CN104334526A - 异吲哚酮衍生物 - Google Patents
异吲哚酮衍生物 Download PDFInfo
- Publication number
- CN104334526A CN104334526A CN201280073829.3A CN201280073829A CN104334526A CN 104334526 A CN104334526 A CN 104334526A CN 201280073829 A CN201280073829 A CN 201280073829A CN 104334526 A CN104334526 A CN 104334526A
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- Prior art keywords
- alkylene
- alkyl
- tetrahydro
- methyl
- isoindol
- Prior art date
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- 0 Cc(c(*)c1*)c(*)c(N)c1[Am] Chemical compound Cc(c(*)c1*)c(*)c(N)c1[Am] 0.000 description 2
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- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2012/074411 WO2013155695A1 (en) | 2012-04-20 | 2012-04-20 | Isoindolone derivatives |
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| CN104334526A true CN104334526A (zh) | 2015-02-04 |
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| EP (2) | EP2838881B1 (enExample) |
| JP (2) | JP5989229B2 (enExample) |
| CN (1) | CN104334526A (enExample) |
| CA (2) | CA2870931A1 (enExample) |
| HK (1) | HK1206744A1 (enExample) |
| MX (2) | MX2014012635A (enExample) |
| WO (2) | WO2013155695A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107810185A (zh) * | 2015-07-02 | 2018-03-16 | 奥赖恩公司 | 作为溴结构域抑制剂的二环杂环衍生物 |
| WO2018086585A1 (zh) * | 2016-11-10 | 2018-05-17 | 山东罗欣药业集团股份有限公司 | 一种含氮杂环类化合物、其制备方法、药物组合物及应用 |
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| JP6171003B2 (ja) | 2012-05-24 | 2017-07-26 | ノバルティス アーゲー | ピロロピロリジノン化合物 |
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| WO2014115077A1 (en) | 2013-01-22 | 2014-07-31 | Novartis Ag | Substituted purinone compounds |
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| WO2014128111A1 (de) | 2013-02-22 | 2014-08-28 | Bayer Pharma Aktiengesellschaft | 4-substituierte pyrrolo- und pyrazolo-diazepine |
| JP2016513117A (ja) | 2013-02-22 | 2016-05-12 | バイエル ファーマ アクチエンゲゼルシャフト | 過剰増殖性疾患を治療するためのbetタンパク質阻害剤としてのピロロ−およびピラゾロ−トリアゾロジアゼピン類 |
| US9675697B2 (en) | 2013-03-11 | 2017-06-13 | The Regents Of The University Of Michigan | BET bromodomain inhibitors and therapeutic methods using the same |
| ES2909778T3 (es) | 2013-03-15 | 2022-05-10 | Incyte Holdings Corp | Heterociclos tricíclicos como inhibidores de proteína BET para su uso en el tratamiento de una enfermedad proliferativa en combinación con un inhibidor de Janus quinasas |
| EP3004109A1 (en) | 2013-05-27 | 2016-04-13 | Novartis AG | Imidazopyrrolidinone derivatives and their use in the treatment of disease |
| JP2016520118A (ja) | 2013-05-28 | 2016-07-11 | ノバルティス アーゲー | Bet阻害剤としてのピラゾロ−ピロリジン−4−オン誘導体および疾患の処置におけるその使用 |
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| WO2015004533A2 (en) | 2013-06-21 | 2015-01-15 | Zenith Epigenetics Corp. | Novel substituted bicyclic compounds as bromodomain inhibitors |
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| SG10201809353TA (en) | 2014-04-23 | 2018-11-29 | Incyte Corp | 1H-PYRROLO[2,3-c]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-c]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS |
| WO2016044130A1 (en) | 2014-09-15 | 2016-03-24 | Incyte Corporation | Tricyclic heterocycles for use as bet protein inhibitors |
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| US10231953B2 (en) | 2014-12-17 | 2019-03-19 | Zenith Epigenetics Ltd. | Inhibitors of bromodomains |
| EP3262045A1 (en) | 2015-02-27 | 2018-01-03 | The Regents of The University of Michigan | 9h-pyrimido [4,5-b]indoles as bet bromodomain inhibitors |
| GB201504694D0 (en) | 2015-03-19 | 2015-05-06 | Glaxosmithkline Ip Dev Ltd | Covalent conjugates |
| JP6913076B2 (ja) * | 2015-08-07 | 2021-08-04 | バイエル・クロップサイエンス・アクチェンゲゼルシャフト | 有害生物防除剤としての2−(ヘタ)アリール−置換縮合ヘテロ環誘導体 |
| AR106520A1 (es) | 2015-10-29 | 2018-01-24 | Incyte Corp | Forma sólida amorfa de un inhibidor de proteína bet |
| ES2882066T3 (es) | 2016-02-15 | 2021-12-01 | Univ Michigan Regents | 1,4-oxazepinas fusionadas y análogos relacionados como inhibidores de bromodominio BET |
| CN113788818A (zh) | 2016-04-06 | 2021-12-14 | 密执安大学评议会 | Mdm2蛋白质降解剂 |
| US10759808B2 (en) | 2016-04-06 | 2020-09-01 | The Regents Of The University Of Michigan | Monofunctional intermediates for ligand-dependent target protein degradation |
| UA123168C2 (uk) | 2016-04-12 | 2021-02-24 | Дзе Ріджентс Оф Дзе Юніверсіті Оф Мічіган | Деструктори білка вет |
| EP3693369A3 (en) | 2016-04-15 | 2020-09-09 | AbbVie Inc. | Bromodomain inhibitors |
| TWI830533B (zh) | 2016-06-20 | 2024-01-21 | 美商英塞特公司 | Bet抑制劑之結晶固體形式 |
| CA3036841A1 (en) | 2016-09-13 | 2018-03-22 | The Regents Of The University Of Michigan | Fused 1,4-diazepines as bet protein degraders |
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| WO2019055444A1 (en) | 2017-09-13 | 2019-03-21 | The Regents Of The University Of Michigan | DEGRADATION AGENTS OF BROMODOMAIN BET PROTEIN WITH CLEAR BINDERS |
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2012
- 2012-04-20 CA CA 2870931 patent/CA2870931A1/en not_active Abandoned
- 2012-04-20 JP JP2015506064A patent/JP5989229B2/ja not_active Expired - Fee Related
- 2012-04-20 HK HK15107457.4A patent/HK1206744A1/xx unknown
- 2012-04-20 WO PCT/CN2012/074411 patent/WO2013155695A1/en not_active Ceased
- 2012-04-20 CN CN201280073829.3A patent/CN104334526A/zh active Pending
- 2012-04-20 EP EP12874480.2A patent/EP2838881B1/en not_active Not-in-force
- 2012-04-20 MX MX2014012635A patent/MX2014012635A/es unknown
-
2013
- 2013-03-12 US US13/796,731 patent/US9776990B2/en not_active Expired - Fee Related
- 2013-04-19 WO PCT/US2013/037297 patent/WO2013158952A1/en not_active Ceased
- 2013-04-19 EP EP13719348.8A patent/EP2850071A1/en not_active Withdrawn
- 2013-04-19 CA CA 2870446 patent/CA2870446A1/en not_active Abandoned
- 2013-04-19 JP JP2015507204A patent/JP2015514780A/ja active Pending
- 2013-04-19 US US14/395,628 patent/US20150111890A1/en not_active Abandoned
- 2013-04-19 MX MX2014012695A patent/MX2014012695A/es unknown
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107810185A (zh) * | 2015-07-02 | 2018-03-16 | 奥赖恩公司 | 作为溴结构域抑制剂的二环杂环衍生物 |
| WO2018086585A1 (zh) * | 2016-11-10 | 2018-05-17 | 山东罗欣药业集团股份有限公司 | 一种含氮杂环类化合物、其制备方法、药物组合物及应用 |
| CN110088101A (zh) * | 2016-11-10 | 2019-08-02 | 罗欣药业(上海)有限公司 | 一种含氮杂环类化合物、其制备方法、药物组合物及应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2015514780A (ja) | 2015-05-21 |
| MX2014012695A (es) | 2014-12-05 |
| HK1206744A1 (en) | 2016-01-15 |
| MX2014012635A (es) | 2015-05-15 |
| EP2838881B1 (en) | 2018-08-08 |
| CA2870446A1 (en) | 2013-10-24 |
| EP2838881A4 (en) | 2015-10-28 |
| WO2013158952A1 (en) | 2013-10-24 |
| US9776990B2 (en) | 2017-10-03 |
| JP5989229B2 (ja) | 2016-09-07 |
| EP2850071A1 (en) | 2015-03-25 |
| CA2870931A1 (en) | 2013-10-24 |
| EP2838881A1 (en) | 2015-02-25 |
| JP2015514725A (ja) | 2015-05-21 |
| US20150111890A1 (en) | 2015-04-23 |
| US20130281450A1 (en) | 2013-10-24 |
| WO2013155695A1 (en) | 2013-10-24 |
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