PT3497222T - Glicosiltransferase dependente de udp para produção de eficácia elevada de rebaudiosídeos - Google Patents

Glicosiltransferase dependente de udp para produção de eficácia elevada de rebaudiosídeos

Info

Publication number
PT3497222T
PT3497222T PT177576410T PT17757641T PT3497222T PT 3497222 T PT3497222 T PT 3497222T PT 177576410 T PT177576410 T PT 177576410T PT 17757641 T PT17757641 T PT 17757641T PT 3497222 T PT3497222 T PT 3497222T
Authority
PT
Portugal
Prior art keywords
rebaudiosides
udp
high efficiency
efficiency production
dependent glycosyltransferase
Prior art date
Application number
PT177576410T
Other languages
English (en)
Original Assignee
Amyris Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amyris Inc filed Critical Amyris Inc
Publication of PT3497222T publication Critical patent/PT3497222T/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52Adding ingredients
    • A23L2/60Sweeteners
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30Artificial sweetening agents
    • A23L27/33Artificial sweetening agents containing sugars or derivatives
    • A23L27/36Terpene glycosides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1048Glycosyltransferases (2.4)
    • C12N9/1051Hexosyltransferases (2.4.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/18Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/44Preparation of O-glycosides, e.g. glucosides
    • C12P19/56Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y204/00Glycosyltransferases (2.4)
    • C12Y204/01Hexosyltransferases (2.4.1)
    • C12Y204/01017Glucuronosyltransferase (2.4.1.17)
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30Artificial sweetening agents
    • A23L27/33Artificial sweetening agents containing sugars or derivatives
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00Food ingredients
    • A23V2250/24Non-sugar sweeteners
    • A23V2250/262Stevioside

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Nutrition Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Seasonings (AREA)
PT177576410T 2016-08-12 2017-08-11 Glicosiltransferase dependente de udp para produção de eficácia elevada de rebaudiosídeos PT3497222T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662374408P 2016-08-12 2016-08-12

Publications (1)

Publication Number Publication Date
PT3497222T true PT3497222T (pt) 2022-02-09

Family

ID=59700219

Family Applications (1)

Application Number Title Priority Date Filing Date
PT177576410T PT3497222T (pt) 2016-08-12 2017-08-11 Glicosiltransferase dependente de udp para produção de eficácia elevada de rebaudiosídeos

Country Status (14)

Country Link
US (3) US11091743B2 (pt)
EP (1) EP3497222B1 (pt)
JP (2) JP7404068B2 (pt)
KR (1) KR102331018B1 (pt)
CN (1) CN109804073B (pt)
AU (1) AU2017308143B2 (pt)
BR (1) BR112018074999A2 (pt)
CA (1) CA3031162A1 (pt)
ES (1) ES2906310T3 (pt)
MX (1) MX2019001631A (pt)
MY (1) MY194280A (pt)
PT (1) PT3497222T (pt)
SG (1) SG11201900930UA (pt)
WO (1) WO2018031955A2 (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2017003666A (es) 2014-09-19 2018-02-01 Purecircle Sdn Bhd Esteviol glicosidos de alta pureza.
BR112018074999A2 (pt) * 2016-08-12 2019-03-12 Amyris, Inc. glicosiltransferase dependente de udp para a produção de alta eficiência de rebaudiosídeo
IL268121B2 (en) 2017-02-03 2024-01-01 Codexis Inc Transgenic glycosyltransferases and steviol glycoside glucosylation methods
CN111093390A (zh) * 2017-05-15 2020-05-01 谱赛科美国股份有限公司 高纯度甜菊醇糖苷
EP3765627A4 (en) * 2018-03-12 2021-10-13 Conagen Inc. BIOSYNTHETIC PRODUCTION OF STEVIOL GLYCOSIDES REBAUDIOSIDE J AND REBAUDIOSIDE N
EP3788059A1 (en) 2018-04-30 2021-03-10 DSM IP Assets B.V. Steviol glycoside transport
CN113260699A (zh) 2018-10-15 2021-08-13 阿迈瑞斯公司 用于高效生成瑞鲍迪苷的甜叶菊异贝壳杉烯酸羟化酶变体
AU2020211408A1 (en) 2019-01-24 2021-08-12 Amyris, Inc. ABC transporters for the high efficiency production of rebaudiosides
MX2022011329A (es) * 2020-03-13 2022-10-07 Amyris Inc Composiciones edulcorantes de rebaudiosido m.
CN111424065B (zh) * 2020-03-24 2022-08-16 金禾益康(北京)生物科技有限公司 使用糖基转移酶对甜菊糖苷类化合物进行糖基化方法
CN111518782B (zh) * 2020-03-24 2022-09-02 广东广业清怡食品科技股份有限公司 一种糖基转移酶ugtzj1突变体及其应用
WO2022216922A1 (en) * 2021-04-08 2022-10-13 Conagen Inc. Biosynthetic production of steviol glycosides
CN115478060B (zh) * 2021-06-16 2023-11-28 弈柯莱生物科技(集团)股份有限公司 一种糖基转移酶及其应用
KR102628374B1 (ko) * 2021-10-19 2024-01-24 씨제이제일제당 주식회사 신규한 당전이효소 및 이의 용도
AR127393A1 (es) * 2021-10-19 2024-01-17 Cj Cheiljedang Corp Métodos para preparar rebaudiósido d y rebaudiósido m
CN114045273B (zh) * 2021-11-15 2022-07-22 四川大学 糖基转移酶OsUGT91C1突变体及其应用
KR20230098495A (ko) * 2021-12-24 2023-07-04 주식회사 삼양사 당전이 효소 변이체 및 이를 이용한 스테비올 배당체의 제조방법
WO2023225604A1 (en) * 2022-05-19 2023-11-23 Amyris, Inc. Compositions and methods for improved production of steviol glycosides
WO2024042486A1 (en) 2022-08-26 2024-02-29 Amyris Bio Products Portugal, Unipessoal, Ltda. Compositions and methods for the production of polyurethanes
WO2024042405A1 (en) 2022-08-26 2024-02-29 Amyris Bio Products Portugal, Unipessoal, Ltda. Compositions and methods for the synthesis of bio-based polymers
WO2024116153A1 (en) 2022-12-02 2024-06-06 Amyris Bio Products Portugal, Unipessoal, Ltda. Compositions and methods for using previously cultured cells

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7838044B2 (en) 2004-12-21 2010-11-23 Purecircle Sdn Bhd Extraction, separation and modification of sweet glycosides from the Stevia rebaudiana plant
KR102061165B1 (ko) 2008-10-03 2019-12-31 모리타 가가쿠 고교 가부시키가이샤 신규 스테비올 배당체
JP4760951B2 (ja) 2009-05-08 2011-08-31 トヨタ自動車株式会社 ブタノール生産能を有する組換え微生物及びブタノールの製造方法
WO2011059954A1 (en) 2009-11-12 2011-05-19 Purecircle Usa Granulation of a stevia sweetener
US10888099B2 (en) 2009-11-12 2021-01-12 Purecircle Sdn Bhd. Granulation of a Stevia sweetener
EP2544538B1 (en) 2010-03-12 2022-06-15 PureCircle USA Inc. High-purity steviol glycosides
JP5056897B2 (ja) 2010-05-14 2012-10-24 トヨタ自動車株式会社 2−ブタノールの製造方法及び2−ブタノール生産能を有する組換え微生物
BR122021005283B1 (pt) 2010-06-02 2022-02-22 Evolva, Inc Hospedeiro recombinante que compreende genes recombinantes para produção deesteviol ou glicosídeo de esteviol, método para produzir esteviol, glicosídeo de esteviol ou composição de glicosídeo de esteviol e método para sintetizar esteviol ou glicosídeo de esteviol
WO2012135591A2 (en) 2011-03-30 2012-10-04 Amyris, Inc. Microbial isoprenoid production using a heterologous dxp pathway
KR102114493B1 (ko) 2011-08-08 2020-05-26 에볼바 에스아 스테비올 글리코시드의 재조합 생산
DK2806754T3 (en) 2012-01-23 2019-02-18 Dsm Ip Assets Bv Diterpene PREPARATION
CA2867112C (en) * 2012-03-16 2021-04-20 Suntory Holdings Limited Steviol glucosyltransferases and genes encoding the same
US10113154B2 (en) 2012-03-27 2018-10-30 Suntory Holdings Limited Method for producing steviol glycoside
US9752174B2 (en) 2013-05-28 2017-09-05 Purecircle Sdn Bhd High-purity steviol glycosides
JP6346174B2 (ja) 2012-05-22 2018-06-20 ピュアサークル スンディリアン ブルハド 高純度ステビオールグリコシド
TW201402599A (zh) 2012-05-30 2014-01-16 Suntory Holdings Ltd 甜菊糖苷糖苷轉化酵素及編碼該酵素之基因
SG11201505597SA (en) 2013-02-06 2015-08-28 Evolva Sa Methods for improved production of rebaudioside d and rebaudioside m
KR20150128705A (ko) 2013-02-11 2015-11-18 에볼바 에스아 재조합 숙주에서 스테비올 글리코시드의 효율적인 생성
KR101404728B1 (ko) 2013-02-28 2014-06-09 씨제이제일제당 (주) 스테비오사이드로부터 리바우디오사이드 a를 제조하는 방법
PE20151544A1 (es) 2013-03-15 2015-11-04 Cargill Inc Plantas de stevia con un contenido de rebaudiosido d incrementado
US10689681B2 (en) 2013-05-31 2020-06-23 Dsm Ip Assets B.V. Microorganisms for diterpene production
WO2015007748A1 (en) 2013-07-15 2015-01-22 Dsm Ip Assets B.V. Diterpene production
AU2014298420B2 (en) 2013-07-31 2018-10-04 Dsm Ip Assets B.V. Recovery of steviol glycosides
AU2013397496B2 (en) 2013-08-07 2020-03-12 Amyris, Inc. Methods for stabilizing production of acetyl-coenzyme a derived compounds
JP2017528125A (ja) 2014-08-11 2017-09-28 エヴォルヴァ エスアー.Evolva Sa. 組み換え宿主におけるステビオールグリコシドの産生
CN114052237A (zh) 2014-08-19 2022-02-18 谱赛科有限责任公司 制备莱鲍迪苷i的方法以及用途
CA2960693A1 (en) * 2014-09-09 2016-03-17 Evolva Sa Production of steviol glycosides in recombinant hosts
MX2017004248A (es) 2014-10-03 2017-05-19 Conagen Inc Edulcorantes no caloricos y metodos para sintetizar.
MY182396A (en) 2014-11-05 2021-01-23 Manus Biosynthesis Inc Microbial production of steviol glycosides
CA2973674A1 (en) 2015-01-30 2016-08-04 Evolva Sa Production of steviol glycosides in recombinant hosts
CN104726523B (zh) 2015-03-28 2018-08-10 南京工业大学 一种酶法制备莱鲍迪苷m的方法
US10815513B2 (en) 2015-05-29 2020-10-27 Cargill, Incorporated Fermentation methods for producing steviol glycosides using high pH and compositions obtained therefrom
JP2018516081A (ja) 2015-05-29 2018-06-21 カーギル・インコーポレイテッド 配糖体を産生するための熱処理
CA2991662A1 (en) 2015-07-10 2017-01-19 Dsm Ip Assets B.V. Steviol glycoside composition
EP4043579A1 (en) 2015-07-10 2022-08-17 DSM IP Assets B.V. Method for preparing a steviol glycoside compostion
CN107922913B (zh) 2015-08-13 2022-04-05 帝斯曼知识产权资产管理有限公司 甜菊醇糖苷转运
WO2017093895A1 (en) 2015-11-30 2017-06-08 Purecircle Sdn Bhd Process for producing high purity steviol glycosides
AU2016367317A1 (en) 2015-12-10 2018-05-24 Evolva Sa Production of steviol glycosides in recombinant hosts
BR112018017259B1 (pt) * 2016-03-01 2022-11-16 Univation Technologies, Llc Método para formar uma composição precursora modificada de um catalisador de ziegler-natta (zn)
WO2017178632A1 (en) 2016-04-13 2017-10-19 Evolva Sa Production of steviol glycosides in recombinant hosts
US10815514B2 (en) 2016-05-16 2020-10-27 Evolva Sa Production of steviol glycosides in recombinant hosts
CN109477128A (zh) 2016-05-16 2019-03-15 埃沃尔瓦公司 在重组宿主中甜菊醇糖苷的生产
BR112019002417B1 (pt) 2016-08-09 2023-05-02 Dsm Ip Assets B.V. Cristalização de glicosídeos de esteviol
BR112018074999A2 (pt) * 2016-08-12 2019-03-12 Amyris, Inc. glicosiltransferase dependente de udp para a produção de alta eficiência de rebaudiosídeo
CN110100006A (zh) 2016-11-07 2019-08-06 埃沃尔瓦公司 重组宿主中甜菊糖苷的生产
CN111093390A (zh) 2017-05-15 2020-05-01 谱赛科美国股份有限公司 高纯度甜菊醇糖苷
AU2018314249A1 (en) * 2017-08-11 2020-03-05 Amyris, Inc. Pisum sativum kaurene oxidase for high efficiency production of rebaudiosides
WO2019099649A1 (en) 2017-11-20 2019-05-23 Manus Bio, Inc. Microbial host cells for production of steviol glycosides
US20190270971A1 (en) 2018-03-01 2019-09-05 Jason Donald Increasing productivity of microbial host cells that functionally express p450 enzymes
GB201805576D0 (en) 2018-04-04 2018-05-16 Optibiotix Ltd Sweeteners and methods of production thereof
EP3788059A1 (en) 2018-04-30 2021-03-10 DSM IP Assets B.V. Steviol glycoside transport
AU2019314181A1 (en) 2018-07-30 2021-02-04 Tate & Lyle Solutions Usa Llc Engineered glycosyltransferases and steviol glycoside glucosylation methods
CA3144658A1 (en) 2019-06-25 2020-12-30 Manus Bio, Inc. Uridine diphosphate-dependent glycosyltransferase enzyme

Also Published As

Publication number Publication date
US20190185826A1 (en) 2019-06-20
JP2022137061A (ja) 2022-09-21
CN109804073B (zh) 2023-05-16
KR20190038612A (ko) 2019-04-08
MY194280A (en) 2022-11-25
EP3497222A2 (en) 2019-06-19
JP2019524134A (ja) 2019-09-05
JP7404068B2 (ja) 2023-12-25
US11091743B2 (en) 2021-08-17
KR102331018B1 (ko) 2021-11-26
AU2017308143B2 (en) 2022-04-07
CN109804073A (zh) 2019-05-24
EP3497222B1 (en) 2021-12-22
MX2019001631A (es) 2019-08-05
WO2018031955A2 (en) 2018-02-15
SG11201900930UA (en) 2019-02-27
RU2019104496A (ru) 2020-09-14
WO2018031955A3 (en) 2018-03-15
AU2017308143A1 (en) 2019-02-07
US20240174987A1 (en) 2024-05-30
ES2906310T3 (es) 2022-04-18
US20210355458A1 (en) 2021-11-18
BR112018074999A2 (pt) 2019-03-12
US11866738B2 (en) 2024-01-09
RU2019104496A3 (pt) 2021-04-09
CA3031162A1 (en) 2018-02-15

Similar Documents

Publication Publication Date Title
PT3497222T (pt) Glicosiltransferase dependente de udp para produção de eficácia elevada de rebaudiosídeos
PT3140454T (pt) Produção de elevada eficiência de celulose nanofibrilada
EP3256421A4 (en) Graphite production from biomass
EP3161143A4 (en) Oligosaccharide production
ZA201800394B (en) Seed production
HUE047041T2 (hu) Eljárás poliéteraminok elõállítására
EP3315827A4 (en) Process for production of gaskets
ZA201604838B (en) Process for the production of synthesis gas
EP3187477A4 (en) Process for producing hydrofluoroolefin
GB201715167D0 (en) Methods for hydrogen production
EP3148934A4 (en) Graphene production process
PL3416936T3 (pl) Sposób wytwarzania metanolu
GB201510659D0 (en) Hydrogen production process
ZA201708219B (en) Fermenter for producing a pseudoplastic medium
GB2529276B (en) Production of Systems
PL3160985T3 (pl) Sposób wytwarzania d-arginylo-2,6-dimetylo-l-tyrozylo-l-lizylo-l-fenyloalaninoamidu
GB201413778D0 (en) Methanol production process
SI3317889T1 (sl) Proizvodnja magneta
ZA201604873B (en) Process for producing synthesis gas
ZA201801650B (en) Process for producing novel 4-benzoazonine derivatives
PT3362405T (pt) Processo e unidade de produção para a produção de metanol
EP3214139A4 (en) Azo compound production method
GB201517784D0 (en) Production of graphene
GB201601249D0 (en) Production of manool
GB201515238D0 (en) Hydrocarbon production process