MX364833B - Sintesis de compuestos polihidroxi cromenona y sus efectos anti-tumor. - Google Patents
Sintesis de compuestos polihidroxi cromenona y sus efectos anti-tumor.Info
- Publication number
- MX364833B MX364833B MX2014008526A MX2014008526A MX364833B MX 364833 B MX364833 B MX 364833B MX 2014008526 A MX2014008526 A MX 2014008526A MX 2014008526 A MX2014008526 A MX 2014008526A MX 364833 B MX364833 B MX 364833B
- Authority
- MX
- Mexico
- Prior art keywords
- polyhydroxy
- ketone compound
- synthesis
- tumor effect
- compound
- Prior art date
Links
- -1 benzopyran ketone compound Chemical class 0.000 title abstract 2
- 230000000259 anti-tumor effect Effects 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 230000002508 compound effect Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 206010006187 Breast cancer Diseases 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 102000015694 estrogen receptors Human genes 0.000 abstract 1
- 108010038795 estrogen receptors Proteins 0.000 abstract 1
- 208000032839 leukemia Diseases 0.000 abstract 1
- 201000007270 liver cancer Diseases 0.000 abstract 1
- 208000014018 liver neoplasm Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
- C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210011031 | 2012-01-13 | ||
| CN201210573072.6A CN103204838B (zh) | 2012-01-13 | 2012-12-25 | 多羟基苯并吡喃酮类化合物的合成及其抗肿瘤作用 |
| PCT/CN2012/088016 WO2013104263A1 (zh) | 2012-01-13 | 2012-12-31 | 多羟基苯并吡喃酮类化合物的合成及其抗肿瘤作用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2014008526A MX2014008526A (es) | 2014-11-25 |
| MX364833B true MX364833B (es) | 2019-05-08 |
Family
ID=48752268
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014008526A MX364833B (es) | 2012-01-13 | 2012-12-31 | Sintesis de compuestos polihidroxi cromenona y sus efectos anti-tumor. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9221781B2 (OSRAM) |
| EP (1) | EP2803665B1 (OSRAM) |
| JP (1) | JP6113751B2 (OSRAM) |
| KR (1) | KR102030207B1 (OSRAM) |
| CN (1) | CN103204838B (OSRAM) |
| AU (1) | AU2012365712B2 (OSRAM) |
| BR (1) | BR112014016635B8 (OSRAM) |
| CA (1) | CA2860999C (OSRAM) |
| ES (1) | ES2627316T3 (OSRAM) |
| MX (1) | MX364833B (OSRAM) |
| WO (1) | WO2013104263A1 (OSRAM) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101784990B1 (ko) * | 2016-01-13 | 2017-10-12 | 주식회사 파이브지티 | 얼굴인식을 이용한 홈 오토메이션 제어 시스템 및 그 방법 |
| CN107216303B (zh) * | 2016-07-15 | 2020-04-21 | 北京盛诺基医药科技股份有限公司 | 氟可拉定的合成方法 |
| CN107298667B (zh) * | 2016-07-15 | 2020-09-08 | 北京盛诺基医药科技股份有限公司 | 淫羊藿素的合成方法 |
| WO2018035246A1 (en) * | 2016-08-16 | 2018-02-22 | Uwm Research Foundation, Inc. | Gaba(a) receptor modulators and methods to control airway hyperresponsiveness and inflammation in asthma |
| US10266510B2 (en) | 2017-01-18 | 2019-04-23 | King Abdulaziz University | Antimicrobial and cytotoxic compounds and methods for treating cancer, a bacterial infection, and/or a fungal infection |
| CN108947949B (zh) * | 2017-05-19 | 2022-08-19 | 泰州华元医药科技有限公司 | 抗焦虑氘代化合物及其医药用途 |
| CN109020938A (zh) * | 2018-08-17 | 2018-12-18 | 昆明龙津药业股份有限公司 | 一种杨梅素的制备方法 |
| CN110092770A (zh) * | 2019-05-31 | 2019-08-06 | 北京盛诺基医药科技有限公司 | 一种黄酮化合物中间体的制备方法 |
| CN110054605A (zh) * | 2019-05-31 | 2019-07-26 | 北京盛诺基医药科技有限公司 | 一种淫羊藿素中间体的制备方法 |
| CN112569222A (zh) * | 2020-12-31 | 2021-03-30 | 赣南医学院 | 三氟淫羊藿素在制备改善疼痛、肿胀及运动功能的药物中的应用 |
| CN112851615B (zh) * | 2021-01-21 | 2023-04-07 | 厦门大学 | 一种异戊烯基黄酮的制备及其作为治疗宫颈癌药物的应用 |
| CN113717138B (zh) * | 2021-10-21 | 2023-02-24 | 沈阳药科大学 | 一类氮芥类色原酮衍生物与应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1786864A (zh) | 2004-12-10 | 2006-06-14 | 上海迪比特实业有限公司 | 一种计算机安全认证方法 |
| JP2007332695A (ja) | 2006-06-16 | 2007-12-27 | Advanced Media Inc | 電子錠装置及び音声認証ロッカーシステム |
| WO2008100977A2 (en) * | 2007-02-14 | 2008-08-21 | N.V. Organon | Carbamates therapeutic release agents as amidase inhibitors |
| CN101104611A (zh) * | 2007-04-29 | 2008-01-16 | 殷正丰 | 一种3-甲氧基黄酮类化合物,其制备方法和应用 |
| JP2011518174A (ja) * | 2008-04-18 | 2011-06-23 | シェノゲン ファーマ グループ リミテッド | エストロゲン受容体に関連する疾患を処置するための化合物及び方法 |
| CN102038673B (zh) * | 2009-10-20 | 2012-07-25 | 北京珅奥基医药科技有限公司 | 羟基苯并吡喃酮类化合物在制备治疗白血病药物中的应用 |
| CN102558164B (zh) | 2010-12-31 | 2016-06-15 | 北京盛诺基医药科技有限公司 | 苯并吡喃酮类雌激素受体调节剂 |
-
2012
- 2012-12-25 CN CN201210573072.6A patent/CN103204838B/zh active Active
- 2012-12-31 MX MX2014008526A patent/MX364833B/es active IP Right Grant
- 2012-12-31 WO PCT/CN2012/088016 patent/WO2013104263A1/zh not_active Ceased
- 2012-12-31 US US14/371,866 patent/US9221781B2/en active Active - Reinstated
- 2012-12-31 KR KR1020147022558A patent/KR102030207B1/ko not_active Expired - Fee Related
- 2012-12-31 EP EP12864757.5A patent/EP2803665B1/en active Active
- 2012-12-31 CA CA2860999A patent/CA2860999C/en active Active
- 2012-12-31 JP JP2014551506A patent/JP6113751B2/ja active Active
- 2012-12-31 ES ES12864757.5T patent/ES2627316T3/es active Active
- 2012-12-31 AU AU2012365712A patent/AU2012365712B2/en not_active Ceased
- 2012-12-31 BR BR112014016635A patent/BR112014016635B8/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2627316T3 (es) | 2017-07-27 |
| CN103204838A (zh) | 2013-07-17 |
| EP2803665B1 (en) | 2017-05-10 |
| BR112014016635A8 (pt) | 2017-07-04 |
| JP6113751B2 (ja) | 2017-04-12 |
| CA2860999C (en) | 2019-12-31 |
| MX2014008526A (es) | 2014-11-25 |
| CA2860999A1 (en) | 2013-07-18 |
| JP2015503596A (ja) | 2015-02-02 |
| WO2013104263A1 (zh) | 2013-07-18 |
| EP2803665A4 (en) | 2015-07-08 |
| KR102030207B1 (ko) | 2019-10-08 |
| BR112014016635B1 (pt) | 2021-07-13 |
| AU2012365712B2 (en) | 2017-04-20 |
| US20150011618A1 (en) | 2015-01-08 |
| BR112014016635A2 (pt) | 2017-06-13 |
| AU2012365712A1 (en) | 2014-07-24 |
| BR112014016635B8 (pt) | 2021-08-24 |
| EP2803665A1 (en) | 2014-11-19 |
| CN103204838B (zh) | 2017-06-09 |
| KR20140109498A (ko) | 2014-09-15 |
| US9221781B2 (en) | 2015-12-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |