JP6208352B2 - ニコチンアミドリボシドおよびその誘導体を調製する方法 - Google Patents

ニコチンアミドリボシドおよびその誘導体を調製する方法 Download PDF

Info

Publication number
JP6208352B2
JP6208352B2 JP2016530446A JP2016530446A JP6208352B2 JP 6208352 B2 JP6208352 B2 JP 6208352B2 JP 2016530446 A JP2016530446 A JP 2016530446A JP 2016530446 A JP2016530446 A JP 2016530446A JP 6208352 B2 JP6208352 B2 JP 6208352B2
Authority
JP
Japan
Prior art keywords
unsubstituted
substituted
optionally
formula
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2016530446A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016530248A (ja
JP2016530248A5 (OSRAM
Inventor
ミゴード，マリー
レッドパス，フィリップ
クロッシー，ケリー
ドハーティ，マーク
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Queens University of Belfast
Original Assignee
Queens University of Belfast
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Queens University of Belfast filed Critical Queens University of Belfast
Publication of JP2016530248A publication Critical patent/JP2016530248A/ja
Publication of JP2016530248A5 publication Critical patent/JP2016530248A5/ja
Application granted granted Critical
Publication of JP6208352B2 publication Critical patent/JP6208352B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/048—Pyridine radicals
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2016530446A 2013-07-29 2014-07-24 ニコチンアミドリボシドおよびその誘導体を調製する方法 Active JP6208352B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1313465.5A GB201313465D0 (en) 2013-07-29 2013-07-29 Methods of preparing nicotinamide riboside and derivatives thereof
GB1313465.5 2013-07-29
PCT/EP2014/065971 WO2015014722A1 (en) 2013-07-29 2014-07-24 Methods of preparing nicotinamide riboside and derivatives thereof

Publications (3)

Publication Number Publication Date
JP2016530248A JP2016530248A (ja) 2016-09-29
JP2016530248A5 JP2016530248A5 (OSRAM) 2017-09-07
JP6208352B2 true JP6208352B2 (ja) 2017-10-04

Family

ID=49167061

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016530446A Active JP6208352B2 (ja) 2013-07-29 2014-07-24 ニコチンアミドリボシドおよびその誘導体を調製する方法

Country Status (14)

Country Link
US (6) US10000519B2 (OSRAM)
EP (2) EP3321274A1 (OSRAM)
JP (1) JP6208352B2 (OSRAM)
KR (2) KR102303966B1 (OSRAM)
CN (2) CN105636973B (OSRAM)
AU (4) AU2014298629B2 (OSRAM)
BR (1) BR112016001774B1 (OSRAM)
CA (2) CA3192957A1 (OSRAM)
ES (1) ES2652654T3 (OSRAM)
GB (1) GB201313465D0 (OSRAM)
HK (1) HK1255037A1 (OSRAM)
MX (1) MX349969B (OSRAM)
WO (1) WO2015014722A1 (OSRAM)
ZA (1) ZA201802315B (OSRAM)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201313465D0 (en) 2013-07-29 2013-09-11 Queens University Of The Belfast Methods of preparing nicotinamide riboside and derivatives thereof
AU2015270130A1 (en) * 2014-06-02 2016-12-15 Glaxosmithkline Intellectual Property (No.2) Limited Preparation and use of crystalline beta-D-nicotinamide riboside
BR112016028672A2 (pt) * 2014-06-06 2017-08-22 Glaxosmithkline Ip No 2 Ltd análogos de ribosídeo de nicotinamida e composições farmacêuticas e usos do mesmo
EP3174891B1 (en) * 2014-07-24 2020-01-29 W.R. Grace & CO. - CONN. Crystalline form of nicotinamide riboside
BR112017019409A2 (pt) * 2015-03-09 2018-04-24 Grace W R & Co forma cristalina de ribosídeo de nicotinamida
MX390185B (es) 2015-03-16 2025-03-20 Chromadex Inc Composiciones de acido nicotinico ribosido o de nicotinamida ribosido, derivados reducidos de los mismos, y su uso.
EP3322419B1 (en) 2015-07-15 2025-09-03 Cornell University Syntheses, activities, and methods of use of dihydronicotinamide riboside derivatives
MX2018001363A (es) 2015-08-05 2018-11-29 Metro Int Biotech Llc Derivados del mononucleotido de nicotinamida y sus usos.
GB2542881B (en) 2015-10-02 2020-01-01 Carr Andrew Crystal forms of ß-nicotinamide mononucleotide
US10611790B2 (en) * 2015-11-02 2020-04-07 Mitobridge, Inc. Nicotinamide riboside and nicotinamide mononucleotide derivatives for use in the treatments of mitochondrial-related diseases
US11248018B2 (en) 2016-02-23 2022-02-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Process for preparation of nicotinamide riboside (NR) and cosmetic composition comprising (NR and a phosphate-binding agent
AU2017232930B2 (en) * 2016-03-16 2021-03-25 ChromaDex Inc. B-vitamin and amino acid conjugates of nicotinoyl ribosides and reduced nicotinoyl ribosides, derivatives thereof, and methods of preparation thereof
KR20190008246A (ko) 2016-04-20 2019-01-23 크로마덱스 아이엔씨. Nad+ 증가용 전구체로서 니코틴산 리보사이드 또는 니코틴아미드 리보사이트 유도체 및 이의 환원된 유도체의 용도
WO2017218580A1 (en) 2016-06-14 2017-12-21 Rejuvenation Therapeutics Corporation Synthetic methods for the preparation of nicotinamide riboside and related compounds
GB2553001A (en) * 2016-08-19 2018-02-21 The Queen's Univ Of Belfast Lactone intermediates of nicotinamide riboside and nicotinate riboside
US10689411B2 (en) 2016-11-11 2020-06-23 The Queen's University Of Belfast Efficient and scalable syntheses of nicotinoyl ribosides and reduced nicotinoyl ribosides, modified derivatives thereof, phosphorylated analogs thereof, adenylyl dinucleotide conjugates thereof, and novel crystalline forms thereof
US11071747B2 (en) 2016-11-29 2021-07-27 University Of Iowa Research Foundation Use of NAD precursors for breast enhancement
MX2019006278A (es) 2016-11-29 2019-08-21 Univ Iowa Res Found Uso de precursores de nad para mejorar la salud materna y/o salud de la descendencia.
US11286274B2 (en) 2017-06-19 2022-03-29 Mitopower Llc Nicotinamide riboside derivatives and their uses
CN111315867A (zh) * 2017-06-30 2020-06-19 益力舒健康公司 合成烟酰胺核苷的方法
WO2019122084A1 (en) 2017-12-22 2019-06-27 Stemtek Therapeutics, S.L. Process for the preparation of nicotinamide riboside chloride derivatives
CN112020363A (zh) 2017-12-22 2020-12-01 益力舒健康公司 烟酰胺核苷氯化物的结晶形式
WO2019152416A1 (en) 2018-01-30 2019-08-08 Metro International Biotech, Llc Nicotinamide riboside analogs, pharmaceutical compositions, and uses thereof
CN110283221A (zh) * 2018-03-19 2019-09-27 药源药物化学（上海）有限公司 杂环化合物的制备和纯化方法
CN110452277A (zh) * 2018-05-07 2019-11-15 明特奇点医疗科技(成都)有限公司 一种烟酰胺核糖的制备方法
EP3797110A1 (en) * 2018-05-22 2021-03-31 Jumpstart Fertility Pty Ltd Amino acid salts of nicotinic acid ribosides as anti-aging agents
AU2019290926B2 (en) * 2018-06-21 2025-01-23 Societe Des Produits Nestle S.A. Compositions and methods using a nicotinamide adenine dinucleotide (NAD+) precursor and at least one ketone or ketone precursor
CN108774278A (zh) * 2018-09-10 2018-11-09 张洪喜 一种制备尼克酰胺核苷盐的方法
KR102060374B1 (ko) * 2018-12-14 2019-12-30 주식회사 휴메딕스 지방알코올 컨쥬게이션된 니코틴아미드 리보사이드 유도체
EP3897666A2 (en) 2018-12-17 2021-10-27 Mitopower LLC Nicotinyl riboside compounds and their uses
US11939348B2 (en) 2019-03-22 2024-03-26 Metro International Biotech, Llc Compositions comprising a phosphorus derivative of nicotinamide riboside and methods for modulation of nicotinamide adenine dinucleotide
US10618927B1 (en) 2019-03-22 2020-04-14 Metro International Biotech, Llc Compositions and methods for modulation of nicotinamide adenine dinucleotide
CN114423771A (zh) 2019-07-19 2022-04-29 生物合成股份公司 制备烟酰胺呋喃核糖苷盐的方法、烟酰胺呋喃核糖苷盐本身及其用途
WO2021030551A1 (en) * 2019-08-14 2021-02-18 Metro International Biotech, Llc Compounds and compositions for differential modulation of nicotinamide adenine dinucleotide
CN110642897B (zh) * 2019-09-27 2021-04-06 武汉一若生物材料有限公司 一种β-烟酰胺核糖氯化物的制备方法
CN110658224B (zh) * 2019-10-15 2022-11-22 中国中医科学院中药研究所 一种氢核磁定量分析技术测定nmn绝对含量的方法
CN111153953A (zh) * 2020-01-07 2020-05-15 杭州洁汉化工有限公司 一种烟酰胺核糖氯化物的高效合成方法
CN111454311B (zh) * 2020-04-03 2021-10-19 深圳市迪克曼科技开发有限公司 烟酰胺核糖的有机酸盐及其组合物与制备方法
CN111647032B (zh) * 2020-06-29 2023-02-24 上海舒泽生物科技研究所 一种β-烟酰胺单核苷酸的合成方法
CN111848710A (zh) * 2020-08-20 2020-10-30 深圳市迪克曼科技开发有限公司 烟酰胺核糖及其还原态、盐的制备方法
EP4214217B1 (en) * 2020-09-15 2024-09-18 Société des Produits Nestlé S.A. Methods for producing dihydronicotinamide riboside from nicotinamide riboside chloride
CN112851730B (zh) * 2021-01-08 2023-02-21 厦门瑞林药业有限公司 一种nmn中间体nr氯化物合成方法
JP2024517260A (ja) 2021-05-04 2024-04-19 ボーハン アンド カンパニー エーエス ニコチンアミドリボシドクロリド（ｎｒｃｌ）の合成プロセス
WO2022251491A1 (en) 2021-05-27 2022-12-01 Metro International Biotech, Llc Crystalline solids of nicotinic acid mononucleotide and esters thereof and methods of making and use
CA3248665A1 (en) 2022-03-04 2023-09-07 Bohan & Co As. PROCESS FOR THE SYNTHESIS OF 1,4-DIHYDRONICOTINAMIDE RIBOSIDE FROM NICOTINAMIDE-BETA-RIBOSIDE TRIACETATE CHLORIDE
CN116462727A (zh) * 2023-04-23 2023-07-21 安徽瑞邦生物科技有限公司 一种β-烟酰胺核糖氯化物的制备方法
US20240415863A1 (en) * 2023-06-14 2024-12-19 ChromaDex Inc. Nicotinamide riboside and derivatives thereof in intravenous formulations and methods of use thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU681337B2 (en) 1991-10-23 1997-08-28 Cancer Research Campaign Technology Limited Bacterial nitroreductase for the reduction of CB 1954 and analogues thereof to a cytotoxic form
US6689760B1 (en) 2000-07-10 2004-02-10 Enzrel Inc. Anti-mycobacterial compositions
DK1957086T3 (en) * 2005-11-18 2018-06-06 Cornell Res Foundation Inc NICOTINOYL RIBOSIDE COMPOSITIONS AND METHODS OF USE
US9603862B2 (en) * 2009-12-14 2017-03-28 Cornell University Activation and activators of SIRT5
BR112012021806A2 (pt) * 2010-03-01 2015-09-08 Myrexis Inc compostos e seus usos terapêusticos.
GB201313465D0 (en) 2013-07-29 2013-09-11 Queens University Of The Belfast Methods of preparing nicotinamide riboside and derivatives thereof
BR112016028672A2 (pt) * 2014-06-06 2017-08-22 Glaxosmithkline Ip No 2 Ltd análogos de ribosídeo de nicotinamida e composições farmacêuticas e usos do mesmo

Also Published As

Publication number Publication date
BR112016001774A8 (pt) 2020-01-21
AU2022203196A1 (en) 2022-06-02
NZ716277A (en) 2021-03-26
US20240101588A1 (en) 2024-03-28
US20240239831A1 (en) 2024-07-18
CN108707174A (zh) 2018-10-26
KR20160043974A (ko) 2016-04-22
BR112016001774B1 (pt) 2021-06-22
CA3192957A1 (en) 2015-02-05
AU2014298629A1 (en) 2016-02-11
ES2652654T3 (es) 2018-02-05
CN105636973B (zh) 2018-06-01
HK1255037A1 (en) 2019-08-02
US11584770B2 (en) 2023-02-21
US11981698B2 (en) 2024-05-14
KR102414886B1 (ko) 2022-07-01
US12252506B2 (en) 2025-03-18
JP2016530248A (ja) 2016-09-29
ZA201802315B (en) 2023-02-22
EP3027635B1 (en) 2017-09-20
US20220259250A1 (en) 2022-08-18
WO2015014722A1 (en) 2015-02-05
HK1218918A1 (en) 2017-03-17
GB201313465D0 (en) 2013-09-11
EP3027635A1 (en) 2016-06-08
CA2918955C (en) 2023-05-09
MX2016001211A (es) 2016-10-28
CN105636973A (zh) 2016-06-01
AU2020201254B2 (en) 2022-05-26
KR102303966B1 (ko) 2021-09-24
US20200291055A1 (en) 2020-09-17
US10000519B2 (en) 2018-06-19
KR20210038718A (ko) 2021-04-07
US20160168184A1 (en) 2016-06-16
AU2018211238A1 (en) 2018-08-16
EP3321274A1 (en) 2018-05-16
AU2022203196B2 (en) 2023-11-23
US10815262B2 (en) 2020-10-27
BR112016001774A2 (pt) 2017-08-01
MX349969B (es) 2017-08-23
CA2918955A1 (en) 2015-02-05
US20180186824A1 (en) 2018-07-05
AU2014298629B2 (en) 2018-08-16
AU2020201254A1 (en) 2020-03-12

Similar Documents

Publication Publication Date Title
JP6208352B2 (ja) ニコチンアミドリボシドおよびその誘導体を調製する方法
EP3302059A1 (en) Selective solvent free phosphorylation
HK1218918B (en) Methods of preparing nicotinamide riboside and derivatives thereof
Lerner Preparation of 9-(5-deoxy-. alpha.-D-arabinofuranosyl) adenine from D-ribose
NZ716277B2 (en) Methods of preparing nicotinamide riboside and derivatives thereof
JPS6259716B2 (OSRAM)
TAKAMURA et al. Syntheses and antitumor activities of N6, N6-dimethyladenosine carboxylate analogues
JPS6346734B2 (OSRAM)
CN101918422A (zh) 呋喃核糖衍生物的制备方法
Weber et al. Synthesis of Spongidine
JPWO1990015812A1 (ja) ２―アルキニルアデノシンの合成中間体、該合成中間体の製造法、該合成中間体を利用した２―アルキニルアデノシンの製造法および安定な２―アルキニルアデノシン誘導体

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170714

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20170714

A871 Explanation of circumstances concerning accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A871

Effective date: 20170714

A975 Report on accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A971005

Effective date: 20170814

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20170829

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20170906

R150 Certificate of patent or registration of utility model

Ref document number: 6208352

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250