MX2019008695A - Compuestos biciclicos como inhibidores alostericos de shp2. - Google Patents
Compuestos biciclicos como inhibidores alostericos de shp2.Info
- Publication number
- MX2019008695A MX2019008695A MX2019008695A MX2019008695A MX2019008695A MX 2019008695 A MX2019008695 A MX 2019008695A MX 2019008695 A MX2019008695 A MX 2019008695A MX 2019008695 A MX2019008695 A MX 2019008695A MX 2019008695 A MX2019008695 A MX 2019008695A
- Authority
- MX
- Mexico
- Prior art keywords
- bicyclic compounds
- shp2 inhibitors
- allosteric shp2
- inhibitors
- allosteric
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 230000003281 allosteric effect Effects 0.000 title 1
- 125000002619 bicyclic group Chemical group 0.000 title 1
- 102100033019 Tyrosine-protein phosphatase non-receptor type 11 Human genes 0.000 abstract 1
- 101710116241 Tyrosine-protein phosphatase non-receptor type 11 Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762449530P | 2017-01-23 | 2017-01-23 | |
| PCT/US2018/013023 WO2018136265A1 (en) | 2017-01-23 | 2018-01-09 | Bicyclic compounds as allosteric shp2 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2019008695A true MX2019008695A (es) | 2019-09-11 |
Family
ID=61054566
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019008695A MX2019008695A (es) | 2017-01-23 | 2018-01-09 | Compuestos biciclicos como inhibidores alostericos de shp2. |
| MX2023004037A MX2023004037A (es) | 2017-01-23 | 2019-07-22 | Compuestos biciclicos como inhibidores alostericos de shp2. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2023004037A MX2023004037A (es) | 2017-01-23 | 2019-07-22 | Compuestos biciclicos como inhibidores alostericos de shp2. |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US11739093B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3571199A1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP7240319B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102665763B1 (cg-RX-API-DMAC7.html) |
| CN (2) | CN110446709B (cg-RX-API-DMAC7.html) |
| AR (1) | AR110740A1 (cg-RX-API-DMAC7.html) |
| AU (2) | AU2018210770B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112019015075A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3051206A1 (cg-RX-API-DMAC7.html) |
| IL (2) | IL296456A (cg-RX-API-DMAC7.html) |
| MX (2) | MX2019008695A (cg-RX-API-DMAC7.html) |
| SG (1) | SG11201906209SA (cg-RX-API-DMAC7.html) |
| TW (1) | TWI820013B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2018136265A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (112)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10280171B2 (en) | 2016-05-31 | 2019-05-07 | Board Of Regents, The University Of Texas System | Heterocyclic inhibitors of PTPN11 |
| US11466017B2 (en) | 2011-03-10 | 2022-10-11 | Board Of Regents, The University Of Texas System | Heterocyclic inhibitors of PTPN11 |
| JO3517B1 (ar) | 2014-01-17 | 2020-07-05 | Novartis Ag | ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2 |
| PL3468972T3 (pl) | 2016-06-14 | 2020-11-16 | Novartis Ag | Związki i kompozycje do hamowania aktywności shp2 |
| JP6916279B2 (ja) | 2016-07-12 | 2021-08-11 | レヴォリューション・メディスンズ，インコーポレイテッド | アロステリックｓｈｐ２阻害剤としての２，５−二置換３−メチルピラジンおよび２，５，６−三置換３−メチルピラジン |
| EP3515916B1 (en) | 2016-09-22 | 2023-06-07 | Relay Therapeutics, Inc. | Shp2 phosphatase inhibitors and methods of use thereof |
| TW202500565A (zh) | 2016-10-24 | 2025-01-01 | 美商傳達治療有限公司 | Shp2磷酸酶抑制劑及其使用方法 |
| WO2018136264A1 (en) | 2017-01-23 | 2018-07-26 | Revolution Medicines, Inc. | Pyridine compounds as allosteric shp2 inhibitors |
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| US11591336B2 (en) | 2017-05-26 | 2023-02-28 | D. E. Shaw Research, Llc | Substituted pyrazolo[3,4-b]pyrazines as SHP2 phosphatase inhibitors |
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| EP4039685A1 (en) | 2021-02-08 | 2022-08-10 | Irbm S.P.A. | Azabicyclic shp2 inhibitors |
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2018
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- 2018-01-09 AR ARP180100059A patent/AR110740A1/es unknown
- 2018-01-09 EP EP18701883.3A patent/EP3571199A1/en active Pending
- 2018-01-09 CN CN202311080113.2A patent/CN117327075A/zh active Pending
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- 2018-01-09 BR BR112019015075-7A patent/BR112019015075A2/pt not_active Application Discontinuation
- 2018-01-09 MX MX2019008695A patent/MX2019008695A/es unknown
- 2018-01-09 SG SG11201906209SA patent/SG11201906209SA/en unknown
- 2018-01-09 WO PCT/US2018/013023 patent/WO2018136265A1/en not_active Ceased
- 2018-01-09 JP JP2019539774A patent/JP7240319B2/ja active Active
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| CN110446709A (zh) | 2019-11-12 |
| KR102665763B1 (ko) | 2024-05-10 |
| RU2019126456A3 (cg-RX-API-DMAC7.html) | 2021-02-26 |
| IL268030B (en) | 2022-10-01 |
| AU2022204275A1 (en) | 2022-07-07 |
| US12365688B2 (en) | 2025-07-22 |
| MX2023004037A (es) | 2023-04-27 |
| IL268030B2 (en) | 2023-02-01 |
| US20240199616A1 (en) | 2024-06-20 |
| CA3051206A1 (en) | 2018-07-26 |
| AR110740A1 (es) | 2019-05-02 |
| JP2023018095A (ja) | 2023-02-07 |
| US20200017511A1 (en) | 2020-01-16 |
| JP7240319B2 (ja) | 2023-03-15 |
| KR20190111079A (ko) | 2019-10-01 |
| IL268030A (en) | 2019-09-26 |
| AU2018210770A1 (en) | 2019-08-15 |
| CN117327075A (zh) | 2024-01-02 |
| JP2020506178A (ja) | 2020-02-27 |
| IL296456A (en) | 2022-11-01 |
| US11739093B2 (en) | 2023-08-29 |
| CN110446709B (zh) | 2023-09-12 |
| RU2019126456A (ru) | 2021-02-24 |
| TW201827435A (zh) | 2018-08-01 |
| EP3571199A1 (en) | 2019-11-27 |
| BR112019015075A2 (pt) | 2020-03-10 |
| TWI820013B (zh) | 2023-11-01 |
| SG11201906209SA (en) | 2019-08-27 |
| WO2018136265A1 (en) | 2018-07-26 |
| AU2018210770B2 (en) | 2022-03-24 |
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