MX341839B - Nuevos procesos para la preparacion de las amidas de prostaglandina. - Google Patents

Nuevos procesos para la preparacion de las amidas de prostaglandina.

Info

Publication number
MX341839B
MX341839B MX2013014034A MX2013014034A MX341839B MX 341839 B MX341839 B MX 341839B MX 2013014034 A MX2013014034 A MX 2013014034A MX 2013014034 A MX2013014034 A MX 2013014034A MX 341839 B MX341839 B MX 341839B
Authority
MX
Mexico
Prior art keywords
group
atom
preparation
aralkyl
stands
Prior art date
Application number
MX2013014034A
Other languages
English (en)
Other versions
MX2013014034A (es
Inventor
Havasi Gábor
Kiss Tibor
Kardos Zsuzsanna
Lászlófi István
Bischof Zoltán
Bódis Ádám
Hortobágyi Irén
Original Assignee
Chinoin Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU1100292A external-priority patent/HU231134B1/hu
Priority claimed from HU1100291A external-priority patent/HU230703B1/hu
Application filed by Chinoin Zrt filed Critical Chinoin Zrt
Publication of MX2013014034A publication Critical patent/MX2013014034A/es
Publication of MX341839B publication Critical patent/MX341839B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/50—Iso-indoles; Hydrogenated iso-indoles with oxygen and nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

La material de la invención es el proceso para la preparación de las amidas de prostaglandina de la fórmula general I, donde, en la fórmula, los enlaces marcados con las líneas discontinuas pueden ser enlaces simples o dobles, en el caso de los enlaces dobles en las posiciones 5,6 y 13,14 pueden estar en la orientación cis o trans, Q representa un grupo hidroxilo y Z representa un grupo hidroxilo u oxo, R1 y R2 representan independientemente el átomo de hidrógeno o un grupo alquilo o aralquilo de 1 a 10 átomos de carbono, lineal o ramificado, opcionalmente sustituido con el grupo ONO2, o un grupo aralquilo o arilo que contiene el heteroátomo, R3 representa un grupo hidrocarburo de 4 a 6 átomos de carbono lineal o ramificado, saturado o no saturado, o un grupo alquilcicloalquilo o cicloalquilo de 4 a 10 átomos de carbono, o grupo fenilo, alquilarilo o hetarilo de 7 a 10 átomos de carbono opcionalmente sustituido con un grupo alquilo o con un átomo de halógeno, Y representa el grupo (CH2) o el átomo O o el átomo S, y donde n0-3.
MX2013014034A 2011-06-02 2012-05-25 Nuevos procesos para la preparacion de las amidas de prostaglandina. MX341839B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU1100292A HU231134B1 (hu) 2011-06-02 2011-06-02 Eljárás a bimatoprost kémiailag stabil új kristályformájának előállítására
HU1100291A HU230703B1 (hu) 2011-06-02 2011-06-02 Új eljárás prosztaglandin amidok előállítására
PCT/HU2012/000045 WO2012164324A1 (en) 2011-06-02 2012-05-25 Novel processes for the preparation of prostaglandin amides

Publications (2)

Publication Number Publication Date
MX2013014034A MX2013014034A (es) 2015-06-17
MX341839B true MX341839B (es) 2016-09-05

Family

ID=89990312

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013014034A MX341839B (es) 2011-06-02 2012-05-25 Nuevos procesos para la preparacion de las amidas de prostaglandina.

Country Status (17)

Country Link
US (3) US9238621B2 (es)
EP (1) EP2723714B1 (es)
JP (3) JP6212485B2 (es)
KR (3) KR102135550B1 (es)
CN (4) CN106316910A (es)
BR (3) BR112013030973B1 (es)
CA (3) CA2837261C (es)
ES (1) ES2636756T3 (es)
HU (1) HUE033642T2 (es)
IL (1) IL229647A (es)
MX (1) MX341839B (es)
PL (1) PL2723714T3 (es)
PT (1) PT2723714T (es)
RU (1) RU2618223C2 (es)
TW (3) TWI653223B (es)
WO (1) WO2012164324A1 (es)
ZA (1) ZA201309357B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU231203B1 (hu) 2011-12-21 2021-10-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Új eljárás travoprost előállítására
AU2013334169B2 (en) 2012-10-26 2018-03-29 Forsight Vision5, Inc. Ophthalmic system for sustained release of drug to eye
US9447014B2 (en) 2012-12-28 2016-09-20 Allergan, Inc. Tromethamine salt of bimatoprost acid in crystalline form, methods for preparation, and methods for use thereof
US9120738B2 (en) * 2012-12-28 2015-09-01 Allergan, Inc. Crystalline forms of bimatoprost acid, methods for preparation, and methods for use thereof
HU231214B1 (hu) * 2014-03-13 2021-11-29 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Új eljárás nagytisztaságú prosztaglandinok előállítására
US10273206B2 (en) 2014-06-27 2019-04-30 Allergan, Inc. Tromethamine salt of bimatoprost acid in crystalline form 1, methods for preparation, and methods for use thereof
WO2015199729A1 (en) * 2014-06-27 2015-12-30 Allergan, Inc. Tromethamine salt of bimatoprost acid in crystalline form 1, methods for preparation, and methods for use thereof
WO2016168141A1 (en) 2015-04-13 2016-10-20 Forsight Vision5, Inc. Ocular insert composition of semi-crystalline or crystalline pharmaceutically active agent
HU231185B1 (hu) * 2017-07-11 2021-07-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Eljárás Misoprostol előállítására és tisztítására
CN113548993B (zh) * 2021-09-01 2022-05-27 河北化工医药职业技术学院 一种卡前列素的制备方法

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3954741A (en) * 1972-06-07 1976-05-04 Pfizer Inc. N-substituted prostaglandin carboxamides
US3984424A (en) * 1972-11-08 1976-10-05 Pfizer Inc. P-biphenyl esters of 15-substituted-ω-pentanorprostaglandins
HU171155B (hu) * 1973-04-30 1977-11-28 Pfizer Sposob poluchenija oksa-prostaglandinov
HU175889B (en) 1976-04-08 1980-11-28 Chinoin Gyogyszer Es Vegyeszet New process for preparing lactol-alcohol derivatives
HU175217B (hu) * 1977-08-03 1980-06-28 Chinoin Gyogyszer Es Vegyeszet Novyj sposob poluchenija biciklicheskikh laktol-metil-ehfirov
HU178202B (en) * 1977-09-26 1982-03-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing new,optically active and racemic bicyclic acetals and merkaptals
FR2550799B1 (fr) * 1983-08-17 1986-02-21 Commissariat Energie Atomique Compose marque par une enzyme, son procede de preparation et son utilisation en enzymoimmunologie
ATE227576T1 (de) * 1988-09-06 2002-11-15 Pharmacia Ab Prostaglandinderivate zur behandlung des grünen stars oder einer okularen hypertension
US5359095A (en) 1990-08-08 1994-10-25 Pharmacia Ab Method for synthesis of prostaglandin derivatives
SE9002596D0 (sv) * 1990-08-08 1990-08-08 Pharmacia Ab A method for synthesis of prostaglandin derivatives
GB9025509D0 (en) * 1990-11-23 1991-01-09 Fujisawa Pharmaceutical Co New amide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same
HU212570B (en) * 1991-06-24 1996-08-29 Chinoin Gyogyszer Es Vegyeszet Process for producing 13,14-dihydro-15(r)-17-phenyl-18,19,20-trinor-pgf2alfa-isopropylester
US5409911A (en) * 1992-09-11 1995-04-25 Merck & Co., Inc. Prostaglandin analog for treating osteoporosis
US5352708A (en) 1992-09-21 1994-10-04 Allergan, Inc. Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
JPH10298446A (ja) * 1997-04-25 1998-11-10 Mitsui Chem Inc 黄色建染染料の製造方法
IL143477A (en) * 2001-05-31 2009-07-20 Finetech Pharmaceutical Ltd Process for the preparation of 17-phenyl-18,19,20-trinor-pgf2?? and its derivatives
US7166730B2 (en) * 2000-01-27 2007-01-23 Fine Tech Laboratories, Ltd Process for the preparation of prostaglandin derivatives
PL366372A1 (en) * 2001-07-17 2005-01-24 Pharmacia & Upjohn Company Process and intermediates to prepare latanoprost
DE10226942A1 (de) * 2002-06-17 2003-12-24 Symrise Gmbh & Co Kg Verwendung von Mandelsäurealkylamiden als Aromastoffe
AU2004215514B2 (en) * 2003-02-26 2010-03-04 Msd K.K. Heteroarylcarbamoylbenzene derivative
GB0329379D0 (en) * 2003-12-19 2004-01-21 Johnson Matthey Plc Prostaglandin synthesis
FR2889523B1 (fr) * 2005-08-03 2007-12-28 Servier Lab Nouvelle forme cristalline v de l'agomelatine, son procede de preparation et les compositions pharmaceutiques qui la contiennent
IL177762A0 (en) * 2006-08-29 2006-12-31 Arieh Gutman Bimatoprost crystalline form i
AR071312A1 (es) * 2008-04-09 2010-06-09 Scinopharm Taiwan Ltd Proceso para la preparacion de analogos de prostaglandina y sus intermediarios
EP2135860A1 (en) * 2008-06-20 2009-12-23 Sandoz AG Improved process for the production of bimatoprost
GB0819182D0 (en) * 2008-10-20 2008-11-26 Actelion Pharmaceuticals Ltd Crystalline forms
US8722739B2 (en) * 2008-10-29 2014-05-13 Novaer Holdings, Inc. Amino acid salts of prostaglandins
JP2012507552A (ja) * 2008-10-29 2012-03-29 アエリエ・ファーマシューティカルズ・インコーポレーテッド プロスタグラジンのアミノ酸塩
CN102361951B (zh) * 2009-03-16 2015-07-22 日产化学工业株式会社 包含低分子胶凝剂的喷射用基材
US8519178B2 (en) * 2009-06-22 2013-08-27 Johnson Matthey Public Limited Company Method for the purification of prostaglandins
GB0911000D0 (en) * 2009-06-25 2009-08-12 Givaudan Sa Compounds
WO2011046569A1 (en) * 2009-10-16 2011-04-21 Cayman Chemical Company Process for the preparation of f-series prostaglandins
KR20120081227A (ko) 2009-11-02 2012-07-18 샹하이 테크웰 바이오파마슈티컬 컴퍼니, 리미티드 비마토프로스트 결정 및 그의 제조방법과 용도
RU2012122367A (ru) 2009-11-05 2013-12-10 Биокон Лимитед Способ получения простагландинов и промежуточные соединения для их получения
AU2010321831B2 (en) * 2009-11-23 2016-07-07 Allergan, Inc. 7-[3,5-dihydroxy-2- (3-hydroxy-5-phenyl-pent-1-enyl)- cyclopentyl]-N-ethyl-hept-5-enamide (bimatoprost) in crystalline form II, methods for preparation, and methods for use thereof
EP2495235B1 (en) * 2011-03-04 2015-08-05 Newchem S.p.A. Process for the synthesis of prostaglandins and intermediates thereof
HU231203B1 (hu) * 2011-12-21 2021-10-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Új eljárás travoprost előállítására

Also Published As

Publication number Publication date
CN106316910A (zh) 2017-01-11
US20160145207A1 (en) 2016-05-26
CA3094762A1 (en) 2012-12-06
IL229647A (en) 2017-09-28
CA3209613A1 (en) 2012-12-06
CA3094762C (en) 2023-09-26
JP2017075165A (ja) 2017-04-20
CN103649047B (zh) 2017-01-11
BR122021008946B1 (pt) 2021-08-10
KR20190124804A (ko) 2019-11-05
JP6693859B2 (ja) 2020-05-13
JP2017061555A (ja) 2017-03-30
TWI653222B (zh) 2019-03-11
US20140135503A1 (en) 2014-05-15
TW201708191A (zh) 2017-03-01
KR20140053941A (ko) 2014-05-08
WO2012164324A1 (en) 2012-12-06
US9573892B2 (en) 2017-02-21
CN106349138A (zh) 2017-01-25
WO2012164324A9 (en) 2014-01-09
KR102038048B1 (ko) 2019-10-30
JP2014527026A (ja) 2014-10-09
CA2837261C (en) 2020-12-15
BR112013030973A8 (pt) 2021-03-30
US20160137602A1 (en) 2016-05-19
HUE033642T2 (en) 2017-12-28
PL2723714T3 (pl) 2018-02-28
JP6212485B2 (ja) 2017-10-11
KR102135550B1 (ko) 2020-07-21
TWI653223B (zh) 2019-03-11
CN103649047A (zh) 2014-03-19
RU2618223C2 (ru) 2017-05-03
BR112013030973B1 (pt) 2021-08-10
US9238621B2 (en) 2016-01-19
EP2723714A1 (en) 2014-04-30
MX2013014034A (es) 2015-06-17
BR112013030973A2 (pt) 2016-08-16
ES2636756T3 (es) 2017-10-09
KR20200087871A (ko) 2020-07-21
KR102277188B1 (ko) 2021-07-15
US9856213B2 (en) 2018-01-02
CN106278982B (zh) 2019-06-14
JP6487410B2 (ja) 2019-03-20
EP2723714B1 (en) 2017-06-21
CN106278982A (zh) 2017-01-04
RU2013158952A (ru) 2015-07-20
TW201311629A (zh) 2013-03-16
ZA201309357B (en) 2014-08-27
PT2723714T (pt) 2017-08-18
IL229647A0 (en) 2014-01-30
TW201708190A (zh) 2017-03-01
TWI632131B (zh) 2018-08-11
BR122021008918B1 (pt) 2021-08-10
CA2837261A1 (en) 2012-12-06

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