MX395376B - Dispositivo para la deteccion de proteinas mal plegadas y metodos de uso del mismo. - Google Patents
Dispositivo para la deteccion de proteinas mal plegadas y metodos de uso del mismo.Info
- Publication number
- MX395376B MX395376B MX2018000528A MX2018000528A MX395376B MX 395376 B MX395376 B MX 395376B MX 2018000528 A MX2018000528 A MX 2018000528A MX 2018000528 A MX2018000528 A MX 2018000528A MX 395376 B MX395376 B MX 395376B
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- detection
- proteins
- disorders
- misfolded proteins
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2828—Prion diseases
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2835—Movement disorders, e.g. Parkinson, Huntington, Tourette
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente invención se refiere a un dispositivo de diagnóstico para la detección de al menos una proteína en una muestra biológica de un mamífero, caracterizado porque comprende;: a) una material de recepción de muestra, en donde dicho material de recepción de muestra es capaz de recibir una muestra bilógica; b) un reactivo de detección, en donde dicho reactivo de detección es reactivo con al menos una proteína presente en dicha muestra biológica; c) una trampa, en donde dicha trampa está en contacto con el material de recepción de muestra y en donde dicha trampa es capaz de separar el reactivo de detección unido a dicha al menos una proteína en dicha muestra biológica del reactivo de detección que no está unido a dicha al menos una proteína en dicha muestra biológica, con lo cual dicho reactivo de detección unido a dicha al menos una proteína en dicha muestra biológica es capaz de fluir a través de dicha trampa, y con lo cual dicho reactivo de detección que no está unido a dicha al menos una proteína en dicha muestra biológica se captura por dicha trampa; d) un leche capilar, en donde dicho lecho capilar está en contacto con dicha trampa, y en donde dicho lecho capilar se configura para contener dicha muestra biológica después de que dicha muestra biológica fluye a través de dicha trampa, en donde dicho material de recepción de muestra , dicha trampa, y dicho lecho capilar se configuran para estar en contacto en secuencia, en donde dicho lecho capilar exhibe al reactivo de detección si dicha al menos una proteína está presente en dicha muestra biológica, y en donde dicho reactivo de detección se une a al menos una proteína seleccionada de grupo que consiste de una proteína mal plegada, un agregado de proteínas, un agregado de proteínas supramoleculares, un fragmento de una proteína mal plegada, un fragmento de un agregado de proteínas, un fragmento de un agregado de proteínas supramoleculares, mezclas de los mismos, y fragmentos de dichas mezclas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562192962P | 2015-07-15 | 2015-07-15 | |
| PCT/US2016/042426 WO2017011727A1 (en) | 2015-07-15 | 2016-07-15 | Device for detecting misfolded proteins and methods of use therof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2018000528A MX2018000528A (es) | 2018-08-21 |
| MX395376B true MX395376B (es) | 2025-03-25 |
Family
ID=57758210
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018000528A MX395376B (es) | 2015-07-15 | 2016-07-15 | Dispositivo para la deteccion de proteinas mal plegadas y metodos de uso del mismo. |
| MX2022010954A MX2022010954A (es) | 2015-07-15 | 2018-01-12 | Dispositivo para la deteccion de proteinas mal plegadas y metodos de uso del mismo. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2022010954A MX2022010954A (es) | 2015-07-15 | 2018-01-12 | Dispositivo para la deteccion de proteinas mal plegadas y metodos de uso del mismo. |
Country Status (14)
| Country | Link |
|---|---|
| US (5) | US10564153B2 (es) |
| EP (2) | EP3322985B1 (es) |
| JP (3) | JP6885608B2 (es) |
| CN (2) | CN108291905B (es) |
| AR (1) | AR105379A1 (es) |
| AU (2) | AU2016293547C1 (es) |
| CA (1) | CA2989444A1 (es) |
| DK (1) | DK3322985T3 (es) |
| ES (1) | ES2903034T3 (es) |
| MX (2) | MX395376B (es) |
| PL (1) | PL3322985T3 (es) |
| PT (1) | PT3322985T (es) |
| TW (3) | TWI856560B (es) |
| WO (1) | WO2017011727A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE112016004413T5 (de) * | 2015-09-29 | 2018-08-02 | Hamamatsu Photonics K.K. | Verfahren zum reinigen von reinem thioflavin t, verfahren zum herstellen von reinem thioflavin t, zusammensetzung, die thioflavin t enthält, und amyloid-nachweisverfahren |
| US20210156853A1 (en) * | 2017-12-28 | 2021-05-27 | Shuwen Biotech Co., Ltd. | Devices, kits and methods for detecting misfolded proteins |
| TWI698641B (zh) * | 2017-12-28 | 2020-07-11 | 大陸商浙江數問生物技術有限公司 | 一種檢測錯誤折疊蛋白質的裝置、試劑盒和方法 |
| US12436155B2 (en) | 2020-04-16 | 2025-10-07 | Kalia Health, Inc. | Preeclampsia screening device and methods measuring activin and/or inhibin A |
| US20230131712A1 (en) * | 2020-04-30 | 2023-04-27 | Daxor Corp. | Blood volume measurement with fluorescent dye |
| WO2022105923A1 (zh) | 2020-11-21 | 2022-05-27 | 浙江数问生物技术有限公司 | 用于检测生物样本中的错误折叠蛋白质的装置和方法 |
| EP4308928A4 (en) * | 2021-03-19 | 2025-02-19 | Kenota Inc. | Assay membrane test region localization |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2684488A (en) * | 1988-06-27 | 1990-01-04 | Carter-Wallace, Inc. | Test device and method for colored particle immunoassay |
| US5252496A (en) * | 1989-12-18 | 1993-10-12 | Princeton Biomeditech Corporation | Carbon black immunochemical label |
| US5451504A (en) * | 1991-07-29 | 1995-09-19 | Serex, Inc. | Method and device for detecting the presence of analyte in a sample |
| US5804452A (en) * | 1995-04-27 | 1998-09-08 | Quidel Corporation | One step urine creatinine assays |
| US6800488B2 (en) * | 2000-12-13 | 2004-10-05 | Lifescan, Inc. | Methods of manufacturing reagent test strips |
| GB2391068A (en) | 2002-07-18 | 2004-01-28 | Sensor Tech Ltd | A lateral flow through device comprising an electrochemical sesor |
| JP2006526786A (ja) * | 2003-06-03 | 2006-11-24 | バイエル・ヘルスケア・エルエルシー | 反射率値を使用する試薬試験ストリップの自動識別 |
| US20070054322A1 (en) * | 2003-07-31 | 2007-03-08 | Hadasit Medical Research Services & Development Lt | Methods and kits for the detection of prion diseases |
| AU2004298660B2 (en) * | 2003-12-12 | 2010-04-22 | Abbott Rapid Diagnostics International Unlimited Company | Assay |
| US7763454B2 (en) | 2004-07-09 | 2010-07-27 | Church & Dwight Co., Inc. | Electronic analyte assaying device |
| DK1804836T3 (da) * | 2004-09-24 | 2011-01-24 | Beth Israel Hospital | Fremgangsmåder til diagnosticering og behandling af graviditetskomplikationer |
| EP1946121A2 (en) | 2005-10-27 | 2008-07-23 | Yale University, Inc. | Urinary proteomic biomarker patterns in preeclampsia |
| TW200801190A (en) * | 2005-11-21 | 2008-01-01 | Trustees Of The University Of Alabama For And On Behalf Of The University Of Board Of | Regulators of protein misfolding and aggregation and methods of using the same |
| CA2654931C (en) * | 2006-06-20 | 2015-05-19 | Amic Ab | Assay device and method with improved control functions |
| CA2690904C (en) | 2007-06-27 | 2015-11-03 | Inbios International, Inc. | Lateral flow assay system and methods for its use |
| WO2010062377A2 (en) * | 2008-10-31 | 2010-06-03 | Yale University | Methods and compositions for the detection and treatment of preeclampsia |
| CN102356161A (zh) * | 2009-03-19 | 2012-02-15 | 株式会社钟化 | 核酸的检测方法以及试剂盒、装置 |
| TWM384314U (en) * | 2010-01-29 | 2010-07-11 | Nat Univ Chin Yi Technology | Protein folding calculation device |
| JP2012068064A (ja) * | 2010-09-22 | 2012-04-05 | Pilot Ink Co Ltd | 液体試料検査具及び液体検査具の採液部構造 |
| DE102011003944A1 (de) | 2011-02-10 | 2012-08-16 | Oxprotect Gmbh | Detektion und Entfernung von missgefalteten Proteinen/Peptiden |
| EP2602620A1 (en) | 2011-12-07 | 2013-06-12 | Nxp B.V. | An electronic lateral flow test arrangement and method |
| IN2014CN04326A (es) * | 2011-12-15 | 2015-09-04 | Pronota Nv | |
| CN104704364B (zh) * | 2012-06-15 | 2018-12-04 | 韦恩州立大学 | 用于先兆子痫和/或hellp综合征的预测或早期检测的生物标记物测试 |
| CN105979962A (zh) * | 2012-12-07 | 2016-09-28 | 比奥根国际神经科学公司 | 使用抗Aβ抗体减少脑淀粉样蛋白斑块的方法 |
| MX2015010174A (es) | 2013-02-08 | 2016-03-31 | Univ Iowa Res Found | Herramientas de diagnostico para predecir la presentacion de preeclampsia. |
| JP6182027B2 (ja) * | 2013-09-10 | 2017-08-16 | デンカ生研株式会社 | Ｂ型インフルエンザウイルスの測定方法 |
| CA3157573C (en) * | 2014-04-10 | 2025-11-18 | Yale University | METHODS AND COMPOSITIONS FOR DETECTING MISFOLDED PROTEINS |
| TWM494304U (zh) * | 2014-10-31 | 2015-01-21 | Anatech Co Ltd | 非酵素型糖化血色素檢測裝置 |
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2016
- 2016-07-15 EP EP16825235.1A patent/EP3322985B1/en active Active
- 2016-07-15 EP EP21198376.2A patent/EP4036574A1/en active Pending
- 2016-07-15 CN CN201680041285.0A patent/CN108291905B/zh active Active
- 2016-07-15 TW TW112109527A patent/TWI856560B/zh active
- 2016-07-15 PL PL16825235T patent/PL3322985T3/pl unknown
- 2016-07-15 CN CN202010812330.6A patent/CN111965343B/zh active Active
- 2016-07-15 US US15/211,957 patent/US10564153B2/en active Active
- 2016-07-15 PT PT168252351T patent/PT3322985T/pt unknown
- 2016-07-15 CA CA2989444A patent/CA2989444A1/en active Pending
- 2016-07-15 AU AU2016293547A patent/AU2016293547C1/en active Active
- 2016-07-15 ES ES16825235T patent/ES2903034T3/es active Active
- 2016-07-15 WO PCT/US2016/042426 patent/WO2017011727A1/en not_active Ceased
- 2016-07-15 TW TW105122413A patent/TWI744239B/zh active
- 2016-07-15 JP JP2018521486A patent/JP6885608B2/ja active Active
- 2016-07-15 AR ARP160102164A patent/AR105379A1/es unknown
- 2016-07-15 DK DK16825235.1T patent/DK3322985T3/da active
- 2016-07-15 TW TW110135659A patent/TWI800009B/zh active
- 2016-07-15 MX MX2018000528A patent/MX395376B/es unknown
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2018
- 2018-01-12 MX MX2022010954A patent/MX2022010954A/es unknown
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2019
- 2019-12-20 US US16/723,500 patent/US11073516B2/en active Active
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2020
- 2020-12-16 JP JP2020208124A patent/JP2021073434A/ja active Pending
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2021
- 2021-06-17 US US17/350,580 patent/US20210318299A1/en not_active Abandoned
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2022
- 2022-12-15 JP JP2022199988A patent/JP7648188B2/ja active Active
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2023
- 2023-03-17 US US18/123,213 patent/US20230251251A1/en active Pending
- 2023-03-23 AU AU2023201820A patent/AU2023201820A1/en not_active Abandoned
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2025
- 2025-06-12 US US19/236,260 patent/US20250306019A1/en active Pending
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