PE20142331A1 - METHOD OF PREPARING A COMPOUND BY THE ADDITION REACTION OF MICHAEL NOVEDOSA USING WATER OR VARIOUS ACIDS AS ADDITIVE - Google Patents

METHOD OF PREPARING A COMPOUND BY THE ADDITION REACTION OF MICHAEL NOVEDOSA USING WATER OR VARIOUS ACIDS AS ADDITIVE

Info

Publication number
PE20142331A1
PE20142331A1 PE2014001218A PE2014001218A PE20142331A1 PE 20142331 A1 PE20142331 A1 PE 20142331A1 PE 2014001218 A PE2014001218 A PE 2014001218A PE 2014001218 A PE2014001218 A PE 2014001218A PE 20142331 A1 PE20142331 A1 PE 20142331A1
Authority
PE
Peru
Prior art keywords
compound
michael
preparing
formula
acid
Prior art date
Application number
PE2014001218A
Other languages
Spanish (es)
Inventor
Ae Ri Park
Bong Chan Kim
Ji Eun An
Hee Bong Lee
Original Assignee
Lg Life Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lg Life Sciences Ltd filed Critical Lg Life Sciences Ltd
Publication of PE20142331A1 publication Critical patent/PE20142331A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/34—Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B37/00—Reactions without formation or introduction of functional groups containing hetero atoms, involving either the formation of a carbon-to-carbon bond between two carbon atoms not directly linked already or the disconnection of two directly linked carbon atoms
    • C07B37/02—Addition
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/58—Preparation of carboxylic acid halides
    • C07C51/64—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C67/347—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to unsaturated carbon-to-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/62—Use of additives, e.g. for stabilisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Abstract

REFERIDA A UN METODO PARA PREPARAR UN COMPUESTO DE FORMULA 1 QUE COMPRENDE ADICIONAR AGUA O ACIDO O UNA MEZCLA DE LOS MISMOS A UNA MEZCLA DE REACCION PARA PREPARAR EL COMPUESTO 1 A TRAVES DE LA REACCION DE ADICION DE MICHAEL ENTRE EL COMPUESTO DE FORMULA 2 Y EL COMPUESTO DE FORMULA 3 EN PRESENCIA DE COBRE, DONDE A ES R1-C(=O), NITRILO, ALQUILSULFONILO C1-C10, ENTRE OTROS; R1 ES H, ALQUILO C1-C10, CICLOALQUILO C3-C10, ENTRE OTROS; R2, R3 Y R4 SON H, ALQUILO C1-C10, CICLOALQUILO C3-C10, ARILO C6-C10, ENTRE OTROS; R5 Y R6 SON H, HALOGENO, ALQUILO C1-C4, ENTRE OTROS; P1 ES BENCILO, METILO, ETILO, i-PROPILO O t-BUTILO; X ES UN HALOGENO. eL ACIDO ES UN ACIDO INORGANICO TAL COMO ACIDO CLORHIDRICO, SULFURICO, NITRICO, ENTRE OTROS O UN ACIDO ORGANICO TAL COMO ACIDO FORMICO, ACETICO Y TARTARICOREFERRING TO A METHOD FOR PREPARING A COMPOUND OF FORMULA 1 WHICH INCLUDES ADDING WATER OR ACID OR A MIX OF THE SAME TO A REACTION MIXTURE TO PREPARE COMPOUND 1 THROUGH THE REACTION OF ADDITION OF MICHAEL AND FORMULA 2 BETWEEN THE COMPOUND 2 OF FORMULA 2 COMPOUND OF FORMULA 3 IN THE PRESENCE OF COPPER, WHERE A IS R1-C (= O), NITRILE, C1-C10 ALKYLSULFONYL, AMONG OTHERS; R1 IS H, C1-C10 ALKYL, C3-C10 CYCLOALKYL, AMONG OTHERS; R2, R3 AND R4 ARE H, C1-C10 ALKYL, C3-C10 CYCLOALKYL, C6-C10 ARYL, AMONG OTHERS; R5 AND R6 ARE H, HALOGEN, C1-C4 ALKYL, AMONG OTHERS; P1 IS BENZYL, METHYL, ETHYL, i-PROPYL OR t-BUTYL; X IS A HALOGEN. THE ACID IS AN INORGANIC ACID SUCH AS HYDROCHLORIC, SULFURIC, NITRIC ACID, AMONG OTHERS OR AN ORGANIC ACID SUCH AS FORMIC, ACETIC AND TARTARIC ACIDS

PE2014001218A 2012-02-03 2013-02-01 METHOD OF PREPARING A COMPOUND BY THE ADDITION REACTION OF MICHAEL NOVEDOSA USING WATER OR VARIOUS ACIDS AS ADDITIVE PE20142331A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR20120011317 2012-02-03

Publications (1)

Publication Number Publication Date
PE20142331A1 true PE20142331A1 (en) 2015-01-17

Family

ID=48905559

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2014001218A PE20142331A1 (en) 2012-02-03 2013-02-01 METHOD OF PREPARING A COMPOUND BY THE ADDITION REACTION OF MICHAEL NOVEDOSA USING WATER OR VARIOUS ACIDS AS ADDITIVE

Country Status (16)

Country Link
KR (1) KR101539761B1 (en)
CN (1) CN104159884B (en)
AU (1) AU2013215796B2 (en)
BR (1) BR112014018985B1 (en)
CL (1) CL2014002029A1 (en)
CO (1) CO7030967A2 (en)
EA (1) EA026411B1 (en)
MA (1) MA35906B1 (en)
MX (1) MX355336B (en)
MY (1) MY168411A (en)
PE (1) PE20142331A1 (en)
PH (1) PH12014501704A1 (en)
SG (1) SG11201404396TA (en)
TN (1) TN2014000329A1 (en)
WO (1) WO2013115595A1 (en)
ZA (1) ZA201405598B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9774740B2 (en) 2008-01-28 2017-09-26 Afiniti Europe Technologies Limited Techniques for benchmarking pairing strategies in a contact center system
CN108191647B (en) * 2018-02-22 2020-09-29 江苏尚莱特医药化工材料有限公司 Synthesis method of 2, 2-difluoro dicarboxylic acid dialkyl ester
CN113149823B (en) * 2021-03-29 2023-12-08 上海青平药业有限公司 2-R 1 Process for preparing valeric acid
CN113354495A (en) * 2021-05-20 2021-09-07 上海应用技术大学 Difluorone carbonyl substituted asymmetric nitrile compound and preparation and application thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS573159B2 (en) * 1973-12-05 1982-01-20
DE3680924D1 (en) * 1985-01-14 1991-09-26 Neorx Corp METAL RADIONUCLIDE MARKED PROTEIN FOR DIAGNOSIS AND THERAPY.
DE60225199T2 (en) * 2001-03-07 2009-03-05 Firmenich S.A. Process for the preparation of Michael adducts
AU2008341352B2 (en) * 2007-12-21 2013-08-01 Lg Chem, Ltd. Dipeptidyl peptidase-IV inhibiting compounds, methods of preparing the same, and pharmaceutical compositions containing the same as active agent

Also Published As

Publication number Publication date
MY168411A (en) 2018-11-09
TN2014000329A1 (en) 2015-12-21
MA35906B1 (en) 2014-12-01
CL2014002029A1 (en) 2014-12-26
BR112014018985A8 (en) 2017-07-11
MX2014009309A (en) 2014-11-10
PH12014501704B1 (en) 2014-10-13
EA026411B1 (en) 2017-04-28
KR20130090360A (en) 2013-08-13
WO2013115595A1 (en) 2013-08-08
AU2013215796A1 (en) 2014-08-21
CN104159884A (en) 2014-11-19
PH12014501704A1 (en) 2014-10-13
SG11201404396TA (en) 2015-06-29
CO7030967A2 (en) 2014-08-21
BR112014018985B1 (en) 2021-01-19
BR112014018985A2 (en) 2017-06-20
ZA201405598B (en) 2015-09-30
KR101539761B1 (en) 2015-07-28
EA201491463A1 (en) 2014-11-28
AU2013215796B2 (en) 2016-09-15
MX355336B (en) 2018-04-16
CN104159884B (en) 2016-01-13

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