ES2807379T3 - Composiciones y métodos para regular la expresión de Tau - Google Patents

Composiciones y métodos para regular la expresión de Tau Download PDF

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Publication number
ES2807379T3
ES2807379T3 ES14767904T ES14767904T ES2807379T3 ES 2807379 T3 ES2807379 T3 ES 2807379T3 ES 14767904 T ES14767904 T ES 14767904T ES 14767904 T ES14767904 T ES 14767904T ES 2807379 T3 ES2807379 T3 ES 2807379T3
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certain embodiments
modified
tau
oligonucleotide
compound
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Spanish (es)
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Frank Rigo
C Bennett
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Ionis Pharmaceuticals Inc
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Ionis Pharmaceuticals Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/32Chemical structure of the sugar
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    • C12N2310/33415-Methylcytosine
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    • C12N2310/00Structure or type of the nucleic acid
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    • C12N2310/34Spatial arrangement of the modifications
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    • C12N2310/351Conjugate
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    • C12N2320/00Applications; Uses
    • C12N2320/30Special therapeutic applications
    • C12N2320/33Alteration of splicing

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  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Epidemiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
ES14767904T 2013-03-14 2014-03-14 Composiciones y métodos para regular la expresión de Tau Active ES2807379T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361785177P 2013-03-14 2013-03-14
US201461943931P 2014-02-24 2014-02-24
PCT/US2014/029752 WO2014153236A1 (en) 2013-03-14 2014-03-14 Compositions and methods for modulating tau expression

Publications (1)

Publication Number Publication Date
ES2807379T3 true ES2807379T3 (es) 2021-02-22

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ES14767904T Active ES2807379T3 (es) 2013-03-14 2014-03-14 Composiciones y métodos para regular la expresión de Tau

Country Status (13)

Country Link
US (3) US9644207B2 (enExample)
EP (2) EP2971142B1 (enExample)
JP (2) JP6629716B2 (enExample)
KR (1) KR20150130430A (enExample)
CN (2) CN111254145A (enExample)
AU (1) AU2014236156C1 (enExample)
BR (1) BR112015022156A2 (enExample)
CA (1) CA2906119A1 (enExample)
ES (1) ES2807379T3 (enExample)
IL (1) IL241439B (enExample)
MX (1) MX2015012621A (enExample)
RU (1) RU2745324C2 (enExample)
WO (1) WO2014153236A1 (enExample)

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WO2013148283A1 (en) 2012-03-30 2013-10-03 Isis Pharmaceuticals, Inc. Compositions and methods for modulating tau expression for reducing seizure and modifying a neurodegenerative syndrome
RU2745324C2 (ru) 2013-03-14 2021-03-23 Ионис Фармасьютикалз, Инк. Композиции и способы модулирования экспрессии tau
TWI657819B (zh) 2013-07-19 2019-05-01 美商Ionis製藥公司 用於調節τ蛋白表現之組合物
CN115181778A (zh) 2015-02-04 2022-10-14 百时美施贵宝公司 选择治疗性分子的方法
US11077132B2 (en) * 2015-02-04 2021-08-03 F. Hoffmann-La Roche Ag Tau antisense oligomers and uses thereof
ES2820713T3 (es) 2015-03-25 2021-04-22 Univ Degli Studi Di Trento Terapia mediada por ARN interferente para enfermedades neurodegenerativas
US10370667B2 (en) 2015-11-18 2019-08-06 Rosalind Franklin University Of Medicine And Science Antisense compounds targeting leucine-rich repeat kinase 2 (LRRK2) for the treatment of parkinsons disease
WO2017087282A1 (en) 2015-11-18 2017-05-26 Rosalind Franklin University Of Medicine And Science Antisense compounds targeting leucine-rich repeat kinase 2 (lrrk2) for the treatment of parkinsons disease
JOP20200228A1 (ar) * 2015-12-21 2017-06-16 Novartis Ag تركيبات وطرق لخفض تعبير البروتين tau
JOP20190065A1 (ar) 2016-09-29 2019-03-28 Ionis Pharmaceuticals Inc مركبات وطرق لتقليل التعبير عن tau
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IL266862B2 (en) * 2016-12-01 2024-01-01 Sangamo Therapeutics Inc Tau modulators and methods and preparations for their administration
EA202092156A1 (ru) * 2018-03-13 2021-04-01 Янссен Фармацевтика Нв Модифицированные олигонуклеотиды и способы применения в лечении таупатий
AU2019297391B2 (en) 2018-07-03 2023-01-12 F. Hoffmann-La Roche Ag Oligonucleotides for modulating Tau expression
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US12281305B2 (en) * 2018-11-21 2025-04-22 Ionis Pharmaceuticals, Inc. Compounds and methods for reducing prion expression
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CN116234585A (zh) * 2020-03-30 2023-06-06 阿尔尼拉姆医药品有限公司 微管相关蛋白TAU(MAPT)iRNA剂组合物及其使用方法
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