IL258737A - Antagonists ep4 - Google Patents

Antagonists ep4

Info

Publication number
IL258737A
IL258737A IL258737A IL25873718A IL258737A IL 258737 A IL258737 A IL 258737A IL 258737 A IL258737 A IL 258737A IL 25873718 A IL25873718 A IL 25873718A IL 258737 A IL258737 A IL 258737A
Authority
IL
Israel
Prior art keywords
antagonists
Prior art date
Application number
IL258737A
Other languages
English (en)
Hebrew (he)
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of IL258737A publication Critical patent/IL258737A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IL258737A 2015-10-16 2018-04-16 Antagonists ep4 IL258737A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562242734P 2015-10-16 2015-10-16
US201562242748P 2015-10-16 2015-10-16
BD2522016 2016-10-13
PCT/US2016/057135 WO2017066633A1 (en) 2015-10-16 2016-10-14 Ep4 antagonists

Publications (1)

Publication Number Publication Date
IL258737A true IL258737A (en) 2018-06-28

Family

ID=58518017

Family Applications (1)

Application Number Title Priority Date Filing Date
IL258737A IL258737A (en) 2015-10-16 2018-04-16 Antagonists ep4

Country Status (11)

Country Link
US (3) US10316040B2 (cg-RX-API-DMAC7.html)
EP (1) EP3362454B1 (cg-RX-API-DMAC7.html)
JP (2) JP6860559B2 (cg-RX-API-DMAC7.html)
KR (1) KR102684436B1 (cg-RX-API-DMAC7.html)
CN (1) CN108473497B (cg-RX-API-DMAC7.html)
AU (1) AU2016338679B2 (cg-RX-API-DMAC7.html)
BR (1) BR112018007664B1 (cg-RX-API-DMAC7.html)
CA (1) CA3002144C (cg-RX-API-DMAC7.html)
IL (1) IL258737A (cg-RX-API-DMAC7.html)
MX (1) MX390051B (cg-RX-API-DMAC7.html)
WO (1) WO2017066633A1 (cg-RX-API-DMAC7.html)

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CR20180323A (es) 2015-11-20 2018-08-06 Idorsia Pharmaceuticals Ltd Derivados de indol n-sustituídos como moduladores de los receptores de pge2
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EP3625227B1 (en) 2017-05-18 2022-09-14 Idorsia Pharmaceuticals Ltd Benzofurane and benzothiophene derivatives as pge2 receptor modulators
AR111808A1 (es) 2017-05-18 2019-08-21 Idorsia Pharmaceuticals Ltd Derivados de pirimidina como moduladores del receptor de pge2
SI3625222T1 (sl) 2017-05-18 2021-11-30 Idorsia Pharmaceuticals Ltd Derivati fenila kot modulatorji receptorja pge2
TWI768043B (zh) 2017-05-18 2022-06-21 瑞士商愛杜西亞製藥有限公司 N-取代吲哚衍生物
WO2019149286A1 (en) * 2018-02-05 2019-08-08 Shenzhen Ionova Life Science Co., Ltd. Heterobicyclic carboxylic acids for treating cancer or inflammatory diseases
CA3092310C (en) * 2018-03-02 2024-01-02 Shenzhen Ionova Life Science Co., Ltd. Heterobicyclic carboxylic acids and salts thereof
CN111989311B (zh) 2019-01-22 2022-03-22 凯复(苏州)生物医药有限公司 抑制pge2/ep4信号传导的化合物、其制备方法及其在医药上的应用
EP4245301A4 (en) 2020-11-13 2024-08-21 ONO Pharmaceutical Co., Ltd. TREATMENT OF CANCER BY COMBINED USE OF AN EP4 ANTAGONIST AND AN IMMUNE CHECKPOINT INHIBITOR

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Also Published As

Publication number Publication date
KR20180083863A (ko) 2018-07-23
US20190315754A1 (en) 2019-10-17
AU2016338679B2 (en) 2021-05-06
JP6860559B2 (ja) 2021-04-14
US10316040B2 (en) 2019-06-11
US20210347779A1 (en) 2021-11-11
CA3002144A1 (en) 2017-04-20
AU2016338679A1 (en) 2018-06-07
CN108473497B (zh) 2021-09-10
JP7090770B2 (ja) 2022-06-24
MX390051B (es) 2025-03-20
KR102684436B1 (ko) 2024-07-15
BR112018007664A2 (pt) 2018-11-06
CN108473497A (zh) 2018-08-31
EP3362454A1 (en) 2018-08-22
CA3002144C (en) 2024-01-23
EP3362454B1 (en) 2021-12-08
JP2018530595A (ja) 2018-10-18
JP2021100969A (ja) 2021-07-08
US20180305362A1 (en) 2018-10-25
US10941148B2 (en) 2021-03-09
US11434246B2 (en) 2022-09-06
MX2018004664A (es) 2018-08-24
BR112018007664B1 (pt) 2023-12-19
WO2017066633A1 (en) 2017-04-20

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