ES2652654T3 - Métodos para preparar ribósido de nicotinamida y derivados del mismo - Google Patents

Métodos para preparar ribósido de nicotinamida y derivados del mismo Download PDF

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Publication number
ES2652654T3
ES2652654T3 ES14744082.0T ES14744082T ES2652654T3 ES 2652654 T3 ES2652654 T3 ES 2652654T3 ES 14744082 T ES14744082 T ES 14744082T ES 2652654 T3 ES2652654 T3 ES 2652654T3
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Spain
Prior art keywords
substituted
unsubstituted
optionally
formula
compound
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
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ES14744082.0T
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English (en)
Spanish (es)
Inventor
Marie MIGAUD
Philip REDPATH
Kerri CROSSEY
Mark Doherty
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Queens University of Belfast
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Queens University of Belfast
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/048—Pyridine radicals
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ES14744082.0T 2013-07-29 2014-07-24 Métodos para preparar ribósido de nicotinamida y derivados del mismo Active ES2652654T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1313465.5A GB201313465D0 (en) 2013-07-29 2013-07-29 Methods of preparing nicotinamide riboside and derivatives thereof
GB201313465 2013-07-29
PCT/EP2014/065971 WO2015014722A1 (en) 2013-07-29 2014-07-24 Methods of preparing nicotinamide riboside and derivatives thereof

Publications (1)

Publication Number Publication Date
ES2652654T3 true ES2652654T3 (es) 2018-02-05

Family

ID=49167061

Family Applications (1)

Application Number Title Priority Date Filing Date
ES14744082.0T Active ES2652654T3 (es) 2013-07-29 2014-07-24 Métodos para preparar ribósido de nicotinamida y derivados del mismo

Country Status (14)

Country Link
US (6) US10000519B2 (OSRAM)
EP (2) EP3321274A1 (OSRAM)
JP (1) JP6208352B2 (OSRAM)
KR (2) KR102303966B1 (OSRAM)
CN (2) CN105636973B (OSRAM)
AU (4) AU2014298629B2 (OSRAM)
BR (1) BR112016001774B1 (OSRAM)
CA (2) CA3192957A1 (OSRAM)
ES (1) ES2652654T3 (OSRAM)
GB (1) GB201313465D0 (OSRAM)
HK (1) HK1255037A1 (OSRAM)
MX (1) MX349969B (OSRAM)
WO (1) WO2015014722A1 (OSRAM)
ZA (1) ZA201802315B (OSRAM)

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MX2018001363A (es) 2015-08-05 2018-11-29 Metro Int Biotech Llc Derivados del mononucleotido de nicotinamida y sus usos.
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GB2553001A (en) * 2016-08-19 2018-02-21 The Queen's Univ Of Belfast Lactone intermediates of nicotinamide riboside and nicotinate riboside
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CN111315867A (zh) * 2017-06-30 2020-06-19 益力舒健康公司 合成烟酰胺核苷的方法
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CN112020363A (zh) 2017-12-22 2020-12-01 益力舒健康公司 烟酰胺核苷氯化物的结晶形式
WO2019152416A1 (en) 2018-01-30 2019-08-08 Metro International Biotech, Llc Nicotinamide riboside analogs, pharmaceutical compositions, and uses thereof
CN110283221A (zh) * 2018-03-19 2019-09-27 药源药物化学（上海）有限公司 杂环化合物的制备和纯化方法
CN110452277A (zh) * 2018-05-07 2019-11-15 明特奇点医疗科技(成都)有限公司 一种烟酰胺核糖的制备方法
EP3797110A1 (en) * 2018-05-22 2021-03-31 Jumpstart Fertility Pty Ltd Amino acid salts of nicotinic acid ribosides as anti-aging agents
AU2019290926B2 (en) * 2018-06-21 2025-01-23 Societe Des Produits Nestle S.A. Compositions and methods using a nicotinamide adenine dinucleotide (NAD+) precursor and at least one ketone or ketone precursor
CN108774278A (zh) * 2018-09-10 2018-11-09 张洪喜 一种制备尼克酰胺核苷盐的方法
KR102060374B1 (ko) * 2018-12-14 2019-12-30 주식회사 휴메딕스 지방알코올 컨쥬게이션된 니코틴아미드 리보사이드 유도체
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CN110658224B (zh) * 2019-10-15 2022-11-22 中国中医科学院中药研究所 一种氢核磁定量分析技术测定nmn绝对含量的方法
CN111153953A (zh) * 2020-01-07 2020-05-15 杭州洁汉化工有限公司 一种烟酰胺核糖氯化物的高效合成方法
CN111454311B (zh) * 2020-04-03 2021-10-19 深圳市迪克曼科技开发有限公司 烟酰胺核糖的有机酸盐及其组合物与制备方法
CN111647032B (zh) * 2020-06-29 2023-02-24 上海舒泽生物科技研究所 一种β-烟酰胺单核苷酸的合成方法
CN111848710A (zh) * 2020-08-20 2020-10-30 深圳市迪克曼科技开发有限公司 烟酰胺核糖及其还原态、盐的制备方法
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CN112851730B (zh) * 2021-01-08 2023-02-21 厦门瑞林药业有限公司 一种nmn中间体nr氯化物合成方法
JP2024517260A (ja) 2021-05-04 2024-04-19 ボーハン アンド カンパニー エーエス ニコチンアミドリボシドクロリド（ｎｒｃｌ）の合成プロセス
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Also Published As

Publication number Publication date
BR112016001774A8 (pt) 2020-01-21
AU2022203196A1 (en) 2022-06-02
NZ716277A (en) 2021-03-26
US20240101588A1 (en) 2024-03-28
US20240239831A1 (en) 2024-07-18
CN108707174A (zh) 2018-10-26
KR20160043974A (ko) 2016-04-22
BR112016001774B1 (pt) 2021-06-22
JP6208352B2 (ja) 2017-10-04
CA3192957A1 (en) 2015-02-05
AU2014298629A1 (en) 2016-02-11
CN105636973B (zh) 2018-06-01
HK1255037A1 (en) 2019-08-02
US11584770B2 (en) 2023-02-21
US11981698B2 (en) 2024-05-14
KR102414886B1 (ko) 2022-07-01
US12252506B2 (en) 2025-03-18
JP2016530248A (ja) 2016-09-29
ZA201802315B (en) 2023-02-22
EP3027635B1 (en) 2017-09-20
US20220259250A1 (en) 2022-08-18
WO2015014722A1 (en) 2015-02-05
HK1218918A1 (en) 2017-03-17
GB201313465D0 (en) 2013-09-11
EP3027635A1 (en) 2016-06-08
CA2918955C (en) 2023-05-09
MX2016001211A (es) 2016-10-28
CN105636973A (zh) 2016-06-01
AU2020201254B2 (en) 2022-05-26
KR102303966B1 (ko) 2021-09-24
US20200291055A1 (en) 2020-09-17
US10000519B2 (en) 2018-06-19
KR20210038718A (ko) 2021-04-07
US20160168184A1 (en) 2016-06-16
AU2018211238A1 (en) 2018-08-16
EP3321274A1 (en) 2018-05-16
AU2022203196B2 (en) 2023-11-23
US10815262B2 (en) 2020-10-27
BR112016001774A2 (pt) 2017-08-01
MX349969B (es) 2017-08-23
CA2918955A1 (en) 2015-02-05
US20180186824A1 (en) 2018-07-05
AU2014298629B2 (en) 2018-08-16
AU2020201254A1 (en) 2020-03-12

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