MX349969B - Metodos de preparación de ribósido de nicotinamida y sus derivados. - Google Patents

Metodos de preparación de ribósido de nicotinamida y sus derivados.

Info

Publication number
MX349969B
MX349969B MX2016001211A MX2016001211A MX349969B MX 349969 B MX349969 B MX 349969B MX 2016001211 A MX2016001211 A MX 2016001211A MX 2016001211 A MX2016001211 A MX 2016001211A MX 349969 B MX349969 B MX 349969B
Authority
MX
Mexico
Prior art keywords
substituted
unsubstituted
derivatives
methods
nicotinamide riboside
Prior art date
Application number
MX2016001211A
Other languages
English (en)
Spanish (es)
Other versions
MX2016001211A (es
Inventor
Migaud Marie
Redpath Philip
CROSSEY Kerri
Doherty Mark
Original Assignee
Univ Belfast
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Belfast filed Critical Univ Belfast
Publication of MX2016001211A publication Critical patent/MX2016001211A/es
Publication of MX349969B publication Critical patent/MX349969B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/048—Pyridine radicals
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
MX2016001211A 2013-07-29 2014-07-24 Metodos de preparación de ribósido de nicotinamida y sus derivados. MX349969B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1313465.5A GB201313465D0 (en) 2013-07-29 2013-07-29 Methods of preparing nicotinamide riboside and derivatives thereof
PCT/EP2014/065971 WO2015014722A1 (en) 2013-07-29 2014-07-24 Methods of preparing nicotinamide riboside and derivatives thereof

Publications (2)

Publication Number Publication Date
MX2016001211A MX2016001211A (es) 2016-10-28
MX349969B true MX349969B (es) 2017-08-23

Family

ID=49167061

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016001211A MX349969B (es) 2013-07-29 2014-07-24 Metodos de preparación de ribósido de nicotinamida y sus derivados.

Country Status (14)

Country Link
US (6) US10000519B2 (OSRAM)
EP (2) EP3321274A1 (OSRAM)
JP (1) JP6208352B2 (OSRAM)
KR (2) KR102303966B1 (OSRAM)
CN (2) CN105636973B (OSRAM)
AU (4) AU2014298629B2 (OSRAM)
BR (1) BR112016001774B1 (OSRAM)
CA (2) CA3192957A1 (OSRAM)
ES (1) ES2652654T3 (OSRAM)
GB (1) GB201313465D0 (OSRAM)
HK (1) HK1255037A1 (OSRAM)
MX (1) MX349969B (OSRAM)
WO (1) WO2015014722A1 (OSRAM)
ZA (1) ZA201802315B (OSRAM)

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GB201313465D0 (en) 2013-07-29 2013-09-11 Queens University Of The Belfast Methods of preparing nicotinamide riboside and derivatives thereof
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BR112016028672A2 (pt) * 2014-06-06 2017-08-22 Glaxosmithkline Ip No 2 Ltd análogos de ribosídeo de nicotinamida e composições farmacêuticas e usos do mesmo
EP3174891B1 (en) * 2014-07-24 2020-01-29 W.R. Grace & CO. - CONN. Crystalline form of nicotinamide riboside
BR112017019409A2 (pt) * 2015-03-09 2018-04-24 Grace W R & Co forma cristalina de ribosídeo de nicotinamida
MX390185B (es) 2015-03-16 2025-03-20 Chromadex Inc Composiciones de acido nicotinico ribosido o de nicotinamida ribosido, derivados reducidos de los mismos, y su uso.
EP3322419B1 (en) 2015-07-15 2025-09-03 Cornell University Syntheses, activities, and methods of use of dihydronicotinamide riboside derivatives
MX2018001363A (es) 2015-08-05 2018-11-29 Metro Int Biotech Llc Derivados del mononucleotido de nicotinamida y sus usos.
GB2542881B (en) 2015-10-02 2020-01-01 Carr Andrew Crystal forms of ß-nicotinamide mononucleotide
US10611790B2 (en) * 2015-11-02 2020-04-07 Mitobridge, Inc. Nicotinamide riboside and nicotinamide mononucleotide derivatives for use in the treatments of mitochondrial-related diseases
US11248018B2 (en) 2016-02-23 2022-02-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Process for preparation of nicotinamide riboside (NR) and cosmetic composition comprising (NR and a phosphate-binding agent
AU2017232930B2 (en) * 2016-03-16 2021-03-25 ChromaDex Inc. B-vitamin and amino acid conjugates of nicotinoyl ribosides and reduced nicotinoyl ribosides, derivatives thereof, and methods of preparation thereof
KR20190008246A (ko) 2016-04-20 2019-01-23 크로마덱스 아이엔씨. Nad+ 증가용 전구체로서 니코틴산 리보사이드 또는 니코틴아미드 리보사이트 유도체 및 이의 환원된 유도체의 용도
WO2017218580A1 (en) 2016-06-14 2017-12-21 Rejuvenation Therapeutics Corporation Synthetic methods for the preparation of nicotinamide riboside and related compounds
GB2553001A (en) * 2016-08-19 2018-02-21 The Queen's Univ Of Belfast Lactone intermediates of nicotinamide riboside and nicotinate riboside
US10689411B2 (en) 2016-11-11 2020-06-23 The Queen's University Of Belfast Efficient and scalable syntheses of nicotinoyl ribosides and reduced nicotinoyl ribosides, modified derivatives thereof, phosphorylated analogs thereof, adenylyl dinucleotide conjugates thereof, and novel crystalline forms thereof
US11071747B2 (en) 2016-11-29 2021-07-27 University Of Iowa Research Foundation Use of NAD precursors for breast enhancement
MX2019006278A (es) 2016-11-29 2019-08-21 Univ Iowa Res Found Uso de precursores de nad para mejorar la salud materna y/o salud de la descendencia.
US11286274B2 (en) 2017-06-19 2022-03-29 Mitopower Llc Nicotinamide riboside derivatives and their uses
CN111315867A (zh) * 2017-06-30 2020-06-19 益力舒健康公司 合成烟酰胺核苷的方法
WO2019122084A1 (en) 2017-12-22 2019-06-27 Stemtek Therapeutics, S.L. Process for the preparation of nicotinamide riboside chloride derivatives
CN112020363A (zh) 2017-12-22 2020-12-01 益力舒健康公司 烟酰胺核苷氯化物的结晶形式
WO2019152416A1 (en) 2018-01-30 2019-08-08 Metro International Biotech, Llc Nicotinamide riboside analogs, pharmaceutical compositions, and uses thereof
CN110283221A (zh) * 2018-03-19 2019-09-27 药源药物化学（上海）有限公司 杂环化合物的制备和纯化方法
CN110452277A (zh) * 2018-05-07 2019-11-15 明特奇点医疗科技(成都)有限公司 一种烟酰胺核糖的制备方法
EP3797110A1 (en) * 2018-05-22 2021-03-31 Jumpstart Fertility Pty Ltd Amino acid salts of nicotinic acid ribosides as anti-aging agents
AU2019290926B2 (en) * 2018-06-21 2025-01-23 Societe Des Produits Nestle S.A. Compositions and methods using a nicotinamide adenine dinucleotide (NAD+) precursor and at least one ketone or ketone precursor
CN108774278A (zh) * 2018-09-10 2018-11-09 张洪喜 一种制备尼克酰胺核苷盐的方法
KR102060374B1 (ko) * 2018-12-14 2019-12-30 주식회사 휴메딕스 지방알코올 컨쥬게이션된 니코틴아미드 리보사이드 유도체
EP3897666A2 (en) 2018-12-17 2021-10-27 Mitopower LLC Nicotinyl riboside compounds and their uses
US11939348B2 (en) 2019-03-22 2024-03-26 Metro International Biotech, Llc Compositions comprising a phosphorus derivative of nicotinamide riboside and methods for modulation of nicotinamide adenine dinucleotide
US10618927B1 (en) 2019-03-22 2020-04-14 Metro International Biotech, Llc Compositions and methods for modulation of nicotinamide adenine dinucleotide
CN114423771A (zh) 2019-07-19 2022-04-29 生物合成股份公司 制备烟酰胺呋喃核糖苷盐的方法、烟酰胺呋喃核糖苷盐本身及其用途
WO2021030551A1 (en) * 2019-08-14 2021-02-18 Metro International Biotech, Llc Compounds and compositions for differential modulation of nicotinamide adenine dinucleotide
CN110642897B (zh) * 2019-09-27 2021-04-06 武汉一若生物材料有限公司 一种β-烟酰胺核糖氯化物的制备方法
CN110658224B (zh) * 2019-10-15 2022-11-22 中国中医科学院中药研究所 一种氢核磁定量分析技术测定nmn绝对含量的方法
CN111153953A (zh) * 2020-01-07 2020-05-15 杭州洁汉化工有限公司 一种烟酰胺核糖氯化物的高效合成方法
CN111454311B (zh) * 2020-04-03 2021-10-19 深圳市迪克曼科技开发有限公司 烟酰胺核糖的有机酸盐及其组合物与制备方法
CN111647032B (zh) * 2020-06-29 2023-02-24 上海舒泽生物科技研究所 一种β-烟酰胺单核苷酸的合成方法
CN111848710A (zh) * 2020-08-20 2020-10-30 深圳市迪克曼科技开发有限公司 烟酰胺核糖及其还原态、盐的制备方法
EP4214217B1 (en) * 2020-09-15 2024-09-18 Société des Produits Nestlé S.A. Methods for producing dihydronicotinamide riboside from nicotinamide riboside chloride
CN112851730B (zh) * 2021-01-08 2023-02-21 厦门瑞林药业有限公司 一种nmn中间体nr氯化物合成方法
JP2024517260A (ja) 2021-05-04 2024-04-19 ボーハン アンド カンパニー エーエス ニコチンアミドリボシドクロリド（ｎｒｃｌ）の合成プロセス
WO2022251491A1 (en) 2021-05-27 2022-12-01 Metro International Biotech, Llc Crystalline solids of nicotinic acid mononucleotide and esters thereof and methods of making and use
CA3248665A1 (en) 2022-03-04 2023-09-07 Bohan & Co As. PROCESS FOR THE SYNTHESIS OF 1,4-DIHYDRONICOTINAMIDE RIBOSIDE FROM NICOTINAMIDE-BETA-RIBOSIDE TRIACETATE CHLORIDE
CN116462727A (zh) * 2023-04-23 2023-07-21 安徽瑞邦生物科技有限公司 一种β-烟酰胺核糖氯化物的制备方法
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Also Published As

Publication number Publication date
BR112016001774A8 (pt) 2020-01-21
AU2022203196A1 (en) 2022-06-02
NZ716277A (en) 2021-03-26
US20240101588A1 (en) 2024-03-28
US20240239831A1 (en) 2024-07-18
CN108707174A (zh) 2018-10-26
KR20160043974A (ko) 2016-04-22
BR112016001774B1 (pt) 2021-06-22
JP6208352B2 (ja) 2017-10-04
CA3192957A1 (en) 2015-02-05
AU2014298629A1 (en) 2016-02-11
ES2652654T3 (es) 2018-02-05
CN105636973B (zh) 2018-06-01
HK1255037A1 (en) 2019-08-02
US11584770B2 (en) 2023-02-21
US11981698B2 (en) 2024-05-14
KR102414886B1 (ko) 2022-07-01
US12252506B2 (en) 2025-03-18
JP2016530248A (ja) 2016-09-29
ZA201802315B (en) 2023-02-22
EP3027635B1 (en) 2017-09-20
US20220259250A1 (en) 2022-08-18
WO2015014722A1 (en) 2015-02-05
HK1218918A1 (en) 2017-03-17
GB201313465D0 (en) 2013-09-11
EP3027635A1 (en) 2016-06-08
CA2918955C (en) 2023-05-09
MX2016001211A (es) 2016-10-28
CN105636973A (zh) 2016-06-01
AU2020201254B2 (en) 2022-05-26
KR102303966B1 (ko) 2021-09-24
US20200291055A1 (en) 2020-09-17
US10000519B2 (en) 2018-06-19
KR20210038718A (ko) 2021-04-07
US20160168184A1 (en) 2016-06-16
AU2018211238A1 (en) 2018-08-16
EP3321274A1 (en) 2018-05-16
AU2022203196B2 (en) 2023-11-23
US10815262B2 (en) 2020-10-27
BR112016001774A2 (pt) 2017-08-01
CA2918955A1 (en) 2015-02-05
US20180186824A1 (en) 2018-07-05
AU2014298629B2 (en) 2018-08-16
AU2020201254A1 (en) 2020-03-12

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