EA201491463A1 - METHOD OF OBTAINING A COMPOUND ON A NEW REACTION OF THE MICHAEL ACCESSION WITH THE APPLICATION OF WATER OR DIFFERENT ACIDS AS ADDITIVE - Google Patents

METHOD OF OBTAINING A COMPOUND ON A NEW REACTION OF THE MICHAEL ACCESSION WITH THE APPLICATION OF WATER OR DIFFERENT ACIDS AS ADDITIVE

Info

Publication number
EA201491463A1
EA201491463A1 EA201491463A EA201491463A EA201491463A1 EA 201491463 A1 EA201491463 A1 EA 201491463A1 EA 201491463 A EA201491463 A EA 201491463A EA 201491463 A EA201491463 A EA 201491463A EA 201491463 A1 EA201491463 A1 EA 201491463A1
Authority
EA
Eurasian Patent Office
Prior art keywords
michael
additive
water
compound
accession
Prior art date
Application number
EA201491463A
Other languages
Russian (ru)
Other versions
EA026411B1 (en
Inventor
Ае Ри Парк
Бонг Чан Ким
Дзи Еун Ан
Хи Бонг Ли
Original Assignee
Эл Джи Лайф Сайенсиз Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эл Джи Лайф Сайенсиз Лтд. filed Critical Эл Джи Лайф Сайенсиз Лтд.
Publication of EA201491463A1 publication Critical patent/EA201491463A1/en
Publication of EA026411B1 publication Critical patent/EA026411B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/34—Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B37/00—Reactions without formation or introduction of functional groups containing hetero atoms, involving either the formation of a carbon-to-carbon bond between two carbon atoms not directly linked already or the disconnection of two directly linked carbon atoms
    • C07B37/02—Addition
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/58—Preparation of carboxylic acid halides
    • C07C51/64—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C67/347—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to unsaturated carbon-to-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/62—Use of additives, e.g. for stabilisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Abstract

Настоящее изобретение относится к новому способу получения соединения, изображенного химической формулой 1, с применением воды или разных кислот в качестве добавки в реакции присоединения Михаэля, происходящей от рецептора Михаэля, изображенного химической формулой 2, и соединения, изображенного химической формулой 3.The present invention relates to a new method for producing a compound represented by chemical formula 1 using water or various acids as an additive in the Michael addition reaction, derived from the Michael receptor represented by chemical formula 2, and a compound represented by chemical formula 3.

EA201491463A 2012-02-03 2013-02-01 Method for preparing a compound by michael addition reaction using water or various acids as additive EA026411B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20120011317 2012-02-03
PCT/KR2013/000829 WO2013115595A1 (en) 2012-02-03 2013-02-01 Method for preparing compound by novel michael addition reaction using water or various acids as additive

Publications (2)

Publication Number Publication Date
EA201491463A1 true EA201491463A1 (en) 2014-11-28
EA026411B1 EA026411B1 (en) 2017-04-28

Family

ID=48905559

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201491463A EA026411B1 (en) 2012-02-03 2013-02-01 Method for preparing a compound by michael addition reaction using water or various acids as additive

Country Status (16)

Country Link
KR (1) KR101539761B1 (en)
CN (1) CN104159884B (en)
AU (1) AU2013215796B2 (en)
BR (1) BR112014018985B1 (en)
CL (1) CL2014002029A1 (en)
CO (1) CO7030967A2 (en)
EA (1) EA026411B1 (en)
MA (1) MA35906B1 (en)
MX (1) MX355336B (en)
MY (1) MY168411A (en)
PE (1) PE20142331A1 (en)
PH (1) PH12014501704A1 (en)
SG (1) SG11201404396TA (en)
TN (1) TN2014000329A1 (en)
WO (1) WO2013115595A1 (en)
ZA (1) ZA201405598B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9774740B2 (en) 2008-01-28 2017-09-26 Afiniti Europe Technologies Limited Techniques for benchmarking pairing strategies in a contact center system
CN108191647B (en) * 2018-02-22 2020-09-29 江苏尚莱特医药化工材料有限公司 Synthesis method of 2, 2-difluoro dicarboxylic acid dialkyl ester
CN113149823B (en) * 2021-03-29 2023-12-08 上海青平药业有限公司 2-R 1 Process for preparing valeric acid
CN113354495A (en) * 2021-05-20 2021-09-07 上海应用技术大学 Difluorone carbonyl substituted asymmetric nitrile compound and preparation and application thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS573159B2 (en) * 1973-12-05 1982-01-20
CA1336076C (en) * 1985-01-14 1995-06-27 Alan R. Fritzberg Metal radionuclide labeled proteins for diagnosis and therapy
ATE387421T1 (en) * 2001-03-07 2008-03-15 Firmenich & Cie METHOD FOR PRODUCING MICHAEL ADDUCTS
CN101903386B (en) * 2007-12-21 2015-04-22 株式会社Lg生命科学 Dipeptidyl peptidase-IV inhibiting compounds, methods of preparing the same, and pharmaceutical compositions containing the same as active agent

Also Published As

Publication number Publication date
PE20142331A1 (en) 2015-01-17
BR112014018985A8 (en) 2017-07-11
KR20130090360A (en) 2013-08-13
CN104159884B (en) 2016-01-13
ZA201405598B (en) 2015-09-30
WO2013115595A1 (en) 2013-08-08
KR101539761B1 (en) 2015-07-28
AU2013215796A1 (en) 2014-08-21
MY168411A (en) 2018-11-09
CO7030967A2 (en) 2014-08-21
MX355336B (en) 2018-04-16
EA026411B1 (en) 2017-04-28
AU2013215796B2 (en) 2016-09-15
CL2014002029A1 (en) 2014-12-26
PH12014501704B1 (en) 2014-10-13
SG11201404396TA (en) 2015-06-29
TN2014000329A1 (en) 2015-12-21
BR112014018985B1 (en) 2021-01-19
PH12014501704A1 (en) 2014-10-13
BR112014018985A2 (en) 2017-06-20
MA35906B1 (en) 2014-12-01
CN104159884A (en) 2014-11-19
MX2014009309A (en) 2014-11-10

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Legal Events

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PD4A Registration of transfer of a eurasian patent in accordance with the succession in title
RH4A Grant of a duplicate of a eurasian patent