MX2019001631A - Glicosiltransferasa dependiente de uridina difosfato para la produccion de alta eficiencia de rebaudiosidos. - Google Patents
Glicosiltransferasa dependiente de uridina difosfato para la produccion de alta eficiencia de rebaudiosidos.Info
- Publication number
- MX2019001631A MX2019001631A MX2019001631A MX2019001631A MX2019001631A MX 2019001631 A MX2019001631 A MX 2019001631A MX 2019001631 A MX2019001631 A MX 2019001631A MX 2019001631 A MX2019001631 A MX 2019001631A MX 2019001631 A MX2019001631 A MX 2019001631A
- Authority
- MX
- Mexico
- Prior art keywords
- udp
- host cell
- glycosyltransferase
- nucleotide sequence
- sequence encoding
- Prior art date
Links
- 102000051366 Glycosyltransferases Human genes 0.000 title 1
- 108700023372 Glycosyltransferases Proteins 0.000 title 1
- 230000001419 dependent effect Effects 0.000 title 1
- 229930188195 rebaudioside Natural products 0.000 title 1
- 239000004383 Steviol glycoside Substances 0.000 abstract 3
- 239000002773 nucleotide Substances 0.000 abstract 3
- 125000003729 nucleotide group Chemical group 0.000 abstract 3
- 229930182488 steviol glycoside Natural products 0.000 abstract 3
- 235000019411 steviol glycoside Nutrition 0.000 abstract 3
- 150000008144 steviol glycosides Chemical class 0.000 abstract 3
- 235000019202 steviosides Nutrition 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- RPYRMTHVSUWHSV-CUZJHZIBSA-N rebaudioside D Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O RPYRMTHVSUWHSV-CUZJHZIBSA-N 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 240000005498 Setaria italica Species 0.000 abstract 1
- 235000007226 Setaria italica Nutrition 0.000 abstract 1
- -1 but not limited to Chemical class 0.000 abstract 1
- 230000037361 pathway Effects 0.000 abstract 1
- GSGVXNMGMKBGQU-PHESRWQRSA-N rebaudioside M Chemical compound C[C@@]12CCC[C@](C)([C@H]1CC[C@@]13CC(=C)[C@@](C1)(CC[C@@H]23)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H]1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H]1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O GSGVXNMGMKBGQU-PHESRWQRSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
- A23L2/52—Adding ingredients
- A23L2/60—Sweeteners
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/30—Artificial sweetening agents
- A23L27/33—Artificial sweetening agents containing sugars or derivatives
- A23L27/36—Terpene glycosides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/01—Hexosyltransferases (2.4.1)
- C12Y204/01017—Glucuronosyltransferase (2.4.1.17)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/30—Artificial sweetening agents
- A23L27/33—Artificial sweetening agents containing sugars or derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/24—Non-sugar sweeteners
- A23V2250/262—Stevioside
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Seasonings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662374408P | 2016-08-12 | 2016-08-12 | |
| PCT/US2017/046637 WO2018031955A2 (en) | 2016-08-12 | 2017-08-11 | Udp-dependent glycosyltransferase for high efficiency production of rebaudiosides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2019001631A true MX2019001631A (es) | 2019-08-05 |
Family
ID=59700219
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019001631A MX2019001631A (es) | 2016-08-12 | 2017-08-11 | Glicosiltransferasa dependiente de uridina difosfato para la produccion de alta eficiencia de rebaudiosidos. |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US11091743B2 (enExample) |
| EP (1) | EP3497222B1 (enExample) |
| JP (2) | JP7404068B2 (enExample) |
| KR (1) | KR102331018B1 (enExample) |
| CN (1) | CN109804073B (enExample) |
| AU (1) | AU2017308143B2 (enExample) |
| BR (1) | BR112018074999A2 (enExample) |
| CA (1) | CA3031162A1 (enExample) |
| ES (1) | ES2906310T3 (enExample) |
| MX (1) | MX2019001631A (enExample) |
| MY (1) | MY194280A (enExample) |
| PT (1) | PT3497222T (enExample) |
| SG (1) | SG11201900930UA (enExample) |
| WO (1) | WO2018031955A2 (enExample) |
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|---|---|---|---|---|
| EP3193636B1 (en) * | 2014-09-19 | 2022-07-06 | PureCircle SDN BHD | High-purity steviol glycosides |
| US11091743B2 (en) | 2016-08-12 | 2021-08-17 | Amyris, Inc. | UDP-dependent glycosyltransferase for high efficiency production of rebaudiosides |
| IL321402A (en) | 2017-02-03 | 2025-08-01 | Tate & Lyle Solutions Usa Llc | Engineered glycosyltransferases and steviol glycoside glucosylation methods |
| SG10202112698PA (en) * | 2017-05-15 | 2021-12-30 | Purecircle Usa Inc | High-purity steviol glycosides |
| JP7365707B2 (ja) * | 2018-03-12 | 2023-10-20 | コナゲン インコーポレイテッド | ステビオール配糖体レバウジオシドｊ及びレバウジオシドｎの生合成による製造 |
| US11608364B2 (en) | 2018-04-30 | 2023-03-21 | Dsm Ip Assets B.V. | Steviol glycoside transport |
| CN112805295B (zh) | 2018-07-30 | 2025-10-14 | 泰莱解决方案美国有限责任公司 | 工程化糖基转移酶和甜菊醇糖苷葡糖基化方法 |
| AU2019360932A1 (en) | 2018-10-15 | 2021-05-06 | Amyris, Inc. | Stevia rebaudiana kaurenoic acid hydroxylase variants for high efficiency production of rebaudiosides |
| WO2020097588A1 (en) | 2018-11-09 | 2020-05-14 | Ginkgo Bioworks, Inc. | Biosynthesis of mogrosides |
| US20220106619A1 (en) | 2019-01-24 | 2022-04-07 | Amyris, Inc. | Abc transporters for the high efficiency production of rebaudiosides |
| BR112021022010A2 (pt) * | 2019-05-03 | 2021-12-21 | Amyris Inc | Polipeptídeo variante de ácido caurenoico hidroxilase, ácido nucleico, célula hospedeira, método para produzir um ou mais glicosídeos de esteviol e composição de fermentação |
| KR20220151205A (ko) * | 2020-03-13 | 2022-11-14 | 아미리스 인코퍼레이티드 | 리바우디오사이드 m 감미료 조성물 |
| CN111518782B (zh) * | 2020-03-24 | 2022-09-02 | 广东广业清怡食品科技股份有限公司 | 一种糖基转移酶ugtzj1突变体及其应用 |
| CN111424065B (zh) * | 2020-03-24 | 2022-08-16 | 金禾益康(北京)生物科技有限公司 | 使用糖基转移酶对甜菊糖苷类化合物进行糖基化方法 |
| JP2024500432A (ja) * | 2020-12-23 | 2024-01-09 | サムヤン コーポレイション | 糖転移酵素およびこれを用いたステビオール配糖体の製造方法 |
| WO2022216922A1 (en) * | 2021-04-08 | 2022-10-13 | Conagen Inc. | Biosynthetic production of steviol glycosides |
| CN115478060B (zh) * | 2021-06-16 | 2023-11-28 | 弈柯莱生物科技(集团)股份有限公司 | 一种糖基转移酶及其应用 |
| MX2024004833A (es) * | 2021-10-19 | 2024-05-03 | Cj Cheiljedang Corp | Procedimiento para producir rebaudiosido d y rebaudiosido m. |
| KR102628374B1 (ko) * | 2021-10-19 | 2024-01-24 | 씨제이제일제당 주식회사 | 신규한 당전이효소 및 이의 용도 |
| CN114045273B (zh) * | 2021-11-15 | 2022-07-22 | 四川大学 | 糖基转移酶OsUGT91C1突变体及其应用 |
| KR20230098493A (ko) * | 2021-12-24 | 2023-07-04 | 주식회사 삼양사 | 레바우디오사이드의 생산 |
| US20250320538A1 (en) * | 2022-05-19 | 2025-10-16 | Amyris, Inc. | Compositions and methods for improved production of steviol glycosides |
| WO2024042405A1 (en) | 2022-08-26 | 2024-02-29 | Amyris Bio Products Portugal, Unipessoal, Ltda. | Compositions and methods for the synthesis of bio-based polymers |
| WO2024042486A1 (en) | 2022-08-26 | 2024-02-29 | Amyris Bio Products Portugal, Unipessoal, Ltda. | Compositions and methods for the production of polyurethanes |
| WO2024116153A1 (en) | 2022-12-02 | 2024-06-06 | Amyris Bio Products Portugal, Unipessoal, Ltda. | Compositions and methods for using previously cultured cells |
| KR20250116575A (ko) * | 2024-01-24 | 2025-08-01 | 씨제이제일제당 (주) | 신규한 변이형 당전이 효소 폴리펩티드 및 이를 이용한 스테비올배당체 생산 방법 |
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| CN104726523B (zh) | 2015-03-28 | 2018-08-10 | 南京工业大学 | 一种酶法制备莱鲍迪苷m的方法 |
| WO2016196345A1 (en) | 2015-05-29 | 2016-12-08 | Cargill, Incorporated | Heat treatment to produce glycosides |
| EP4134442A1 (en) | 2015-05-29 | 2023-02-15 | Cargill, Incorporated | Fermentation methods for producing steviol glycosides using high ph |
| US11124535B2 (en) | 2015-07-10 | 2021-09-21 | Dsm Ip Assets B.V. | Steviol glycoside composition |
| US11066688B2 (en) | 2015-07-10 | 2021-07-20 | Dsm Ip Assets B.V. | Method for preparing a steviol glycoside composition |
| WO2017025649A1 (en) | 2015-08-13 | 2017-02-16 | Dsm Ip Assets B.V. | Steviol glycoside transport |
| WO2017093895A1 (en) | 2015-11-30 | 2017-06-08 | Purecircle Sdn Bhd | Process for producing high purity steviol glycosides |
| BR112018011611A2 (pt) | 2015-12-10 | 2018-11-27 | Evolva Sa | produção de glicosídeos de esteviol em hospedeiros recombinantes |
| JP6880052B2 (ja) * | 2016-03-01 | 2021-06-02 | ユニベーション・テクノロジーズ・エルエルシー | チーグラー・ナッタ触媒活性を改善するための方法 |
| BR112018071144B1 (pt) | 2016-04-13 | 2023-04-18 | Evolva Sa | Célula hospedeira recombinante que produz um ou mais glicosídeos de esteviol ou uma composição de glicosídeo de esteviol em uma cultura de células e métodos para produzir um ou mais glicosídeos de esteviol ou uma composição de glicosídeo de esteviol, bem como cultura de células e lisado celular da dita célula hospedeira recombinante |
| EP3458599A1 (en) | 2016-05-16 | 2019-03-27 | Evolva SA | Production of steviol glycosides in recombinant hosts |
| AU2017267214A1 (en) | 2016-05-16 | 2018-11-15 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| US11878992B2 (en) | 2016-08-09 | 2024-01-23 | Dsm Ip Assets B.V. | Crystallization of steviol glycosides |
| US11091743B2 (en) * | 2016-08-12 | 2021-08-17 | Amyris, Inc. | UDP-dependent glycosyltransferase for high efficiency production of rebaudiosides |
| CN110100006A (zh) | 2016-11-07 | 2019-08-06 | 埃沃尔瓦公司 | 重组宿主中甜菊糖苷的生产 |
| SG10202112698PA (en) | 2017-05-15 | 2021-12-30 | Purecircle Usa Inc | High-purity steviol glycosides |
| MA49836A (fr) * | 2017-08-11 | 2020-06-17 | Amyris Inc | Kaurène oxydase de pisum sativum pour la production à haut rendement de rebaudiosides |
| WO2019099649A1 (en) | 2017-11-20 | 2019-05-23 | Manus Bio, Inc. | Microbial host cells for production of steviol glycosides |
| US20190270971A1 (en) | 2018-03-01 | 2019-09-05 | Jason Donald | Increasing productivity of microbial host cells that functionally express p450 enzymes |
| GB201805576D0 (en) | 2018-04-04 | 2018-05-16 | Optibiotix Ltd | Sweeteners and methods of production thereof |
| US11608364B2 (en) | 2018-04-30 | 2023-03-21 | Dsm Ip Assets B.V. | Steviol glycoside transport |
| CN112805295B (zh) | 2018-07-30 | 2025-10-14 | 泰莱解决方案美国有限责任公司 | 工程化糖基转移酶和甜菊醇糖苷葡糖基化方法 |
| MX2022000150A (es) | 2019-06-25 | 2022-05-20 | Manus Bio Inc | Enzima de glicosiltransferasa dependiente de difosfato de uridina. |
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2017
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- 2017-08-11 WO PCT/US2017/046637 patent/WO2018031955A2/en not_active Ceased
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2022
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| WO2018031955A2 (en) | 2018-02-15 |
| US11866738B2 (en) | 2024-01-09 |
| BR112018074999A2 (pt) | 2019-03-12 |
| SG11201900930UA (en) | 2019-02-27 |
| US12371677B2 (en) | 2025-07-29 |
| JP2022137061A (ja) | 2022-09-21 |
| MY194280A (en) | 2022-11-25 |
| CA3031162A1 (en) | 2018-02-15 |
| CN109804073B (zh) | 2023-05-16 |
| US20240174987A1 (en) | 2024-05-30 |
| KR20190038612A (ko) | 2019-04-08 |
| CN109804073A (zh) | 2019-05-24 |
| US20210355458A1 (en) | 2021-11-18 |
| PT3497222T (pt) | 2022-02-09 |
| US11091743B2 (en) | 2021-08-17 |
| JP2019524134A (ja) | 2019-09-05 |
| AU2017308143A1 (en) | 2019-02-07 |
| EP3497222B1 (en) | 2021-12-22 |
| JP7404068B2 (ja) | 2023-12-25 |
| EP3497222A2 (en) | 2019-06-19 |
| ES2906310T3 (es) | 2022-04-18 |
| RU2019104496A (ru) | 2020-09-14 |
| RU2019104496A3 (enExample) | 2021-04-09 |
| WO2018031955A3 (en) | 2018-03-15 |
| US20190185826A1 (en) | 2019-06-20 |
| AU2017308143B2 (en) | 2022-04-07 |
| KR102331018B1 (ko) | 2021-11-26 |
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