MX2018007844A - Derivado de benzopiperidina, metodo de preparacion del mismo y su uso medico del mismo. - Google Patents
Derivado de benzopiperidina, metodo de preparacion del mismo y su uso medico del mismo.Info
- Publication number
- MX2018007844A MX2018007844A MX2018007844A MX2018007844A MX2018007844A MX 2018007844 A MX2018007844 A MX 2018007844A MX 2018007844 A MX2018007844 A MX 2018007844A MX 2018007844 A MX2018007844 A MX 2018007844A MX 2018007844 A MX2018007844 A MX 2018007844A
- Authority
- MX
- Mexico
- Prior art keywords
- preparation
- derivative
- medical use
- benzopiperidine
- benzopiperidine derivative
- Prior art date
Links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Reproductive Health (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Psychology (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Gastroenterology & Hepatology (AREA)
- Vascular Medicine (AREA)
Abstract
La presente invención se refiere a un derivado de benzopiperidina, a un método de preparación del mismo y a un uso médico del mismo. En particular, la presente invención se refiere a un derivado de benzopiperidina, como se muestra en la fórmula general (I), a un método de preparación del mismo y a una composición farmacéutica que contiene el derivado, así como un uso del mismo como modulador del receptor de estrógenos en la prevención y/o el tratamiento de enfermedades o afecciones dependientes o mediadas por receptores de estrógenos. Preferiblemente, la enfermedad es cáncer de mama. Los sustituyentes en la fórmula general (I) son los mismos que los definidos en la descripción. (ver Fórmula).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510975923 | 2015-12-22 | ||
PCT/CN2016/108367 WO2017107754A1 (zh) | 2015-12-22 | 2016-12-02 | 苯并哌啶类衍生物、其制备方法及其在医药上的应用 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018007844A true MX2018007844A (es) | 2019-01-21 |
Family
ID=59088987
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018007844A MX2018007844A (es) | 2015-12-22 | 2016-12-02 | Derivado de benzopiperidina, metodo de preparacion del mismo y su uso medico del mismo. |
Country Status (13)
Country | Link |
---|---|
US (1) | US10398689B2 (es) |
EP (1) | EP3395809A4 (es) |
JP (1) | JP2019503346A (es) |
KR (1) | KR20180095564A (es) |
CN (1) | CN107428721B (es) |
AU (1) | AU2016379672A1 (es) |
BR (1) | BR112018011817A2 (es) |
CA (1) | CA3006683A1 (es) |
HK (1) | HK1244808A1 (es) |
MX (1) | MX2018007844A (es) |
RU (1) | RU2727705C1 (es) |
TW (1) | TWI732810B (es) |
WO (1) | WO2017107754A1 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2019503346A (ja) | 2015-12-22 | 2019-02-07 | ジエンス ヘンルイ メデイシンカンパニー リミテッドJiangsu Hengrui Medicine Co.,Ltd. | ベンゾピペリジン誘導体、その製造方法及びその医薬用途 |
WO2017182493A1 (en) | 2016-04-20 | 2017-10-26 | Astrazeneca Ab | Indazole derivatives for use in down-regulation of the estrogen receptor for the treatment of cancer |
WO2018019793A1 (en) | 2016-07-25 | 2018-02-01 | Astrazeneca Ab | N-(2-(4-((1r,3r)-3-methyl-2,3,4,9-tetrahydro-1h-pyrido[3,4-b]indol-1-yl)phenoxy)ethyl)propan-1-amine derivatives and related compounds as selective down-regulators of the estrogen receptor for treating cancer |
HRP20220255T1 (hr) | 2016-10-24 | 2022-04-29 | Astrazeneca Ab | Derivati 6,7,8,9-tetrahidro-3h-pirazolo[4,3-f]izokinolina koji su korisni u liječenju raka |
LT3494116T (lt) | 2017-01-30 | 2020-01-10 | Astrazeneca Ab | Estrogeno receptorių moduliatoriai |
WO2018233591A1 (zh) * | 2017-06-20 | 2018-12-27 | 江苏恒瑞医药股份有限公司 | 一种苯并哌啶类衍生物的盐、其晶型及盐、其晶型的制备方法 |
CN109867659A (zh) * | 2017-12-04 | 2019-06-11 | 江苏恒瑞医药股份有限公司 | 苯并哌啶类衍生物的制备方法 |
CN111601797B (zh) * | 2018-05-23 | 2022-11-22 | 江苏恒瑞医药股份有限公司 | 苯并哌啶或杂芳基并哌啶类衍生物、其制备方法及其在医药上的应用 |
CN111205188A (zh) * | 2018-11-22 | 2020-05-29 | 上海盛迪医药有限公司 | 环烷烃化合物的制备方法 |
CN111349076B (zh) * | 2018-12-20 | 2022-07-26 | 江苏恒瑞医药股份有限公司 | 一种苯并哌啶类衍生物的l-赖氨酸盐的晶型及其制备方法 |
CN112830919B (zh) * | 2019-11-22 | 2022-05-27 | 江苏恒瑞医药股份有限公司 | 苯并哌啶衍生物可药用盐及其制备方法 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
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US5455252A (en) | 1993-03-31 | 1995-10-03 | Syntex (U.S.A.) Inc. | Optionally substituted 6,8-quinolines |
US6262098B1 (en) * | 1998-08-07 | 2001-07-17 | Chiron Corporation | Estrogen receptor modulators |
NZ514144A (en) * | 1999-04-01 | 2001-09-28 | Pfizer Prod Inc | Aminopyrimidines as sorbitol dehydrogenase inhibitors |
CN1390126B (zh) * | 1999-07-06 | 2012-06-13 | 恩多研究公司 | 选择性雌激素受体调节剂在制备用于治疗或降低肥胖症发展危险性的药物中的用途 |
EP1113007A1 (en) * | 1999-12-24 | 2001-07-04 | Pfizer Inc. | Tetrahydroisoquinoline compounds as estrogen agonists/antagonists |
CN1777596A (zh) * | 2003-02-28 | 2006-05-24 | 先灵公司 | 作为选择性mch受体拮抗剂用于治疗肥胖及相关病症的联芳基四氢异喹啉哌啶 |
BRPI0518874A2 (pt) * | 2004-12-09 | 2008-12-16 | Merck & Co Inc | composto, composiÇço farmacÊutica, e, usos de um composto, e de uma composiÇço |
US8354411B2 (en) | 2009-02-05 | 2013-01-15 | Takeda Pharmaceutical Company Limited | 1-phenyl-3-pyrazolylpyridazin-4(1H)-one compound |
EP2941421A4 (en) | 2013-01-07 | 2016-09-21 | Bg Negev Technologies & Applic Ltd | COUMESTAN, COUMESTROL, COUMESTAN DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF AND USE THEREOF |
JP6387023B2 (ja) | 2013-02-28 | 2018-09-05 | ティウムバイオ カンパニー、リミテッドTiumBio Co., Ltd. | 三環式化合物およびその使用 |
IN2013MU00646A (es) | 2013-03-04 | 2015-06-26 | Intas Pharmaceuticals Ltd | |
ZA201401636B (en) | 2013-03-05 | 2014-11-26 | Cipla Ltd | Oxalic acid addition salts and/or solvates of a selective estrogen receptor modulator |
CA2899969A1 (en) | 2013-03-14 | 2014-09-25 | Seragon Pharmaceuticals, Inc. | Polycyclic estrogen receptor modulators and uses thereof |
CA2904533C (en) | 2013-04-04 | 2022-01-04 | The Administrators Of The Tulane Educational Fund | Enhanced osteogenic activity of daidzein analogs on human mesenchymal stem cells |
UY35590A (es) | 2013-05-28 | 2014-11-28 | Astrazeneca Ab | Nuevos compuestos para el tratamiento del cáncer |
WO2015092634A1 (en) * | 2013-12-16 | 2015-06-25 | Novartis Ag | 1,2,3,4-tetrahydroisoquinoline compounds and compositions as selective estrogen receptor antagonists and degraders |
JP2019503346A (ja) | 2015-12-22 | 2019-02-07 | ジエンス ヘンルイ メデイシンカンパニー リミテッドJiangsu Hengrui Medicine Co.,Ltd. | ベンゾピペリジン誘導体、その製造方法及びその医薬用途 |
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2016
- 2016-12-02 JP JP2018528988A patent/JP2019503346A/ja active Pending
- 2016-12-02 RU RU2018121642A patent/RU2727705C1/ru not_active IP Right Cessation
- 2016-12-02 AU AU2016379672A patent/AU2016379672A1/en not_active Abandoned
- 2016-12-02 CN CN201680013279.4A patent/CN107428721B/zh active Active
- 2016-12-02 US US16/061,676 patent/US10398689B2/en not_active Expired - Fee Related
- 2016-12-02 EP EP16877565.8A patent/EP3395809A4/en not_active Withdrawn
- 2016-12-02 KR KR1020187019436A patent/KR20180095564A/ko unknown
- 2016-12-02 BR BR112018011817A patent/BR112018011817A2/pt not_active Application Discontinuation
- 2016-12-02 WO PCT/CN2016/108367 patent/WO2017107754A1/zh active Application Filing
- 2016-12-02 MX MX2018007844A patent/MX2018007844A/es unknown
- 2016-12-02 CA CA3006683A patent/CA3006683A1/en not_active Abandoned
- 2016-12-19 TW TW105142052A patent/TWI732810B/zh active
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2018
- 2018-04-02 HK HK18104375.7A patent/HK1244808A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
CN107428721B (zh) | 2020-07-28 |
EP3395809A1 (en) | 2018-10-31 |
CA3006683A1 (en) | 2017-06-29 |
RU2727705C1 (ru) | 2020-07-23 |
KR20180095564A (ko) | 2018-08-27 |
EP3395809A4 (en) | 2019-06-19 |
US20180318284A1 (en) | 2018-11-08 |
US10398689B2 (en) | 2019-09-03 |
TW201722929A (zh) | 2017-07-01 |
CN107428721A (zh) | 2017-12-01 |
HK1244808A1 (zh) | 2018-08-17 |
JP2019503346A (ja) | 2019-02-07 |
BR112018011817A2 (pt) | 2018-12-04 |
WO2017107754A1 (zh) | 2017-06-29 |
TWI732810B (zh) | 2021-07-11 |
AU2016379672A1 (en) | 2018-06-21 |
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