MX2015012621A - Composiciones y metodos para modular la expresion de tau. - Google Patents

Composiciones y metodos para modular la expresion de tau.

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Publication number
MX2015012621A
MX2015012621A MX2015012621A MX2015012621A MX2015012621A MX 2015012621 A MX2015012621 A MX 2015012621A MX 2015012621 A MX2015012621 A MX 2015012621A MX 2015012621 A MX2015012621 A MX 2015012621A MX 2015012621 A MX2015012621 A MX 2015012621A
Authority
MX
Mexico
Prior art keywords
methods
tau
compositions
animal
disclosed
Prior art date
Application number
MX2015012621A
Other languages
English (en)
Spanish (es)
Inventor
Frank Rigo
C Frank Bennett
Original Assignee
Ionis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ionis Pharmaceuticals Inc filed Critical Ionis Pharmaceuticals Inc
Publication of MX2015012621A publication Critical patent/MX2015012621A/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
    • C12N2310/3181—Peptide nucleic acid, PNA
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/3341—5-Methylcytosine
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/345—Spatial arrangement of the modifications having at least two different backbone modifications
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
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    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/33—Alteration of splicing

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  • Biomedical Technology (AREA)
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  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Epidemiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
MX2015012621A 2013-03-14 2014-03-14 Composiciones y metodos para modular la expresion de tau. MX2015012621A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361785177P 2013-03-14 2013-03-14
US201461943931P 2014-02-24 2014-02-24
PCT/US2014/029752 WO2014153236A1 (en) 2013-03-14 2014-03-14 Compositions and methods for modulating tau expression

Publications (1)

Publication Number Publication Date
MX2015012621A true MX2015012621A (es) 2016-05-31

Family

ID=51581461

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015012621A MX2015012621A (es) 2013-03-14 2014-03-14 Composiciones y metodos para modular la expresion de tau.

Country Status (13)

Country Link
US (3) US9644207B2 (enExample)
EP (2) EP2971142B1 (enExample)
JP (2) JP6629716B2 (enExample)
KR (1) KR20150130430A (enExample)
CN (2) CN111254145A (enExample)
AU (1) AU2014236156C1 (enExample)
BR (1) BR112015022156A2 (enExample)
CA (1) CA2906119A1 (enExample)
ES (1) ES2807379T3 (enExample)
IL (1) IL241439B (enExample)
MX (1) MX2015012621A (enExample)
RU (1) RU2745324C2 (enExample)
WO (1) WO2014153236A1 (enExample)

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TWI657819B (zh) 2013-07-19 2019-05-01 美商Ionis製藥公司 用於調節τ蛋白表現之組合物
CN115181778A (zh) 2015-02-04 2022-10-14 百时美施贵宝公司 选择治疗性分子的方法
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EA202092156A1 (ru) * 2018-03-13 2021-04-01 Янссен Фармацевтика Нв Модифицированные олигонуклеотиды и способы применения в лечении таупатий
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