EA201491448A1 - Применение 1h-индазол-3-карбоксамидных соединений в качестве ингибиторов гликогенсинтазы киназы 3-бета - Google Patents

Применение 1h-индазол-3-карбоксамидных соединений в качестве ингибиторов гликогенсинтазы киназы 3-бета

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Publication number
EA201491448A1
EA201491448A1 EA201491448A EA201491448A EA201491448A1 EA 201491448 A1 EA201491448 A1 EA 201491448A1 EA 201491448 A EA201491448 A EA 201491448A EA 201491448 A EA201491448 A EA 201491448A EA 201491448 A1 EA201491448 A1 EA 201491448A1
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Eurasian Patent Office
Prior art keywords
disorders
inhibitors
carboxamide compounds
indazol
bet
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EA201491448A
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English (en)
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EA026952B1 (ru
Inventor
Мария Алессандра Ализи
Никола Каццолла
Барбара Гарофало
Гвидо Фурлотти
Габриеле Магаро'
Розелла Омбрато
Франческа Манчини
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Ацьенде Кимике Рьюните Анджелини Франческо А.К.Р.А.Ф. С.П.А.
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Publication of EA201491448A1 publication Critical patent/EA201491448A1/ru
Publication of EA026952B1 publication Critical patent/EA026952B1/ru

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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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  • Health & Medical Sciences (AREA)
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  • Obesity (AREA)
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  • Plural Heterocyclic Compounds (AREA)

Abstract

Изобретение относится к новому применению 1Н-индазол-3-карбоксамидных соединений в качестве ингибиторов гликогенсинтазы киназы 3-бета (GSK-3β) и к их применению при лечении связанных с GSK-3β заболеваний, таких как, например, (i) инсулинрезистентные нарушения; (ii) нейродегенеративные заболевания; (iii) расстройства настроения; (iv) шизофренические расстройства; (v) злокачественные расстройства; (vi) воспаление, (vii) расстройства вследствие токсикомании; (viii) эпилепсии.
EA201491448A 2012-02-21 2013-02-08 Применение 1h-индазол-3-карбоксамидных соединений в качестве ингибиторов гликогенсинтазы киназы 3-бета EA026952B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12156298 2012-02-21
PCT/EP2013/052523 WO2013124169A1 (en) 2012-02-21 2013-02-08 Use of 1h-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors

Publications (2)

Publication Number Publication Date
EA201491448A1 true EA201491448A1 (ru) 2014-11-28
EA026952B1 EA026952B1 (ru) 2017-06-30

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EA201491448A EA026952B1 (ru) 2012-02-21 2013-02-08 Применение 1h-индазол-3-карбоксамидных соединений в качестве ингибиторов гликогенсинтазы киназы 3-бета

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US (2) US9163013B2 (ru)
EP (1) EP2817301B1 (ru)
JP (1) JP6285873B2 (ru)
KR (1) KR102101702B1 (ru)
CN (1) CN104080781B (ru)
AR (1) AR090085A1 (ru)
AU (1) AU2013224313B2 (ru)
BR (1) BR112014018657B1 (ru)
CA (1) CA2860466C (ru)
CY (1) CY1117467T1 (ru)
DK (1) DK2817301T3 (ru)
EA (1) EA026952B1 (ru)
ES (1) ES2564033T3 (ru)
GE (1) GEP201606552B (ru)
HK (1) HK1203931A1 (ru)
HR (1) HRP20160124T1 (ru)
HU (1) HUE027445T2 (ru)
IL (1) IL233825A (ru)
MX (1) MX351288B (ru)
PL (1) PL2817301T3 (ru)
PT (1) PT2817301E (ru)
RS (1) RS54539B1 (ru)
SG (2) SG10201701171TA (ru)
SI (1) SI2817301T1 (ru)
SM (1) SMT201600054B (ru)
UA (1) UA113189C2 (ru)
WO (1) WO2013124169A1 (ru)

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Publication number Priority date Publication date Assignee Title
MX351288B (es) * 2012-02-21 2017-10-09 Acraf Uso de compuestos de 1h-indazol-3-carboxamida como beta inhibidores de glucogeno sintasa quinasa 3 beta.
US10954240B2 (en) 2014-09-03 2021-03-23 Merck Sharp & Dohme Corp. Compounds inhibiting leucine-rich repeat kinase enzyme activity
AU2016275764B8 (en) 2015-06-11 2021-03-04 Basilea Pharmaceutica International AG Efflux-pump inhibitors and therapeutic uses thereof
WO2017093157A1 (en) * 2015-11-30 2017-06-08 Basilea Pharmaceutica Ag Piperidine, pyrrolidine and 2-oxo-1,3-oxazinane derivatives as inhibitors of bacterial efflux-pumps for the treatment of microbial infections
EP3468960B1 (en) * 2016-06-08 2022-03-23 GlaxoSmithKline Intellectual Property Development Limited Chemical compounds as atf4 pathway inhibitors
EA202092422A1 (ru) 2018-05-07 2021-02-12 Ацьенде Кимике Рьюните Анджелини Франческо - А.К.Р.А.Ф. С.П.А. 1h-индазол-3-карбоксамидные соединения в качестве ингибиторов киназы гликогенсинтазы 3-бета
CN117186027B (zh) * 2023-09-11 2024-04-19 上海蓝木化工有限公司 一种糖原合酶激酶-3抑制剂及其制备方法

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WO1994010174A1 (en) 1992-11-05 1994-05-11 Smithkline Beecham Plc Piperidine derivatives as 5-ht4 receptor antagonists
KR19990022096A (ko) * 1995-05-31 1999-03-25 쇼다 오사무 모노시클릭 아미노기를 갖는 인다졸 유도체
IT1291569B1 (it) * 1997-04-15 1999-01-11 Angelini Ricerche Spa Indazolammidi come agenti serotoninergici
GB0218625D0 (en) 2002-08-10 2002-09-18 Astex Technology Ltd Pharmaceutical compounds
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ITMI20030972A1 (it) 2003-05-15 2004-11-16 Acraf Indazolo dotato di attivita' analgesica, metodo per prepararlo e composizione farmaceutica che lo comprende.
UA99927C2 (ru) 2007-11-12 2012-10-25 Ацьенде Кимике Риуните Анджелини Франческо А.Чи.Р.А.Ф. С.П.А. Медикамент, который является активным при невропатической боли
TW201040191A (en) 2009-03-27 2010-11-16 Abbott Gmbh & Co Kg Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors
US7947728B1 (en) * 2009-11-11 2011-05-24 Hoffmann-La Roche Inc. Indole and indazole analogs as glycogen synthase activators
PL2817302T3 (pl) 2012-02-21 2016-06-30 Acraf Związki 1H-indazolo-3-karboksyamidowe jako inhibitory kinazy syntazy glikogenu 3-beta
MX351288B (es) * 2012-02-21 2017-10-09 Acraf Uso de compuestos de 1h-indazol-3-carboxamida como beta inhibidores de glucogeno sintasa quinasa 3 beta.

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CN104080781B (zh) 2016-05-11
SG10201701171TA (en) 2017-04-27
BR112014018657B1 (pt) 2022-08-02
EA026952B1 (ru) 2017-06-30
ES2564033T3 (es) 2016-03-17
DK2817301T3 (en) 2016-03-14
US20160045485A1 (en) 2016-02-18
HRP20160124T1 (hr) 2016-03-11
EP2817301B1 (en) 2015-12-23
US9700551B2 (en) 2017-07-11
CA2860466A1 (en) 2013-08-29
EP2817301A1 (en) 2014-12-31
MX351288B (es) 2017-10-09
WO2013124169A1 (en) 2013-08-29
BR112014018657A8 (pt) 2017-07-11
AR090085A1 (es) 2014-10-15
JP6285873B2 (ja) 2018-02-28
AU2013224313A8 (en) 2014-09-18
SG11201403788VA (en) 2014-08-28
SMT201600054B (it) 2016-04-29
AU2013224313B2 (en) 2017-03-30
HK1203931A1 (zh) 2015-11-06
US20140378455A1 (en) 2014-12-25
CN104080781A (zh) 2014-10-01
AU2013224313A1 (en) 2014-07-17
GEP201606552B (en) 2016-10-10
KR20140122725A (ko) 2014-10-20
PT2817301E (pt) 2016-03-14
IL233825A0 (en) 2014-09-30
CA2860466C (en) 2020-02-18
MX2014009298A (es) 2014-10-14
IL233825A (en) 2017-03-30
KR102101702B1 (ko) 2020-04-20
RS54539B1 (en) 2016-06-30
PL2817301T3 (pl) 2016-05-31
BR112014018657A2 (ru) 2017-06-20
UA113189C2 (xx) 2016-12-26
HUE027445T2 (en) 2016-09-28
JP2015506995A (ja) 2015-03-05
US9163013B2 (en) 2015-10-20
SI2817301T1 (sl) 2016-03-31
CY1117467T1 (el) 2017-04-26

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