ES2170274T3 - Metodo y preparaciones para estabilizar materiales biologicos por metodos de secado sin congelamiento. - Google Patents
Metodo y preparaciones para estabilizar materiales biologicos por metodos de secado sin congelamiento.Info
- Publication number
- ES2170274T3 ES2170274T3 ES96934811T ES96934811T ES2170274T3 ES 2170274 T3 ES2170274 T3 ES 2170274T3 ES 96934811 T ES96934811 T ES 96934811T ES 96934811 T ES96934811 T ES 96934811T ES 2170274 T3 ES2170274 T3 ES 2170274T3
- Authority
- ES
- Spain
- Prior art keywords
- solution
- substances
- procedure
- freezing
- preparations
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 4
- 230000008014 freezing Effects 0.000 title abstract 2
- 238000007710 freezing Methods 0.000 title abstract 2
- 239000012620 biological material Substances 0.000 title 1
- 238000001035 drying Methods 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 230000000087 stabilizing effect Effects 0.000 title 1
- 239000011149 active material Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000036571 hydration Effects 0.000 abstract 1
- 238000006703 hydration reaction Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1816—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/44—Oxidoreductases (1)
- A61K38/443—Oxidoreductases (1) acting on CH-OH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B5/00—Drying solid materials or objects by processes not involving the application of heat
- F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
Abstract
LA PRESENTE INVENCION TRATA DE UN PROCEDIMIENTO PARA PRODUCIR PRODUCTOS QUE CONTIENEN MATERIAL SECO, SEMIAMORFO, BIOLOGICO Y EN ESPECIAL TERAPEUTICAMENTE ACTIVO, QUE REPRESENTAN MEZCLAS DE SUSTANCIAS MACROSCOPICAMENTE HOMOGENEAS, A CUYO EFECTO LAS MEZCLAS DE SUSTANCIAS ESTAN SELECCIONADAS AL MENOS A PARTIR DE UNA SUSTANCIA DEL GRUPO QUE COMPRENDE: (I) HIDRATO DE CARBONO O ION BIPOLAR CON RADICAL POLAR Y SUS DERIVADOS, Y (II) ION BIPOLAR CON UN RADICAL APOLAR Y SUS DERIVADOS. EL PROCEDIMIENTO ESTA CARACTERIZADO PORQUE SE PRODUCE UNA SOLUCION DEL MATERIAL BIOLOGICO O TERAPEUTICAMENTE ACTIVO Y LAS SUSTANCIAS (I) Y (II) Y SE SECA LA SOLUCION A UNA TEMPERATURA DEL PRODUCTO POR ENCIMA DEL PUNTO DE CONGELACION DE LA SOLUCION. ADEMAS, LA INVENCION TRATA DE NUEVAS MEZCLAS DE SUSTANCIAS QUE SE OBTIENEN SEGUN EL PROCEDIMIENTO MENCIONADO, ASI COMO DE SU EMPLEO EN PROCEDIMIENTOS DIAGNOSTICOS O TERAPEUTICOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19539574A DE19539574A1 (de) | 1995-10-25 | 1995-10-25 | Zubereitungen und Verfahren zur Stabilisierung biologischer Materialien mittels Trocknungsverfahren ohne Einfrieren |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2170274T3 true ES2170274T3 (es) | 2002-08-01 |
Family
ID=7775640
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96934811T Expired - Lifetime ES2170274T3 (es) | 1995-10-25 | 1996-10-24 | Metodo y preparaciones para estabilizar materiales biologicos por metodos de secado sin congelamiento. |
Country Status (25)
Country | Link |
---|---|
US (3) | US7172999B2 (es) |
EP (1) | EP0857060B1 (es) |
JP (2) | JPH11513700A (es) |
KR (1) | KR100466670B1 (es) |
CN (1) | CN1130196C (es) |
AT (1) | ATE212541T1 (es) |
AU (1) | AU712489B2 (es) |
BR (1) | BR9611265A (es) |
CA (1) | CA2235243C (es) |
CZ (1) | CZ293456B6 (es) |
DE (2) | DE19539574A1 (es) |
DK (1) | DK0857060T3 (es) |
ES (1) | ES2170274T3 (es) |
HU (1) | HU222601B1 (es) |
IL (1) | IL124204A (es) |
MX (1) | MX9803264A (es) |
NO (1) | NO324728B1 (es) |
NZ (1) | NZ320276A (es) |
PL (1) | PL190657B1 (es) |
PT (1) | PT857060E (es) |
RU (1) | RU2191003C2 (es) |
SK (1) | SK283664B6 (es) |
TR (1) | TR199800715T2 (es) |
WO (1) | WO1997015288A2 (es) |
ZA (1) | ZA968930B (es) |
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DE19539574A1 (de) * | 1995-10-25 | 1997-04-30 | Boehringer Mannheim Gmbh | Zubereitungen und Verfahren zur Stabilisierung biologischer Materialien mittels Trocknungsverfahren ohne Einfrieren |
EP0852951A1 (de) * | 1996-11-19 | 1998-07-15 | Roche Diagnostics GmbH | Stabile lyophilisierte pharmazeutische Zubereitungen von mono- oder polyklonalen Antikörpern |
EP0913177A1 (de) * | 1997-11-03 | 1999-05-06 | Roche Diagnostics GmbH | Verfahren zur Herstellung trockener, amorpher Produkte enthaltend biologisch aktive Materialien mittels Konvektionstrocknung, insbesondere Sprühtrocknung |
EP0913178A1 (en) * | 1997-11-03 | 1999-05-06 | Boehringer Mannheim Gmbh | Process for the manufacture of dry, amorphous products comprising biologically active material by means of convection drying and products obtainable by the process |
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RU2225221C2 (ru) * | 1999-04-09 | 2004-03-10 | Орто-Макнейл Фармасьютикал, Инк. | ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ Эритропоэтина |
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US20060099567A1 (en) * | 2004-04-08 | 2006-05-11 | Biomatrica, Inc. | Integration of sample storage and sample management for life science |
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GB0523638D0 (en) * | 2005-11-21 | 2005-12-28 | Cambridge Biostability Ltd | Pharmaceutical device for the administration of substances to patients |
DK1973406T3 (da) | 2005-12-28 | 2014-06-23 | Advanced Bionutrition Corp | Fremføringsmiddel til probiotiske bakerier omfattende en tør blanding af polysaccharider, saccharider, polyoler i glasform |
US8968721B2 (en) | 2005-12-28 | 2015-03-03 | Advanced Bionutrition Corporation | Delivery vehicle for probiotic bacteria comprising a dry matrix of polysaccharides, saccharides and polyols in a glass form and methods of making same |
US8460726B2 (en) | 2006-12-18 | 2013-06-11 | Advanced Bionutrition Corporation | Dry food product containing live probiotic |
US8466187B2 (en) * | 2007-09-18 | 2013-06-18 | Thermolife International, Llc | Amino acid compositions |
CA2756883C (en) | 2009-03-27 | 2018-01-09 | Advanced Bionutrition Corp. | Microparticulated vaccines for the oral or nasal vaccination and boostering of animals including fish |
EP2236520A1 (en) * | 2009-03-31 | 2010-10-06 | Leukocare Ag | Stabilizing composition for immobilized biomolecules |
MY157343A (en) | 2009-05-26 | 2016-05-31 | Advanced Bionutrition Corp | Stable dry powder composition comprising biologically active microorganisms and/or bioactive materials and methods of making |
TWI505838B (zh) * | 2010-01-20 | 2015-11-01 | Chugai Pharmaceutical Co Ltd | Stabilized antibody solution containing |
US9504750B2 (en) | 2010-01-28 | 2016-11-29 | Advanced Bionutrition Corporation | Stabilizing composition for biological materials |
JP5886763B2 (ja) | 2010-01-28 | 2016-03-16 | アドバンスド バイオニュートリション コーポレーション | 生物活性物質を含む乾燥ガラス状組成物 |
EP2598661B1 (en) | 2010-07-26 | 2017-09-27 | Biomatrica, INC. | Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures |
WO2012018638A2 (en) | 2010-07-26 | 2012-02-09 | Biomatrica, Inc. | Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures |
AU2011289272B2 (en) | 2010-08-13 | 2015-02-05 | Advanced Bionutrition Corporation | Dry storage stabilizing composition for biological materials |
CN102408467B (zh) * | 2010-09-26 | 2014-03-05 | 海口维瑅瑷生物研究院 | 真空干燥蛋白的方法、制得的蛋白产品和试剂盒 |
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EP3942931A1 (en) | 2014-06-10 | 2022-01-26 | Biomatrica, INC. | Stabilization of thrombocytes at ambient temperatures |
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-
1995
- 1995-10-25 DE DE19539574A patent/DE19539574A1/de not_active Withdrawn
-
1996
- 1996-10-24 DK DK96934811T patent/DK0857060T3/da active
- 1996-10-24 US US09/051,918 patent/US7172999B2/en not_active Expired - Fee Related
- 1996-10-24 AU AU72984/96A patent/AU712489B2/en not_active Ceased
- 1996-10-24 ZA ZA9608930A patent/ZA968930B/xx unknown
- 1996-10-24 DE DE59608684T patent/DE59608684D1/de not_active Revoked
- 1996-10-24 SK SK509-98A patent/SK283664B6/sk not_active IP Right Cessation
- 1996-10-24 TR TR1998/00715T patent/TR199800715T2/xx unknown
- 1996-10-24 PL PL96326358A patent/PL190657B1/pl not_active IP Right Cessation
- 1996-10-24 BR BR9611265A patent/BR9611265A/pt not_active IP Right Cessation
- 1996-10-24 IL IL12420496A patent/IL124204A/en not_active IP Right Cessation
- 1996-10-24 KR KR10-1998-0703022A patent/KR100466670B1/ko not_active IP Right Cessation
- 1996-10-24 AT AT96934811T patent/ATE212541T1/de active
- 1996-10-24 CA CA002235243A patent/CA2235243C/en not_active Expired - Fee Related
- 1996-10-24 PT PT96934811T patent/PT857060E/pt unknown
- 1996-10-24 CN CN96199329A patent/CN1130196C/zh not_active Expired - Fee Related
- 1996-10-24 HU HU9901314A patent/HU222601B1/hu not_active IP Right Cessation
- 1996-10-24 WO PCT/EP1996/004627 patent/WO1997015288A2/de not_active Application Discontinuation
- 1996-10-24 JP JP9516286A patent/JPH11513700A/ja active Pending
- 1996-10-24 ES ES96934811T patent/ES2170274T3/es not_active Expired - Lifetime
- 1996-10-24 CZ CZ19981179A patent/CZ293456B6/cs not_active IP Right Cessation
- 1996-10-24 NZ NZ320276A patent/NZ320276A/xx not_active IP Right Cessation
- 1996-10-24 EP EP96934811A patent/EP0857060B1/de not_active Revoked
- 1996-10-24 RU RU98109886/14A patent/RU2191003C2/ru not_active IP Right Cessation
-
1998
- 1998-04-24 NO NO19981868A patent/NO324728B1/no not_active IP Right Cessation
- 1998-04-24 MX MX9803264A patent/MX9803264A/es not_active IP Right Cessation
-
2002
- 2002-05-10 US US10/141,960 patent/US20030059468A1/en not_active Abandoned
-
2006
- 2006-06-09 US US11/449,781 patent/US20070020289A1/en not_active Abandoned
-
2007
- 2007-05-28 JP JP2007141138A patent/JP2007236975A/ja active Pending
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