HK1206744A1 - Isoindolone derivatives - Google Patents
Isoindolone derivatives Download PDFInfo
- Publication number
- HK1206744A1 HK1206744A1 HK15107457.4A HK15107457A HK1206744A1 HK 1206744 A1 HK1206744 A1 HK 1206744A1 HK 15107457 A HK15107457 A HK 15107457A HK 1206744 A1 HK1206744 A1 HK 1206744A1
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- HK
- Hong Kong
- Prior art keywords
- alkylene
- alkyl
- tetrahydro
- isoindol
- methyl
- Prior art date
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- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2012/074411 WO2013155695A1 (en) | 2012-04-20 | 2012-04-20 | Isoindolone derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1206744A1 true HK1206744A1 (en) | 2016-01-15 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK15107457.4A HK1206744A1 (en) | 2012-04-20 | 2012-04-20 | Isoindolone derivatives |
Country Status (8)
| Country | Link |
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| US (2) | US9776990B2 (enExample) |
| EP (2) | EP2838881B1 (enExample) |
| JP (2) | JP5989229B2 (enExample) |
| CN (1) | CN104334526A (enExample) |
| CA (2) | CA2870931A1 (enExample) |
| HK (1) | HK1206744A1 (enExample) |
| MX (2) | MX2014012635A (enExample) |
| WO (2) | WO2013155695A1 (enExample) |
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| HK1206744A1 (en) * | 2012-04-20 | 2016-01-15 | Abbvie Inc. | Isoindolone derivatives |
| WO2013175417A1 (en) | 2012-05-24 | 2013-11-28 | Novartis Ag | Pyrrolopyrrolidinone compounds |
| WO2014080291A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Biaryl derivatives as bromodomain inhibitors |
| WO2014080290A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Cyclic amines as bromodomain inhibitors |
| AU2013365926B9 (en) | 2012-12-21 | 2019-01-17 | Zenith Epigenetics Ltd. | Novel heterocyclic compounds as bromodomain inhibitors |
| WO2014115077A1 (en) | 2013-01-22 | 2014-07-31 | Novartis Ag | Substituted purinone compounds |
| EP2948453B1 (en) | 2013-01-22 | 2017-08-02 | Novartis AG | Pyrazolo[3,4-d]pyrimidinone compounds as inhibitors of the p53/mdm2 interaction |
| CA2901352A1 (en) | 2013-02-19 | 2014-08-28 | Bayer Pharma Aktiengesellschaft | Bicyclo 2,3-benzodiazepines and spirocyclically substituted 2,3-benzodiazepines |
| WO2014128070A1 (de) | 2013-02-22 | 2014-08-28 | Bayer Pharma Aktiengesellschaft | Pyrrolo- und pyrazolo-triazolodiazepine als bet-proteininhibitoren zur behandlung von hyper-proliferativen erkrankungen |
| HK1212345A1 (en) | 2013-02-22 | 2016-06-10 | Bayer Pharma Aktiengesellschaft | 4-substituted pyrrolo- and pyrazolo-diazepines |
| CN105377851B (zh) | 2013-03-11 | 2018-07-20 | 密执安州立大学董事会 | Bet布罗莫结构域抑制剂和使用这些抑制剂的治疗方法 |
| TWI719464B (zh) | 2013-03-15 | 2021-02-21 | 美商英塞特控股公司 | 作為bet蛋白抑制劑之三環雜環 |
| MX2015016344A (es) | 2013-05-27 | 2016-03-01 | Novartis Ag | Derivados de imidazo-pirrolidinona y su uso en el tratamiento de enfermedades. |
| BR112015029353A2 (pt) | 2013-05-28 | 2017-07-25 | Novartis Ag | derivados de pirazolo-pirrolidin-4-ona e seu uso no tratamento de doenças |
| KR20160012195A (ko) | 2013-05-28 | 2016-02-02 | 노파르티스 아게 | Bet 억제제로서의 피라졸로-피롤리딘-4-온 유도체 및 질환의 치료에서의 그의 용도 |
| SI3010503T1 (sl) | 2013-06-21 | 2020-07-31 | Zenith Epigenetics Ltd. | Novi biciklični inhibitorji bromodomene |
| ES2661437T3 (es) | 2013-06-21 | 2018-04-02 | Zenith Epigenetics Corp. | Nuevos compuestos bicíclicos sustituidos como inhibidores de bromodominio |
| JP2016523964A (ja) | 2013-07-08 | 2016-08-12 | インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation | Betタンパク質阻害剤としての三環式複素環 |
| CN105593224B (zh) | 2013-07-31 | 2021-05-25 | 恒元生物医药科技(苏州)有限公司 | 作为溴结构域抑制剂的新型喹唑啉酮类化合物 |
| AU2014351413B2 (en) | 2013-11-21 | 2017-06-01 | Novartis Ag | Pyrrolopyrrolone derivatives and their use as BET inhibitors |
| WO2015081189A1 (en) | 2013-11-26 | 2015-06-04 | Incyte Corporation | Bicyclic heterocycles as bet protein inhibitors |
| WO2015081203A1 (en) | 2013-11-26 | 2015-06-04 | Incyte Corporation | Bicyclic heterocycles as bet protein inhibitors |
| US9309246B2 (en) | 2013-12-19 | 2016-04-12 | Incyte Corporation | Tricyclic heterocycles as BET protein inhibitors |
| WO2015131005A1 (en) | 2014-02-28 | 2015-09-03 | The Regents Of The University Of Michigan | 9h-pyrimido[4,5-b]indoles and related analogs as bet bromodomain inhibitors |
| KR20240134245A (ko) | 2014-04-23 | 2024-09-06 | 인사이트 홀딩스 코포레이션 | BET 단백질의 저해제로서의 1H-피롤로[2,3-c]피리딘-7(6H)-온 및 피라졸로[3,4-c]피리딘-7(6H)-온 |
| US9527864B2 (en) | 2014-09-15 | 2016-12-27 | Incyte Corporation | Tricyclic heterocycles as BET protein inhibitors |
| US10710992B2 (en) | 2014-12-01 | 2020-07-14 | Zenith Epigenetics Ltd. | Substituted pyridinones as bromodomain inhibitors |
| EP3227280B1 (en) | 2014-12-01 | 2019-04-24 | Zenith Epigenetics Ltd. | Substituted pyridines as bromodomain inhibitors |
| US10292968B2 (en) | 2014-12-11 | 2019-05-21 | Zenith Epigenetics Ltd. | Substituted heterocycles as bromodomain inhibitors |
| CA2966450A1 (en) | 2014-12-17 | 2016-06-23 | Olesya KHARENKO | Inhibitors of bromodomains |
| EP3262045A1 (en) | 2015-02-27 | 2018-01-03 | The Regents of The University of Michigan | 9h-pyrimido [4,5-b]indoles as bet bromodomain inhibitors |
| GB201504694D0 (en) | 2015-03-19 | 2015-05-06 | Glaxosmithkline Ip Dev Ltd | Covalent conjugates |
| KR20180022992A (ko) * | 2015-07-02 | 2018-03-06 | 오리온 코포레이션 | 브로모도메인 억제제로서 바이사이클릭 헤테로사이클 유도체 |
| CA2994604A1 (en) * | 2015-08-07 | 2017-02-16 | Bayer Cropscience Aktiengesellschaft | 2-(het)aryl-substituted condensed heterocyclic derivatives as pest control agents |
| US20170121347A1 (en) | 2015-10-29 | 2017-05-04 | Incyte Corporation | Amorphous solid form of a bet protein inhibitor |
| CA3014644A1 (en) | 2016-02-15 | 2017-08-24 | The Regents Of The University Of Michigan | Fused 1,4-oxazepines and related analogs as bet bromodomain inhibitors |
| WO2017176958A1 (en) | 2016-04-06 | 2017-10-12 | The Regents Of The University Of Michigan | Monofunctional intermediates for ligand-dependent target protein degradation |
| KR102387316B1 (ko) | 2016-04-06 | 2022-04-15 | 더 리젠츠 오브 더 유니버시티 오브 미시간 | Mdm2 단백질 분해제 |
| RU2752677C2 (ru) | 2016-04-12 | 2021-07-29 | Дзе Риджентс Оф Дзе Юниверсити Оф Мичиган | Деструкторы белка вет |
| WO2017177955A1 (en) | 2016-04-15 | 2017-10-19 | Abbvie Inc. | Bromodomain inhibitors |
| EP4234554A3 (en) | 2016-06-20 | 2023-12-27 | Incyte Corporation | Crystalline solid forms of a bet inhibitor |
| JP6961684B2 (ja) | 2016-09-13 | 2021-11-05 | ザ リージェンツ オブ ザ ユニヴァシティ オブ ミシガン | Betタンパク質分解物質としての縮合1,4−オキサゼピン |
| ES2857743T3 (es) | 2016-09-13 | 2021-09-29 | Univ Michigan Regents | 1,4-diazepinas fusionadas como degradadores de proteína BET |
| CN108069959A (zh) * | 2016-11-10 | 2018-05-25 | 凯惠科技发展(上海)有限公司 | 一种含氮杂环类化合物、其制备方法、药物组合物及应用 |
| EP3577120A1 (en) | 2017-02-03 | 2019-12-11 | The Regents of The University of Michigan | Fused 1,4-diazepines as bet bromodomain inhibitors |
| US11267822B2 (en) | 2017-09-13 | 2022-03-08 | The Regents Of The University Of Michigan | BET bromodomain protein degraders with cleavable linkers |
| US20220055989A1 (en) * | 2018-12-21 | 2022-02-24 | Albert Ludwing Universität Freiburg | Condensed pyrroles as novel bromodomain inhibitors |
| US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
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| GB0919432D0 (en) | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Use |
| WO2011054851A1 (en) | 2009-11-05 | 2011-05-12 | Glaxosmithkline Llc | Novel process |
| ES2652304T3 (es) | 2009-11-05 | 2018-02-01 | Glaxosmithkline Llc | Compuesto de benzodiacepina novedoso |
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| HK1206744A1 (en) * | 2012-04-20 | 2016-01-15 | Abbvie Inc. | Isoindolone derivatives |
-
2012
- 2012-04-20 HK HK15107457.4A patent/HK1206744A1/xx unknown
- 2012-04-20 MX MX2014012635A patent/MX2014012635A/es unknown
- 2012-04-20 CA CA 2870931 patent/CA2870931A1/en not_active Abandoned
- 2012-04-20 JP JP2015506064A patent/JP5989229B2/ja not_active Expired - Fee Related
- 2012-04-20 CN CN201280073829.3A patent/CN104334526A/zh active Pending
- 2012-04-20 WO PCT/CN2012/074411 patent/WO2013155695A1/en not_active Ceased
- 2012-04-20 EP EP12874480.2A patent/EP2838881B1/en not_active Not-in-force
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2013
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- 2013-04-19 CA CA 2870446 patent/CA2870446A1/en not_active Abandoned
- 2013-04-19 MX MX2014012695A patent/MX2014012695A/es unknown
- 2013-04-19 WO PCT/US2013/037297 patent/WO2013158952A1/en not_active Ceased
- 2013-04-19 EP EP13719348.8A patent/EP2850071A1/en not_active Withdrawn
- 2013-04-19 US US14/395,628 patent/US20150111890A1/en not_active Abandoned
- 2013-04-19 JP JP2015507204A patent/JP2015514780A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP2838881A1 (en) | 2015-02-25 |
| JP2015514725A (ja) | 2015-05-21 |
| US20150111890A1 (en) | 2015-04-23 |
| WO2013158952A1 (en) | 2013-10-24 |
| EP2838881A4 (en) | 2015-10-28 |
| WO2013155695A1 (en) | 2013-10-24 |
| MX2014012695A (es) | 2014-12-05 |
| JP2015514780A (ja) | 2015-05-21 |
| US9776990B2 (en) | 2017-10-03 |
| CA2870931A1 (en) | 2013-10-24 |
| EP2850071A1 (en) | 2015-03-25 |
| CN104334526A (zh) | 2015-02-04 |
| EP2838881B1 (en) | 2018-08-08 |
| JP5989229B2 (ja) | 2016-09-07 |
| MX2014012635A (es) | 2015-05-15 |
| CA2870446A1 (en) | 2013-10-24 |
| US20130281450A1 (en) | 2013-10-24 |
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