PT2666462T - Gel de colagénio de ligação cruzada por radiação, e método de preparação e usos daquele - Google Patents
Gel de colagénio de ligação cruzada por radiação, e método de preparação e usos daqueleInfo
- Publication number
- PT2666462T PT2666462T PT118560002T PT11856000T PT2666462T PT 2666462 T PT2666462 T PT 2666462T PT 118560002 T PT118560002 T PT 118560002T PT 11856000 T PT11856000 T PT 11856000T PT 2666462 T PT2666462 T PT 2666462T
- Authority
- PT
- Portugal
- Prior art keywords
- preparation
- collagen gel
- linked collagen
- radiation cross
- radiation
- Prior art date
Links
- 239000000512 collagen gel Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 230000005855 radiation Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
- A61L15/325—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0212—Face masks
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/60—Materials for use in artificial skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/81—Preparation or application process involves irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Birds (AREA)
- Biophysics (AREA)
- Materials Engineering (AREA)
- Hematology (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Botany (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Inorganic Chemistry (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020110005588A KR101272484B1 (ko) | 2011-01-19 | 2011-01-19 | 방사선 가교화된 콜라겐 겔 및 그 제조방법과 사용방법 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT2666462T true PT2666462T (pt) | 2018-05-16 |
Family
ID=46515897
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT118560002T PT2666462T (pt) | 2011-01-19 | 2011-02-17 | Gel de colagénio de ligação cruzada por radiação, e método de preparação e usos daquele |
Country Status (22)
Country | Link |
---|---|
US (1) | US20130287746A1 (pt) |
EP (1) | EP2666462B1 (pt) |
JP (2) | JP6104818B2 (pt) |
KR (1) | KR101272484B1 (pt) |
CN (1) | CN103402489B (pt) |
AU (1) | AU2011355853B2 (pt) |
BR (1) | BR112013018508B1 (pt) |
CA (1) | CA2823686C (pt) |
CL (1) | CL2013001999A1 (pt) |
CY (1) | CY1120157T1 (pt) |
DK (1) | DK2666462T3 (pt) |
ES (1) | ES2668783T3 (pt) |
HR (1) | HRP20180619T1 (pt) |
HU (1) | HUE037171T2 (pt) |
LT (1) | LT2666462T (pt) |
MX (1) | MX348572B (pt) |
NO (1) | NO2666462T3 (pt) |
PL (1) | PL2666462T3 (pt) |
PT (1) | PT2666462T (pt) |
SG (1) | SG192023A1 (pt) |
SI (1) | SI2666462T1 (pt) |
WO (1) | WO2012099293A1 (pt) |
Families Citing this family (19)
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KR20150053606A (ko) * | 2013-11-08 | 2015-05-18 | 세원셀론텍(주) | 콜라겐과 히알루론산의 천연가교를 통한 고무성질의 물성이 강화된 생체재료물질 및 그 제조방법 |
KR101523878B1 (ko) * | 2014-03-26 | 2015-05-29 | 주식회사 엘앤씨바이오 | 입자형 무세포 진피와 히알루론산이 가교된 생체 이식용 조성물의 제조방법 |
KR101650273B1 (ko) * | 2014-06-11 | 2016-08-23 | 주식회사 엘앤씨바이오 | 무세포 진피의 가교 및 생체 이식 또는 삽입용 조성물의 제조방법 |
KR101582660B1 (ko) * | 2014-07-14 | 2016-01-08 | 한국원자력연구원 | 방사선을 이용한 콜라겐 함유 하이드로겔 마스크 팩 제조 |
KR101669478B1 (ko) | 2015-11-23 | 2016-10-26 | 세원셀론텍(주) | 콜라겐의 수득율을 높이는 방법 |
US20170342218A1 (en) * | 2016-05-26 | 2017-11-30 | Integra Lifesciences Corporation | Process for Preparing Tissue Regeneration Matrix |
KR101861814B1 (ko) * | 2016-06-08 | 2018-05-29 | 한국원자력연구원 | 이온 전도성 실리콘 하이드로겔과 이의 제조방법 |
JP7156665B2 (ja) * | 2017-06-13 | 2022-10-19 | 国立研究開発法人量子科学技術研究開発機構 | 医薬、並びにその製造方法 |
JP6995437B2 (ja) * | 2017-11-10 | 2022-02-04 | 多木化学株式会社 | コラーゲン-コンドロイチン硫酸のゲル材料 |
KR102157742B1 (ko) * | 2018-01-16 | 2020-09-18 | 한국원자력연구원 | 장기 유착 방지용 수화겔의 제조방법, 이를 이용한 수화겔, 필름 및 다공성 재료 |
TW202016288A (zh) * | 2018-06-29 | 2020-05-01 | 國立研究開發法人量子科學技術研究開發機構 | 細胞培養用水凝膠、凝膠套組、細胞培養物之製造方法、及細胞培養用水凝膠之製造方法 |
CN109762184B (zh) * | 2019-02-12 | 2022-03-08 | 河北考力森生物科技有限公司 | 一种胶原蛋白水凝胶的制备方法 |
CN112717200B (zh) * | 2021-01-13 | 2022-06-07 | 常州市中辉医疗器械有限公司 | 一种重组人胶原蛋白可吸收水凝胶皮肤支架及其制备方法、使用方法 |
CN113842502B (zh) * | 2021-09-29 | 2022-12-02 | 西安德诺海思医疗科技有限公司 | 一种含有去蛋白骨的注射填充剂及其制备方法 |
CN114085394B (zh) * | 2021-12-16 | 2023-04-18 | 西安德诺海思医疗科技有限公司 | 一种重组胶原蛋白双相凝胶及其制备方法和应用 |
KR102466953B1 (ko) | 2022-04-14 | 2022-11-15 | 주식회사 제브 | 전자빔 조사에 의한 가교 구조 제어를 이용한 하이드로겔 제조방법과 이에 의해 제조된 천연다당류 하이드로겔 |
CN115124613A (zh) * | 2022-07-19 | 2022-09-30 | 广州创尔生物技术股份有限公司 | 一种高流动性高浓度胶原蛋白溶液及其制备方法 |
CN117327300A (zh) * | 2023-08-29 | 2024-01-02 | 江苏艾玮得生物科技有限公司 | 水凝胶及其制备方法、类器官及其培养方法、药物检测的方法 |
CN117298327A (zh) * | 2023-11-15 | 2023-12-29 | 北京帝康医药投资管理有限公司 | 一种止血微球颗粒及其制备方法和应用 |
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DE102006033168A1 (de) * | 2006-07-10 | 2008-01-17 | Gelita Ag | Verwendung von Gelatine und einem Vernetzungsmittel zur Herstellung einer vernetzenden therapeutischen Zusammensetzung |
JPWO2008016163A1 (ja) * | 2006-08-01 | 2009-12-24 | ニチバン株式会社 | 架橋ゼラチンゲル多層構造体、生理活性因子用担体、生理活性因子放出用製剤、及びこれらの製造方法 |
TWI436793B (zh) * | 2006-08-02 | 2014-05-11 | Baxter Int | 快速作用之乾密封膠及其使用和製造方法 |
KR100783228B1 (ko) * | 2006-08-29 | 2007-12-06 | 가톨릭대학교 산학협력단 | 세포배양용 폴리비닐알코올-콜라겐 하이드로젤 스캐폴드 및그 제조방법 |
KR100837858B1 (ko) | 2006-12-18 | 2008-06-13 | 한국식품연구원 | 방사선 조사에 의한 돈피 콜라겐의 수용성 올리고펩타이드의 제조방법 |
JP5099623B2 (ja) * | 2007-03-01 | 2012-12-19 | 独立行政法人日本原子力研究開発機構 | 免疫蛋白質の製造方法 |
KR100848712B1 (ko) * | 2007-03-30 | 2008-07-28 | 강원대학교산학협력단 | 광가교 가능한 온도 감응성 수화겔 조성물 및 이의제조방법 |
AU2009208729A1 (en) * | 2008-01-31 | 2009-08-06 | Sofradim Production | Preparation of terminally-sterilized collagen that is soluble at neutral pH |
-
2011
- 2011-01-19 KR KR1020110005588A patent/KR101272484B1/ko active IP Right Grant
- 2011-02-17 WO PCT/KR2011/001040 patent/WO2012099293A1/ko active Application Filing
- 2011-02-17 MX MX2013008467A patent/MX348572B/es active IP Right Grant
- 2011-02-17 US US13/979,807 patent/US20130287746A1/en not_active Abandoned
- 2011-02-17 CN CN201180065262.0A patent/CN103402489B/zh active Active
- 2011-02-17 SI SI201131469T patent/SI2666462T1/en unknown
- 2011-02-17 SG SG2013054838A patent/SG192023A1/en unknown
- 2011-02-17 LT LTEP11856000.2T patent/LT2666462T/lt unknown
- 2011-02-17 EP EP11856000.2A patent/EP2666462B1/en active Active
- 2011-02-17 ES ES11856000.2T patent/ES2668783T3/es active Active
- 2011-02-17 BR BR112013018508-2A patent/BR112013018508B1/pt not_active IP Right Cessation
- 2011-02-17 DK DK11856000.2T patent/DK2666462T3/en active
- 2011-02-17 NO NO11856000A patent/NO2666462T3/no unknown
- 2011-02-17 AU AU2011355853A patent/AU2011355853B2/en not_active Ceased
- 2011-02-17 PL PL11856000T patent/PL2666462T3/pl unknown
- 2011-02-17 HU HUE11856000A patent/HUE037171T2/hu unknown
- 2011-02-17 PT PT118560002T patent/PT2666462T/pt unknown
- 2011-02-17 CA CA2823686A patent/CA2823686C/en not_active Expired - Fee Related
- 2011-02-17 JP JP2013548330A patent/JP6104818B2/ja active Active
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2013
- 2013-07-08 CL CL2013001999A patent/CL2013001999A1/es unknown
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2015
- 2015-10-23 JP JP2015208871A patent/JP6228960B2/ja active Active
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- 2018-05-03 CY CY20181100468T patent/CY1120157T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
AU2011355853B2 (en) | 2016-04-21 |
CN103402489A (zh) | 2013-11-20 |
PL2666462T3 (pl) | 2018-07-31 |
HRP20180619T1 (hr) | 2018-06-01 |
CN103402489B (zh) | 2016-05-11 |
HUE037171T2 (hu) | 2018-08-28 |
SI2666462T1 (en) | 2018-06-29 |
MX2013008467A (es) | 2013-08-12 |
JP2016052314A (ja) | 2016-04-14 |
CA2823686C (en) | 2017-09-05 |
EP2666462A1 (en) | 2013-11-27 |
BR112013018508B1 (pt) | 2020-03-10 |
EP2666462A4 (en) | 2016-03-09 |
WO2012099293A1 (ko) | 2012-07-26 |
CY1120157T1 (el) | 2018-12-12 |
JP6228960B2 (ja) | 2017-11-08 |
KR20120084189A (ko) | 2012-07-27 |
AU2011355853A1 (en) | 2013-08-15 |
LT2666462T (lt) | 2018-05-25 |
NO2666462T3 (pt) | 2018-09-08 |
KR101272484B1 (ko) | 2013-06-10 |
DK2666462T3 (en) | 2018-05-22 |
EP2666462B1 (en) | 2018-04-11 |
CL2013001999A1 (es) | 2014-04-04 |
CA2823686A1 (en) | 2012-07-26 |
JP6104818B2 (ja) | 2017-04-05 |
JP2014507135A (ja) | 2014-03-27 |
BR112013018508A2 (pt) | 2019-01-08 |
SG192023A1 (en) | 2013-08-30 |
US20130287746A1 (en) | 2013-10-31 |
MX348572B (es) | 2017-06-15 |
ES2668783T3 (es) | 2018-05-22 |
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