 9803264 A MX9803264 A MX 9803264A MX 9803264 A MX9803264 A MX 9803264A MX 9803264 A MX9803264 A MX 9803264A MX 9803264 A MX9803264 A MX 9803264A
Authority
MX
Mexico
Prior art keywords
freezing
preparations
biological materials
substance mixtures
drying methods
Prior art date
Application number
MX9803264A
Other languages
English (en)
Inventor
Markus Mattern
Gerhard Winter
Original Assignee
Roche Diagnostics Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7775640&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX9803264(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Roche Diagnostics Gmbh filed Critical Roche Diagnostics Gmbh
Publication of MX9803264A publication Critical patent/MX9803264A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A61K38/443—Oxidoreductases (1) acting on CH-OH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00—Drying solid materials or objects by processes not involving the application of heat
    • F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Drying Of Solid Materials (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Storage Of Fruits Or Vegetables (AREA)

Abstract

La presente invencion se relaciona con procesos para la produccion de productos secos, parcialmente amorfos que contienen material biologicamente activo y en particular terapéuticamente activo, los cuales son mezclas de sustancias macroscopicamente homogéneas, las mezclas de sustancias se seleccionan de al menos una sustancia de cada uno de los grupos. (1) carbohidrato o zwitterion con un residuo polar y derivados de los mimos, y (ii) switterion con un residuo apolar y derivados de los mismos, en donde se preparo una solucion biologica o terapéuticamente activo y de sustancias (i) e (ii) y la solucion se seca a una temperatura de producto superior al punto de congelamiento de la solucion. Además la invencion se relaciona con mezclas de sustancias novedosas, las cuales se obtienen por dicho proceso así como el uso de las mismas en métodos de diagnosticos o terapéuticos.
MX9803264A 1995-10-25 1998-04-24 Metodo y preparaciones para estabilizar materiales biologicos por metodos de secado sin congelamiento. MX9803264A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19539574A DE19539574A1 (de) 1995-10-25 1995-10-25 Zubereitungen und Verfahren zur Stabilisierung biologischer Materialien mittels Trocknungsverfahren ohne Einfrieren

Publications (1)

Publication Number Publication Date
MX9803264A true MX9803264A (es) 1998-09-30

Family

ID=7775640

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9803264A MX9803264A (es) 1995-10-25 1998-04-24 Metodo y preparaciones para estabilizar materiales biologicos por metodos de secado sin congelamiento.

Country Status (25)

Country Link
US (3) US7172999B2 (es)
EP (1) EP0857060B1 (es)
JP (2) JPH11513700A (es)
KR (1) KR100466670B1 (es)
CN (1) CN1130196C (es)
AT (1) ATE212541T1 (es)
AU (1) AU712489B2 (es)
BR (1) BR9611265A (es)
CA (1) CA2235243C (es)
CZ (1) CZ293456B6 (es)
DE (2) DE19539574A1 (es)
DK (1) DK0857060T3 (es)
ES (1) ES2170274T3 (es)
HU (1) HU222601B1 (es)
IL (1) IL124204A (es)
MX (1) MX9803264A (es)
NO (1) NO324728B1 (es)
NZ (1) NZ320276A (es)
PL (1) PL190657B1 (es)
PT (1) PT857060E (es)
RU (1) RU2191003C2 (es)
SK (1) SK283664B6 (es)
TR (1) TR199800715T2 (es)
WO (1) WO1997015288A2 (es)
ZA (1) ZA968930B (es)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6582728B1 (en) 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
DE19539574A1 (de) * 1995-10-25 1997-04-30 Boehringer Mannheim Gmbh Zubereitungen und Verfahren zur Stabilisierung biologischer Materialien mittels Trocknungsverfahren ohne Einfrieren
EP0852951A1 (de) * 1996-11-19 1998-07-15 Roche Diagnostics GmbH Stabile lyophilisierte pharmazeutische Zubereitungen von mono- oder polyklonalen Antikörpern
EP0913177A1 (de) * 1997-11-03 1999-05-06 Roche Diagnostics GmbH Verfahren zur Herstellung trockener, amorpher Produkte enthaltend biologisch aktive Materialien mittels Konvektionstrocknung, insbesondere Sprühtrocknung
EP0913178A1 (en) * 1997-11-03 1999-05-06 Boehringer Mannheim Gmbh Process for the manufacture of dry, amorphous products comprising biologically active material by means of convection drying and products obtainable by the process
BR9905867A (pt) * 1998-11-06 2001-01-23 Bio Sidus S A Linhagem celular produtora de eritropoietina humana recombinante e a eritropoietina humana recombinante produzida por esta célula
US6696056B1 (en) * 1999-04-09 2004-02-24 Ortho Mcneil Pharmaceutical, Inc. Pharmaceutical compositions of erythropoietin
DE10026698A1 (de) 2000-05-30 2001-12-06 Basf Ag Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
AU2000264912A1 (en) * 2000-06-07 2001-12-17 Universal Preservation Technologies, Inc. Industrial scale barrier technology for preservation of sensitive biological materials
GB0017999D0 (en) * 2000-07-21 2000-09-13 Smithkline Beecham Biolog Novel device
CZ303145B6 (cs) * 2002-01-16 2012-05-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Zpusob výroby dvojvrstevné farmaceutické tablety obsahující telmisartan a hydrochlorthiazid
KR100556503B1 (ko) * 2002-11-26 2006-03-03 엘지전자 주식회사 건조기의 건조 시간제어 방법
US8377952B2 (en) * 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
US20060099567A1 (en) * 2004-04-08 2006-05-11 Biomatrica, Inc. Integration of sample storage and sample management for life science
CA2560513A1 (en) * 2004-04-08 2005-12-01 Biomatrica, Inc. Integration of sample storage and sample management for life science
US20080176209A1 (en) * 2004-04-08 2008-07-24 Biomatrica, Inc. Integration of sample storage and sample management for life science
GB0517688D0 (en) * 2005-08-31 2005-10-05 Cambridge Biostability Ltd Improvements in the stabilisation of biological materials
GB2430880A (en) * 2005-10-04 2007-04-11 Cambridge Biostability Ltd Pharmaceutical compositions stabilized in glassy particles
GB0523638D0 (en) * 2005-11-21 2005-12-28 Cambridge Biostability Ltd Pharmaceutical device for the administration of substances to patients
US8968721B2 (en) 2005-12-28 2015-03-03 Advanced Bionutrition Corporation Delivery vehicle for probiotic bacteria comprising a dry matrix of polysaccharides, saccharides and polyols in a glass form and methods of making same
JP5214464B2 (ja) 2005-12-28 2013-06-19 アドバンスド バイオニュートリション コーポレーション 多糖類、糖類およびポリオール類の乾燥マトリックスを含む、ガラス形態の、プロバイオティクス細菌用送達媒体およびその製造方法
WO2008076975A1 (en) 2006-12-18 2008-06-26 Advanced Bionutrition Corporation A dry food product containing live probiotic
US8466187B2 (en) * 2007-09-18 2013-06-18 Thermolife International, Llc Amino acid compositions
EP3266448B1 (en) 2009-03-27 2022-02-16 Intervet International B.V. Microparticulated vaccines for the oral or nasal vaccination and boostering of animals including fish
EP2236520A1 (en) * 2009-03-31 2010-10-06 Leukocare Ag Stabilizing composition for immobilized biomolecules
EP2435554B1 (en) * 2009-05-26 2017-07-26 Advanced Bionutrition Corporation Stable dry powder composition comprising biologically active microorganisms and/or bioactive materials and methods of making
TWI609698B (zh) * 2010-01-20 2018-01-01 Chugai Pharmaceutical Co Ltd 穩定化的含抗體溶液製劑
ES2639397T3 (es) 2010-01-28 2017-10-26 Advanced Bionutrition Corporation Composición vítrea seca que comprende un material bioactivo
US9504750B2 (en) 2010-01-28 2016-11-29 Advanced Bionutrition Corporation Stabilizing composition for biological materials
CA2806734A1 (en) 2010-07-26 2012-02-09 Biomatrica, Inc. Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures
JP5933544B2 (ja) 2010-07-26 2016-06-08 バイオマトリカ， インコーポレーテッド 外界温度で出荷および貯蔵中の血中ｄｎａ、ｒｎａおよびタンパク質ならびに他の生体試料を安定化させるための組成物
PL2603100T3 (pl) 2010-08-13 2019-06-28 Advanced Bionutrition Corp. Kompozycja stabilizująca przechowywanie na sucho materiałów biologicznych
CN102408467B (zh) * 2010-09-26 2014-03-05 海口维瑅瑷生物研究院 真空干燥蛋白的方法、制得的蛋白产品和试剂盒
AU2012242565B2 (en) 2011-04-13 2017-05-11 Thermolife International, Llc N-Acetyl Beta Alanine methods of use
EP2934572A4 (en) 2012-12-20 2016-11-23 Biomatrica Inc FORMULATIONS AND METHODS FOR STABILIZING PCR REAGENTS
CN106572650B (zh) 2014-06-10 2021-08-31 生物马特里卡公司 在环境温度下稳定凝血细胞
US9868944B2 (en) * 2014-12-19 2018-01-16 Roche Molecular Systems, Inc. Reaction mixtures
BR112017017147B1 (pt) * 2015-02-11 2024-02-20 Prevtec Microbia Inc Processo para fornecimento de escherichia coli (e. coli) viável embebida em uma matriz na forma de uma partícula
RU2747228C2 (ru) 2015-04-29 2021-04-29 Радиус Фармасьютикалз, Инк. Способы лечения рака
DK3328215T3 (da) 2015-07-29 2021-09-13 Advanced Bionutrition Corp Stabilt tørre probiotiske sammensætninger til særlige kostanvendelser
KR20230145258A (ko) 2015-12-08 2023-10-17 바이오매트리카 인코포레이티드 적혈구 침강 속도의 감소
CN106831466B (zh) * 2016-12-28 2018-05-22 安徽省虹升生物股份有限公司 一种β-丙氨酸的常规储存方法
PL3565542T3 (pl) 2017-01-05 2024-07-29 Radius Pharmaceuticals, Inc. Postacie polimorficzne rad1901-2hcl
AU2019254473A1 (en) * 2018-04-16 2020-12-03 Merck Patent Gmbh Additives for protein formulations to improve thermal stability
WO2020010216A1 (en) 2018-07-04 2020-01-09 Radius Pharmaceuticals, Inc. Polymorphic forms of rad 1901-2hcl
CN115803011A (zh) * 2020-07-13 2023-03-14 默克专利股份有限公司 用于高度浓缩蛋白质制剂的粘度降低赋形剂及其组合
US11865139B2 (en) 2020-11-12 2024-01-09 Thermolife International, Llc Method of treating migraines and headaches
CN114480129A (zh) * 2022-01-13 2022-05-13 力因精准医疗产品（上海）有限公司 一种人粪便保存液及使用方法

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3714353A (en) * 1959-08-11 1973-01-30 Upjohn Co THERAPEUTIC COMPOSITIONS COMPRISING A 6 alpha ; 9 alpha -DIFLUORO-11 beta ,17 alpha ,21-TRIHYDROXY-16 alpha -METHYL-1,4-PREGNADIENE-3,20-DIONE AND 21-ACYLATES
US3852461A (en) * 1971-08-04 1974-12-03 Upjohn Co Benzodiapines used as minor tranquilizers
JPS5836954B2 (ja) * 1980-03-31 1983-08-12 栄研化学株式会社 酵素の安定化剤
JPS5967228A (ja) 1982-10-07 1984-04-16 Green Cross Corp:The 寒冷不溶性グロブリンの凍結乾燥方法
JPS6197229A (ja) * 1984-10-18 1986-05-15 Chugai Pharmaceut Co Ltd 安定なエリトロポエチン製剤
US4732889A (en) * 1985-02-06 1988-03-22 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical composition for the treatment of the anemia of rheumatoid arthritis
US4788072A (en) * 1985-08-15 1988-11-29 Toshimitsu Kawamura Method of dehydrating foods
US4808617A (en) 1985-12-18 1989-02-28 Bristol-Myers Company Lyophilized or precipitated cephalosporin zwitterion and salt combination
WO1988006457A1 (en) * 1987-03-04 1988-09-07 Nippon Hypox Laboratories Incorporated Medicinal composition containing albumin as carrier and process for its preparation
DE3729863A1 (de) 1987-09-05 1989-03-16 Boehringer Mannheim Gmbh Stabilisierte erythropoietin-lyophilisate
US4886742A (en) * 1987-06-15 1989-12-12 Coulter Corporation Enzyme immunoassay for detecting HIV antigens in human sera
DE3801179A1 (de) 1988-01-18 1989-07-27 Hoechst Ag Stabilisierung von cephalosporinderivaten durch trocknung mit einem stabilisator sowie stabile zubereitungsformen mit cephalosporinderivaten
JPH0761955B2 (ja) 1988-04-28 1995-07-05 国立予防衛生研究所長 凍結乾燥ａ型肝炎ワクチン
CA1339071C (en) 1988-08-24 1997-07-29 Koichiro Tsuji Thrombus control agent
JPH0296536A (ja) 1988-09-29 1990-04-09 Green Cross Corp:The プラスミノゲン乾燥製剤
JP2739584B2 (ja) 1989-01-06 1998-04-15 株式会社ミドリ十字 ウロキナーゼ型プラスミノーゲンアクチベーター乾燥製剤
US5186944A (en) * 1989-02-15 1993-02-16 Eimei Company Ltd. Therapeutic medicament for thrombosis
EP0420964A4 (en) 1989-04-11 1991-09-25 Immunobiology Research Institute, Inc. Lyophilized peptide formulations
JPH0775519B2 (ja) 1989-10-06 1995-08-16 東洋製罐株式会社 ドライパック包装食品の製造方法
GB9001987D0 (en) * 1990-01-29 1990-03-28 Janssen Pharmaceutica Nv Improved cyclodextrin based erythropietin formulation
JPH0813750B2 (ja) 1990-03-01 1996-02-14 持田製薬株式会社 経口用トロンビン製剤
US5200399A (en) * 1990-09-14 1993-04-06 Boyce Thompson Institute For Plant Research, Inc. Method of protecting biological materials from destructive reactions in the dry state
US5217741A (en) 1991-01-25 1993-06-08 Snow Brand Milk Products Co., Ltd. Solution containing whey protein, whey protein gel, whey protein powder and processed food product produced by using the same
AU659645B2 (en) * 1991-06-26 1995-05-25 Inhale Therapeutic Systems Storage of materials
JP2818834B2 (ja) * 1991-08-12 1998-10-30 大塚製薬株式会社 ＩＬ−１α安定化医薬製剤
DE4141351A1 (de) * 1991-12-14 1993-06-17 Basf Ag Stabile pulverfoermige vitamin- und/oder carotinoid-praeparate und verfahren zu deren herstellung
SE9201073D0 (sv) 1992-04-03 1992-04-03 Kabi Pharmacia Ab Protein formulation
IL105553A (en) 1992-05-06 1998-01-04 Janssen Pharmaceutica Inc Solid dosage forms consisting of a porous network of matrix that releases a substance that dissipates rapidly in water
IT1254359B (it) 1992-05-11 1995-09-14 Serono Cesare Ist Ricerca Composizioni farmaceutiche contenenti il-6
US6582728B1 (en) 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
JP3168550B2 (ja) * 1992-12-02 2001-05-21 株式会社林原生物化学研究所 脱水剤およびそれを用いる含水物の脱水方法並びにその方法で得られる脱水物品
DE4242863A1 (de) * 1992-12-18 1994-06-23 Boehringer Mannheim Gmbh Stabile lyophilisierte pharmazeutische Zubereitungen von G-CSF
US5354934A (en) * 1993-02-04 1994-10-11 Amgen Inc. Pulmonary administration of erythropoietin
ES2218543T3 (es) 1994-03-07 2004-11-16 Nektar Therapeutics Procedimiento y preparacion para la administracion de insulina por via pulmonar.
US5955448A (en) * 1994-08-19 1999-09-21 Quadrant Holdings Cambridge Limited Method for stabilization of biological substances during drying and subsequent storage and compositions thereof
FR2719479B1 (fr) * 1994-05-04 1996-07-26 Sanofi Elf Formulation stable lyophilisée comprenant une protéine: kit de dosage.
NZ285664A (en) 1994-05-18 1998-07-28 Inhale Therapeutic Syst Dry powder interferon composition adapted for pulmonary delivery
IL116085A (en) 1994-12-16 1999-12-31 Ortho Pharma Corp Spray dried erythropoietin
EP0820277B1 (en) 1995-04-14 2005-01-26 Nektar Therapeutics Powdered pharmaceutical formulations having improved dispersibility
US5728678A (en) 1995-06-06 1998-03-17 Nestec Ltd. Method and composition for providing nutrition to a renal failure patient
DE19538687A1 (de) 1995-10-17 1997-04-24 Boehringer Mannheim Gmbh Stabile pharmazeutische Darreichungsformen enthaltend Parathormon
DE19539574A1 (de) * 1995-10-25 1997-04-30 Boehringer Mannheim Gmbh Zubereitungen und Verfahren zur Stabilisierung biologischer Materialien mittels Trocknungsverfahren ohne Einfrieren

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CA2235243A1 (en) 1997-05-01
NO981868L (no) 1998-06-25
DE59608684D1 (de) 2002-03-14
WO1997015288A2 (de) 1997-05-01
JPH11513700A (ja) 1999-11-24
ATE212541T1 (de) 2002-02-15
US7172999B2 (en) 2007-02-06
RU2191003C2 (ru) 2002-10-20
AU712489B2 (en) 1999-11-11
DE19539574A1 (de) 1997-04-30
NO324728B1 (no) 2007-12-03
CZ117998A3 (cs) 1998-11-11
PL326358A1 (en) 1998-09-14
US20010055617A1 (en) 2001-12-27
DK0857060T3 (da) 2002-05-13
JP2007236975A (ja) 2007-09-20
HUP9901314A2 (hu) 1999-07-28
PL190657B1 (pl) 2005-12-30
ES2170274T3 (es) 2002-08-01
AU7298496A (en) 1997-05-15
NO981868D0 (no) 1998-04-24
PT857060E (pt) 2002-07-31
EP0857060B1 (de) 2002-01-30
WO1997015288A3 (de) 1997-05-29
CA2235243C (en) 2003-04-22
ZA968930B (en) 1998-04-24
CZ293456B6 (cs) 2004-05-12
NZ320276A (en) 1999-11-29
CN1130196C (zh) 2003-12-10
SK283664B6 (sk) 2003-11-04
EP0857060A2 (de) 1998-08-12
CN1205628A (zh) 1999-01-20
IL124204A (en) 2001-10-31
KR100466670B1 (ko) 2005-09-07
KR19990067082A (ko) 1999-08-16
US20030059468A1 (en) 2003-03-27
SK50998A3 (en) 1998-12-02
HUP9901314A3 (en) 2000-02-28
TR199800715T2 (xx) 1998-08-21
HU222601B1 (hu) 2003-08-28
US20070020289A1 (en) 2007-01-25
BR9611265A (pt) 1999-05-04

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