MX2014012635A - Derivados de isoindolona. - Google Patents
Derivados de isoindolona.Info
- Publication number
- MX2014012635A MX2014012635A MX2014012635A MX2014012635A MX2014012635A MX 2014012635 A MX2014012635 A MX 2014012635A MX 2014012635 A MX2014012635 A MX 2014012635A MX 2014012635 A MX2014012635 A MX 2014012635A MX 2014012635 A MX2014012635 A MX 2014012635A
- Authority
- MX
- Mexico
- Prior art keywords
- carbon atoms
- alkylene
- alkyl
- tetrahydro
- methyl
- Prior art date
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Classifications
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- C07—ORGANIC CHEMISTRY
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- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2012/074411 WO2013155695A1 (en) | 2012-04-20 | 2012-04-20 | Isoindolone derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2014012635A true MX2014012635A (es) | 2015-05-15 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014012635A MX2014012635A (es) | 2012-04-20 | 2012-04-20 | Derivados de isoindolona. |
| MX2014012695A MX2014012695A (es) | 2012-04-20 | 2013-04-19 | Derivados de isoindolona. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014012695A MX2014012695A (es) | 2012-04-20 | 2013-04-19 | Derivados de isoindolona. |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US9776990B2 (enExample) |
| EP (2) | EP2838881B1 (enExample) |
| JP (2) | JP5989229B2 (enExample) |
| CN (1) | CN104334526A (enExample) |
| CA (2) | CA2870931A1 (enExample) |
| HK (1) | HK1206744A1 (enExample) |
| MX (2) | MX2014012635A (enExample) |
| WO (2) | WO2013155695A1 (enExample) |
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| WO2013097052A1 (en) * | 2011-12-30 | 2013-07-04 | Abbott Laboratories | Bromodomain inhibitors |
| CN104334526A (zh) * | 2012-04-20 | 2015-02-04 | 艾伯维公司 | 异吲哚酮衍生物 |
| US9365576B2 (en) | 2012-05-24 | 2016-06-14 | Novartis Ag | Pyrrolopyrrolidinone compounds |
| WO2014080291A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Biaryl derivatives as bromodomain inhibitors |
| WO2014080290A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Cyclic amines as bromodomain inhibitors |
| JP2016507496A (ja) | 2012-12-21 | 2016-03-10 | ゼニス・エピジェネティクス・コーポレイションZenith Epigenetics Corp. | ブロモドメイン阻害剤としての新規複素環式化合物 |
| US9556180B2 (en) | 2013-01-22 | 2017-01-31 | Novartis Ag | Pyrazolo[3,4-d]pyrimidinone compounds as inhibitors of the P53/MDM2 interaction |
| US9403827B2 (en) | 2013-01-22 | 2016-08-02 | Novartis Ag | Substituted purinone compounds |
| AU2014220838A1 (en) | 2013-02-19 | 2015-09-10 | Bayer Pharma Aktiengesellschaft | Bicyclo 2,3-benzodiazepines and spirocyclically substituted 2,3-benzodiazepines |
| JP2016513117A (ja) | 2013-02-22 | 2016-05-12 | バイエル ファーマ アクチエンゲゼルシャフト | 過剰増殖性疾患を治療するためのbetタンパク質阻害剤としてのピロロ−およびピラゾロ−トリアゾロジアゼピン類 |
| HK1212345A1 (en) | 2013-02-22 | 2016-06-10 | Bayer Pharma Aktiengesellschaft | 4-substituted pyrrolo- and pyrazolo-diazepines |
| EP2970312B1 (en) | 2013-03-11 | 2017-11-15 | The Regents of The University of Michigan | Bet bromodomain inhibitors and therapeutic methods using the same |
| CA2903881C (en) | 2013-03-15 | 2021-05-18 | Incyte Corporation | Tricyclic heterocycles as bet protein inhibitors |
| WO2014191894A1 (en) | 2013-05-27 | 2014-12-04 | Novartis Ag | Imidazopyrrolidinone derivatives and their use in the treatment of disease |
| MX2015016421A (es) | 2013-05-28 | 2016-03-03 | Novartis Ag | Derivados de pirazolo-pirrolidin-4-ona como inhibidores de bet y su uso en el tratamiento de enfermedades. |
| PT3004112T (pt) | 2013-05-28 | 2017-12-11 | Novartis Ag | Derivados de pirazolo-pirrolidin-4-ona e sua utilização no tratamento de doença |
| MX365864B (es) | 2013-06-21 | 2019-06-18 | Zenith Epigenetics Ltd | Inhibidores de bromodominio biciclicos novedosos. |
| CA2915622C (en) | 2013-06-21 | 2020-08-18 | Zenith Epigenetics Corp. | Novel substituted bicyclic compounds as bromodomain inhibitors |
| EP3019502B1 (en) | 2013-07-08 | 2017-05-17 | Incyte Holdings Corporation | Tricyclic heterocycles as bet protein inhibitors |
| EA201690087A1 (ru) | 2013-07-31 | 2016-08-31 | Зенит Эпидженетикс Корп. | Новые квиназолиноны как ингибиторы бромодомена |
| WO2015075665A1 (en) | 2013-11-21 | 2015-05-28 | Novartis Ag | Pyrrolopyrrolone derivatives and their use as bet inhibitors |
| WO2015081203A1 (en) | 2013-11-26 | 2015-06-04 | Incyte Corporation | Bicyclic heterocycles as bet protein inhibitors |
| US9315501B2 (en) | 2013-11-26 | 2016-04-19 | Incyte Corporation | Bicyclic heterocycles as BET protein inhibitors |
| US9309246B2 (en) | 2013-12-19 | 2016-04-12 | Incyte Corporation | Tricyclic heterocycles as BET protein inhibitors |
| AU2015222887B2 (en) | 2014-02-28 | 2019-06-27 | The Regents Of The University Of Michigan | 9H-pyrimido[4,5-b]indoles and related analogs as BET bromodomain inhibitors |
| WO2015164480A1 (en) | 2014-04-23 | 2015-10-29 | Incyte Corporation | 1H-PYRROLO[2,3-c]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-c]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS |
| US9527864B2 (en) | 2014-09-15 | 2016-12-27 | Incyte Corporation | Tricyclic heterocycles as BET protein inhibitors |
| US10179125B2 (en) | 2014-12-01 | 2019-01-15 | Zenith Epigenetics Ltd. | Substituted pyridines as bromodomain inhibitors |
| WO2016087936A1 (en) | 2014-12-01 | 2016-06-09 | Zenith Epigenetics Corp. | Substituted pyridinones as bromodomain inhibitors |
| CN107207474B (zh) | 2014-12-11 | 2021-05-07 | 恒翼生物医药科技(上海)有限公司 | 被取代的杂环作为溴结构域抑制剂 |
| JP2017538721A (ja) | 2014-12-17 | 2017-12-28 | ゼニス・エピジェネティクス・リミテッドZenith Epigenetics Ltd. | ブロモドメインの阻害剤 |
| EP3262045A1 (en) | 2015-02-27 | 2018-01-03 | The Regents of The University of Michigan | 9h-pyrimido [4,5-b]indoles as bet bromodomain inhibitors |
| GB201504694D0 (en) | 2015-03-19 | 2015-05-06 | Glaxosmithkline Ip Dev Ltd | Covalent conjugates |
| KR20180022992A (ko) * | 2015-07-02 | 2018-03-06 | 오리온 코포레이션 | 브로모도메인 억제제로서 바이사이클릭 헤테로사이클 유도체 |
| WO2017025419A2 (de) | 2015-08-07 | 2017-02-16 | Bayer Cropscience Aktiengesellschaft | 2-(het)aryl-substituierte kondensierte heterocyclen-derivate als schädlingsbekämpfungsmittel |
| TW201722966A (zh) | 2015-10-29 | 2017-07-01 | 英塞特公司 | Bet蛋白質抑制劑之非晶固體形式 |
| WO2017142881A1 (en) | 2016-02-15 | 2017-08-24 | The Regents Of The University Of Michigan | Fused 1,4-oxazepines and related analogs as bet bromodomain inhibitors |
| CA3020281A1 (en) | 2016-04-06 | 2017-10-12 | The Regents Of The University Of Michigan | Monofunctional intermediates for ligand-dependent target protein degradation |
| JP7037500B2 (ja) | 2016-04-06 | 2022-03-16 | ザ リージェンツ オブ ザ ユニヴァシティ オブ ミシガン | Mdm2タンパク質分解剤 |
| UA123168C2 (uk) | 2016-04-12 | 2021-02-24 | Дзе Ріджентс Оф Дзе Юніверсіті Оф Мічіган | Деструктори білка вет |
| ES2793239T3 (es) | 2016-04-15 | 2020-11-13 | Abbvie Inc | Inhibidores del bromodominio |
| SMT202300155T1 (it) | 2016-06-20 | 2023-07-20 | Incyte Corp | Forme solide cristalline di un inibitore di bet |
| JP7035027B2 (ja) | 2016-09-13 | 2022-03-14 | ザ リージェンツ オブ ザ ユニヴァシティ オブ ミシガン | Betタンパク質分解物質としての縮合1,4-ジアゼピン |
| CN110062759B (zh) | 2016-09-13 | 2022-05-24 | 密执安大学评议会 | 作为bet蛋白降解剂的稠合的1,4-氧氮杂䓬 |
| CN108069959A (zh) * | 2016-11-10 | 2018-05-25 | 凯惠科技发展(上海)有限公司 | 一种含氮杂环类化合物、其制备方法、药物组合物及应用 |
| EP3577120A1 (en) | 2017-02-03 | 2019-12-11 | The Regents of The University of Michigan | Fused 1,4-diazepines as bet bromodomain inhibitors |
| US11267822B2 (en) | 2017-09-13 | 2022-03-08 | The Regents Of The University Of Michigan | BET bromodomain protein degraders with cleavable linkers |
| US20220055989A1 (en) | 2018-12-21 | 2022-02-24 | Albert Ludwing Universität Freiburg | Condensed pyrroles as novel bromodomain inhibitors |
| US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
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| GB0919432D0 (en) | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Use |
| GB0919434D0 (en) | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Novel compounds |
| GB0919426D0 (en) | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Novel compounds |
| ES2539964T3 (es) | 2009-11-05 | 2015-07-07 | Glaxosmithkline Llc | Procedimiento novedoso |
| MX2012005295A (es) | 2009-11-05 | 2012-06-19 | Glaxosmithkline Llc | Inhibidor de bromodominio de benzodiazepina. |
| GB0919423D0 (en) | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Novel compounds |
| WO2012075456A1 (en) | 2010-12-02 | 2012-06-07 | Constellation Pharmaceuticals | Bromodomain inhibitors and uses thereof |
| CN104334526A (zh) * | 2012-04-20 | 2015-02-04 | 艾伯维公司 | 异吲哚酮衍生物 |
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2012
- 2012-04-20 CN CN201280073829.3A patent/CN104334526A/zh active Pending
- 2012-04-20 MX MX2014012635A patent/MX2014012635A/es unknown
- 2012-04-20 WO PCT/CN2012/074411 patent/WO2013155695A1/en not_active Ceased
- 2012-04-20 JP JP2015506064A patent/JP5989229B2/ja not_active Expired - Fee Related
- 2012-04-20 HK HK15107457.4A patent/HK1206744A1/xx unknown
- 2012-04-20 EP EP12874480.2A patent/EP2838881B1/en not_active Not-in-force
- 2012-04-20 CA CA 2870931 patent/CA2870931A1/en not_active Abandoned
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2013
- 2013-03-12 US US13/796,731 patent/US9776990B2/en not_active Expired - Fee Related
- 2013-04-19 WO PCT/US2013/037297 patent/WO2013158952A1/en not_active Ceased
- 2013-04-19 US US14/395,628 patent/US20150111890A1/en not_active Abandoned
- 2013-04-19 EP EP13719348.8A patent/EP2850071A1/en not_active Withdrawn
- 2013-04-19 MX MX2014012695A patent/MX2014012695A/es unknown
- 2013-04-19 CA CA 2870446 patent/CA2870446A1/en not_active Abandoned
- 2013-04-19 JP JP2015507204A patent/JP2015514780A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA2870931A1 (en) | 2013-10-24 |
| EP2838881A4 (en) | 2015-10-28 |
| HK1206744A1 (en) | 2016-01-15 |
| MX2014012695A (es) | 2014-12-05 |
| EP2838881B1 (en) | 2018-08-08 |
| JP2015514725A (ja) | 2015-05-21 |
| JP2015514780A (ja) | 2015-05-21 |
| US20150111890A1 (en) | 2015-04-23 |
| WO2013158952A1 (en) | 2013-10-24 |
| EP2850071A1 (en) | 2015-03-25 |
| EP2838881A1 (en) | 2015-02-25 |
| CN104334526A (zh) | 2015-02-04 |
| CA2870446A1 (en) | 2013-10-24 |
| WO2013155695A1 (en) | 2013-10-24 |
| JP5989229B2 (ja) | 2016-09-07 |
| US20130281450A1 (en) | 2013-10-24 |
| US9776990B2 (en) | 2017-10-03 |
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