MX342913B - Formas solidas de romidepsina y sus usos. - Google Patents

Formas solidas de romidepsina y sus usos.

Info

Publication number
MX342913B
MX342913B MX2013000446A MX2013000446A MX342913B MX 342913 B MX342913 B MX 342913B MX 2013000446 A MX2013000446 A MX 2013000446A MX 2013000446 A MX2013000446 A MX 2013000446A MX 342913 B MX342913 B MX 342913B
Authority
MX
Mexico
Prior art keywords
solid forms
present disclosure
disclosure provides
compound
romidepsin
Prior art date
Application number
MX2013000446A
Other languages
English (en)
Other versions
MX2013000446A (es
Inventor
Smolenskaya Valeriya
Vrolijk Nicholas
Hanko Jason
Alan Engers David
Hagen Eric
Scott Stults Jeffrey
Harishchandra Naringrekar Vijay
Tzatchev Peykov Viktor
Rodney Foss Willard
Lawrence Darling Neil
Original Assignee
Celgene Corp *
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp * filed Critical Celgene Corp *
Publication of MX2013000446A publication Critical patent/MX2013000446A/es
Publication of MX342913B publication Critical patent/MX342913B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/15—Depsipeptides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

La presente invención se refiere a formas sólidas de un compuesto que tiene la fórmula I. En algunas modalidades la presente descripción proporciona formas cristalinas del Compuesto I. En algunas modalidades la presente descripción proporciona formas solvatadas del Compuesto I. En algunas modalidades la presente descripción proporciona formas amorfas del Compuesto I.
MX2013000446A 2010-07-12 2011-07-12 Formas solidas de romidepsina y sus usos. MX342913B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36352210P 2010-07-12 2010-07-12
PCT/US2011/043680 WO2012009336A1 (en) 2010-07-12 2011-07-12 Romidepsin solid forms and uses thereof

Publications (2)

Publication Number Publication Date
MX2013000446A MX2013000446A (es) 2013-05-01
MX342913B true MX342913B (es) 2016-10-19

Family

ID=44514993

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013000446A MX342913B (es) 2010-07-12 2011-07-12 Formas solidas de romidepsina y sus usos.

Country Status (16)

Country Link
US (5) US20120190817A2 (es)
EP (1) EP2593123B1 (es)
JP (3) JP6049614B2 (es)
KR (1) KR20130092557A (es)
CN (1) CN103108648A (es)
AU (1) AU2011279303B2 (es)
BR (1) BR112013000673A2 (es)
CA (1) CA2804795A1 (es)
ES (1) ES2755909T3 (es)
MX (1) MX342913B (es)
MY (1) MY185130A (es)
NZ (2) NZ605526A (es)
RU (2) RU2607634C2 (es)
SG (2) SG10201505475XA (es)
UA (1) UA114074C2 (es)
WO (1) WO2012009336A1 (es)

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CA2863291A1 (en) 2012-01-12 2013-07-18 Celgene Corporation Romidepsin formulations and uses thereof
AU2013202506B2 (en) 2012-09-07 2015-06-18 Celgene Corporation Resistance biomarkers for hdac inhibitors
CN103877010B (zh) * 2012-12-21 2018-06-01 正大天晴药业集团股份有限公司 一种罗米地辛溶液的制备方法
WO2014102731A1 (en) * 2012-12-31 2014-07-03 Leiutis Pharmaceuticals Pvt. Ltd Novel pharmaceutical compositions of romidepsin
ITMI20131856A1 (it) * 2013-11-08 2015-05-09 Gnosis Spa Processo per la preparazione di differenti forme cristalline del s-acetil glutatione e loro utilizzi in formulazioni farmaceutiche e nutraceutiche
CN103861084A (zh) * 2014-02-12 2014-06-18 新乡医学院 Romidepsin在治疗帕金森病中的应用
CN104262456B (zh) * 2014-09-11 2018-01-09 浙江海正药业股份有限公司 一种罗米地辛的新晶型及其制备方法和用途
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US20190119642A1 (en) 2016-03-15 2019-04-25 Children's Medical Center Corporation Methods and compositions relating to hematopoietic stem cell expansion
CN105801667B (zh) * 2016-03-22 2019-04-09 浙江海正药业股份有限公司 一种制备无定型罗米地辛的方法
KR20190086712A (ko) * 2016-11-22 2019-07-23 알칼리디엑스, 인크. 리도카인-비유효 병태 및 저칼륨혈성 병태의 치료를 위한 요법
CN109796521B (zh) * 2017-11-17 2022-04-19 上海医药工业研究院 一种罗米地辛醋酸盐晶型及其制备方法
CN111187337B (zh) * 2018-11-15 2023-01-24 上海医药工业研究院 罗米地辛一异丙醇溶剂合物及其晶型、制备方法和应用
US20220049213A1 (en) * 2018-12-24 2022-02-17 Marrone Bio Innovations, Inc. A method for increasing romidepsin production from fermentation broth
CN113813366A (zh) * 2020-06-18 2021-12-21 中国科学院深圳先进技术研究院 罗米地辛在制备预防和治疗抗新冠肺炎新型冠状病毒的药物中的应用
WO2021253338A1 (zh) * 2020-06-18 2021-12-23 中国科学院深圳先进技术研究院 罗米地辛在预防和治疗冠状病毒相关疾病中的应用

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Also Published As

Publication number Publication date
KR20130092557A (ko) 2013-08-20
US20140256637A1 (en) 2014-09-11
AU2011279303B2 (en) 2015-07-16
ES2755909T3 (es) 2020-04-24
WO2012009336A1 (en) 2012-01-19
US9518094B2 (en) 2016-12-13
CN103108648A (zh) 2013-05-15
JP2013532632A (ja) 2013-08-19
NZ605526A (en) 2015-04-24
EP2593123B1 (en) 2019-09-04
US20120046442A1 (en) 2012-02-23
US9624271B2 (en) 2017-04-18
RU2013105700A (ru) 2014-08-20
CA2804795A1 (en) 2012-01-19
MY185130A (en) 2021-04-30
MX2013000446A (es) 2013-05-01
JP2017008067A (ja) 2017-01-12
RU2016149485A (ru) 2018-10-31
NZ706052A (en) 2016-07-29
JP6049614B2 (ja) 2016-12-21
JP6490632B2 (ja) 2019-03-27
SG10201505475XA (en) 2015-09-29
JP2019052177A (ja) 2019-04-04
US20140336132A1 (en) 2014-11-13
US20150218225A1 (en) 2015-08-06
AU2011279303A1 (en) 2013-01-31
SG187032A1 (en) 2013-02-28
US20160060300A1 (en) 2016-03-03
BR112013000673A2 (pt) 2016-05-31
EP2593123A1 (en) 2013-05-22
RU2607634C2 (ru) 2017-01-10
US8980825B2 (en) 2015-03-17
UA114074C2 (xx) 2017-04-25
US20120190817A2 (en) 2012-07-26

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