PT3497222T - Glicosiltransferase dependente de udp para produção de eficácia elevada de rebaudiosídeos - Google Patents
Glicosiltransferase dependente de udp para produção de eficácia elevada de rebaudiosídeosInfo
- Publication number
- PT3497222T PT3497222T PT177576410T PT17757641T PT3497222T PT 3497222 T PT3497222 T PT 3497222T PT 177576410 T PT177576410 T PT 177576410T PT 17757641 T PT17757641 T PT 17757641T PT 3497222 T PT3497222 T PT 3497222T
- Authority
- PT
- Portugal
- Prior art keywords
- rebaudiosides
- udp
- high efficiency
- efficiency production
- dependent glycosyltransferase
- Prior art date
Links
- 102000051366 Glycosyltransferases Human genes 0.000 title 1
- 108700023372 Glycosyltransferases Proteins 0.000 title 1
- 230000001419 dependent effect Effects 0.000 title 1
- 229930188195 rebaudioside Natural products 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
- A23L2/52—Adding ingredients
- A23L2/60—Sweeteners
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/30—Artificial sweetening agents
- A23L27/33—Artificial sweetening agents containing sugars or derivatives
- A23L27/36—Terpene glycosides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/01—Hexosyltransferases (2.4.1)
- C12Y204/01017—Glucuronosyltransferase (2.4.1.17)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/30—Artificial sweetening agents
- A23L27/33—Artificial sweetening agents containing sugars or derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/24—Non-sugar sweeteners
- A23V2250/262—Stevioside
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Mycology (AREA)
- Polymers & Plastics (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Seasonings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662374408P | 2016-08-12 | 2016-08-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3497222T true PT3497222T (pt) | 2022-02-09 |
Family
ID=59700219
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT177576410T PT3497222T (pt) | 2016-08-12 | 2017-08-11 | Glicosiltransferase dependente de udp para produção de eficácia elevada de rebaudiosídeos |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US11091743B2 (enExample) |
| EP (1) | EP3497222B1 (enExample) |
| JP (2) | JP7404068B2 (enExample) |
| KR (1) | KR102331018B1 (enExample) |
| CN (1) | CN109804073B (enExample) |
| AU (1) | AU2017308143B2 (enExample) |
| BR (1) | BR112018074999A2 (enExample) |
| CA (1) | CA3031162A1 (enExample) |
| ES (1) | ES2906310T3 (enExample) |
| MX (1) | MX2019001631A (enExample) |
| MY (1) | MY194280A (enExample) |
| PT (1) | PT3497222T (enExample) |
| SG (1) | SG11201900930UA (enExample) |
| WO (1) | WO2018031955A2 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX389746B (es) | 2014-09-19 | 2025-03-20 | Purecircle Sdn Bhd | Esteviol glicosidos de alta pureza. |
| SG11201900930UA (en) | 2016-08-12 | 2019-02-27 | Amyris Inc | Udp-dependent glycosyltransferase for high efficiency production of rebaudiosides |
| AU2018215335B2 (en) | 2017-02-03 | 2020-10-01 | Tate & Lyle Solutions Usa Llc | Engineered glycosyltransferases and steviol glycoside glucosylation methods |
| PE20200291A1 (es) * | 2017-05-15 | 2020-02-05 | Purecircle Usa Inc | Glicosidos de esteviol de alta pureza |
| EP3765627A4 (en) * | 2018-03-12 | 2021-10-13 | Conagen Inc. | BIOSYNTHETIC PRODUCTION OF STEVIOL GLYCOSIDE REBAUDIOSIDE J AND REBAUDIOSIDE N |
| US11608364B2 (en) | 2018-04-30 | 2023-03-21 | Dsm Ip Assets B.V. | Steviol glycoside transport |
| BR112021001661A8 (pt) | 2018-07-30 | 2022-08-09 | Codexis Inc | Glicosiltransferase modificada, polinucleotídeo modificado, vetor, célula hospedeira, métodos para produzir pelo menos uma glicosiltransferase modificada, para produzir pelo menos uma variante de sacarose sintase, para glicosilação de um substrato, para produzir rebaudiosídeo m, rebaudiosídeo a e/ou rebaudiosídeo i e rebaudiosídeo d, composição, sacarose sintase modificada, pelo menos um rebaudiosídeo, rebaudiosídeo m, rebaudiosídeo a, rebaudiosídeo i, e, rebaudiosídeo d. |
| CA3114953A1 (en) | 2018-10-15 | 2020-04-23 | Amyris, Inc. | Stevia rebaudiana kaurenoic acid hydroxylase variants for high efficiency production of rebaudiosides |
| JP7498708B2 (ja) | 2018-11-09 | 2024-06-12 | ギンゴー バイオワークス， インコーポレイテッド | モグロシドの生合成 |
| PH12021551733A1 (en) | 2019-01-24 | 2022-07-25 | Amyris Inc | Abc transporters for the high efficiency production of rebaudiosides |
| MX2021013124A (es) * | 2019-05-03 | 2022-01-24 | Amyris Inc | Variantes del ácido kaurenoico 13-hidroxilasa (kah) y usos del mismo. |
| US20230101937A1 (en) * | 2020-03-13 | 2023-03-30 | Amyris, Inc. | Rebaudioside m sweetener compositions |
| CN111518782B (zh) * | 2020-03-24 | 2022-09-02 | 广东广业清怡食品科技股份有限公司 | 一种糖基转移酶ugtzj1突变体及其应用 |
| CN111424065B (zh) * | 2020-03-24 | 2022-08-16 | 金禾益康(北京)生物科技有限公司 | 使用糖基转移酶对甜菊糖苷类化合物进行糖基化方法 |
| US20250320470A1 (en) * | 2020-12-23 | 2025-10-16 | Samyang Corporation | Glycosyltransferase and steviol glucoside preparation method using same |
| WO2022216922A1 (en) * | 2021-04-08 | 2022-10-13 | Conagen Inc. | Biosynthetic production of steviol glycosides |
| CN115478060B (zh) * | 2021-06-16 | 2023-11-28 | 弈柯莱生物科技(集团)股份有限公司 | 一种糖基转移酶及其应用 |
| KR102628374B1 (ko) * | 2021-10-19 | 2024-01-24 | 씨제이제일제당 주식회사 | 신규한 당전이효소 및 이의 용도 |
| EP4417699A4 (en) * | 2021-10-19 | 2025-12-24 | Cj Cheiljedang Corp | PROCESS FOR THE PRODUCTION OF REBAUDIOSIDE D AND REBAUDIOSIDE M |
| CN114045273B (zh) * | 2021-11-15 | 2022-07-22 | 四川大学 | 糖基转移酶OsUGT91C1突变体及其应用 |
| KR20230098495A (ko) * | 2021-12-24 | 2023-07-04 | 주식회사 삼양사 | 당전이 효소 변이체 및 이를 이용한 스테비올 배당체의 제조방법 |
| EP4525636A1 (en) * | 2022-05-19 | 2025-03-26 | Amyris, Inc. | Compositions and methods for improved production of steviol glycosides |
| WO2024042486A1 (en) | 2022-08-26 | 2024-02-29 | Amyris Bio Products Portugal, Unipessoal, Ltda. | Compositions and methods for the production of polyurethanes |
| WO2024042405A1 (en) | 2022-08-26 | 2024-02-29 | Amyris Bio Products Portugal, Unipessoal, Ltda. | Compositions and methods for the synthesis of bio-based polymers |
| WO2024116153A1 (en) | 2022-12-02 | 2024-06-06 | Amyris Bio Products Portugal, Unipessoal, Ltda. | Compositions and methods for using previously cultured cells |
| WO2025159542A1 (ko) * | 2024-01-24 | 2025-07-31 | 씨제이제일제당 (주) | 신규한 변이형 당전이 효소 폴리펩티드 및 이를 이용한 스테비올배당체 생산 방법 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7838044B2 (en) | 2004-12-21 | 2010-11-23 | Purecircle Sdn Bhd | Extraction, separation and modification of sweet glycosides from the Stevia rebaudiana plant |
| JP5604426B2 (ja) | 2008-10-03 | 2014-10-08 | 守田化学工業株式会社 | 新規ステビオール配糖体 |
| JP4760951B2 (ja) | 2009-05-08 | 2011-08-31 | トヨタ自動車株式会社 | ブタノール生産能を有する組換え微生物及びブタノールの製造方法 |
| US10888099B2 (en) | 2009-11-12 | 2021-01-12 | Purecircle Sdn Bhd. | Granulation of a Stevia sweetener |
| US10004245B2 (en) | 2009-11-12 | 2018-06-26 | Purecircle Sdn Bhd | Granulation of a stevia sweetener |
| US8981081B2 (en) | 2010-03-12 | 2015-03-17 | Purecircle Usa Inc. | High-purity steviol glycosides |
| JP5056897B2 (ja) | 2010-05-14 | 2012-10-24 | トヨタ自動車株式会社 | ２−ブタノールの製造方法及び２−ブタノール生産能を有する組換え微生物 |
| BR122021005283B1 (pt) | 2010-06-02 | 2022-02-22 | Evolva, Inc | Hospedeiro recombinante que compreende genes recombinantes para produção deesteviol ou glicosídeo de esteviol, método para produzir esteviol, glicosídeo de esteviol ou composição de glicosídeo de esteviol e método para sintetizar esteviol ou glicosídeo de esteviol |
| CA2819253A1 (en) * | 2010-11-30 | 2012-06-07 | Massachusetts Institute Of Technology | Microbial production of natural sweeteners, diterpenoid steviol glycosides |
| WO2012135591A2 (en) | 2011-03-30 | 2012-10-04 | Amyris, Inc. | Microbial isoprenoid production using a heterologous dxp pathway |
| BR122021015509B1 (pt) | 2011-08-08 | 2022-03-29 | Evolva Sa | Método para produzir um glicosídeo de esteviol alvo |
| EA201400836A8 (ru) | 2012-01-23 | 2016-03-31 | ДСМ АйПи АССЕТС Б.В. | Получение дитерпена |
| EP2826861B1 (en) | 2012-03-16 | 2020-04-29 | Suntory Holdings Limited | Steviol glycosyltransferase and gene encoding same |
| US10113154B2 (en) | 2012-03-27 | 2018-10-30 | Suntory Holdings Limited | Method for producing steviol glycoside |
| MX395285B (es) | 2012-05-22 | 2025-03-25 | Purecircle Sdn Bhd | Glucosidos de esteviol de alta pureza. |
| US9752174B2 (en) | 2013-05-28 | 2017-09-05 | Purecircle Sdn Bhd | High-purity steviol glycosides |
| TW201402599A (zh) | 2012-05-30 | 2014-01-16 | Suntory Holdings Ltd | 甜菊糖苷糖苷轉化酵素及編碼該酵素之基因 |
| CN105051195B (zh) | 2013-02-06 | 2019-09-06 | 埃沃尔瓦公司 | 用于提高莱鲍迪苷d和莱鲍迪苷m之产生的方法 |
| MX2015010098A (es) * | 2013-02-11 | 2016-04-19 | Evolva Sa | Producción eficiente de glicosidos de esteviol en huéspedes recombinantes. |
| KR101404728B1 (ko) | 2013-02-28 | 2014-06-09 | 씨제이제일제당 (주) | 스테비오사이드로부터 리바우디오사이드 a를 제조하는 방법 |
| PE20151544A1 (es) | 2013-03-15 | 2015-11-04 | Cargill Inc | Plantas de stevia con un contenido de rebaudiosido d incrementado |
| MX367033B (es) | 2013-05-31 | 2019-08-02 | Dsm Ip Assets Bv | Microorganismos para la produccion de diterpeno. |
| CA2914900A1 (en) | 2013-07-15 | 2015-01-22 | Dsm Ip Assets B.V. | Recombinant microorganism and process for the production of steviol glycosides |
| DK3027632T3 (da) | 2013-07-31 | 2019-06-17 | Dsm Ip Assets Bv | Indvinding af steviolglycosider fra et fermenteringsmedium |
| US10563229B2 (en) | 2013-08-07 | 2020-02-18 | Amyris, Inc. | Methods for stabilizing production of acetyl-coenzyme a derived compounds |
| BR112017002783A2 (pt) | 2014-08-11 | 2017-12-19 | Evolva Sa | produção de glicosídeos de esteviol em hospedeiros recombinantes |
| EP3683315A1 (en) | 2014-08-19 | 2020-07-22 | Purecircle SDN BHD | Method for preparing rebaudioside m |
| US10612064B2 (en) | 2014-09-09 | 2020-04-07 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| MX368414B (es) | 2014-10-03 | 2019-10-02 | Conagen Inc | Edulcorantes no caloricos y metodos para sintetizar. |
| WO2016073740A1 (en) | 2014-11-05 | 2016-05-12 | Manus Biosynthesis, Inc. | Microbial production of steviol glycosides |
| CA2973674A1 (en) | 2015-01-30 | 2016-08-04 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| CN104726523B (zh) | 2015-03-28 | 2018-08-10 | 南京工业大学 | 一种酶法制备莱鲍迪苷m的方法 |
| AU2016271628B2 (en) | 2015-05-29 | 2020-01-30 | Cargill, Incorporated | Fermentation methods for producing steviol glycosides using high pH and compositions obtained therefrom |
| CN107613786A (zh) | 2015-05-29 | 2018-01-19 | 嘉吉公司 | 产生糖苷的热处理 |
| CA2991662A1 (en) | 2015-07-10 | 2017-01-19 | Dsm Ip Assets B.V. | Steviol glycoside composition |
| EP3320104B1 (en) | 2015-07-10 | 2021-11-10 | DSM IP Assets B.V. | Method for preparing a steviol glycoside composition |
| CN107922913B (zh) | 2015-08-13 | 2022-04-05 | 帝斯曼知识产权资产管理有限公司 | 甜菊醇糖苷转运 |
| CN108884484A (zh) | 2015-11-30 | 2018-11-23 | 谱赛科有限责任公司 | 用于制备高纯度甜菊醇糖苷的方法 |
| SG11201803918VA (en) | 2015-12-10 | 2018-06-28 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| WO2017151592A1 (en) * | 2016-03-01 | 2017-09-08 | Univation Technologies, Llc | Method for improving ziegler-natta catalyst activity |
| SG11201808856TA (en) | 2016-04-13 | 2018-11-29 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| CN109312378A (zh) | 2016-05-16 | 2019-02-05 | 埃沃尔瓦公司 | 在重组宿主中产生甜菊醇糖苷 |
| WO2017198681A1 (en) | 2016-05-16 | 2017-11-23 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| CA3032656A1 (en) | 2016-08-09 | 2018-02-15 | Dsm Ip Assets B.V. | Crystallization of steviol glycosides |
| SG11201900930UA (en) * | 2016-08-12 | 2019-02-27 | Amyris Inc | Udp-dependent glycosyltransferase for high efficiency production of rebaudiosides |
| US11396669B2 (en) | 2016-11-07 | 2022-07-26 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| PE20200291A1 (es) | 2017-05-15 | 2020-02-05 | Purecircle Usa Inc | Glicosidos de esteviol de alta pureza |
| SG11202001058TA (en) * | 2017-08-11 | 2020-03-30 | Amyris Inc | Pisum sativum kaurene oxidase for high efficiency production of rebaudiosides |
| WO2019099649A1 (en) | 2017-11-20 | 2019-05-23 | Manus Bio, Inc. | Microbial host cells for production of steviol glycosides |
| US20190270971A1 (en) | 2018-03-01 | 2019-09-05 | Jason Donald | Increasing productivity of microbial host cells that functionally express p450 enzymes |
| GB201805576D0 (en) | 2018-04-04 | 2018-05-16 | Optibiotix Ltd | Sweeteners and methods of production thereof |
| US11608364B2 (en) | 2018-04-30 | 2023-03-21 | Dsm Ip Assets B.V. | Steviol glycoside transport |
| BR112021001661A8 (pt) | 2018-07-30 | 2022-08-09 | Codexis Inc | Glicosiltransferase modificada, polinucleotídeo modificado, vetor, célula hospedeira, métodos para produzir pelo menos uma glicosiltransferase modificada, para produzir pelo menos uma variante de sacarose sintase, para glicosilação de um substrato, para produzir rebaudiosídeo m, rebaudiosídeo a e/ou rebaudiosídeo i e rebaudiosídeo d, composição, sacarose sintase modificada, pelo menos um rebaudiosídeo, rebaudiosídeo m, rebaudiosídeo a, rebaudiosídeo i, e, rebaudiosídeo d. |
| CA3144658A1 (en) | 2019-06-25 | 2020-12-30 | Manus Bio, Inc. | Uridine diphosphate-dependent glycosyltransferase enzyme |
-
2017
- 2017-08-11 SG SG11201900930UA patent/SG11201900930UA/en unknown
- 2017-08-11 US US16/323,756 patent/US11091743B2/en active Active
- 2017-08-11 BR BR112018074999-0A patent/BR112018074999A2/pt not_active Application Discontinuation
- 2017-08-11 JP JP2019507224A patent/JP7404068B2/ja active Active
- 2017-08-11 PT PT177576410T patent/PT3497222T/pt unknown
- 2017-08-11 MX MX2019001631A patent/MX2019001631A/es unknown
- 2017-08-11 CN CN201780049312.3A patent/CN109804073B/zh active Active
- 2017-08-11 WO PCT/US2017/046637 patent/WO2018031955A2/en not_active Ceased
- 2017-08-11 EP EP17757641.0A patent/EP3497222B1/en active Active
- 2017-08-11 MY MYPI2019000757A patent/MY194280A/en unknown
- 2017-08-11 AU AU2017308143A patent/AU2017308143B2/en active Active
- 2017-08-11 KR KR1020197006546A patent/KR102331018B1/ko not_active Expired - Fee Related
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2023
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Also Published As
| Publication number | Publication date |
|---|---|
| MX2019001631A (es) | 2019-08-05 |
| CA3031162A1 (en) | 2018-02-15 |
| KR102331018B1 (ko) | 2021-11-26 |
| KR20190038612A (ko) | 2019-04-08 |
| US20190185826A1 (en) | 2019-06-20 |
| ES2906310T3 (es) | 2022-04-18 |
| JP2019524134A (ja) | 2019-09-05 |
| EP3497222B1 (en) | 2021-12-22 |
| WO2018031955A3 (en) | 2018-03-15 |
| EP3497222A2 (en) | 2019-06-19 |
| RU2019104496A (ru) | 2020-09-14 |
| US11866738B2 (en) | 2024-01-09 |
| US12371677B2 (en) | 2025-07-29 |
| RU2019104496A3 (enExample) | 2021-04-09 |
| US20210355458A1 (en) | 2021-11-18 |
| SG11201900930UA (en) | 2019-02-27 |
| JP2022137061A (ja) | 2022-09-21 |
| CN109804073A (zh) | 2019-05-24 |
| WO2018031955A2 (en) | 2018-02-15 |
| AU2017308143B2 (en) | 2022-04-07 |
| AU2017308143A1 (en) | 2019-02-07 |
| BR112018074999A2 (pt) | 2019-03-12 |
| MY194280A (en) | 2022-11-25 |
| US11091743B2 (en) | 2021-08-17 |
| US20240174987A1 (en) | 2024-05-30 |
| CN109804073B (zh) | 2023-05-16 |
| JP7404068B2 (ja) | 2023-12-25 |
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