RU2745324C2 - Композиции и способы модулирования экспрессии tau - Google Patents

Композиции и способы модулирования экспрессии tau Download PDF

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RU2745324C2
RU2745324C2 RU2015143286A RU2015143286A RU2745324C2 RU 2745324 C2 RU2745324 C2 RU 2745324C2 RU 2015143286 A RU2015143286 A RU 2015143286A RU 2015143286 A RU2015143286 A RU 2015143286A RU 2745324 C2 RU2745324 C2 RU 2745324C2
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modified
compound according
tau
internucleoside bond
compound
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RU2015143286A (ru
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Фрэнк РИГО
С. Фрэнк БЕННЕТТ
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Ионис Фармасьютикалз, Инк.
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RU2015143286A 2013-03-14 2014-03-14 Композиции и способы модулирования экспрессии tau RU2745324C2 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361785177P 2013-03-14 2013-03-14
US61/785,177 2013-03-14
US201461943931P 2014-02-24 2014-02-24
US61/943,931 2014-02-24
PCT/US2014/029752 WO2014153236A1 (en) 2013-03-14 2014-03-14 Compositions and methods for modulating tau expression

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RU2015143286A RU2015143286A (ru) 2017-04-17
RU2745324C2 true RU2745324C2 (ru) 2021-03-23

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US (3) US9644207B2 (enExample)
EP (2) EP2971142B1 (enExample)
JP (2) JP6629716B2 (enExample)
KR (1) KR20150130430A (enExample)
CN (2) CN111254145A (enExample)
AU (1) AU2014236156C1 (enExample)
BR (1) BR112015022156A2 (enExample)
CA (1) CA2906119A1 (enExample)
ES (1) ES2807379T3 (enExample)
IL (1) IL241439B (enExample)
MX (1) MX2015012621A (enExample)
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WO (1) WO2014153236A1 (enExample)

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TWI657819B (zh) 2013-07-19 2019-05-01 美商Ionis製藥公司 用於調節τ蛋白表現之組合物
CN115181778A (zh) 2015-02-04 2022-10-14 百时美施贵宝公司 选择治疗性分子的方法
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ES2820713T3 (es) 2015-03-25 2021-04-22 Univ Degli Studi Di Trento Terapia mediada por ARN interferente para enfermedades neurodegenerativas
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JOP20200228A1 (ar) * 2015-12-21 2017-06-16 Novartis Ag تركيبات وطرق لخفض تعبير البروتين tau
JOP20190065A1 (ar) 2016-09-29 2019-03-28 Ionis Pharmaceuticals Inc مركبات وطرق لتقليل التعبير عن tau
JP2019535839A (ja) 2016-11-29 2019-12-12 ピュアテック ヘルス エルエルシー 治療剤の送達のためのエクソソーム
IL266862B2 (en) * 2016-12-01 2024-01-01 Sangamo Therapeutics Inc Tau modulators and methods and preparations for their administration
EA202092156A1 (ru) * 2018-03-13 2021-04-01 Янссен Фармацевтика Нв Модифицированные олигонуклеотиды и способы применения в лечении таупатий
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US12281305B2 (en) * 2018-11-21 2025-04-22 Ionis Pharmaceuticals, Inc. Compounds and methods for reducing prion expression
WO2020247419A2 (en) * 2019-06-03 2020-12-10 Quralis Corporation Oligonucleotides and methods of use for treating neurological diseases
CN116234585A (zh) * 2020-03-30 2023-06-06 阿尔尼拉姆医药品有限公司 微管相关蛋白TAU(MAPT)iRNA剂组合物及其使用方法
EP4373938A2 (en) * 2021-07-23 2024-05-29 University Of Kentucky Research Foundation Inhibition of neurofibrillary tangles using oligonucleotides against circular rnas from the microtubule associated protein tau (mapt) locus
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