MX375936B - Composiciones farmaceuticas mejoradas de pimobendan. - Google Patents
Composiciones farmaceuticas mejoradas de pimobendan.Info
- Publication number
- MX375936B MX375936B MX2016007134A MX2016007134A MX375936B MX 375936 B MX375936 B MX 375936B MX 2016007134 A MX2016007134 A MX 2016007134A MX 2016007134 A MX2016007134 A MX 2016007134A MX 375936 B MX375936 B MX 375936B
- Authority
- MX
- Mexico
- Prior art keywords
- pimobendan
- pharmaceutical compositions
- improved pharmaceutical
- particles
- microencapsulation
- Prior art date
Links
- 229960002164 pimobendan Drugs 0.000 title abstract 3
- GLBJJMFZWDBELO-UHFFFAOYSA-N pimobendane Chemical group C1=CC(OC)=CC=C1C1=NC2=CC=C(C=3C(CC(=O)NN=3)C)C=C2N1 GLBJJMFZWDBELO-UHFFFAOYSA-N 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 2
- 239000002245 particle Substances 0.000 abstract 2
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000007921 spray Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HUP1300702 | 2013-12-04 | ||
| PCT/EP2014/076073 WO2015082389A1 (en) | 2013-12-04 | 2014-12-01 | Improved pharmaceutical compositions of pimobendan |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2016007134A MX2016007134A (es) | 2016-09-08 |
| MX375936B true MX375936B (es) | 2025-03-07 |
Family
ID=89708176
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016007134A MX375936B (es) | 2013-12-04 | 2014-12-01 | Composiciones farmaceuticas mejoradas de pimobendan. |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US10172804B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP2925305B1 (cg-RX-API-DMAC7.html) |
| JP (3) | JP5905999B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102308973B1 (cg-RX-API-DMAC7.html) |
| CN (2) | CN110721164B (cg-RX-API-DMAC7.html) |
| AU (2) | AU2014359427B2 (cg-RX-API-DMAC7.html) |
| BR (2) | BR112016011111B1 (cg-RX-API-DMAC7.html) |
| CA (2) | CA2930033C (cg-RX-API-DMAC7.html) |
| DK (2) | DK3106150T3 (cg-RX-API-DMAC7.html) |
| EA (2) | EA034054B1 (cg-RX-API-DMAC7.html) |
| ES (2) | ES2593210T3 (cg-RX-API-DMAC7.html) |
| HU (2) | HUE032347T2 (cg-RX-API-DMAC7.html) |
| MX (1) | MX375936B (cg-RX-API-DMAC7.html) |
| PL (2) | PL2925305T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015082389A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201602447B (cg-RX-API-DMAC7.html) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8980894B2 (en) | 2004-03-25 | 2015-03-17 | Boehringer Ingelheim Vetmedica Gmbh | Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure |
| EP1579862A1 (en) | 2004-03-25 | 2005-09-28 | Boehringer Ingelheim Vetmedica Gmbh | Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure |
| EP1920785A1 (en) | 2006-11-07 | 2008-05-14 | Boehringer Ingelheim Vetmedica Gmbh | Liquid preparation comprising a complex of pimobendan and cyclodextrin |
| EP2825159B1 (en) * | 2012-03-15 | 2022-06-22 | Boehringer Ingelheim Vetmedica GmbH | Pharmaceutical tablet formulation for the veterinary medical sector, method of production and use thereof |
| PL3021832T3 (pl) | 2013-07-19 | 2021-08-23 | Boehringer Ingelheim Vetmedica Gmbh | Konserwowana ciekła wodna kompozycja farmaceutyczna zawierająca eteryfikowane pochodne cyklodekstryny |
| AU2014359427B2 (en) | 2013-12-04 | 2017-04-20 | Boehringer Ingelheim Vetmedica Gmbh | Improved pharmaceutical compositions of pimobendan |
| US10537570B2 (en) | 2016-04-06 | 2020-01-21 | Boehringer Ingelheim Vetmedica Gmbh | Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease |
| EP3257574A1 (en) * | 2016-06-15 | 2017-12-20 | Clariant International Ltd | Method for producing a particle-shaped material |
| BR112021016480A2 (pt) | 2019-02-20 | 2021-10-13 | Zoetis Services Llc | Formulações palatáveis |
| JP2022554144A (ja) * | 2019-10-23 | 2022-12-28 | ピードモント アニマル ヘルス インコーポレイテッド | ピモベンダン製剤およびその使用方法 |
| RU2762989C1 (ru) * | 2020-09-28 | 2021-12-24 | федеральное государственное автономное образовательное учреждение высшего образования "Российский университет дружбы народов" (РУДН) | Способ лечения собак, больных дилатационной кардиомиопатией, осложненной застойной сердечной недостаточностью |
| WO2022073954A1 (en) | 2020-10-08 | 2022-04-14 | Boehringer Ingelheim Vetmedica Gmbh | Use of pimobendan in the anaesthesia of non-human mammals |
| CN113804793B (zh) * | 2021-09-24 | 2023-10-31 | 青岛欧博方医药科技有限公司 | 匹莫苯丹软咀嚼剂型的杂质检测方法 |
| AR131339A1 (es) | 2022-12-15 | 2025-03-12 | Boehringer Ingelheim Vetmedica Gmbh | Dispersiones sólidas que comprenden pimobendan amorfo y uno o más polímeros estabilizantes |
| WO2024240632A1 (en) | 2023-05-24 | 2024-11-28 | Boehringer Ingelheim Vetmedica Gmbh | Combination treatment and/or prevention of cardiac diseases in non-human mammals comprising one or more sglt-2 inhibitors and pimobendan and/or telmisartan |
Family Cites Families (151)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1045031A (en) | 1963-04-30 | 1966-10-05 | Iwao Kawakami | Dentifrice |
| US3574859A (en) | 1968-07-05 | 1971-04-13 | Carl M Kosti | Process for the treatment of hypertrophied gums |
| US3822349A (en) | 1969-06-02 | 1974-07-02 | C Kosti | Vasoconstrictor-antihistamine composition for the treatment of hypertrophied oral tissue |
| CA950833A (en) | 1971-02-02 | 1974-07-09 | Carl M. Kosti | Composition for the treatment of hypertrophied oral tissue |
| GB1338169A (en) | 1971-03-09 | 1973-11-21 | Smith Kline French Lab | Ureas thioureas and guanidines |
| US3832460A (en) | 1971-03-19 | 1974-08-27 | C Kosti | Anesthetic-vasoconstrictor-antihistamine composition for the treatment of hypertrophied oral tissue |
| US3839522A (en) | 1971-08-02 | 1974-10-01 | Batley Janss Enterprises | Process for the manufacture of dog bedding |
| CH630808A5 (en) | 1976-05-08 | 1982-07-15 | Uscio Heinz D | Process for aromatising pharmaceutical preparations for veterinary medicine |
| GB1565966A (en) | 1976-08-04 | 1980-04-23 | Allen & Hanburys Ltd | Aminoalkyl furan derivatives |
| ES8101067A1 (es) | 1978-08-25 | 1980-12-01 | Thomae Gmbh Dr K | Procedimiento para la preparacion de nuevos bencimidazoles sustituidos en posicion 5 o 6 con un anillo de piridazinona |
| DE2841668A1 (de) | 1978-09-25 | 1980-04-10 | Bayer Ag | Medikiertes tierfutter auf basis lebermehl |
| US4256743A (en) | 1979-02-22 | 1981-03-17 | President And Fellows Of Harvard College | Inhibition of bone resorption with H1 -blocking antihistamines |
| JPS6056143B2 (ja) | 1979-08-02 | 1985-12-09 | 山之内製薬株式会社 | アミジン誘導体ならびにその製造法 |
| US4293557A (en) | 1979-07-03 | 1981-10-06 | Teikoku Hormone Mfg. Co., Ltd. | Antiulcer phenoxypropylamine derivatives |
| US4375547A (en) | 1980-10-02 | 1983-03-01 | Eli Lilly And Company | N-Methyl-N'-2-([(2-dimethylaminomethyl)-4-thiazolyl]methylthio)ethyl 2-nitro-1,1-ethenediamine |
| IT1209431B (it) | 1980-11-28 | 1989-07-16 | Angeli Inst Spa | Imidazolilfenil amidine, processi per la loro preparazione e loro impiego farmaceutico, ed intermedi di preparazione. |
| DE3124090A1 (de) | 1981-06-19 | 1983-01-05 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue orale dipyridamolformen |
| US4704284A (en) | 1982-08-12 | 1987-11-03 | Pfizer Inc. | Long-acting matrix tablet formulations |
| DE3237575A1 (de) | 1982-10-09 | 1984-04-12 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue orale mopidamolformen |
| GB8313217D0 (en) | 1983-05-13 | 1983-06-22 | Glaxo Group Ltd | Pharmaceutical compositions |
| JPS59222406A (ja) | 1983-06-01 | 1984-12-14 | Teijin Ltd | 歯周疾患治療用製剤及びその製造法 |
| US4732915A (en) | 1983-11-02 | 1988-03-22 | Alza Corporation | Process for increasing solubility of drug |
| DE3346123A1 (de) | 1983-12-21 | 1985-06-27 | Janssen Pharmaceutica, N.V., Beerse | Pharmazeutische praeparate von in wasser schwerloeslichen oder instabilen arzneistoffen und verfahren zu ihrer herstellung |
| GB8400863D0 (en) | 1984-01-13 | 1984-02-15 | Smith Kline French Lab | Chemical compounds |
| US6407079B1 (en) | 1985-07-03 | 2002-06-18 | Janssen Pharmaceutica N.V. | Pharmaceutical compositions containing drugs which are instable or sparingly soluble in water and methods for their preparation |
| PT83530B (pt) | 1985-10-17 | 1989-05-31 | Smith Kline French Lab | Processo de preparacao de derivados da piridona, em especial derivados fenilicos |
| IE63321B1 (en) | 1986-02-03 | 1995-04-05 | Elan Corp Plc | Drug delivery system |
| JPS62223112A (ja) | 1986-03-25 | 1987-10-01 | Rooto Seiyaku Kk | 歯周病治療剤 |
| JPH0759496B2 (ja) | 1986-03-25 | 1995-06-28 | ロ−ト製薬株式会社 | 歯周病治療剤 |
| IT1204901B (it) | 1986-06-25 | 1989-03-10 | Iscofar Sas | Composizioni contenenti acido usnico o suoi derivati atte all'impiego nel trattamento della carie dentaria |
| US4868182A (en) | 1986-11-05 | 1989-09-19 | Merrell Dow Pharmaceuticals Inc. | Enhancement of prazosin |
| ZA878182B (en) | 1986-11-05 | 1988-05-02 | Merrell Dow Pharmaceuticals Inc. | Enhancement of prazosin |
| NL193682C (nl) | 1987-05-14 | 2000-07-04 | Glaxo Group Ltd | Beklede cefuroximaxetilsamenstelling. |
| DE3728244A1 (de) | 1987-08-25 | 1989-03-09 | Thomae Gmbh Dr K | Neue (-)-benzimidazole, deren herstellung und diese verbindungen enthaltende arzneimittel |
| EP0306846A3 (de) | 1987-09-11 | 1990-05-02 | Dr. Karl Thomae GmbH | Neue synergistische Kombination bestehend aus einem Phosphodiesterase-Hemmer und einem Thromboxan-A2-Antagonisten und deren Verwendung bzw. Herstellung |
| SE8704436D0 (sv) | 1987-11-13 | 1987-11-13 | Pm Konsult Handelsbolag | Anvendning av antisekretoriska substanser for nya indikationer |
| US4851226A (en) | 1987-11-16 | 1989-07-25 | Mcneil Consumer Products Company | Chewable medicament tablet containing means for taste masking |
| US5002935A (en) | 1987-12-30 | 1991-03-26 | University Of Florida | Improvements in redox systems for brain-targeted drug delivery |
| DE3804490A1 (de) | 1988-02-12 | 1989-08-24 | Heumann Pharma Gmbh & Co | Substituierte 6-phenyldihydro-3(2h)-pyridazinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE3805635A1 (de) | 1988-02-24 | 1989-09-07 | Thomae Gmbh Dr K | Verwendung von benzimidazolen zur herstellung eines arzneimittels mit antiischaemischen wirkungen am herzen und dessen kombinationen mit ss-blockern oder bradycardica |
| DE68906942T3 (de) | 1988-03-29 | 1999-05-12 | University Of Florida, Gainesville, Fla. | Pharmazeutische Zusammensetzungen für die parenterale Anwendung. |
| IE62095B1 (en) | 1988-03-29 | 1994-12-14 | Univ Florida | Pharmaceutical formulations for parenteral use |
| EP0349657A1 (en) | 1988-06-06 | 1990-01-10 | Carl Richard Thornfeldt | Manufacture of a medicament for the treatment of teething and colic |
| GB8824458D0 (en) | 1988-10-19 | 1988-11-23 | Orion Yhtymae Oy | Substituted pyridazinones |
| GB8903130D0 (en) | 1989-02-11 | 1989-03-30 | Orion Yhtymae Oy | Substituted pyridazinones |
| JP2916689B2 (ja) | 1989-11-16 | 1999-07-05 | 株式会社資生堂 | 化粧料 |
| US5364646A (en) | 1990-01-10 | 1994-11-15 | Dr. Karl Thomae Gmbh | Oral pharmaceutical forms of pimobendan |
| DE4001622A1 (de) * | 1990-01-20 | 1991-07-25 | Thomae Gmbh Dr K | Orale arzneimittelformen von pimobendan |
| DE4001623A1 (de) | 1990-01-20 | 1991-07-25 | Thomae Gmbh Dr K | Verwendung von benzimidazolen zur herstellung eines zur behandlung von akuten und chronischen obstruktiven atemwegserkrankungen geeigneten arzneimittels |
| US5188836A (en) | 1990-07-27 | 1993-02-23 | Warner-Lambert Company | Sustained release formulations |
| JPH0489428A (ja) | 1990-07-30 | 1992-03-23 | Kao Corp | 多形核白血球活性化剤 |
| GB2251615B (en) | 1991-01-03 | 1995-02-08 | Orion Yhtymae Oy | (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]pro panedinitrile |
| JPH0570612A (ja) | 1991-09-12 | 1993-03-23 | Toyobo Co Ltd | 二軸配向ポリエステルフイルム |
| US5571533A (en) | 1992-02-07 | 1996-11-05 | Recordati, S.A., Chemical And Pharmaceutical Company | Controlled-release mucoadhesive pharmaceutical composition for the oral administration of furosemide |
| US5472954A (en) | 1992-07-14 | 1995-12-05 | Cyclops H.F. | Cyclodextrin complexation |
| JPH10501211A (ja) | 1994-05-20 | 1998-02-03 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 飼育動物用のチュワブル・フルベンダゾール錠剤 |
| GB9711643D0 (en) | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
| US20030059471A1 (en) * | 1997-12-15 | 2003-03-27 | Compton Bruce Jon | Oral delivery formulation |
| JPH11228302A (ja) | 1998-02-18 | 1999-08-24 | Taisho Technos Co Ltd | 抗菌防黴組成物 |
| US6476078B2 (en) | 1999-08-11 | 2002-11-05 | Sepracor, Inc. | Methods of using sibutramine metabolites in combination with a phosphodiesterase inhibitor to treat sexual dysfunction |
| US20020127205A1 (en) | 1998-08-31 | 2002-09-12 | Albert Edge | Cells expressing immunoregulatory molecules and uses therefor |
| US20040152664A1 (en) | 1998-09-02 | 2004-08-05 | Allergan, Inc. | Prednisolone compositions |
| AU757896B2 (en) | 1998-09-02 | 2003-03-13 | Allergan, Inc. | Preserved cyclodextrin-containing compositions |
| DE69823240T2 (de) | 1998-10-23 | 2005-04-28 | Toray Industries, Inc. | Immunmodulierende arzneimittelzusammenstellung |
| FR2790668B1 (fr) | 1999-03-12 | 2002-07-26 | D B F | Granules contenant une substance vegetale et leur procede de preparation |
| ATE318585T1 (de) | 1999-05-17 | 2006-03-15 | D B F | Pflanzenmaterial enthaltendes granulat und verfahren zur herstellung |
| FR2793688B1 (fr) * | 1999-05-21 | 2003-06-13 | Ethypharm Lab Prod Ethiques | Microgranules gastroproteges, procede d'obtention et preparations pharmaceutiques |
| US6369087B1 (en) | 1999-08-26 | 2002-04-09 | Robert R. Whittle | Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
| GB2356346A (en) | 1999-11-19 | 2001-05-23 | Mars Uk Ltd | Food product for oral delivery of a pharmaceutical agent to a non-human animal comprising encapsulated particles of said agent distributed within the product |
| CN1416341B (zh) | 2000-02-04 | 2010-05-05 | 武田药品工业株式会社 | 稳定的乳液组合物 |
| PT1260215E (pt) | 2000-03-01 | 2009-09-03 | Eisai R&D Man Co Ltd | Comprimido de desintegração rápida que contém poli(álcool vinílico) |
| JP5026630B2 (ja) | 2000-03-31 | 2012-09-12 | 小林製薬株式会社 | 造粒粉体及びその製造方法及び圧縮成形固形物 |
| AU2001271435A1 (en) | 2000-06-21 | 2002-01-02 | Bristol-Myers Squibb Pharma Company | Vitronectin receptor antagonist pharmaceuticals |
| PT1913939T (pt) | 2000-06-27 | 2017-07-19 | Vectura Ltd | Formulações para utilização em dispositivos inalatórios |
| US6620439B1 (en) | 2000-10-03 | 2003-09-16 | Atul M. Mehta | Chrono delivery formulations and method of use thereof |
| UA80393C2 (uk) | 2000-12-07 | 2007-09-25 | Алтана Фарма Аг | Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці |
| AU2001225816B2 (en) | 2000-12-18 | 2005-10-13 | Novartis Ag | Therapeutic combination of amlodipine and benazepril |
| EP1247456A3 (en) | 2001-02-28 | 2003-12-10 | Pfizer Products Inc. | Palatable pharmaceutical compositions for companion animals |
| CA2438272A1 (en) | 2001-03-02 | 2002-10-10 | John Macor | Compounds useful as modulators of melanocortin receptors and pharmaceutical compositions comprising same |
| US20040214797A1 (en) | 2001-05-07 | 2004-10-28 | Allergan, Inc. | Preserved pharmaceutical compositions comprising cyclodextrins |
| JP2004536614A (ja) | 2001-08-01 | 2004-12-09 | ユニバーシティ オブ ユタ | Ｐｄｅ３環状ヌクレオチド・ホスホジエステラーゼのアイソフォーム選択的な阻害剤および活性化剤 |
| US6669955B2 (en) | 2001-08-28 | 2003-12-30 | Longwood Pharmaceutical Research, Inc. | Combination dosage form containing individual dosage units of a cholesterol-lowering agent, an inhibitor of the renin-angiotensin system, and aspirin |
| WO2003033025A2 (en) | 2001-10-18 | 2003-04-24 | Decode Genetics Ehf | Cyclodextrin complexes |
| TW200303749A (en) | 2002-02-22 | 2003-09-16 | Pharmacia Corp | Ophthalmic antibiotic drug formulations containing a cyclodextrin compound and cetyl pyridinium chloride |
| US20030190343A1 (en) | 2002-03-05 | 2003-10-09 | Pfizer Inc. | Palatable pharmaceutical compositions for companion animals |
| DE10209982A1 (de) | 2002-03-07 | 2003-09-25 | Boehringer Ingelheim Pharma | Oral zu applizierende Darreichungsform für schwerlösliche basische Wirkstoffe |
| CO5400144A1 (es) | 2002-03-11 | 2004-05-31 | Novartis Ag | Compuestos organicos |
| TW200306799A (en) | 2002-05-17 | 2003-12-01 | Novartis Ag | Combination of organic compounds |
| PL374198A1 (en) | 2002-05-23 | 2005-10-03 | Pfizer Inc. | Novel combination |
| SI21223A (sl) | 2002-06-19 | 2003-12-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Farmacevtska formulacija s stabiliziranim amorfnim donepezilijevim kloridom |
| DE10228049A1 (de) | 2002-06-24 | 2004-01-15 | Merck Patent Gmbh | Flüssige Zubereitung enthaltend Oligopeptide |
| US20040037869A1 (en) | 2002-08-16 | 2004-02-26 | Douglas Cleverly | Non-animal product containing veterinary formulations |
| PL376405A1 (en) | 2002-10-07 | 2005-12-27 | Artesian Therapeutics, Inc. | Dihydropyridine compounds having simultaneous ability to block l-type calcium channels and to inhibit phosphodiesterase type 3 activity |
| US7544674B2 (en) | 2002-10-25 | 2009-06-09 | Galderma S.A. | Topical skin care composition |
| WO2004050657A2 (en) | 2002-11-27 | 2004-06-17 | Artesian Therapeutics, Inc. | COMPOUNDS WITH MIXED PDE-INHIBITORY AND β-ADRENERGIC ANTAGONIST OR PARTIAL AGONIST ACTIVITY FOR TREATMENT OF HEART FAILURE |
| JP2006513238A (ja) * | 2002-12-19 | 2006-04-20 | ファルマシア・コーポレーション | 吸湿性薬物を含む非‐吸湿性製剤 |
| EP1575923A2 (en) | 2002-12-23 | 2005-09-21 | Artesian Therapeutics, Inc. | CARDIOTONIC COMPOUNDS WITH INHIBITORY ACTIVITY AGAINST &bgr;-ADRENERGIC RECEPTORS AND PHOSPHODIESTERASE |
| US20050085446A1 (en) | 2003-04-14 | 2005-04-21 | Babu M.K. M. | Fluoroquinolone formulations and methods of making and using the same |
| WO2005035505A2 (en) | 2003-09-30 | 2005-04-21 | Artesian Therapeutics, Inc. | Compounds with phosphodiesterase inhibiting and calcium channel blocking activities |
| LT1713504T (lt) | 2004-01-30 | 2017-09-11 | Zoetis Services Llc | Antimikrobinis konservantas, skirtas multi-dozinėms kompozicijoms, panaudojant beta-ciklodekstrinus, skirtas skystoms vaisto formoms |
| DE102004011512B4 (de) | 2004-03-08 | 2022-01-13 | Boehringer Ingelheim Vetmedica Gmbh | Pharmazeutische Zubereitung enthaltend Pimobendan |
| EP1579862A1 (en) | 2004-03-25 | 2005-09-28 | Boehringer Ingelheim Vetmedica Gmbh | Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure |
| US8980894B2 (en) | 2004-03-25 | 2015-03-17 | Boehringer Ingelheim Vetmedica Gmbh | Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure |
| JP2005281283A (ja) | 2004-03-31 | 2005-10-13 | Akira Matsumori | ベンズイミダゾール系薬剤の併用医薬 |
| AU2005249372A1 (en) | 2004-05-06 | 2005-12-15 | Cydex Pharmaceuticals, Inc. | Taste-masked formulations containing sertraline and sulfoalkyl ether cyclodextrin |
| FI20040675A0 (fi) | 2004-05-12 | 2004-05-12 | Orion Corp | Menetelmä sydämen hypertrofian hoitoon ja estoon |
| US20090181083A1 (en) | 2004-06-28 | 2009-07-16 | Lifebycle Pharmas A/S | Porous tablets as carriers for liquid formulations |
| NZ534939A (en) | 2004-08-26 | 2007-04-27 | Bomac Research Ltd | Injectable formulation comprising an anthelmintic compound with complexing compound for improved solubility |
| EP1830852A2 (en) | 2004-11-30 | 2007-09-12 | Artesian Therapeutics, Inc. | Compounds with mixed pde-inhibitory and beta-adrenergic antagonist or partial agonist activity for treatment of heart failure |
| WO2006060122A2 (en) | 2004-11-30 | 2006-06-08 | Artesian Therapeutics, Inc. | Cardiotonic compounds with inhibitory activity against beta-adrenergic receptors and phosphodiesterase |
| CN1702243A (zh) | 2005-05-31 | 2005-11-30 | 刘坚雄 | 无壁板框架结构装配组合式房屋建筑及其建造方法 |
| US20090036406A1 (en) | 2005-06-13 | 2009-02-05 | Takeda Pharmaceutical Company Limited | Injection |
| WO2007038796A1 (en) * | 2005-09-29 | 2007-04-05 | Repros Therapeutics Inc. | Formulations with improved bioavailability, comprising a steroid derivative and a polyglycolysed glyceride |
| FR2891459B1 (fr) | 2005-09-30 | 2007-12-28 | Flamel Technologies Sa | Microparticules a liberation modifiee d'au moins un principe actif et forme galenique orale en comprenant |
| PL1951227T3 (pl) | 2005-11-14 | 2017-09-29 | Boehringer Ingelheim Vetmedica Gmbh | Zastosowania pimobendanu do leczenia bezobjawowej(utajonej) niewydolności serca |
| ES2276627B1 (es) | 2005-12-02 | 2008-04-16 | Bsh Electrodomesticos España, S.A. | Tambor de lavadora. |
| JP4572300B2 (ja) * | 2006-01-19 | 2010-11-04 | トーアエイヨー株式会社 | ピモベンダン経口投与製剤 |
| JP2008534681A (ja) | 2006-02-09 | 2008-08-28 | テバ ファーマシューティカル インダストリーズ リミティド | ジピリダモール持続放出製剤及びそれを調製のための方法 |
| CA2647533A1 (en) | 2006-03-28 | 2007-10-04 | Javelin Pharmaceuticals, Inc. | Formulations of low dose non-steroidal anti-inflammatory drugs and beta-cyclodextrin |
| PE20080697A1 (es) | 2006-05-03 | 2008-08-05 | Boehringer Ingelheim Int | Derivados de benzonitrilo sustituidos con glucopiranosilo, composiciones farmaceuticas que contienen compuestos de este tipo, su uso y procedimiento para su fabricacion |
| EP1920785A1 (en) * | 2006-11-07 | 2008-05-14 | Boehringer Ingelheim Vetmedica Gmbh | Liquid preparation comprising a complex of pimobendan and cyclodextrin |
| FR2917975B1 (fr) | 2007-06-26 | 2009-10-16 | Ceva Sante Animale Sa | Compositions et traitement de l'insuffisance cardiaque chez les animaux mammiferes non humains |
| JP5227569B2 (ja) | 2007-11-09 | 2013-07-03 | 東京インキ株式会社 | 微粒子乾式コーティング製剤 |
| EP2057982A1 (en) | 2007-11-09 | 2009-05-13 | Archimedes Development Limited | Intranasal compositions |
| EP2106786A1 (de) | 2008-04-04 | 2009-10-07 | Roewer, Norbert, Univ.-Prof. Dr. med. | Pharmazeutische Zubereitung mit permethyliertem Cyclodextrin |
| FR2934156B1 (fr) | 2008-07-23 | 2010-09-24 | Virbac | Medicament appetissant a administration orale sous forme solide |
| WO2010055119A2 (en) | 2008-11-17 | 2010-05-20 | Novartis Ag | Pharmaceutical composition comprising pimobendan |
| CA2744505A1 (en) | 2008-11-25 | 2010-06-03 | Boehringer Ingelheim Vetmedica Gmbh | Phosphodiesterase type iii (pde iii) inhibitors or ca2+-sensitizing agents for the treatment of hypertrophic cardiomyopathy |
| WO2010078429A1 (en) | 2008-12-30 | 2010-07-08 | Impax Laboratories, Inc. | Pharmaceutical dosage forms and methods of manufacturing same |
| GB0912646D0 (en) * | 2009-07-21 | 2009-08-26 | Jagotec Ag | Improvements in or relating to organic compounds |
| US8586092B2 (en) | 2009-08-31 | 2013-11-19 | Xi'an Libang Pharmaceutical Technology Co., Ltd. | Fulvestrant nanosphere/microsphere and preparative method and use thereof |
| CN102647978A (zh) | 2009-10-07 | 2012-08-22 | 力奇制药公司 | 包含溶解性差的活性成分和高支化聚合物的药物组合物 |
| NL1037569C2 (en) | 2009-12-18 | 2011-06-21 | Eurovet Animal Health B V | Crystalline pimobendan, process for the preparation thereof, pharmaceutical composition and use. |
| EP2338480A1 (en) | 2009-12-22 | 2011-06-29 | LEK Pharmaceuticals d.d. | Coating of particles comprising a pharmaceutically active ingredient with a carbonate salt or phosphate salt |
| EP2380604A1 (en) | 2010-04-19 | 2011-10-26 | InnoRa Gmbh | Improved coating formulations for scoring or cutting balloon catheters |
| JP5813391B2 (ja) * | 2011-06-24 | 2015-11-17 | 日東電工株式会社 | 粒子製剤の製造方法 |
| CN102805733B (zh) | 2011-06-01 | 2016-03-09 | 日东电工株式会社 | 颗粒制剂及其制造方法 |
| EP2741736B1 (en) | 2011-08-12 | 2017-11-22 | Boehringer Ingelheim Vetmedica GmbH | Taste masked pharmaceutical composition |
| AU2012101682B4 (en) | 2011-11-20 | 2013-10-24 | Betrola Investments Pty Limited | Formulation |
| HRP20151347T1 (hr) * | 2011-12-21 | 2016-01-01 | Novartis Tiergesundheit Ag | Nova kombinacija |
| EP2825159B1 (en) | 2012-03-15 | 2022-06-22 | Boehringer Ingelheim Vetmedica GmbH | Pharmaceutical tablet formulation for the veterinary medical sector, method of production and use thereof |
| GB201207886D0 (en) | 2012-05-04 | 2012-06-20 | Jagotec Ag | Improvements in or relating to organic compounds |
| SG11201407200TA (en) | 2012-05-18 | 2014-12-30 | Luoda Pharma Pty Ltd | Liquid formulation |
| CN103655502A (zh) | 2012-08-31 | 2014-03-26 | 瑞普（天津）生物药业有限公司 | 一种宠物用匹莫苯丹缓释片及其制备方法 |
| FR3002736B1 (fr) | 2013-03-04 | 2015-06-26 | Virbac | Composition orale nutritionnelle et medicamenteuse a usage veterinaire |
| PL3021832T3 (pl) | 2013-07-19 | 2021-08-23 | Boehringer Ingelheim Vetmedica Gmbh | Konserwowana ciekła wodna kompozycja farmaceutyczna zawierająca eteryfikowane pochodne cyklodekstryny |
| AU2014359427B2 (en) | 2013-12-04 | 2017-04-20 | Boehringer Ingelheim Vetmedica Gmbh | Improved pharmaceutical compositions of pimobendan |
| EP3389638B1 (en) | 2015-12-17 | 2023-08-02 | Ceva Santé Animale | Pharmaceutical composition comprising pimobendan |
| US10537570B2 (en) | 2016-04-06 | 2020-01-21 | Boehringer Ingelheim Vetmedica Gmbh | Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease |
| JP2022554144A (ja) | 2019-10-23 | 2022-12-28 | ピードモント アニマル ヘルス インコーポレイテッド | ピモベンダン製剤およびその使用方法 |
| CN112618505B (zh) | 2020-12-30 | 2022-11-15 | 南京朗博特动物药业有限公司 | 一种宠物用含有贝那普利和匹莫苯丹的复方药物组合物及其制备方法 |
-
2014
- 2014-12-01 AU AU2014359427A patent/AU2014359427B2/en active Active
- 2014-12-01 EA EA201600438A patent/EA034054B1/ru not_active IP Right Cessation
- 2014-12-01 EP EP14824382.7A patent/EP2925305B1/en active Active
- 2014-12-01 CA CA2930033A patent/CA2930033C/en active Active
- 2014-12-01 CA CA3176466A patent/CA3176466A1/en active Pending
- 2014-12-01 EP EP16177625.7A patent/EP3106150B1/en active Active
- 2014-12-01 BR BR112016011111-7A patent/BR112016011111B1/pt active IP Right Grant
- 2014-12-01 BR BR122019024673-4A patent/BR122019024673B1/pt active IP Right Grant
- 2014-12-01 KR KR1020167017949A patent/KR102308973B1/ko active Active
- 2014-12-01 WO PCT/EP2014/076073 patent/WO2015082389A1/en not_active Ceased
- 2014-12-01 PL PL14824382T patent/PL2925305T3/pl unknown
- 2014-12-01 ES ES14824382.7T patent/ES2593210T3/es active Active
- 2014-12-01 DK DK16177625.7T patent/DK3106150T3/da active
- 2014-12-01 EA EA201992230A patent/EA201992230A1/ru unknown
- 2014-12-01 HU HUE14824382A patent/HUE032347T2/en unknown
- 2014-12-01 CN CN201911179250.5A patent/CN110721164B/zh active Active
- 2014-12-01 ES ES16177625T patent/ES2883448T3/es active Active
- 2014-12-01 JP JP2015554220A patent/JP5905999B2/ja active Active
- 2014-12-01 PL PL16177625T patent/PL3106150T3/pl unknown
- 2014-12-01 CN CN201480066115.9A patent/CN105813633B/zh active Active
- 2014-12-01 HU HUE16177625A patent/HUE056143T2/hu unknown
- 2014-12-01 MX MX2016007134A patent/MX375936B/es active IP Right Grant
- 2014-12-01 DK DK14824382.7T patent/DK2925305T3/en active
- 2014-12-03 US US14/558,828 patent/US10172804B2/en active Active
-
2016
- 2016-03-17 JP JP2016054145A patent/JP6506711B2/ja active Active
- 2016-04-11 ZA ZA2016/02447A patent/ZA201602447B/en unknown
-
2017
- 2017-06-08 AU AU2017203887A patent/AU2017203887B2/en active Active
-
2018
- 2018-11-16 US US16/193,413 patent/US10653633B2/en active Active
- 2018-11-16 US US16/193,425 patent/US10874620B2/en active Active
-
2019
- 2019-03-29 JP JP2019066575A patent/JP2019123737A/ja active Pending
-
2020
- 2020-11-13 US US17/097,039 patent/US11298325B2/en active Active
-
2022
- 2022-03-03 US US17/685,830 patent/US12257350B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX375936B (es) | Composiciones farmaceuticas mejoradas de pimobendan. | |
| IL239325A0 (en) | An oral dosage form that includes crush-resistant coated particles for immediate release of at least one active compound | |
| EP2917180A4 (en) | GPR40 RECEPTOR AGONIST, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS THEREFORE AS AN ACTIVE SUBSTANCE | |
| EP2958913A4 (en) | SPHINGOSINE 1 PHOSPHATE RECEPTOR AGONISTS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS THEREFOR AS ACTIVE AGENT | |
| EA201400972A1 (ru) | Лекарственные формы немедленного высвобождения с защитой от несанкционированного применения | |
| BR112015012547A2 (pt) | composições de prostaciclina e métodos de sua utilização | |
| HUE060743T2 (hu) | Gyógyszerészeti kompozíciók, amelyek tartalmaznak imidazothiadiazol- és imidazopiridazinszármazékokat mint proteáz aktívált receptor 4 (PAR4) inhibitorokat trombocitaaggregációk kezelésére | |
| EP2506835A4 (en) | COMPRESSIBLE COATED PHARMACEUTICAL COMPOSITION, TABLETS AND MANUFACTURING METHOD THEREFOR | |
| CL2014000849A1 (es) | Compuestos derivados de benzilindazoles sustituido, inhibidores de la quinasa bub1; procedimiento de fabricacion; composicion farmaceutica; combinacion farmaceutica; y su uso en el tratamiento de enfermedades hiperproliferativas. | |
| EA201200616A1 (ru) | Производные 2-оксо-1-пирролидинилимидазотиадиазола | |
| EA201790950A1 (ru) | Способы и композиции, в частности, для лечения синдрома дефицита внимания | |
| PH12012502083A1 (en) | Manufacturing of active-free granules and tablets comprising the same | |
| EA201291211A1 (ru) | Фармацевтические композиции, содержащие гидроморфон и налоксон | |
| EA201400737A1 (ru) | Система доставки на основе множества пеллет с немедленным высвобождением активного вещества | |
| EA201400444A1 (ru) | Производные 2-оксопиперидинила | |
| EP2655607A4 (en) | METHOD AND COMPOSITIONS FOR PRODUCING ACTIVE VITAMIN K-DEPENDENT PROTEINS | |
| EA201200210A1 (ru) | Состав, содержащий производное витамина k3 и нестероидный противовоспалительный препарат | |
| DK2964199T3 (da) | Tørre farmaceutiske sammensætninger omfattende aktivstof-nanopartikler bundet til bærerpartikler | |
| EP2452678A3 (en) | Pulsatile-release pharmaceutical formulation of dexlansoprazole | |
| UY35690A (es) | Composiciones farmacéuticas de ranolazina y dronedarona | |
| EP2939663A4 (en) | MELT EXTRUDED PHARMACEUTICAL COMPOSITION FOR CONTROLLED RELEASE AND MEDICAMENT FOR ORAL ADMINISTRATION THEREWITH | |
| MX2015006356A (es) | Formulacion de capsula de acido 5-aminosalicilico. | |
| MX2015013470A (es) | Microcapsulas de piperaquina y composiciones que las contienen. | |
| EP2883546A4 (en) | NEW PHARMACEUTICAL COMPOSITION COMPRISING THREE ACTIVE SUBSTANCES WITH DIFFERENTIAL RELEASE | |
| BR112013009647A2 (pt) | derivado de vitamina, composição farmacêutica, agente terapêutico, e, composto |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |