MX341839B - Novel processes for the preparation of prostaglandin amides. - Google Patents

Novel processes for the preparation of prostaglandin amides.

Info

Publication number
MX341839B
MX341839B MX2013014034A MX2013014034A MX341839B MX 341839 B MX341839 B MX 341839B MX 2013014034 A MX2013014034 A MX 2013014034A MX 2013014034 A MX2013014034 A MX 2013014034A MX 341839 B MX341839 B MX 341839B
Authority
MX
Mexico
Prior art keywords
group
atom
preparation
aralkyl
stands
Prior art date
Application number
MX2013014034A
Other languages
Spanish (es)
Other versions
MX2013014034A (en
Inventor
Havasi Gábor
Kiss Tibor
Kardos Zsuzsanna
Lászlófi István
Bischof Zoltán
Bódis Ádám
Hortobágyi Irén
Original Assignee
Chinoin Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU1100292A external-priority patent/HU231134B1/en
Priority claimed from HU1100291A external-priority patent/HU230703B1/en
Application filed by Chinoin Zrt filed Critical Chinoin Zrt
Publication of MX2013014034A publication Critical patent/MX2013014034A/en
Publication of MX341839B publication Critical patent/MX341839B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/50—Iso-indoles; Hydrogenated iso-indoles with oxygen and nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

The subject of the invention is process for the preparation of the prostaglandin amides of the general formula I, - where in the formula the bonds marked with dotted lines may be single or double bonds, in the case of double bounds at positions 5,6 and 13,14 they may be in cis or in trans orientation, Q stands for a hydroxyl-group and Z stands for a hydroxyl- or oxo-group, R1 and R2 independently represent hydrogen atom or a straight or branched C1-10 alkyl- or aralkyl- group, optionally substituted with -ONO2 group, or an aralkyl- or aryl- group, which contains heteroatom, R3 represents a straight or branched, saturated or unsaturated C4-6 hydrocarbon group, or a C4-10 alkylcycloalkyl- or cycloalkyl- group, or an optionally with alkyl group or halogen atom substituted phenyl-, C7-10 alkylaryl- or hetaryl- group, Y represents (CH2)n group or 0 atom or S atom, and where n=0-3.
MX2013014034A 2011-06-02 2012-05-25 Novel processes for the preparation of prostaglandin amides. MX341839B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU1100292A HU231134B1 (en) 2011-06-02 2011-06-02 Process for the preparation of chemically stable novel crystalline form of bimatoprost
HU1100291A HU230703B1 (en) 2011-06-02 2011-06-02 Process for the preparation of prostaglandin amides
PCT/HU2012/000045 WO2012164324A1 (en) 2011-06-02 2012-05-25 Novel processes for the preparation of prostaglandin amides

Publications (2)

Publication Number Publication Date
MX2013014034A MX2013014034A (en) 2015-06-17
MX341839B true MX341839B (en) 2016-09-05

Family

ID=89990312

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013014034A MX341839B (en) 2011-06-02 2012-05-25 Novel processes for the preparation of prostaglandin amides.

Country Status (17)

Country Link
US (3) US9238621B2 (en)
EP (1) EP2723714B1 (en)
JP (3) JP6212485B2 (en)
KR (3) KR102277188B1 (en)
CN (4) CN106349138A (en)
BR (3) BR122021008918B1 (en)
CA (3) CA3094762C (en)
ES (1) ES2636756T3 (en)
HU (1) HUE033642T2 (en)
IL (1) IL229647A (en)
MX (1) MX341839B (en)
PL (1) PL2723714T3 (en)
PT (1) PT2723714T (en)
RU (1) RU2618223C2 (en)
TW (3) TWI632131B (en)
WO (1) WO2012164324A1 (en)
ZA (1) ZA201309357B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU231203B1 (en) 2011-12-21 2021-10-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Novel process for the preparation of travoprost
CN104884006B (en) 2012-10-26 2017-12-15 弗赛特影像5股份有限公司 Ophthalmic system for sustained release drugs to eyes
US9447014B2 (en) 2012-12-28 2016-09-20 Allergan, Inc. Tromethamine salt of bimatoprost acid in crystalline form, methods for preparation, and methods for use thereof
US9120738B2 (en) * 2012-12-28 2015-09-01 Allergan, Inc. Crystalline forms of bimatoprost acid, methods for preparation, and methods for use thereof
HU231214B1 (en) * 2014-03-13 2021-11-29 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. New process for preparing high purity prostaglandins
US10273206B2 (en) 2014-06-27 2019-04-30 Allergan, Inc. Tromethamine salt of bimatoprost acid in crystalline form 1, methods for preparation, and methods for use thereof
WO2015199729A1 (en) * 2014-06-27 2015-12-30 Allergan, Inc. Tromethamine salt of bimatoprost acid in crystalline form 1, methods for preparation, and methods for use thereof
EP3283004A4 (en) 2015-04-13 2018-12-05 Forsight Vision5, Inc. Ocular insert composition of semi-crystalline or crystalline pharmaceutically active agent
HU231185B1 (en) * 2017-07-11 2021-07-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Process for preparation and purification of misoprostol
CN113548993B (en) * 2021-09-01 2022-05-27 河北化工医药职业技术学院 Preparation method of carboprost

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3954741A (en) * 1972-06-07 1976-05-04 Pfizer Inc. N-substituted prostaglandin carboxamides
US3984424A (en) * 1972-11-08 1976-10-05 Pfizer Inc. P-biphenyl esters of 15-substituted-ω-pentanorprostaglandins
HU171155B (en) * 1973-04-30 1977-11-28 Pfizer Process for preparing oxa-prostaglandines
HU175889B (en) 1976-04-08 1980-11-28 Chinoin Gyogyszer Es Vegyeszet New process for preparing lactol-alcohol derivatives
HU175217B (en) * 1977-08-03 1980-06-28 Chinoin Gyogyszer Es Vegyeszet New process for preparing bicyclic lactol methyl ethers
HU178202B (en) 1977-09-26 1982-03-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing new,optically active and racemic bicyclic acetals and merkaptals
FR2550799B1 (en) * 1983-08-17 1986-02-21 Commissariat Energie Atomique COMPOUND MARKED BY AN ENZYME, ITS PREPARATION METHOD AND ITS USE IN ENZYMOIMMUNOLOGY
JP2721414B2 (en) * 1988-09-06 1998-03-04 フアーマシア・アンド・アツプジヨン・アー・ベー Prostaglandin derivatives for the treatment of limb disorders or elevated intraocular pressure
SE9002596D0 (en) * 1990-08-08 1990-08-08 Pharmacia Ab A METHOD OF SYNTHESIS OF PROSTAGLANDIN DERIVATIVES
US5359095A (en) 1990-08-08 1994-10-25 Pharmacia Ab Method for synthesis of prostaglandin derivatives
GB9025509D0 (en) * 1990-11-23 1991-01-09 Fujisawa Pharmaceutical Co New amide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same
HU212570B (en) * 1991-06-24 1996-08-29 Chinoin Gyogyszer Es Vegyeszet Process for producing 13,14-dihydro-15(r)-17-phenyl-18,19,20-trinor-pgf2alfa-isopropylester
US5409911A (en) * 1992-09-11 1995-04-25 Merck & Co., Inc. Prostaglandin analog for treating osteoporosis
US5352708A (en) * 1992-09-21 1994-10-04 Allergan, Inc. Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
JPH10298446A (en) * 1997-04-25 1998-11-10 Mitsui Chem Inc Production of yellow vat dye
US7166730B2 (en) * 2000-01-27 2007-01-23 Fine Tech Laboratories, Ltd Process for the preparation of prostaglandin derivatives
IL143477A (en) * 2001-05-31 2009-07-20 Finetech Pharmaceutical Ltd Process for the preparation of 17-phenyl-18,19,20-trinor-pgf2?? and its derivatives
KR100581647B1 (en) * 2001-07-17 2006-05-22 파마시아 앤드 업존 캄파니 엘엘씨 Process and Intermediates to Prepare Latanoprost
DE10226942A1 (en) * 2002-06-17 2003-12-24 Symrise Gmbh & Co Kg Use of mandelic acid alkyl amides as flavorings
US7432287B2 (en) * 2003-02-26 2008-10-07 Banyu Pharmeceutical Co., Ltd. Heteroarylcarbamoylbenzene derivative
GB0329379D0 (en) 2003-12-19 2004-01-21 Johnson Matthey Plc Prostaglandin synthesis
FR2889523B1 (en) * 2005-08-03 2007-12-28 Servier Lab NOVEL CRYSTALLINE FORM V OF AGOMELATIN, PROCESS FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
IL177762A0 (en) * 2006-08-29 2006-12-31 Arieh Gutman Bimatoprost crystalline form i
AR071312A1 (en) * 2008-04-09 2010-06-09 Scinopharm Taiwan Ltd PROCESS FOR THE PREPARATION OF PROSTAGLANDINE ANALOGS AND THEIR INTERMEDIARIES
EP2135860A1 (en) * 2008-06-20 2009-12-23 Sandoz AG Improved process for the production of bimatoprost
GB0819182D0 (en) * 2008-10-20 2008-11-26 Actelion Pharmaceuticals Ltd Crystalline forms
US8722739B2 (en) * 2008-10-29 2014-05-13 Novaer Holdings, Inc. Amino acid salts of prostaglandins
EP2349242B1 (en) * 2008-10-29 2018-12-05 Novaer Holdings, Inc. Amino acid salts of prostaglandins
KR101736169B1 (en) * 2009-03-16 2017-05-16 닛산 가가쿠 고교 가부시키 가이샤 Base material for spraying comprising low-molecular gelling agent
US8519178B2 (en) * 2009-06-22 2013-08-27 Johnson Matthey Public Limited Company Method for the purification of prostaglandins
GB0911000D0 (en) * 2009-06-25 2009-08-12 Givaudan Sa Compounds
WO2011046569A1 (en) * 2009-10-16 2011-04-21 Cayman Chemical Company Process for the preparation of f-series prostaglandins
WO2011050638A1 (en) 2009-11-02 2011-05-05 上海天伟生物制药有限公司 A crystalline form of bimatoprost, preparation method and use thereof
RU2012122367A (en) 2009-11-05 2013-12-10 Биокон Лимитед METHOD FOR PRODUCING PROSTAGLANDINES AND INTERMEDIATE COMPOUNDS FOR THEIR PRODUCTION
MX2012005968A (en) * 2009-11-23 2012-08-15 Allergan Inc 7-[3,5-dihydroxy-2- (3-hydroxy-5-phenyl-pent-1-enyl)- cyclopentyl]-n-ethyl-hept-5-enamide (bimatoprost) in crystalline form ii, methods for preparation, and methods for use thereof.
EP2495235B1 (en) * 2011-03-04 2015-08-05 Newchem S.p.A. Process for the synthesis of prostaglandins and intermediates thereof
HU231203B1 (en) * 2011-12-21 2021-10-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Novel process for the preparation of travoprost

Also Published As

Publication number Publication date
KR102277188B1 (en) 2021-07-15
RU2618223C2 (en) 2017-05-03
EP2723714A1 (en) 2014-04-30
CN106278982B (en) 2019-06-14
US9238621B2 (en) 2016-01-19
HUE033642T2 (en) 2017-12-28
US20140135503A1 (en) 2014-05-15
TWI632131B (en) 2018-08-11
CN106349138A (en) 2017-01-25
JP2017061555A (en) 2017-03-30
JP2014527026A (en) 2014-10-09
IL229647A0 (en) 2014-01-30
JP6693859B2 (en) 2020-05-13
MX2013014034A (en) 2015-06-17
CN106316910A (en) 2017-01-11
TW201311629A (en) 2013-03-16
KR20190124804A (en) 2019-11-05
TW201708191A (en) 2017-03-01
EP2723714B1 (en) 2017-06-21
KR102038048B1 (en) 2019-10-30
CN106278982A (en) 2017-01-04
PL2723714T3 (en) 2018-02-28
CN103649047A (en) 2014-03-19
KR20140053941A (en) 2014-05-08
BR122021008946B1 (en) 2021-08-10
BR112013030973B1 (en) 2021-08-10
TWI653222B (en) 2019-03-11
CA2837261C (en) 2020-12-15
ZA201309357B (en) 2014-08-27
US9573892B2 (en) 2017-02-21
JP6212485B2 (en) 2017-10-11
WO2012164324A1 (en) 2012-12-06
BR122021008918B1 (en) 2021-08-10
KR102135550B1 (en) 2020-07-21
CA3094762A1 (en) 2012-12-06
JP6487410B2 (en) 2019-03-20
US20160145207A1 (en) 2016-05-26
WO2012164324A9 (en) 2014-01-09
KR20200087871A (en) 2020-07-21
TW201708190A (en) 2017-03-01
BR112013030973A2 (en) 2016-08-16
IL229647A (en) 2017-09-28
PT2723714T (en) 2017-08-18
US20160137602A1 (en) 2016-05-19
CN103649047B (en) 2017-01-11
CA3094762C (en) 2023-09-26
TWI653223B (en) 2019-03-11
US9856213B2 (en) 2018-01-02
CA2837261A1 (en) 2012-12-06
JP2017075165A (en) 2017-04-20
ES2636756T3 (en) 2017-10-09
CA3209613A1 (en) 2012-12-06
BR112013030973A8 (en) 2021-03-30
RU2013158952A (en) 2015-07-20

Similar Documents

Publication Publication Date Title
MX341839B (en) Novel processes for the preparation of prostaglandin amides.
MX2016004406A (en) 1,4-cyclohexylamine derivatives and processes for the preparation thereof.
EP3051350A3 (en) Alcoholic compound and method for producing alcoholic compound
FR2929271B1 (en) PROCESS FOR THE PREPARATION OF 1,2,3,3,3-PENTAFLUOROPROPENE-1
PH12015501494A1 (en) Method for producing substituted 5-fluoro-1h-pyrazolopyrimidines
MY159186A (en) Method for preparing small crystal ssz-32
MX336160B (en) Novel solvents for the production of polyutherane dispersions.
MX352470B (en) Malonic acid di-salts and a method for preparing malonyl dihalides.
NZ717098A (en) Vancomycin derivative, and preparation method and application thereof
IN2012DN03379A (en)
WO2018125983A8 (en) Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (acmsd) inhibitors
UA110332C2 (en) Use of 2,3-dihydroxypropyldodecanoate for treatment of seborrhea
MX2020001431A (en) Process for preparing bicyclic enolether.
EP4282973A3 (en) Processes for the preparation of pyrimidinylcyclopentane compounds
TW201129575A (en) Metal complex having pyridylphosphine compound, and method for producing alkyl methacrylate
EA201491463A1 (en) METHOD OF OBTAINING A COMPOUND ON A NEW REACTION OF THE MICHAEL ACCESSION WITH THE APPLICATION OF WATER OR DIFFERENT ACIDS AS ADDITIVE
MY160625A (en) Process for preparing pan-cdk inhibitors of the formula(i), and intermediates in the preparation
EA027831B9 (en) METHOD FOR TREATMENT OF INFLAMMATORY CONDITIONS USING S-[4-(3-FLUORO-3-METHYLBUTYRYLOXY)BUT-2-YNYL]-6α,9α-DIFLUORO-17α-(FURAN-2-YL)CARBONYLOXY-11β-HYDROXY-16α-METHYL-3-OXOANDROSTA-1,4-DIENE-17β-CARBOTHIOATE
IN2013MU01290A (en)
MX2021006498A (en) Process for the preparation of a cyclic dinucleotide.
MX2019011142A (en) Benzothiazole-containing silanes, method for the preparation and use thereof.
MX2020010348A (en) Process for the fermentation of ascomycota.
MX2016016895A (en) Novel polymorphic form of n-[2-(6-fluoro-lh-indol-3-yl)ethyl]-3-( 2,2,3,3-tetrafluoropropoxy)benzylamine hydrochloride for the treatment of alzheimer's.
IN2014DN07166A (en)
IN2014DN05745A (en)

Legal Events

Date Code Title Description
FG Grant or registration