MX390051B - Antagonistas de ep4. - Google Patents

Antagonistas de ep4.

Info

Publication number
MX390051B
MX390051B MX2018004664A MX2018004664A MX390051B MX 390051 B MX390051 B MX 390051B MX 2018004664 A MX2018004664 A MX 2018004664A MX 2018004664 A MX2018004664 A MX 2018004664A MX 390051 B MX390051 B MX 390051B
Authority
MX
Mexico
Prior art keywords
formulations
antagonists
cancer
formula
treatment
Prior art date
Application number
MX2018004664A
Other languages
English (en)
Spanish (es)
Other versions
MX2018004664A (es
Inventor
Daniel Custar
Frank Fang
Hong Du
Hyeong- Wook Choi
Jaemoon Lee
Jing Li
Maarten Postema
Robert Yu
Wanjun Zheng
Xiaojie Zhu
Yimin Jiang
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of MX2018004664A publication Critical patent/MX2018004664A/es
Publication of MX390051B publication Critical patent/MX390051B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
MX2018004664A 2015-10-16 2016-10-14 Antagonistas de ep4. MX390051B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562242734P 2015-10-16 2015-10-16
US201562242748P 2015-10-16 2015-10-16
BD2522016 2016-10-13
PCT/US2016/057135 WO2017066633A1 (en) 2015-10-16 2016-10-14 Ep4 antagonists

Publications (2)

Publication Number Publication Date
MX2018004664A MX2018004664A (es) 2018-08-24
MX390051B true MX390051B (es) 2025-03-20

Family

ID=58518017

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018004664A MX390051B (es) 2015-10-16 2016-10-14 Antagonistas de ep4.

Country Status (11)

Country Link
US (3) US10316040B2 (cg-RX-API-DMAC7.html)
EP (1) EP3362454B1 (cg-RX-API-DMAC7.html)
JP (2) JP6860559B2 (cg-RX-API-DMAC7.html)
KR (1) KR102684436B1 (cg-RX-API-DMAC7.html)
CN (1) CN108473497B (cg-RX-API-DMAC7.html)
AU (1) AU2016338679B2 (cg-RX-API-DMAC7.html)
BR (1) BR112018007664B1 (cg-RX-API-DMAC7.html)
CA (1) CA3002144C (cg-RX-API-DMAC7.html)
IL (1) IL258737A (cg-RX-API-DMAC7.html)
MX (1) MX390051B (cg-RX-API-DMAC7.html)
WO (1) WO2017066633A1 (cg-RX-API-DMAC7.html)

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AR111808A1 (es) 2017-05-18 2019-08-21 Idorsia Pharmaceuticals Ltd Derivados de pirimidina como moduladores del receptor de pge2
SI3625222T1 (sl) 2017-05-18 2021-11-30 Idorsia Pharmaceuticals Ltd Derivati fenila kot modulatorji receptorja pge2
TWI768043B (zh) 2017-05-18 2022-06-21 瑞士商愛杜西亞製藥有限公司 N-取代吲哚衍生物
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CA3092310C (en) * 2018-03-02 2024-01-02 Shenzhen Ionova Life Science Co., Ltd. Heterobicyclic carboxylic acids and salts thereof
CN111989311B (zh) 2019-01-22 2022-03-22 凯复(苏州)生物医药有限公司 抑制pge2/ep4信号传导的化合物、其制备方法及其在医药上的应用
EP4245301A4 (en) 2020-11-13 2024-08-21 ONO Pharmaceutical Co., Ltd. TREATMENT OF CANCER BY COMBINED USE OF AN EP4 ANTAGONIST AND AN IMMUNE CHECKPOINT INHIBITOR

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Also Published As

Publication number Publication date
KR20180083863A (ko) 2018-07-23
US20190315754A1 (en) 2019-10-17
IL258737A (en) 2018-06-28
AU2016338679B2 (en) 2021-05-06
JP6860559B2 (ja) 2021-04-14
US10316040B2 (en) 2019-06-11
US20210347779A1 (en) 2021-11-11
CA3002144A1 (en) 2017-04-20
AU2016338679A1 (en) 2018-06-07
CN108473497B (zh) 2021-09-10
JP7090770B2 (ja) 2022-06-24
KR102684436B1 (ko) 2024-07-15
BR112018007664A2 (pt) 2018-11-06
CN108473497A (zh) 2018-08-31
EP3362454A1 (en) 2018-08-22
CA3002144C (en) 2024-01-23
EP3362454B1 (en) 2021-12-08
JP2018530595A (ja) 2018-10-18
JP2021100969A (ja) 2021-07-08
US20180305362A1 (en) 2018-10-25
US10941148B2 (en) 2021-03-09
US11434246B2 (en) 2022-09-06
MX2018004664A (es) 2018-08-24
BR112018007664B1 (pt) 2023-12-19
WO2017066633A1 (en) 2017-04-20

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