MX386337B - Métodos para determinar la eficacia del fármaco para el tratamiento de linfoma difuso de células b grandes, mieloma múltiple, y cánceres mieloides. - Google Patents

Métodos para determinar la eficacia del fármaco para el tratamiento de linfoma difuso de células b grandes, mieloma múltiple, y cánceres mieloides.

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Publication number
MX386337B
MX386337B MX2016007239A MX2016007239A MX386337B MX 386337 B MX386337 B MX 386337B MX 2016007239 A MX2016007239 A MX 2016007239A MX 2016007239 A MX2016007239 A MX 2016007239A MX 386337 B MX386337 B MX 386337B
Authority
MX
Mexico
Prior art keywords
methods
cell lymphoma
multiple myeloma
diffuse large
treatment
Prior art date
Application number
MX2016007239A
Other languages
English (en)
Other versions
MX2016007239A (es
Inventor
Anita Gandhi
Anke Klippel
Courtney G Havens
Kyle Macbeth
Maria Yinglin Wang
Matthew William Burnell Trotter
Mike Breider
Patrick Hagner
Paul Hollenbach
Rajesh Chopra
Suzana Sturlini Couto
Yan Ren
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of MX2016007239A publication Critical patent/MX2016007239A/es
Publication of MX386337B publication Critical patent/MX386337B/es

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Abstract

La presente invención se refiere a un método para evaluar monitorear la eficacia de un compuesto de tratamiento para tratar un cáncer, o predecir la sensibilidad de un sujeto que tiene o se sospecha que tiene un cáncer a un compuesto de tratamiento, caracterizado porque comprende: (a) determinar el nivel de un biomarcador en una primera muestra de un sujeto que tiene o se sospecha que tiene un cáncer, a quien fue administrado con un compuesto de tratamiento; y (b) comparar el nivel del biomarcador de la etapa (a) con el nivel de la misma proteína obtenida de una muestra de referencia, en donde un cambio en el nivel del biomarcador cuando se compara con la muestra de referencia es indicativo de la eficacia del compuesto en tratar el cáncer o sensibilidad del sujeto al compuesto de tratamiento; en donde el compuesto de tratamiento es lenalidomida, pomalidomida, talidomida, Compuesto A o Compuesto B; en donde el biomarcador es caseína cinasa 1, alfa 1 (CSNKIAI) o ZFP91; en donde el cáncer se selecciona del grupo que consiste de (i) linfoma, tal como linfoma difuso de células B grandes (DLBCL) (ii) mieloma múltiple( MM), (iii) síndrome mielodisplástico (MDS) y (iv) leucemia mieloide agua (AML).
MX2016007239A 2013-12-06 2014-12-05 Métodos para determinar la eficacia del fármaco para el tratamiento de linfoma difuso de células b grandes, mieloma múltiple, y cánceres mieloides. MX386337B (es)

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US201462064413P 2014-10-15 2014-10-15
US201462077835P 2014-11-10 2014-11-10
US201462087111P 2014-12-03 2014-12-03
PCT/US2014/068795 WO2015085172A2 (en) 2013-12-06 2014-12-05 Methods for determining drug efficacy for the treatment of diffuse large b-cell lymphoma, multiple myeloma, and myeloid cancers

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CA3206268A1 (en) 2015-06-11
EP3077548A4 (en) 2017-08-30
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KR102299801B1 (ko) 2021-09-10
US20220003749A1 (en) 2022-01-06
KR20160090345A (ko) 2016-07-29
EA201691144A1 (ru) 2016-11-30
WO2015085172A2 (en) 2015-06-11
JP7142612B2 (ja) 2022-09-27
IL278381B1 (en) 2024-04-01
BR112016012795A2 (pt) 2017-08-08
AU2014360328A1 (en) 2016-06-16
US10996215B2 (en) 2021-05-04
US20160313300A1 (en) 2016-10-27
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