MX348572B - Gel de colageno reticulado por radiacion, y metodo de preparacion y metodo de uso del mismo. - Google Patents
Gel de colageno reticulado por radiacion, y metodo de preparacion y metodo de uso del mismo.Info
- Publication number
- MX348572B MX348572B MX2013008467A MX2013008467A MX348572B MX 348572 B MX348572 B MX 348572B MX 2013008467 A MX2013008467 A MX 2013008467A MX 2013008467 A MX2013008467 A MX 2013008467A MX 348572 B MX348572 B MX 348572B
- Authority
- MX
- Mexico
- Prior art keywords
- cross
- present
- collagen
- preparation
- linked collagen
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 239000000512 collagen gel Substances 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 3
- 230000005855 radiation Effects 0.000 title abstract 3
- 102000008186 Collagen Human genes 0.000 abstract 4
- 108010035532 Collagen Proteins 0.000 abstract 4
- 229920001436 collagen Polymers 0.000 abstract 4
- 239000000463 material Substances 0.000 abstract 2
- 239000000560 biocompatible material Substances 0.000 abstract 1
- 238000004113 cell culture Methods 0.000 abstract 1
- 238000010382 chemical cross-linking Methods 0.000 abstract 1
- 238000004132 cross linking Methods 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000000017 hydrogel Substances 0.000 abstract 1
- 230000001678 irradiating effect Effects 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000002285 radioactive effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
- A61L15/325—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0212—Face masks
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/60—Materials for use in artificial skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/81—Preparation or application process involves irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Birds (AREA)
- Biophysics (AREA)
- Materials Engineering (AREA)
- Hematology (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Botany (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Inorganic Chemistry (AREA)
- Materials For Medical Uses (AREA)
Abstract
La presente invención se refiere a un método para fabricar un gel de colágeno reticulado por radiación, adecuado para obtener un colágeno reticulado al irradiar un colágeno líquido que tiene una concentración de colágeno de 0.1-10% )p/v) con radiación en una dosis (tasa de dosis por tiempo) de 0.1 a 40 kGy, el método se caracteriza porque comprende: mezclar 3% (P/V) de colágeno con cada uno de 3% )p/v) de un polímero sintético Pluronic F-127, 1% (p/v) de óxido de polietileno (PEO) y 3% (p/v) de hidroxiapatita para dar una mezcla y después reticular la mezcla por irradiación con rayos gamma.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020110005588A KR101272484B1 (ko) | 2011-01-19 | 2011-01-19 | 방사선 가교화된 콜라겐 겔 및 그 제조방법과 사용방법 |
PCT/KR2011/001040 WO2012099293A1 (ko) | 2011-01-19 | 2011-02-17 | 방사선 가교화된 콜라겐 겔 및 그 제조방법과 사용방법 |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2013008467A MX2013008467A (es) | 2013-08-12 |
MX348572B true MX348572B (es) | 2017-06-15 |
Family
ID=46515897
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013008467A MX348572B (es) | 2011-01-19 | 2011-02-17 | Gel de colageno reticulado por radiacion, y metodo de preparacion y metodo de uso del mismo. |
Country Status (22)
Country | Link |
---|---|
US (1) | US20130287746A1 (es) |
EP (1) | EP2666462B1 (es) |
JP (2) | JP6104818B2 (es) |
KR (1) | KR101272484B1 (es) |
CN (1) | CN103402489B (es) |
AU (1) | AU2011355853B2 (es) |
BR (1) | BR112013018508B1 (es) |
CA (1) | CA2823686C (es) |
CL (1) | CL2013001999A1 (es) |
CY (1) | CY1120157T1 (es) |
DK (1) | DK2666462T3 (es) |
ES (1) | ES2668783T3 (es) |
HR (1) | HRP20180619T1 (es) |
HU (1) | HUE037171T2 (es) |
LT (1) | LT2666462T (es) |
MX (1) | MX348572B (es) |
NO (1) | NO2666462T3 (es) |
PL (1) | PL2666462T3 (es) |
PT (1) | PT2666462T (es) |
SG (1) | SG192023A1 (es) |
SI (1) | SI2666462T1 (es) |
WO (1) | WO2012099293A1 (es) |
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KR20150053606A (ko) * | 2013-11-08 | 2015-05-18 | 세원셀론텍(주) | 콜라겐과 히알루론산의 천연가교를 통한 고무성질의 물성이 강화된 생체재료물질 및 그 제조방법 |
KR101523878B1 (ko) * | 2014-03-26 | 2015-05-29 | 주식회사 엘앤씨바이오 | 입자형 무세포 진피와 히알루론산이 가교된 생체 이식용 조성물의 제조방법 |
KR101650273B1 (ko) * | 2014-06-11 | 2016-08-23 | 주식회사 엘앤씨바이오 | 무세포 진피의 가교 및 생체 이식 또는 삽입용 조성물의 제조방법 |
KR101582660B1 (ko) * | 2014-07-14 | 2016-01-08 | 한국원자력연구원 | 방사선을 이용한 콜라겐 함유 하이드로겔 마스크 팩 제조 |
KR101669478B1 (ko) | 2015-11-23 | 2016-10-26 | 세원셀론텍(주) | 콜라겐의 수득율을 높이는 방법 |
US20170342218A1 (en) * | 2016-05-26 | 2017-11-30 | Integra Lifesciences Corporation | Process for Preparing Tissue Regeneration Matrix |
KR101861814B1 (ko) * | 2016-06-08 | 2018-05-29 | 한국원자력연구원 | 이온 전도성 실리콘 하이드로겔과 이의 제조방법 |
JP7156665B2 (ja) * | 2017-06-13 | 2022-10-19 | 国立研究開発法人量子科学技術研究開発機構 | 医薬、並びにその製造方法 |
JP6995437B2 (ja) * | 2017-11-10 | 2022-02-04 | 多木化学株式会社 | コラーゲン-コンドロイチン硫酸のゲル材料 |
KR102157742B1 (ko) * | 2018-01-16 | 2020-09-18 | 한국원자력연구원 | 장기 유착 방지용 수화겔의 제조방법, 이를 이용한 수화겔, 필름 및 다공성 재료 |
TW202016288A (zh) * | 2018-06-29 | 2020-05-01 | 國立研究開發法人量子科學技術研究開發機構 | 細胞培養用水凝膠、凝膠套組、細胞培養物之製造方法、及細胞培養用水凝膠之製造方法 |
CN109762184B (zh) * | 2019-02-12 | 2022-03-08 | 河北考力森生物科技有限公司 | 一种胶原蛋白水凝胶的制备方法 |
CN112717200B (zh) * | 2021-01-13 | 2022-06-07 | 常州市中辉医疗器械有限公司 | 一种重组人胶原蛋白可吸收水凝胶皮肤支架及其制备方法、使用方法 |
CN113842502B (zh) * | 2021-09-29 | 2022-12-02 | 西安德诺海思医疗科技有限公司 | 一种含有去蛋白骨的注射填充剂及其制备方法 |
CN114085394B (zh) * | 2021-12-16 | 2023-04-18 | 西安德诺海思医疗科技有限公司 | 一种重组胶原蛋白双相凝胶及其制备方法和应用 |
KR102466953B1 (ko) | 2022-04-14 | 2022-11-15 | 주식회사 제브 | 전자빔 조사에 의한 가교 구조 제어를 이용한 하이드로겔 제조방법과 이에 의해 제조된 천연다당류 하이드로겔 |
CN115124613A (zh) * | 2022-07-19 | 2022-09-30 | 广州创尔生物技术股份有限公司 | 一种高流动性高浓度胶原蛋白溶液及其制备方法 |
CN117327300A (zh) * | 2023-08-29 | 2024-01-02 | 江苏艾玮得生物科技有限公司 | 水凝胶及其制备方法、类器官及其培养方法、药物检测的方法 |
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- 2011-02-17 CN CN201180065262.0A patent/CN103402489B/zh active Active
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AU2011355853B2 (en) | 2016-04-21 |
CN103402489A (zh) | 2013-11-20 |
PL2666462T3 (pl) | 2018-07-31 |
HRP20180619T1 (hr) | 2018-06-01 |
CN103402489B (zh) | 2016-05-11 |
HUE037171T2 (hu) | 2018-08-28 |
SI2666462T1 (en) | 2018-06-29 |
MX2013008467A (es) | 2013-08-12 |
JP2016052314A (ja) | 2016-04-14 |
CA2823686C (en) | 2017-09-05 |
EP2666462A1 (en) | 2013-11-27 |
BR112013018508B1 (pt) | 2020-03-10 |
EP2666462A4 (en) | 2016-03-09 |
WO2012099293A1 (ko) | 2012-07-26 |
CY1120157T1 (el) | 2018-12-12 |
JP6228960B2 (ja) | 2017-11-08 |
KR20120084189A (ko) | 2012-07-27 |
AU2011355853A1 (en) | 2013-08-15 |
LT2666462T (lt) | 2018-05-25 |
NO2666462T3 (es) | 2018-09-08 |
KR101272484B1 (ko) | 2013-06-10 |
DK2666462T3 (en) | 2018-05-22 |
EP2666462B1 (en) | 2018-04-11 |
CL2013001999A1 (es) | 2014-04-04 |
CA2823686A1 (en) | 2012-07-26 |
JP6104818B2 (ja) | 2017-04-05 |
JP2014507135A (ja) | 2014-03-27 |
BR112013018508A2 (pt) | 2019-01-08 |
SG192023A1 (en) | 2013-08-30 |
US20130287746A1 (en) | 2013-10-31 |
PT2666462T (pt) | 2018-05-16 |
ES2668783T3 (es) | 2018-05-22 |
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