CY1117467T1 - Χρηση των ενωσεων 1η-ινδαζολης-3- καρβοξαμιδης ως αναστολεις της κινασης 3 β της συνθασης γλυκογονου - Google Patents

Χρηση των ενωσεων 1η-ινδαζολης-3- καρβοξαμιδης ως αναστολεις της κινασης 3 β της συνθασης γλυκογονου

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Publication number
CY1117467T1
CY1117467T1 CY20161100218T CY161100218T CY1117467T1 CY 1117467 T1 CY1117467 T1 CY 1117467T1 CY 20161100218 T CY20161100218 T CY 20161100218T CY 161100218 T CY161100218 T CY 161100218T CY 1117467 T1 CY1117467 T1 CY 1117467T1
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Cyprus
Prior art keywords
disorders
compounds
inhibitors
carboxamide
indiazol
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CY20161100218T
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English (en)
Inventor
Maria Alessandra Alisi
Nicola Cazzolla
Barbara Garofalo
Guido Furlotti
Gabriele Magaro'
Rosella Ombrato
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Aziende Chimiche Riunite Angelini Francesco - A.C.R.A.F. - S.P.A.
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Application filed by Aziende Chimiche Riunite Angelini Francesco - A.C.R.A.F. - S.P.A. filed Critical Aziende Chimiche Riunite Angelini Francesco - A.C.R.A.F. - S.P.A.
Publication of CY1117467T1 publication Critical patent/CY1117467T1/el

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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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Abstract

Ενώσεις 1Η-ινδαζολη-3-καρβοξαμίδης ως αναστολείς της κινάσης 3 βήτα της συνθάσης γλυκογόνου. Η παρούσα εφεύρεση αναφέρεται σε ενώσεις 1Η-ινδαζολη-3-καρβοξαμίδης που χρησιμοποιούνται ως αναστολείς της κινάσης 3 βήτα της συνθάσης του γλυκογόνου (GSK-3β) και στην χρήση τους για την αντιμετώπιση διαταραχών που σχετίζονται με την GSΚ-3β όπως είναι, για παράδειγμα, (i) οι διαταραχές ανθεκτικότητας στην ινσουλίνη, (ii) νευροεκφυλιστικές παθήσεις, (iii) διαταραχές της διάθεσης, (iv) σχιζοφρενικές διαταραχές, (v) καρκινικές διαταραχές, (vi) η φλεγμονή, (vii) οι διαταραχές κατάχρησης ουσιών, και (viii) οι επιληψίες.
CY20161100218T 2012-02-21 2016-03-15 Χρηση των ενωσεων 1η-ινδαζολης-3- καρβοξαμιδης ως αναστολεις της κινασης 3 β της συνθασης γλυκογονου CY1117467T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12156298 2012-02-21
EP13703799.0A EP2817301B1 (en) 2012-02-21 2013-02-08 Use of 1h-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors

Publications (1)

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CY1117467T1 true CY1117467T1 (el) 2017-04-26

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US (2) US9163013B2 (el)
EP (1) EP2817301B1 (el)
JP (1) JP6285873B2 (el)
KR (1) KR102101702B1 (el)
CN (1) CN104080781B (el)
AR (1) AR090085A1 (el)
AU (1) AU2013224313B2 (el)
BR (1) BR112014018657B1 (el)
CA (1) CA2860466C (el)
CY (1) CY1117467T1 (el)
DK (1) DK2817301T3 (el)
EA (1) EA026952B1 (el)
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GE (1) GEP201606552B (el)
HK (1) HK1203931A1 (el)
HR (1) HRP20160124T1 (el)
HU (1) HUE027445T2 (el)
IL (1) IL233825A (el)
MX (1) MX351288B (el)
PL (1) PL2817301T3 (el)
PT (1) PT2817301E (el)
RS (1) RS54539B1 (el)
SG (2) SG10201701171TA (el)
SI (1) SI2817301T1 (el)
SM (1) SMT201600054B (el)
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KR102101702B1 (ko) * 2012-02-21 2020-04-20 아지엔드 키미쉐 리유나이트 안젤리니 프란체스코 에이.씨.알.에이.에프. 에스.피.에이 글리코겐 합성효소 키나아제 3 베타 억제제로서 1h-인다졸-3-카복사미드 화합물의 용도
US10954240B2 (en) 2014-09-03 2021-03-23 Merck Sharp & Dohme Corp. Compounds inhibiting leucine-rich repeat kinase enzyme activity
EP3307725A1 (en) 2015-06-11 2018-04-18 Basilea Pharmaceutica International AG Efflux-pump inhibitors and therapeutic uses thereof
WO2017093157A1 (en) * 2015-11-30 2017-06-08 Basilea Pharmaceutica Ag Piperidine, pyrrolidine and 2-oxo-1,3-oxazinane derivatives as inhibitors of bacterial efflux-pumps for the treatment of microbial infections
KR20190015748A (ko) * 2016-06-08 2019-02-14 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 Atf4 경로 억제제로서의 화학적 화합물
PT3790873T (pt) 2018-05-07 2022-05-11 Acraf Compostos de 1h-indazole-3-carboxamida como inibidores da glicogénio sintase cinase 3 beta
CN117186027B (zh) * 2023-09-11 2024-04-19 上海蓝木化工有限公司 一种糖原合酶激酶-3抑制剂及其制备方法

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HK1203931A1 (zh) 2015-11-06
US20140378455A1 (en) 2014-12-25
MX351288B (es) 2017-10-09
BR112014018657A8 (pt) 2017-07-11
DK2817301T3 (en) 2016-03-14
WO2013124169A1 (en) 2013-08-29
SI2817301T1 (sl) 2016-03-31
JP2015506995A (ja) 2015-03-05
HRP20160124T1 (hr) 2016-03-11
UA113189C2 (xx) 2016-12-26
US9163013B2 (en) 2015-10-20
KR102101702B1 (ko) 2020-04-20
CA2860466A1 (en) 2013-08-29
SG10201701171TA (en) 2017-04-27
IL233825A (en) 2017-03-30
PT2817301E (pt) 2016-03-14
GEP201606552B (en) 2016-10-10
PL2817301T3 (pl) 2016-05-31
RS54539B1 (en) 2016-06-30
EA201491448A1 (ru) 2014-11-28
HUE027445T2 (en) 2016-09-28
US20160045485A1 (en) 2016-02-18
CN104080781A (zh) 2014-10-01
AU2013224313A8 (en) 2014-09-18
BR112014018657A2 (el) 2017-06-20
CA2860466C (en) 2020-02-18
EA026952B1 (ru) 2017-06-30
EP2817301B1 (en) 2015-12-23
CN104080781B (zh) 2016-05-11
SMT201600054B (it) 2016-04-29
EP2817301A1 (en) 2014-12-31
BR112014018657B1 (pt) 2022-08-02
ES2564033T3 (es) 2016-03-17
KR20140122725A (ko) 2014-10-20
AU2013224313A1 (en) 2014-07-17
MX2014009298A (es) 2014-10-14
SG11201403788VA (en) 2014-08-28
JP6285873B2 (ja) 2018-02-28
US9700551B2 (en) 2017-07-11
AR090085A1 (es) 2014-10-15
AU2013224313B2 (en) 2017-03-30
IL233825A0 (en) 2014-09-30

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