AU2014236156C1 - Compositions and methods for modulating Tau expression - Google Patents

Compositions and methods for modulating Tau expression Download PDF

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AU2014236156C1
AU2014236156C1 AU2014236156A AU2014236156A AU2014236156C1 AU 2014236156 C1 AU2014236156 C1 AU 2014236156C1 AU 2014236156 A AU2014236156 A AU 2014236156A AU 2014236156 A AU2014236156 A AU 2014236156A AU 2014236156 C1 AU2014236156 C1 AU 2014236156C1
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compound
modified
certain embodiments
tau
modified oligonucleotide
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AU2014236156A1 (en
AU2014236156B2 (en
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C. Frank Bennett
Frank Rigo
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Ionis Pharmaceuticals Inc
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Ionis Pharmaceuticals Inc
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
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    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/33—Chemical structure of the base
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    • C12N2310/3341—5-Methylcytosine
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/345—Spatial arrangement of the modifications having at least two different backbone modifications
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    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/351—Conjugate
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/33—Alteration of splicing

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  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Epidemiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU2014236156A 2013-03-14 2014-03-14 Compositions and methods for modulating Tau expression Active AU2014236156C1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361785177P 2013-03-14 2013-03-14
US61/785,177 2013-03-14
US201461943931P 2014-02-24 2014-02-24
US61/943,931 2014-02-24
PCT/US2014/029752 WO2014153236A1 (en) 2013-03-14 2014-03-14 Compositions and methods for modulating tau expression

Publications (3)

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AU2014236156A1 AU2014236156A1 (en) 2015-09-24
AU2014236156B2 AU2014236156B2 (en) 2020-05-28
AU2014236156C1 true AU2014236156C1 (en) 2020-12-17

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US (3) US9644207B2 (enExample)
EP (2) EP2971142B1 (enExample)
JP (2) JP6629716B2 (enExample)
KR (1) KR20150130430A (enExample)
CN (2) CN111254145A (enExample)
AU (1) AU2014236156C1 (enExample)
BR (1) BR112015022156A2 (enExample)
CA (1) CA2906119A1 (enExample)
ES (1) ES2807379T3 (enExample)
IL (1) IL241439B (enExample)
MX (1) MX2015012621A (enExample)
RU (1) RU2745324C2 (enExample)
WO (1) WO2014153236A1 (enExample)

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